Application 021254

Type: NDA
Sponsor: GLAXO GRP LTD

Application Products#

Product, Drug, Ingredient table
Product	Drug	Ingredient	Form	Strength	Reference drug	Reference standard
001	ADVAIR HFA	FLUTICASONE PROPIONATE; SALMETEROL XINAFOATE	AEROSOL, METERED;INHALATION	0.045MG/INH;EQ 0.021MG BASE/INH	Yes	Yes
002	ADVAIR HFA	FLUTICASONE PROPIONATE; SALMETEROL XINAFOATE	AEROSOL, METERED;INHALATION	0.115MG/INH;EQ 0.021MG BASE/INH	Yes	Yes
003	ADVAIR HFA	FLUTICASONE PROPIONATE; SALMETEROL XINAFOATE	AEROSOL, METERED;INHALATION	0.23MG/INH;EQ 0.021MG BASE/INH	Yes	Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 3 matching rows.

Application-product, Trade name, Ingredient table
Application-product	Trade name	Ingredient	Strength	Dosage form / route	RLD / RS	Approval date
N021254-001	ADVAIR HFA	FLUTICASONE PROPIONATE; SALMETEROL XINAFOATE	0.045MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08
N021254-002	ADVAIR HFA	FLUTICASONE PROPIONATE; SALMETEROL XINAFOATE	0.115MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08
N021254-003	ADVAIR HFA	FLUTICASONE PROPIONATE; SALMETEROL XINAFOATE	0.23MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 4 · 123 observed states.

Captured, Edition, Application-product table
Captured	Edition	Application-product	Trade name	Strength	Dosage form / route	RLD / RS	Approval date	Source SHA-256
2026-02-19 14:30 UTC	2026-02	N021254-001	ADVAIR HFA	0.045MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`011fe1cb6892…`
2026-02-19 14:30 UTC	2026-02	N021254-002	ADVAIR HFA	0.115MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`011fe1cb6892…`
2026-02-19 14:30 UTC	2026-02	N021254-003	ADVAIR HFA	0.23MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`011fe1cb6892…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N021254-001	ADVAIR HFA	0.045MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`31067a03dcf5…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N021254-002	ADVAIR HFA	0.115MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`31067a03dcf5…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N021254-003	ADVAIR HFA	0.23MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`31067a03dcf5…`
2025-08-23 18:47 UTC	2025-08	N021254-001	ADVAIR HFA	0.045MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`6a471c1ec25d…`
2025-08-23 18:47 UTC	2025-08	N021254-002	ADVAIR HFA	0.115MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`6a471c1ec25d…`
2025-08-23 18:47 UTC	2025-08	N021254-003	ADVAIR HFA	0.23MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`6a471c1ec25d…`
2025-03-22 03:13 UTC · 3 captures of this ZIP	2025-03	N021254-001	ADVAIR HFA	0.045MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`fd3edfee7708…`
2025-03-22 03:13 UTC · 3 captures of this ZIP	2025-03	N021254-002	ADVAIR HFA	0.115MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`fd3edfee7708…`
2025-03-22 03:13 UTC · 3 captures of this ZIP	2025-03	N021254-003	ADVAIR HFA	0.23MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`fd3edfee7708…`
2025-02-26 10:13 UTC · 3 captures of this ZIP	2025-02	N021254-001	ADVAIR HFA	0.045MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`b8a1b40f171c…`
2025-02-26 10:13 UTC · 3 captures of this ZIP	2025-02	N021254-002	ADVAIR HFA	0.115MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`b8a1b40f171c…`
2025-02-26 10:13 UTC · 3 captures of this ZIP	2025-02	N021254-003	ADVAIR HFA	0.23MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`b8a1b40f171c…`
2025-01-19 17:59 UTC · 7 captures of this ZIP	2025-01	N021254-001	ADVAIR HFA	0.045MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`03ed91905a0d…`
2025-01-19 17:59 UTC · 7 captures of this ZIP	2025-01	N021254-002	ADVAIR HFA	0.115MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`03ed91905a0d…`
2025-01-19 17:59 UTC · 7 captures of this ZIP	2025-01	N021254-003	ADVAIR HFA	0.23MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`03ed91905a0d…`
2024-12-13 21:23 UTC · 2 captures of this ZIP	2024-12	N021254-001	ADVAIR HFA	0.045MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`2680178bc6a6…`
2024-12-13 21:23 UTC · 2 captures of this ZIP	2024-12	N021254-002	ADVAIR HFA	0.115MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`2680178bc6a6…`
2024-12-13 21:23 UTC · 2 captures of this ZIP	2024-12	N021254-003	ADVAIR HFA	0.23MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`2680178bc6a6…`
2024-09-14 05:58 UTC · 2 captures of this ZIP	2024-09	N021254-001	ADVAIR HFA	0.045MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`5bbf6a4d5a75…`
2024-09-14 05:58 UTC · 2 captures of this ZIP	2024-09	N021254-002	ADVAIR HFA	0.115MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`5bbf6a4d5a75…`
2024-09-14 05:58 UTC · 2 captures of this ZIP	2024-09	N021254-003	ADVAIR HFA	0.23MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`5bbf6a4d5a75…`
2024-11-08 22:44 UTC · 3 captures of this ZIP	2024-11	N021254-001	ADVAIR HFA	0.045MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`d8e5a09893c0…`
2024-11-08 22:44 UTC · 3 captures of this ZIP	2024-11	N021254-002	ADVAIR HFA	0.115MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`d8e5a09893c0…`
2024-11-08 22:44 UTC · 3 captures of this ZIP	2024-11	N021254-003	ADVAIR HFA	0.23MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`d8e5a09893c0…`
2024-10-29 15:01 UTC	2024-10	N021254-001	ADVAIR HFA	0.045MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`d06236e962d9…`
2024-10-29 15:01 UTC	2024-10	N021254-002	ADVAIR HFA	0.115MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`d06236e962d9…`
2024-10-29 15:01 UTC	2024-10	N021254-003	ADVAIR HFA	0.23MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`d06236e962d9…`
2024-08-13 05:28 UTC · 3 captures of this ZIP	2024-08	N021254-001	ADVAIR HFA	0.045MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`79d66fd596c7…`
2024-08-13 05:28 UTC · 3 captures of this ZIP	2024-08	N021254-002	ADVAIR HFA	0.115MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`79d66fd596c7…`
2024-08-13 05:28 UTC · 3 captures of this ZIP	2024-08	N021254-003	ADVAIR HFA	0.23MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`79d66fd596c7…`
2024-07-13 05:37 UTC · 2 captures of this ZIP	2024-07	N021254-001	ADVAIR HFA	0.045MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`301d65b070ca…`
2024-07-13 05:37 UTC · 2 captures of this ZIP	2024-07	N021254-002	ADVAIR HFA	0.115MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`301d65b070ca…`
2024-07-13 05:37 UTC · 2 captures of this ZIP	2024-07	N021254-003	ADVAIR HFA	0.23MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`301d65b070ca…`
2024-06-18 03:08 UTC · 5 captures of this ZIP	2024-06	N021254-001	ADVAIR HFA	0.045MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`1e350fbaab3a…`
2024-06-18 03:08 UTC · 5 captures of this ZIP	2024-06	N021254-002	ADVAIR HFA	0.115MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`1e350fbaab3a…`
2024-06-18 03:08 UTC · 5 captures of this ZIP	2024-06	N021254-003	ADVAIR HFA	0.23MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`1e350fbaab3a…`
2024-05-31 18:47 UTC	2024-05	N021254-001	ADVAIR HFA	0.045MG/INH;EQ 0.021MG BASE/INH	AEROSOL, METERED / INHALATION	RLD, RS	2006-06-08	`8072bd15b7f6…`

Observed Orange Book patent history#

Patent history page 1 of 9 · 326 observed states.

Captured, Edition, Application-product table
Captured	Edition	Application-product	Patent	Expiration	Coverage / status	Submission date	Source SHA-256
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N021254-001	7832351	2023-06-19	Drug product	2012-09-06	`5c6f7cd8ea54…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N021254-001	7832351*PED	2023-12-19	Pediatric extension		`5c6f7cd8ea54…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N021254-001	7500444	2026-02-26	Drug product		`5c6f7cd8ea54…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N021254-001	7500444*PED	2026-08-26	Pediatric extension		`5c6f7cd8ea54…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N021254-002	7832351	2023-06-19	Drug product		`5c6f7cd8ea54…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N021254-002	7832351*PED	2023-12-19	Pediatric extension		`5c6f7cd8ea54…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N021254-002	7500444	2026-02-26	Drug product		`5c6f7cd8ea54…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N021254-002	7500444*PED	2026-08-26	Pediatric extension		`5c6f7cd8ea54…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N021254-003	7832351	2023-06-19	Drug product		`5c6f7cd8ea54…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N021254-003	7832351*PED	2023-12-19	Pediatric extension		`5c6f7cd8ea54…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N021254-003	7500444	2026-02-26	Drug product		`5c6f7cd8ea54…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N021254-003	7500444*PED	2026-08-26	Pediatric extension		`5c6f7cd8ea54…`
2022-04-08 23:34 UTC	2022-04	N021254-001	7832351	2023-06-19	Drug product	2012-09-06	`5d02ea3f76ae…`
2022-04-08 23:34 UTC	2022-04	N021254-001	7832351*PED	2023-12-19	Pediatric extension		`5d02ea3f76ae…`
2022-04-08 23:34 UTC	2022-04	N021254-001	7500444	2026-02-26	Drug product		`5d02ea3f76ae…`
2022-04-08 23:34 UTC	2022-04	N021254-001	7500444*PED	2026-08-26	Pediatric extension		`5d02ea3f76ae…`
2022-04-08 23:34 UTC	2022-04	N021254-002	7832351	2023-06-19	Drug product		`5d02ea3f76ae…`
2022-04-08 23:34 UTC	2022-04	N021254-002	7832351*PED	2023-12-19	Pediatric extension		`5d02ea3f76ae…`
2022-04-08 23:34 UTC	2022-04	N021254-002	7500444	2026-02-26	Drug product		`5d02ea3f76ae…`
2022-04-08 23:34 UTC	2022-04	N021254-002	7500444*PED	2026-08-26	Pediatric extension		`5d02ea3f76ae…`
2022-04-08 23:34 UTC	2022-04	N021254-003	7832351	2023-06-19	Drug product		`5d02ea3f76ae…`
2022-04-08 23:34 UTC	2022-04	N021254-003	7832351*PED	2023-12-19	Pediatric extension		`5d02ea3f76ae…`
2022-04-08 23:34 UTC	2022-04	N021254-003	7500444	2026-02-26	Drug product		`5d02ea3f76ae…`
2022-04-08 23:34 UTC	2022-04	N021254-003	7500444*PED	2026-08-26	Pediatric extension		`5d02ea3f76ae…`
2022-04-04 05:41 UTC	2022-04	N021254-001	7832351	2023-06-19	Drug product	2012-09-06	`4b0b4de00fa7…`
2022-04-04 05:41 UTC	2022-04	N021254-001	7832351*PED	2023-12-19	Pediatric extension		`4b0b4de00fa7…`
2022-04-04 05:41 UTC	2022-04	N021254-001	7500444	2026-02-26	Drug product		`4b0b4de00fa7…`
2022-04-04 05:41 UTC	2022-04	N021254-001	7500444*PED	2026-08-26	Pediatric extension		`4b0b4de00fa7…`
2022-04-04 05:41 UTC	2022-04	N021254-002	7832351	2023-06-19	Drug product		`4b0b4de00fa7…`
2022-04-04 05:41 UTC	2022-04	N021254-002	7832351*PED	2023-12-19	Pediatric extension		`4b0b4de00fa7…`
2022-04-04 05:41 UTC	2022-04	N021254-002	7500444	2026-02-26	Drug product		`4b0b4de00fa7…`
2022-04-04 05:41 UTC	2022-04	N021254-002	7500444*PED	2026-08-26	Pediatric extension		`4b0b4de00fa7…`
2022-04-04 05:41 UTC	2022-04	N021254-003	7832351	2023-06-19	Drug product		`4b0b4de00fa7…`
2022-04-04 05:41 UTC	2022-04	N021254-003	7832351*PED	2023-12-19	Pediatric extension		`4b0b4de00fa7…`
2022-04-04 05:41 UTC	2022-04	N021254-003	7500444	2026-02-26	Drug product		`4b0b4de00fa7…`
2022-04-04 05:41 UTC	2022-04	N021254-003	7500444*PED	2026-08-26	Pediatric extension		`4b0b4de00fa7…`
2019-12-13 00:20 UTC	2019-12	N021254-001	7350676*PED	2019-02-24	Pediatric extension		`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N021254-001	9861771	2020-10-11	Drug product	2018-03-22	`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N021254-001	7832351	2023-06-19	Drug product	2012-09-06	`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N021254-001	7832351*PED	2023-12-19	Pediatric extension		`74a2ff9319b5…`

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 4 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
ADVAIR HFA	FLUTICASONE PROPIONATE AND SALMETEROL XINAFOATE	A-S Medication Solutions	80b36523-4ae4-463e-b1fd-b929fb802b76	2025-08-08	Warnings, Adverse reactions	Exact identifier application applno (NDA): 021254 application number: NDA021254
ADVAIR HFA	FLUTICASONE PROPIONATE AND SALMETEROL XINAFOATE	A-S Medication Solutions	223fd5d4-3bd2-4e45-b72e-699438c32206	2025-08-08	Warnings, Adverse reactions	Exact identifier application applno (NDA): 021254 application number: NDA021254
Fluticasone Propionate and Salmeterol HFA	FLUTICASONE PROPIONATE AND SALMETEROL XINAFOATE	Prasco Laboratories	666c5b12-a4f7-4c53-8261-4742b5e5a6df	2024-05-29	Warnings, Adverse reactions	Exact identifier application applno (NDA): 021254 application number: NDA021254
ADVAIR HFA	FLUTICASONE PROPIONATE AND SALMETEROL XINAFOATE	GlaxoSmithKline LLC	dfaca6f9-3277-47b2-319d-1377917cb54c	2024-05-23	Warnings, Adverse reactions	Exact identifier application applno (NDA): 021254 application number: NDA021254 ndc (product): 0173-0717 ndc (product): 0173-0716 ndc (product): 0173-0715

NDC Listings For This Application#

NDC listings for this application page 1 of 1 · 18 matching rows.

NDC, Name, Nonproprietary name table
NDC	Name	Nonproprietary name	Labeler	Marketing category	Status
0173-0715	ADVAIR HFA	fluticasone propionate and salmeterol xinafoate	GlaxoSmithKline LLC	NDA	Current
0173-0715	ADVAIR HFA	fluticasone propionate and salmeterol xinafoate	GlaxoSmithKline LLC	NDA	Current
0173-0715	ADVAIR HFA	fluticasone propionate and salmeterol xinafoate	GlaxoSmithKline LLC	NDA	Current
0173-0715	ADVAIR HFA	fluticasone propionate and salmeterol xinafoate	GlaxoSmithKline LLC	NDA	Current
0173-0715	ADVAIR HFA	fluticasone propionate and salmeterol xinafoate	GlaxoSmithKline LLC	NDA	Current
0173-0715	ADVAIR HFA	fluticasone propionate and salmeterol xinafoate	GlaxoSmithKline LLC	NDA	Current
0173-0716	ADVAIR HFA	fluticasone propionate and salmeterol xinafoate	GlaxoSmithKline LLC	NDA	Current
0173-0716	ADVAIR HFA	fluticasone propionate and salmeterol xinafoate	GlaxoSmithKline LLC	NDA	Current
0173-0716	ADVAIR HFA	fluticasone propionate and salmeterol xinafoate	GlaxoSmithKline LLC	NDA	Current
0173-0716	ADVAIR HFA	fluticasone propionate and salmeterol xinafoate	GlaxoSmithKline LLC	NDA	Current
0173-0716	ADVAIR HFA	fluticasone propionate and salmeterol xinafoate	GlaxoSmithKline LLC	NDA	Current
0173-0716	ADVAIR HFA	fluticasone propionate and salmeterol xinafoate	GlaxoSmithKline LLC	NDA	Current
0173-0717	ADVAIR HFA	fluticasone propionate and salmeterol xinafoate	GlaxoSmithKline LLC	NDA	Current
0173-0717	ADVAIR HFA	fluticasone propionate and salmeterol xinafoate	GlaxoSmithKline LLC	NDA	Current
0173-0717	ADVAIR HFA	fluticasone propionate and salmeterol xinafoate	GlaxoSmithKline LLC	NDA	Current
0173-0717	ADVAIR HFA	fluticasone propionate and salmeterol xinafoate	GlaxoSmithKline LLC	NDA	Current
0173-0717	ADVAIR HFA	fluticasone propionate and salmeterol xinafoate	GlaxoSmithKline LLC	NDA	Current
0173-0717	ADVAIR HFA	fluticasone propionate and salmeterol xinafoate	GlaxoSmithKline LLC	NDA	Current

Documents#

Document, Submission type, Date table
Document	Submission type	Date
68420	SUPPL	2021-08-19
68408	SUPPL	2021-08-19
57518	SUPPL	2019-02-13
57131	SUPPL	2019-01-08
50875	SUPPL	2017-12-27
50841	SUPPL	2017-12-22
47492	SUPPL	2017-03-08
47457	SUPPL	2017-03-03
36479	SUPPL	2014-12-20
4798	SUPPL	2014-12-12
36480	SUPPL	2014-12-11
4797	SUPPL	2014-11-14
27227	SUPPL	2012-12-21
14761	SUPPL	2012-12-21
4796	SUPPL	2012-08-13
27231	SUPPL	2011-07-05
36478	SUPPL	2011-05-16
27230	SUPPL	2011-05-12
27228	SUPPL	2011-01-07
27229	SUPPL	2010-06-29
14762	SUPPL	2010-06-28
4795	SUPPL	2009-10-26
36477	SUPPL	2009-09-21
4794	SUPPL	2008-08-05
21551	ORIG	2008-05-06
36476	SUPPL	2008-03-24
4793	SUPPL	2008-03-21
23639	ORIG	2006-06-19
36475	ORIG	2006-06-14
4792	ORIG	2006-06-14
51121	SUPPL	1900-01-01
51120	SUPPL	1900-01-01
51119	SUPPL	1900-01-01