Application 216590

Type
ANDA
Sponsor
MEITHEAL

Application Products#

Product, Drug, Ingredient table
ProductDrugIngredientFormStrengthReference drugReference standard
001LEUCOVORIN CALCIUMLEUCOVORIN CALCIUMINJECTABLE;INJECTIONEQ 50MG BASE/VIALNoNo
002LEUCOVORIN CALCIUMLEUCOVORIN CALCIUMINJECTABLE;INJECTIONEQ 100MG BASE/VIALNoNo
003LEUCOVORIN CALCIUMLEUCOVORIN CALCIUMINJECTABLE;INJECTIONEQ 200MG BASE/VIALNoNo
004LEUCOVORIN CALCIUMLEUCOVORIN CALCIUMINJECTABLE;INJECTIONEQ 350MG BASE/VIALNoNo
005LEUCOVORIN CALCIUMLEUCOVORIN CALCIUMINJECTABLE;INJECTIONEQ 500MG BASE/VIALNoNo

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 5 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A216590-001LEUCOVORIN CALCIUMLEUCOVORIN CALCIUMEQ 50MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-19
A216590-002LEUCOVORIN CALCIUMLEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-19
A216590-003LEUCOVORIN CALCIUMLEUCOVORIN CALCIUMEQ 200MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-19
A216590-004LEUCOVORIN CALCIUMLEUCOVORIN CALCIUMEQ 350MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-19
A216590-005LEUCOVORIN CALCIUMLEUCOVORIN CALCIUMEQ 500MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-19

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 5 matching rows.

Application-product, TE code table
Application-productTE code
A216590-001AP
A216590-002AP
A216590-003AP
A216590-004AP
A216590-005AP

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 3 · 100 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02A216590-001LEUCOVORIN CALCIUMEQ 50MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-19011fe1cb6892…
2026-02-19 14:30 UTC2026-02A216590-002LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-19011fe1cb6892…
2026-02-19 14:30 UTC2026-02A216590-003LEUCOVORIN CALCIUMEQ 200MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-19011fe1cb6892…
2026-02-19 14:30 UTC2026-02A216590-004LEUCOVORIN CALCIUMEQ 350MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-19011fe1cb6892…
2026-02-19 14:30 UTC2026-02A216590-005LEUCOVORIN CALCIUMEQ 500MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-19011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A216590-001LEUCOVORIN CALCIUMEQ 50MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-1931067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A216590-002LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-1931067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A216590-003LEUCOVORIN CALCIUMEQ 200MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-1931067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A216590-004LEUCOVORIN CALCIUMEQ 350MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-1931067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A216590-005LEUCOVORIN CALCIUMEQ 500MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-1931067a03dcf5…
2025-08-23 18:47 UTC2025-08A216590-001LEUCOVORIN CALCIUMEQ 50MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-196a471c1ec25d…
2025-08-23 18:47 UTC2025-08A216590-002LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-196a471c1ec25d…
2025-08-23 18:47 UTC2025-08A216590-003LEUCOVORIN CALCIUMEQ 200MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-196a471c1ec25d…
2025-08-23 18:47 UTC2025-08A216590-004LEUCOVORIN CALCIUMEQ 350MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-196a471c1ec25d…
2025-08-23 18:47 UTC2025-08A216590-005LEUCOVORIN CALCIUMEQ 500MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-196a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A216590-001LEUCOVORIN CALCIUMEQ 50MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-19fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A216590-002LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-19fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A216590-003LEUCOVORIN CALCIUMEQ 200MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-19fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A216590-004LEUCOVORIN CALCIUMEQ 350MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-19fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A216590-005LEUCOVORIN CALCIUMEQ 500MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-19fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A216590-001LEUCOVORIN CALCIUMEQ 50MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-19b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A216590-002LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-19b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A216590-003LEUCOVORIN CALCIUMEQ 200MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-19b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A216590-004LEUCOVORIN CALCIUMEQ 350MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-19b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A216590-005LEUCOVORIN CALCIUMEQ 500MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-19b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A216590-001LEUCOVORIN CALCIUMEQ 50MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-1903ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A216590-002LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-1903ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A216590-003LEUCOVORIN CALCIUMEQ 200MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-1903ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A216590-004LEUCOVORIN CALCIUMEQ 350MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-1903ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A216590-005LEUCOVORIN CALCIUMEQ 500MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-1903ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A216590-001LEUCOVORIN CALCIUMEQ 50MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-192680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A216590-002LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-192680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A216590-003LEUCOVORIN CALCIUMEQ 200MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-192680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A216590-004LEUCOVORIN CALCIUMEQ 350MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-192680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A216590-005LEUCOVORIN CALCIUMEQ 500MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-192680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A216590-001LEUCOVORIN CALCIUMEQ 50MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-195bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A216590-002LEUCOVORIN CALCIUMEQ 100MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-195bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A216590-003LEUCOVORIN CALCIUMEQ 200MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-195bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A216590-004LEUCOVORIN CALCIUMEQ 350MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-195bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A216590-005LEUCOVORIN CALCIUMEQ 500MG BASE/VIALINJECTABLE / INJECTIONAP2023-07-195bbf6a4d5a75…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 3 · 100 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02A216590-001AP1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A216590-002AP1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A216590-003AP1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A216590-004AP1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A216590-005AP1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A216590-001AP131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A216590-002AP131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A216590-003AP131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A216590-004AP131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A216590-005AP131067a03dcf5…
2025-08-23 18:47 UTC2025-08A216590-001AP16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A216590-002AP16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A216590-003AP16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A216590-004AP16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A216590-005AP16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A216590-001AP1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A216590-002AP1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A216590-003AP1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A216590-004AP1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A216590-005AP1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A216590-001AP1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A216590-002AP1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A216590-003AP1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A216590-004AP1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A216590-005AP1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A216590-001AP103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A216590-002AP103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A216590-003AP103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A216590-004AP103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A216590-005AP103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A216590-001AP12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A216590-002AP12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A216590-003AP12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A216590-004AP12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A216590-005AP12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A216590-001AP15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A216590-002AP15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A216590-003AP15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A216590-004AP15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A216590-005AP15bbf6a4d5a75…

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 2 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
leucovorin calciumLEUCOVORIN CALCIUMBluePoint Laboratoriesf579879c-7d53-4663-8ad8-84b8b645cda52025-09-29Warnings, Adverse reactionsExact identifier
application applno (ANDA): 216590
application number: ANDA216590
leucovorin calciumLEUCOVORIN CALCIUMMeitheal Pharmaceuticals Inc.9df20901-6980-4d4e-89ec-40f3c1f918522025-03-19Warnings, Adverse reactionsExact identifier
application applno (ANDA): 216590
application number: ANDA216590