Application 021936

Type: NDA
Sponsor: BOEHRINGER INGELHEIM

Application Products#

Product, Drug, Ingredient table
Product	Drug	Ingredient	Form	Strength	Reference drug	Reference standard
001	SPIRIVA RESPIMAT	TIOTROPIUM BROMIDE	SPRAY, METERED;INHALATION	EQ 0.0025MG BASE/INH	Yes	Yes
002	SPIRIVA RESPIMAT	TIOTROPIUM BROMIDE	SPRAY, METERED;INHALATION	EQ 0.00125MG BASE/INH	Yes	No

Source provenance: Browse the complete Orange Book source catalog · source snapshot 44.

Orange Book products#

Current product rows page 1 of 1 · 2 matching rows.

Application-product, Trade name, Ingredient table
Application-product	Trade name	Ingredient	Strength	Dosage form / route	TE codes	RLD / RS	Approval date
N021936-001	SPIRIVA RESPIMAT	TIOTROPIUM BROMIDE	EQ 0.0025MG BASE/INH	SPRAY, METERED / INHALATION		RLD, RS	2014-09-24
N021936-002	SPIRIVA RESPIMAT	TIOTROPIUM BROMIDE	EQ 0.00125MG BASE/INH	SPRAY, METERED / INHALATION		RLD, RS	2015-09-15

Orange Book patents#

Current patent rows page 1 of 1 · 8 matching rows.

Application-product, Patent, Expiration table
Application-product	Patent	Expiration	Coverage / status	Submission date
N021936-001	7396341	2026-10-10	Drug product, Delist requested	2014-10-20
N021936-001	9027967	2027-03-31	Drug product, Delist requested	2015-09-15
N021936-001	7396341*PED	2027-04-10	Pediatric extension
N021936-001	9027967*PED	2027-09-30	Pediatric extension
N021936-001	7837235	2028-03-13	Drug product, Delist requested	2014-10-20
N021936-001	7837235*PED	2028-09-13	Pediatric extension
N021936-001	8733341	2030-10-16	Drug product, Delist requested	2015-09-15
N021936-001	8733341*PED	2031-04-16	Pediatric extension

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 2 of 3 · 88 observed states.

Captured, Edition, Application-product table
Captured	Edition	Application-product	Trade name	Strength	Dosage form / route	RLD / RS	Approval date	Source SHA-256
2019-12-13 00:20 UTC	2019-12	N021936-001	SPIRIVA RESPIMAT	EQ 0.0025MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2014-09-24	`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N021936-002	SPIRIVA RESPIMAT	EQ 0.00125MG BASE/INH	SPRAY, METERED / INHALATION	RLD	2015-09-15	`74a2ff9319b5…`
2022-03-09 01:35 UTC	2022-03	N021936-001	SPIRIVA RESPIMAT	EQ 0.0025MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2014-09-24	`bb7c543d1eb4…`
2022-03-09 01:35 UTC	2022-03	N021936-002	SPIRIVA RESPIMAT	EQ 0.00125MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2015-09-15	`bb7c543d1eb4…`
2021-12-28 21:50 UTC	2021-12	N021936-001	SPIRIVA RESPIMAT	EQ 0.0025MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2014-09-24	`782e0a99824c…`
2021-12-28 21:50 UTC	2021-12	N021936-002	SPIRIVA RESPIMAT	EQ 0.00125MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2015-09-15	`782e0a99824c…`
2021-05-05 16:15 UTC · 3 captures of this ZIP	2021-05	N021936-001	SPIRIVA RESPIMAT	EQ 0.0025MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2014-09-24	`87673890dc5c…`
2021-05-05 16:15 UTC · 3 captures of this ZIP	2021-05	N021936-002	SPIRIVA RESPIMAT	EQ 0.00125MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2015-09-15	`87673890dc5c…`
2021-03-12 10:30 UTC	2021-03	N021936-001	SPIRIVA RESPIMAT	EQ 0.0025MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2014-09-24	`5aa47cf7b7d7…`
2021-03-12 10:30 UTC	2021-03	N021936-002	SPIRIVA RESPIMAT	EQ 0.00125MG BASE/INH	SPRAY, METERED / INHALATION	RLD	2015-09-15	`5aa47cf7b7d7…`
2020-12-22 03:56 UTC	2020-12	N021936-001	SPIRIVA RESPIMAT	EQ 0.0025MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2014-09-24	`8869cabd3fbd…`
2020-12-22 03:56 UTC	2020-12	N021936-002	SPIRIVA RESPIMAT	EQ 0.00125MG BASE/INH	SPRAY, METERED / INHALATION	RLD	2015-09-15	`8869cabd3fbd…`
2020-11-12 02:37 UTC	2020-11	N021936-001	SPIRIVA RESPIMAT	EQ 0.0025MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2014-09-24	`c0c555d07b60…`
2020-11-12 02:37 UTC	2020-11	N021936-002	SPIRIVA RESPIMAT	EQ 0.00125MG BASE/INH	SPRAY, METERED / INHALATION	RLD	2015-09-15	`c0c555d07b60…`
2019-12-14 00:12 UTC	2019-12	N021936-001	SPIRIVA RESPIMAT	EQ 0.0025MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2014-09-24	`3f01610625f2…`
2019-12-14 00:12 UTC	2019-12	N021936-002	SPIRIVA RESPIMAT	EQ 0.00125MG BASE/INH	SPRAY, METERED / INHALATION	RLD	2015-09-15	`3f01610625f2…`
2019-09-15 20:21 UTC	2019-09	N021936-001	SPIRIVA RESPIMAT	EQ 0.0025MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2014-09-24	`b00525d2431f…`
2019-09-15 20:21 UTC	2019-09	N021936-002	SPIRIVA RESPIMAT	EQ 0.00125MG BASE/INH	SPRAY, METERED / INHALATION	RLD	2015-09-15	`b00525d2431f…`
2019-07-19 19:46 UTC	2019-07	N021936-001	SPIRIVA RESPIMAT	EQ 0.0025MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2014-09-24	`ea99ee380514…`
2019-07-19 19:46 UTC	2019-07	N021936-002	SPIRIVA RESPIMAT	EQ 0.00125MG BASE/INH	SPRAY, METERED / INHALATION	RLD	2015-09-15	`ea99ee380514…`
2024-03-16 18:09 UTC · 4 captures of this ZIP	2024-03	N021936-001	SPIRIVA RESPIMAT	EQ 0.0025MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2014-09-24	`6a51e52b5d6a…`
2024-03-16 18:09 UTC · 4 captures of this ZIP	2024-03	N021936-002	SPIRIVA RESPIMAT	EQ 0.00125MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2015-09-15	`6a51e52b5d6a…`
2024-02-18 07:12 UTC	2024-02	N021936-001	SPIRIVA RESPIMAT	EQ 0.0025MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2014-09-24	`1c564ffb4f44…`
2024-02-18 07:12 UTC	2024-02	N021936-002	SPIRIVA RESPIMAT	EQ 0.00125MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2015-09-15	`1c564ffb4f44…`
2023-12-20 04:57 UTC	2023-12	N021936-001	SPIRIVA RESPIMAT	EQ 0.0025MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2014-09-24	`ea1830bbd6c7…`
2023-12-20 04:57 UTC	2023-12	N021936-002	SPIRIVA RESPIMAT	EQ 0.00125MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2015-09-15	`ea1830bbd6c7…`
2023-11-28 05:40 UTC · 2 captures of this ZIP	2023-11	N021936-001	SPIRIVA RESPIMAT	EQ 0.0025MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2014-09-24	`a72a2bbeb626…`
2023-11-28 05:40 UTC · 2 captures of this ZIP	2023-11	N021936-002	SPIRIVA RESPIMAT	EQ 0.00125MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2015-09-15	`a72a2bbeb626…`
2023-10-25 00:34 UTC · 2 captures of this ZIP	2023-10	N021936-001	SPIRIVA RESPIMAT	EQ 0.0025MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2014-09-24	`9b2671bbb829…`
2023-10-25 00:34 UTC · 2 captures of this ZIP	2023-10	N021936-002	SPIRIVA RESPIMAT	EQ 0.00125MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2015-09-15	`9b2671bbb829…`
2023-07-15 15:27 UTC · 2 captures of this ZIP	2023-07	N021936-001	SPIRIVA RESPIMAT	EQ 0.0025MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2014-09-24	`a67488948f0b…`
2023-07-15 15:27 UTC · 2 captures of this ZIP	2023-07	N021936-002	SPIRIVA RESPIMAT	EQ 0.00125MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2015-09-15	`a67488948f0b…`
2023-06-13 01:57 UTC · 3 captures of this ZIP	2023-06	N021936-001	SPIRIVA RESPIMAT	EQ 0.0025MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2014-09-24	`3f0d92c62455…`
2023-06-13 01:57 UTC · 3 captures of this ZIP	2023-06	N021936-002	SPIRIVA RESPIMAT	EQ 0.00125MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2015-09-15	`3f0d92c62455…`
2023-05-13 08:27 UTC	2023-05	N021936-001	SPIRIVA RESPIMAT	EQ 0.0025MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2014-09-24	`053a50430f4f…`
2023-05-13 08:27 UTC	2023-05	N021936-002	SPIRIVA RESPIMAT	EQ 0.00125MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2015-09-15	`053a50430f4f…`
2023-01-26 05:58 UTC	2023-01	N021936-001	SPIRIVA RESPIMAT	EQ 0.0025MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2014-09-24	`3bdfa0b2c4d7…`
2023-01-26 05:58 UTC	2023-01	N021936-002	SPIRIVA RESPIMAT	EQ 0.00125MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2015-09-15	`3bdfa0b2c4d7…`
2022-11-12 20:34 UTC · 5 captures of this ZIP	2022-11	N021936-001	SPIRIVA RESPIMAT	EQ 0.0025MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2014-09-24	`3a93d1ddd44b…`
2022-11-12 20:34 UTC · 5 captures of this ZIP	2022-11	N021936-002	SPIRIVA RESPIMAT	EQ 0.00125MG BASE/INH	SPRAY, METERED / INHALATION	RLD, RS	2015-09-15	`3a93d1ddd44b…`

Observed Orange Book patent history#

Patent history page 1 of 27 · 1,064 observed states.

Captured, Edition, Application-product table
Captured	Edition	Application-product	Patent	Expiration	Coverage / status	Submission date	Source SHA-256
2026-10-15 13:18:30	2026-09	N021936-001	7396341	2026-10-10	Drug product, Delist requested	2014-10-20	`c2088c7a36db…`
2026-10-15 13:18:30	2026-09	N021936-001	9027967	2027-03-31	Drug product, Delist requested	2015-09-15	`c2088c7a36db…`
2026-10-15 13:18:30	2026-09	N021936-001	7396341*PED	2027-04-10	Pediatric extension		`c2088c7a36db…`
2026-10-15 13:18:30	2026-09	N021936-001	9027967*PED	2027-09-30	Pediatric extension		`c2088c7a36db…`
2026-10-15 13:18:30	2026-09	N021936-001	7837235	2028-03-13	Drug product, Delist requested	2014-10-20	`c2088c7a36db…`
2026-10-15 13:18:30	2026-09	N021936-001	7837235*PED	2028-09-13	Pediatric extension		`c2088c7a36db…`
2026-10-15 13:18:30	2026-09	N021936-001	8733341	2030-10-16	Drug product, Delist requested	2015-09-15	`c2088c7a36db…`
2026-10-15 13:18:30	2026-09	N021936-001	8733341*PED	2031-04-16	Pediatric extension		`c2088c7a36db…`
2026-09-14 22:38:34	2026-08	N021936-001	7396341	2026-10-10	Drug product, Delist requested	2014-10-20	`84e616aacf4f…`
2026-09-14 22:38:34	2026-08	N021936-001	9027967	2027-03-31	Drug product, Delist requested	2015-09-15	`84e616aacf4f…`
2026-09-14 22:38:34	2026-08	N021936-001	7396341*PED	2027-04-10	Pediatric extension		`84e616aacf4f…`
2026-09-14 22:38:34	2026-08	N021936-001	9027967*PED	2027-09-30	Pediatric extension		`84e616aacf4f…`
2026-09-14 22:38:34	2026-08	N021936-001	7837235	2028-03-13	Drug product, Delist requested	2014-10-20	`84e616aacf4f…`
2026-09-14 22:38:34	2026-08	N021936-001	7837235*PED	2028-09-13	Pediatric extension		`84e616aacf4f…`
2026-09-14 22:38:34	2026-08	N021936-001	8733341	2030-10-16	Drug product, Delist requested	2015-09-15	`84e616aacf4f…`
2026-09-14 22:38:34	2026-08	N021936-001	8733341*PED	2031-04-16	Pediatric extension		`84e616aacf4f…`
2026-08-18 06:07:40	2026-07	N021936-001	7396341	2026-10-10	Drug product, Delist requested	2014-10-20	`caaa826d4ba7…`
2026-08-18 06:07:40	2026-07	N021936-001	9027967	2027-03-31	Drug product, Delist requested	2015-09-15	`caaa826d4ba7…`
2026-08-18 06:07:40	2026-07	N021936-001	7396341*PED	2027-04-10	Pediatric extension		`caaa826d4ba7…`
2026-08-18 06:07:40	2026-07	N021936-001	9027967*PED	2027-09-30	Pediatric extension		`caaa826d4ba7…`
2026-08-18 06:07:40	2026-07	N021936-001	7837235	2028-03-13	Drug product, Delist requested	2014-10-20	`caaa826d4ba7…`
2026-08-18 06:07:40	2026-07	N021936-001	7837235*PED	2028-09-13	Pediatric extension		`caaa826d4ba7…`
2026-08-18 06:07:40	2026-07	N021936-001	8733341	2030-10-16	Drug product, Delist requested	2015-09-15	`caaa826d4ba7…`
2026-08-18 06:07:40	2026-07	N021936-001	8733341*PED	2031-04-16	Pediatric extension		`caaa826d4ba7…`
2026-02-19 14:30 UTC	2026-02	N021936-001	7396341	2026-10-10	Drug product, Delist requested	2014-10-20	`011fe1cb6892…`
2026-02-19 14:30 UTC	2026-02	N021936-001	9027967	2027-03-31	Drug product, Delist requested	2015-09-15	`011fe1cb6892…`
2026-02-19 14:30 UTC	2026-02	N021936-001	7396341*PED	2027-04-10	Pediatric extension		`011fe1cb6892…`
2026-02-19 14:30 UTC	2026-02	N021936-001	9027967*PED	2027-09-30	Pediatric extension		`011fe1cb6892…`
2026-02-19 14:30 UTC	2026-02	N021936-001	7837235	2028-03-13	Drug product, Delist requested	2014-10-20	`011fe1cb6892…`
2026-02-19 14:30 UTC	2026-02	N021936-001	7837235*PED	2028-09-13	Pediatric extension		`011fe1cb6892…`
2026-02-19 14:30 UTC	2026-02	N021936-001	8733341	2030-10-16	Drug product, Delist requested	2015-09-15	`011fe1cb6892…`
2026-02-19 14:30 UTC	2026-02	N021936-001	8733341*PED	2031-04-16	Pediatric extension		`011fe1cb6892…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N021936-001	7284474	2024-08-26	Drug product	2014-10-20	`31067a03dcf5…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N021936-001	7284474*PED	2025-02-26	Pediatric extension		`31067a03dcf5…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N021936-001	7396341	2026-10-10	Drug product, Delist requested	2014-10-20	`31067a03dcf5…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N021936-001	9027967	2027-03-31	Drug product, Delist requested	2015-09-15	`31067a03dcf5…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N021936-001	7396341*PED	2027-04-10	Pediatric extension		`31067a03dcf5…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N021936-001	9027967*PED	2027-09-30	Pediatric extension		`31067a03dcf5…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N021936-001	7837235	2028-03-13	Drug product, Delist requested	2014-10-20	`31067a03dcf5…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N021936-001	7837235*PED	2028-09-13	Pediatric extension		`31067a03dcf5…`

Observed Orange Book exclusivity history#

Captured, Edition, Application-product table
Captured	Edition	Application-product	Exclusivity code	Expiration	Source SHA-256
2019-12-13 00:20 UTC	2019-12	N021936-001	NPP	2020-02-15	`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N021936-001	PED	2020-08-15	`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N021936-002	PED	2019-03-15	`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N021936-002	NPP	2020-02-15	`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N021936-002	PED	2020-08-15	`74a2ff9319b5…`
2020-12-22 03:56 UTC	2020-12	N021936-001	NPP	2020-02-15	`8869cabd3fbd…`
2020-12-22 03:56 UTC	2020-12	N021936-001	PED	2020-08-15	`8869cabd3fbd…`
2020-12-22 03:56 UTC	2020-12	N021936-002	NPP	2020-02-15	`8869cabd3fbd…`
2020-12-22 03:56 UTC	2020-12	N021936-002	PED	2020-08-15	`8869cabd3fbd…`
2020-11-12 02:37 UTC	2020-11	N021936-001	NPP	2020-02-15	`c0c555d07b60…`
2020-11-12 02:37 UTC	2020-11	N021936-001	PED	2020-08-15	`c0c555d07b60…`
2020-11-12 02:37 UTC	2020-11	N021936-002	NPP	2020-02-15	`c0c555d07b60…`
2020-11-12 02:37 UTC	2020-11	N021936-002	PED	2020-08-15	`c0c555d07b60…`
2019-12-14 00:12 UTC	2019-12	N021936-001	NPP	2020-02-15	`3f01610625f2…`
2019-12-14 00:12 UTC	2019-12	N021936-001	PED	2020-08-15	`3f01610625f2…`
2019-12-14 00:12 UTC	2019-12	N021936-002	PED	2019-03-15	`3f01610625f2…`
2019-12-14 00:12 UTC	2019-12	N021936-002	NPP	2020-02-15	`3f01610625f2…`
2019-12-14 00:12 UTC	2019-12	N021936-002	PED	2020-08-15	`3f01610625f2…`
2019-09-15 20:21 UTC	2019-09	N021936-001	NPP	2020-02-15	`b00525d2431f…`
2019-09-15 20:21 UTC	2019-09	N021936-001	PED	2020-08-15	`b00525d2431f…`
2019-09-15 20:21 UTC	2019-09	N021936-002	PED	2019-03-15	`b00525d2431f…`
2019-09-15 20:21 UTC	2019-09	N021936-002	NPP	2020-02-15	`b00525d2431f…`
2019-09-15 20:21 UTC	2019-09	N021936-002	PED	2020-08-15	`b00525d2431f…`
2019-07-19 19:46 UTC	2019-07	N021936-001	NPP	2020-02-15	`ea99ee380514…`
2019-07-19 19:46 UTC	2019-07	N021936-001	PED	2020-08-15	`ea99ee380514…`
2019-07-19 19:46 UTC	2019-07	N021936-002	PED	2019-03-15	`ea99ee380514…`
2019-07-19 19:46 UTC	2019-07	N021936-002	NPP	2020-02-15	`ea99ee380514…`
2019-07-19 19:46 UTC	2019-07	N021936-002	PED	2020-08-15	`ea99ee380514…`

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
Spiriva Respimat	TIOTROPIUM BROMIDE INHALATION SPRAY	Boehringer Ingelheim Pharmaceuticals, Inc.	7b656b14-fcaa-2741-f6f0-e0be48971c02	2026-08-17	Warnings, Adverse reactions	Exact identifier application applno (NDA): 021936 application number: NDA021936 ndc (product): 0597-0100

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

NDC Listings For This Application#

NDC listings for this application page 1 of 1 · 4 matching rows.

NDC, Name, Nonproprietary name table
NDC	Name	Nonproprietary name	Labeler	Marketing category	Status
0597-0100	Spiriva Respimat	tiotropium bromide inhalation spray	Boehringer Ingelheim Pharmaceuticals, Inc.	NDA	Current
0597-0100	Spiriva Respimat	tiotropium bromide inhalation spray	Boehringer Ingelheim Pharmaceuticals, Inc.	NDA	Current
0597-0100	Spiriva Respimat	tiotropium bromide inhalation spray	Boehringer Ingelheim Pharmaceuticals, Inc.	NDA	Current
0597-0100	Spiriva Respimat	tiotropium bromide inhalation spray	Boehringer Ingelheim Pharmaceuticals, Inc.	NDA	Current

Documents#

Document, Submission type, Date table
Document	Submission type	Date
80798	SUPPL	2025-01-02
80786	SUPPL	2024-12-30
57726	SUPPL	2019-02-21
57701	SUPPL	2019-02-19
47252	SUPPL	2017-02-16
16602	SUPPL	2016-06-13
6490	SUPPL	2016-06-10
37907	SUPPL	2016-02-17
28878	SUPPL	2016-01-20
44659	ORIG	2015-07-02
42354	ORIG	2015-07-02
37906	ORIG	2014-09-26
6489	ORIG	2014-09-26
52375	ORIG	1900-01-01
51572	ORIG	1900-01-01
51571	ORIG	1900-01-01
51570	ORIG	1900-01-01