Application 022466

Type
NDA
Sponsor
PIERREL

Application Products#

Product, Drug, Ingredient table
ProductDrugIngredientFormStrengthReference drugReference standard
001ORABLOCARTICAINE HYDROCHLORIDE; EPINEPHRINE BITARTRATEINJECTABLE;INJECTION4%;EQ 0.009MG BASE/1.8ML (EQ 0.005MG BASE/ML)YesNo
002ORABLOCARTICAINE HYDROCHLORIDE; EPINEPHRINE BITARTRATEINJECTABLE;INJECTION4%;EQ 0.018MG BASE/1.8ML (EQ 0.01MG BASE/ML)YesYes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 2 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
N022466-001ORABLOCARTICAINE HYDROCHLORIDE; EPINEPHRINE BITARTRATE4%;EQ 0.009MG BASE/1.8ML (EQ 0.005MG BASE/ML)INJECTABLE / INJECTIONRLD2010-02-26
N022466-002ORABLOCARTICAINE HYDROCHLORIDE; EPINEPHRINE BITARTRATE4%;EQ 0.018MG BASE/1.8ML (EQ 0.01MG BASE/ML)INJECTABLE / INJECTIONRLD, RS2010-02-26

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 3 · 82 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02N022466-001ORABLOC4%;EQ 0.009MG BASE/1.8ML (EQ 0.005MG BASE/ML)INJECTABLE / INJECTIONRLD2010-02-26011fe1cb6892…
2026-02-19 14:30 UTC2026-02N022466-002ORABLOC4%;EQ 0.018MG BASE/1.8ML (EQ 0.01MG BASE/ML)INJECTABLE / INJECTIONRLD, RS2010-02-26011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N022466-001ORABLOC4%;EQ 0.009MG BASE/1.8ML (EQ 0.005MG BASE/ML)INJECTABLE / INJECTIONRLD2010-02-2631067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N022466-002ORABLOC4%;EQ 0.018MG BASE/1.8ML (EQ 0.01MG BASE/ML)INJECTABLE / INJECTIONRLD, RS2010-02-2631067a03dcf5…
2025-08-23 18:47 UTC2025-08N022466-001ORABLOC4%;EQ 0.009MG BASE/1.8ML (EQ 0.005MG BASE/ML)INJECTABLE / INJECTIONRLD2010-02-266a471c1ec25d…
2025-08-23 18:47 UTC2025-08N022466-002ORABLOC4%;EQ 0.018MG BASE/1.8ML (EQ 0.01MG BASE/ML)INJECTABLE / INJECTIONRLD, RS2010-02-266a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N022466-001ORABLOC4%;EQ 0.009MG BASE/1.8ML (EQ 0.005MG BASE/ML)INJECTABLE / INJECTIONRLD2010-02-26fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N022466-002ORABLOC4%;EQ 0.018MG BASE/1.8ML (EQ 0.01MG BASE/ML)INJECTABLE / INJECTIONRLD, RS2010-02-26fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N022466-001ORABLOC4%;EQ 0.009MG BASE/1.8ML (EQ 0.005MG BASE/ML)INJECTABLE / INJECTIONRLD2010-02-26b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N022466-002ORABLOC4%;EQ 0.018MG BASE/1.8ML (EQ 0.01MG BASE/ML)INJECTABLE / INJECTIONRLD, RS2010-02-26b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N022466-001ORABLOC4%;EQ 0.009MG BASE/1.8ML (EQ 0.005MG BASE/ML)INJECTABLE / INJECTIONRLD2010-02-2603ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N022466-002ORABLOC4%;EQ 0.018MG BASE/1.8ML (EQ 0.01MG BASE/ML)INJECTABLE / INJECTIONRLD, RS2010-02-2603ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N022466-001ORABLOC4%;EQ 0.009MG BASE/1.8ML (EQ 0.005MG BASE/ML)INJECTABLE / INJECTIONRLD2010-02-262680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N022466-002ORABLOC4%;EQ 0.018MG BASE/1.8ML (EQ 0.01MG BASE/ML)INJECTABLE / INJECTIONRLD, RS2010-02-262680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N022466-001ORABLOC4%;EQ 0.009MG BASE/1.8ML (EQ 0.005MG BASE/ML)INJECTABLE / INJECTIONRLD2010-02-265bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N022466-002ORABLOC4%;EQ 0.018MG BASE/1.8ML (EQ 0.01MG BASE/ML)INJECTABLE / INJECTIONRLD, RS2010-02-265bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N022466-001ORABLOC4%;EQ 0.009MG BASE/1.8ML (EQ 0.005MG BASE/ML)INJECTABLE / INJECTIONRLD2010-02-26d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N022466-002ORABLOC4%;EQ 0.018MG BASE/1.8ML (EQ 0.01MG BASE/ML)INJECTABLE / INJECTIONRLD, RS2010-02-26d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N022466-001ORABLOC4%;EQ 0.009MG BASE/1.8ML (EQ 0.005MG BASE/ML)INJECTABLE / INJECTIONRLD2010-02-26d06236e962d9…
2024-10-29 15:01 UTC2024-10N022466-002ORABLOC4%;EQ 0.018MG BASE/1.8ML (EQ 0.01MG BASE/ML)INJECTABLE / INJECTIONRLD, RS2010-02-26d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N022466-001ORABLOC4%;EQ 0.009MG BASE/1.8ML (EQ 0.005MG BASE/ML)INJECTABLE / INJECTIONRLD2010-02-2679d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N022466-002ORABLOC4%;EQ 0.018MG BASE/1.8ML (EQ 0.01MG BASE/ML)INJECTABLE / INJECTIONRLD, RS2010-02-2679d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N022466-001ORABLOC4%;EQ 0.009MG BASE/1.8ML (EQ 0.005MG BASE/ML)INJECTABLE / INJECTIONRLD2010-02-26301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N022466-002ORABLOC4%;EQ 0.018MG BASE/1.8ML (EQ 0.01MG BASE/ML)INJECTABLE / INJECTIONRLD, RS2010-02-26301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N022466-001ORABLOC4%;EQ 0.009MG BASE/1.8ML (EQ 0.005MG BASE/ML)INJECTABLE / INJECTIONRLD2010-02-261e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N022466-002ORABLOC4%;EQ 0.018MG BASE/1.8ML (EQ 0.01MG BASE/ML)INJECTABLE / INJECTIONRLD, RS2010-02-261e350fbaab3a…
2024-05-31 18:47 UTC2024-05N022466-001ORABLOC4%;EQ 0.009MG BASE/1.8ML (EQ 0.005MG BASE/ML)INJECTABLE / INJECTIONRLD2010-02-268072bd15b7f6…
2024-05-31 18:47 UTC2024-05N022466-002ORABLOC4%;EQ 0.018MG BASE/1.8ML (EQ 0.01MG BASE/ML)INJECTABLE / INJECTIONRLD, RS2010-02-268072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N022466-001ORABLOC4%;EQ 0.009MG BASE/1.8ML (EQ 0.005MG BASE/ML)INJECTABLE / INJECTIONRLD2010-02-265c6f7cd8ea54…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N022466-002ORABLOC4%;EQ 0.018MG BASE/1.8ML (EQ 0.01MG BASE/ML)INJECTABLE / INJECTIONRLD, RS2010-02-265c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04N022466-001ORABLOC4%;EQ 0.009MG BASE/1.8ML (EQ 0.005MG BASE/ML)INJECTABLE / INJECTIONRLD2010-02-265d02ea3f76ae…
2022-04-08 23:34 UTC2022-04N022466-002ORABLOC4%;EQ 0.018MG BASE/1.8ML (EQ 0.01MG BASE/ML)INJECTABLE / INJECTIONRLD, RS2010-02-265d02ea3f76ae…
2022-04-04 05:41 UTC2022-04N022466-001ORABLOC4%;EQ 0.009MG BASE/1.8ML (EQ 0.005MG BASE/ML)INJECTABLE / INJECTIONRLD2010-02-264b0b4de00fa7…
2022-04-04 05:41 UTC2022-04N022466-002ORABLOC4%;EQ 0.018MG BASE/1.8ML (EQ 0.01MG BASE/ML)INJECTABLE / INJECTIONRLD, RS2010-02-264b0b4de00fa7…
2019-12-13 00:20 UTC2019-12N022466-001ORABLOC4%;EQ 0.009MG BASE/1.8ML (EQ 0.005MG BASE/ML)INJECTABLE / INJECTIONRLD2010-02-2674a2ff9319b5…
2019-12-13 00:20 UTC2019-12N022466-002ORABLOC4%;EQ 0.018MG BASE/1.8ML (EQ 0.01MG BASE/ML)INJECTABLE / INJECTIONRLD, RS2010-02-2674a2ff9319b5…
2022-03-09 01:35 UTC2022-03N022466-001ORABLOC4%;EQ 0.009MG BASE/1.8ML (EQ 0.005MG BASE/ML)INJECTABLE / INJECTIONRLD2010-02-26bb7c543d1eb4…
2022-03-09 01:35 UTC2022-03N022466-002ORABLOC4%;EQ 0.018MG BASE/1.8ML (EQ 0.01MG BASE/ML)INJECTABLE / INJECTIONRLD, RS2010-02-26bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12N022466-001ORABLOC4%;EQ 0.009MG BASE/1.8ML (EQ 0.005MG BASE/ML)INJECTABLE / INJECTIONRLD2010-02-26782e0a99824c…
2021-12-28 21:50 UTC2021-12N022466-002ORABLOC4%;EQ 0.018MG BASE/1.8ML (EQ 0.01MG BASE/ML)INJECTABLE / INJECTIONRLD, RS2010-02-26782e0a99824c…

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 3 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Articaine Hydrochloride and EpinephrineARTICAINE HYDROCHLORIDE, EPINEPHRINE BITARTRATEBurkhart Dental Supply Co., Inc4f11bb06-c71b-4d96-9baa-2a17ad473a052024-11-18Warnings, Adverse reactionsExact identifier
application applno (NDA): 022466
application number: NDA022466
Articaine HCl and EpinephrineARTICAINE HYDROCHLORIDE AND EPINEPHRINE BITARTRATESafco Dental Supply Co.0536a4de-578d-497e-a01b-0b1887344cc82023-01-14Warnings, Adverse reactionsExact identifier
application applno (NDA): 022466
application number: NDA022466
ndc (product): 67239-0210
ndc (product): 67239-0209
OrablocARTICAINE HYDROCHLORIDE AND EPINEPHRINE BITARTRATEPierrel S.p.A.d18424f0-a691-11dd-ad8b-0800200c9a662018-11-22Warnings, Adverse reactionsExact identifier
application applno (NDA): 022466
application number: NDA022466
ndc (product): 45146-120
ndc (product): 45146-110

NDC Listings For This Application#

NDC listings for this application page 1 of 1 · 14 matching rows.

NDC, Name, Nonproprietary name table
NDCNameNonproprietary nameLabelerMarketing categoryStatus
45146-110Orablocarticaine hydrochloride and epinephrine bitartratePierrel S.p.A.NDACurrent
45146-110Orablocarticaine hydrochloride and epinephrine bitartratePierrel S.p.A.NDACurrent
45146-120Orablocarticaine hydrochloride and epinephrine bitartratePierrel S.p.A.NDACurrent
45146-120Orablocarticaine hydrochloride and epinephrine bitartratePierrel S.p.A.NDACurrent
67239-0209Articaine HCl and Epinephrinearticaine hydrochloride and epinephrine bitartrateSafco Dental Supply Co.NDACurrent
67239-0209Articaine HCl and Epinephrinearticaine hydrochloride and epinephrine bitartrateSafco Dental Supply Co.NDACurrent
67239-0210Articaine HCl and Epinephrinearticaine hydrochloride and epinephrine bitartrateSafco Dental Supply Co.NDACurrent
67239-0210Articaine HCl and Epinephrinearticaine hydrochloride and epinephrine bitartrateSafco Dental Supply Co.NDACurrent
72304-015Articaine Hydrochloride and EpinephrineARTICAINE HYDROCHLORIDE, EPINEPHRINE BITARTRATEMidway Dental Supply, LLCNDACurrent
72304-015Articaine Hydrochloride and EpinephrineARTICAINE HYDROCHLORIDE, EPINEPHRINE BITARTRATEMidway Dental Supply, LLCNDACurrent
72304-015Articaine Hydrochloride and EpinephrineARTICAINE HYDROCHLORIDE, EPINEPHRINE BITARTRATEMidway Dental Supply, LLCNDACurrent
72304-016Articaine Hydrochloride and EpinephrineARTICAINE HYDROCHLORIDE,EPINEPHRINE BITARTRATEMidway Dental Supply, LLCNDACurrent
72304-016Articaine Hydrochloride and EpinephrineARTICAINE HYDROCHLORIDE,EPINEPHRINE BITARTRATEMidway Dental Supply, LLCNDACurrent
72304-016Articaine Hydrochloride and EpinephrineARTICAINE HYDROCHLORIDE,EPINEPHRINE BITARTRATEMidway Dental Supply, LLCNDACurrent

Documents#

Document, Submission type, Date table
DocumentSubmission typeDate
82756SUPPL 2025-07-08
82729SUPPL 2025-07-03
56401SUPPL2018-11-09
56275SUPPL2018-11-05
24316ORIG2011-02-17
7433SUPPL2011-01-25
38742SUPPL2011-01-24
42532ORIG2010-12-01
7432ORIG2010-03-04
17616ORIG2010-03-02