Application 204803

Type
NDA
Sponsor
DURECT CORP

Application Products#

Product, Drug, Ingredient table
ProductDrugIngredientFormStrengthReference drugReference standard
001POSIMIRBUPIVACAINEINJECTABLE;INJECTION132MG/MLYesNo

Source provenance: Browse the complete Orange Book source catalog · source snapshot 42.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
N204803-001POSIMIRBUPIVACAINE660MG/5ML (132MG/ML)SOLUTION / INFILTRATIONRLD2021-02-01

Orange Book patents#

Current patent rows page 1 of 1 · 2 matching rows.

Application-product, Patent, Expiration table
Application-productPatentExpirationUse codeCoverage / statusSubmission date
N204803-001114000192041-01-12Drug product2022-09-01
N204803-001117716242041-01-12U-37242023-11-02

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-08-18 06:07:402026-07N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION / INFILTRATIONRLD2021-02-01caaa826d4ba7…
2026-02-19 14:30 UTC2026-02N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION / INFILTRATIONRLD2021-02-01011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION / INFILTRATIONRLD2021-02-0131067a03dcf5…
2025-08-23 18:47 UTC2025-08N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION / INFILTRATIONRLD2021-02-016a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION / INFILTRATIONRLD2021-02-01fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION / INFILTRATIONRLD2021-02-01b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION / INFILTRATIONRLD2021-02-0103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION / INFILTRATIONRLD2021-02-012680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION / INFILTRATIONRLD, RS2021-02-015bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION / INFILTRATIONRLD, RS2021-02-01d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION / INFILTRATIONRLD, RS2021-02-01d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION, EXTENDED RELEASE / INFILTRATIONRLD, RS2021-02-0179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION, EXTENDED RELEASE / INFILTRATIONRLD, RS2021-02-01301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION, EXTENDED RELEASE / INFILTRATIONRLD, RS2021-02-011e350fbaab3a…
2024-05-31 18:47 UTC2024-05N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION, EXTENDED RELEASE / INFILTRATIONRLD, RS2021-02-018072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION, EXTENDED RELEASE / INFILTRATIONRLD, RS2021-02-015c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION, EXTENDED RELEASE / INFILTRATIONRLD2021-02-015d02ea3f76ae…
2022-04-04 05:41 UTC2022-04N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION, EXTENDED RELEASE / INFILTRATIONRLD2021-02-014b0b4de00fa7…
2022-03-09 01:35 UTC2022-03N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION, EXTENDED RELEASE / INFILTRATIONRLD2021-02-01bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION, EXTENDED RELEASE / INFILTRATIONRLD2021-02-01782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION, EXTENDED RELEASE / INFILTRATIONRLD2021-02-0187673890dc5c…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION, EXTENDED RELEASE / INFILTRATIONRLD, RS2021-02-016a51e52b5d6a…
2024-02-18 07:12 UTC2024-02N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION, EXTENDED RELEASE / INFILTRATIONRLD, RS2021-02-011c564ffb4f44…
2023-12-20 04:57 UTC2023-12N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION, EXTENDED RELEASE / INFILTRATIONRLD, RS2021-02-01ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION, EXTENDED RELEASE / INFILTRATIONRLD, RS2021-02-01a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION, EXTENDED RELEASE / INFILTRATIONRLD, RS2021-02-019b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION, EXTENDED RELEASE / INFILTRATIONRLD, RS2021-02-01a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION, EXTENDED RELEASE / INFILTRATIONRLD, RS2021-02-013f0d92c62455…
2023-05-13 08:27 UTC2023-05N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION, EXTENDED RELEASE / INFILTRATIONRLD, RS2021-02-01053a50430f4f…
2023-01-26 05:58 UTC2023-01N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION, EXTENDED RELEASE / INFILTRATIONRLD, RS2021-02-013bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION, EXTENDED RELEASE / INFILTRATIONRLD, RS2021-02-013a93d1ddd44b…
2022-10-28 04:53 UTC2022-10N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION, EXTENDED RELEASE / INFILTRATIONRLD, RS2021-02-01f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION, EXTENDED RELEASE / INFILTRATIONRLD, RS2021-02-01e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION, EXTENDED RELEASE / INFILTRATIONRLD, RS2021-02-01cb3db0bc1861…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06N204803-001POSIMIR660MG/5ML (132MG/ML)SOLUTION / INFILTRATIONRLD2021-02-01a50c72e98297…

Observed Orange Book patent history#

Patent history page 1 of 5 · 176 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productPatentExpirationUse codeCoverage / statusSubmission dateSource SHA-256
2026-08-18 06:07:402026-07N204803-001114000192041-01-12Drug product2022-09-01caaa826d4ba7…
2026-08-18 06:07:402026-07N204803-001117716242041-01-12U-37242023-11-02caaa826d4ba7…
2026-02-19 14:30 UTC2026-02N204803-001114000192041-01-12Drug product2022-09-01011fe1cb6892…
2026-02-19 14:30 UTC2026-02N204803-001117716242041-01-12U-37242023-11-02011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N204803-00181531492025-09-15Drug product2021-03-0231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N204803-00181536612025-09-15U-30742021-03-0231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N204803-00187536652025-09-15U-3074Drug product2021-03-0231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N204803-00188460722025-09-15U-3074Drug product2021-03-0231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N204803-001114000192041-01-12Drug product2022-09-0131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N204803-001117716242041-01-12U-37242023-11-0231067a03dcf5…
2025-08-23 18:47 UTC2025-08N204803-00181531492025-09-15Drug product2021-03-026a471c1ec25d…
2025-08-23 18:47 UTC2025-08N204803-00181536612025-09-15U-30742021-03-026a471c1ec25d…
2025-08-23 18:47 UTC2025-08N204803-00187536652025-09-15U-3074Drug product2021-03-026a471c1ec25d…
2025-08-23 18:47 UTC2025-08N204803-00188460722025-09-15U-3074Drug product2021-03-026a471c1ec25d…
2025-08-23 18:47 UTC2025-08N204803-001114000192041-01-12Drug product2022-09-016a471c1ec25d…
2025-08-23 18:47 UTC2025-08N204803-001117716242041-01-12U-37242023-11-026a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N204803-00181531492025-09-15Drug product2021-03-02fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N204803-00181536612025-09-15U-30742021-03-02fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N204803-00187536652025-09-15U-3074Drug product2021-03-02fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N204803-00188460722025-09-15U-3074Drug product2021-03-02fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N204803-001114000192041-01-12Drug product2022-09-01fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N204803-001117716242041-01-12U-37242023-11-02fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N204803-00181531492025-09-15Drug product2021-03-02b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N204803-00181536612025-09-15U-30742021-03-02b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N204803-00187536652025-09-15U-3074Drug product2021-03-02b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N204803-00188460722025-09-15U-3074Drug product2021-03-02b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N204803-001114000192041-01-12Drug product2022-09-01b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N204803-001117716242041-01-12U-37242023-11-02b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N204803-00181531492025-09-15Drug product2021-03-0203ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N204803-00181536612025-09-15U-30742021-03-0203ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N204803-00187536652025-09-15U-3074Drug product2021-03-0203ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N204803-00188460722025-09-15U-3074Drug product2021-03-0203ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N204803-001114000192041-01-12Drug product2022-09-0103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N204803-001117716242041-01-12U-37242023-11-0203ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N204803-00181531492025-09-15Drug product2021-03-022680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N204803-00181536612025-09-15U-30742021-03-022680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N204803-00187536652025-09-15U-3074Drug product2021-03-022680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N204803-00188460722025-09-15U-3074Drug product2021-03-022680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N204803-001114000192041-01-12Drug product2022-09-012680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N204803-001117716242041-01-12U-37242023-11-022680178bc6a6…

Observed Orange Book exclusivity history#

Captured, Edition, Application-product table
CapturedEditionApplication-productExclusivity codeExpirationSource SHA-256
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N204803-001NP2024-02-0103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N204803-001NP2024-02-012680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N204803-001NP2024-02-015bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N204803-001NP2024-02-01d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N204803-001NP2024-02-01d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N204803-001NP2024-02-0179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N204803-001NP2024-02-01301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N204803-001NP2024-02-011e350fbaab3a…
2024-05-31 18:47 UTC2024-05N204803-001NP2024-02-018072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N204803-001NP2024-02-015c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04N204803-001NP2024-02-015d02ea3f76ae…
2022-04-04 05:41 UTC2022-04N204803-001NP2024-02-014b0b4de00fa7…
2022-03-09 01:35 UTC2022-03N204803-001NP2024-02-01bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12N204803-001NP2024-02-01782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N204803-001NP2024-02-0187673890dc5c…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03N204803-001NP2024-02-016a51e52b5d6a…
2024-02-18 07:12 UTC2024-02N204803-001NP2024-02-011c564ffb4f44…
2023-12-20 04:57 UTC2023-12N204803-001NP2024-02-01ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11N204803-001NP2024-02-01a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10N204803-001NP2024-02-019b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07N204803-001NP2024-02-01a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06N204803-001NP2024-02-013f0d92c62455…
2023-05-13 08:27 UTC2023-05N204803-001NP2024-02-01053a50430f4f…
2023-01-26 05:58 UTC2023-01N204803-001NP2024-02-013bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11N204803-001NP2024-02-013a93d1ddd44b…
2022-10-28 04:53 UTC2022-10N204803-001NP2024-02-01f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09N204803-001NP2024-02-01e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07N204803-001NP2024-02-01cb3db0bc1861…

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 2 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
EXPARELBUPIVACAINEPacira Pharmaceuticals, Inc.bb5a9e59-0f51-11df-8a39-0800200c9a662025-12-12Warnings, Adverse reactionsName fallback
generic name: BUPIVACAINE
BupivacaineBUPIVACAINEJiangsu Hengrui Pharmaceuticals Co., Ltd.0af296bb-1599-4b35-b66b-994924d3e8982024-07-09Warnings, Adverse reactionsName fallback
generic name: BUPIVACAINE

NDC Listings For This Application#

NDC listings for this application page 1 of 1 · 3 matching rows.

NDC, Name, Nonproprietary name table
NDCNameNonproprietary nameLabelerMarketing categoryStatus
49396-6601POSIMIRBupivacaineRenaissance Lakewood, LLCNDACurrent
51715-660POSIMIRbupivacaineINNOCOLL PHARMACEUTICALSNDACurrent
51715-660POSIMIRbupivacaineINNOCOLL PHARMACEUTICALSNDACurrent

Documents#

Document, Submission type, Date table
DocumentSubmission typeDate
71731SUPPL2022-08-05
71720SUPPL2022-08-04
71163ORIG2022-05-31
66072ORIG2021-02-03
66054ORIG2021-02-02