Application 216778

Type
NDA
Sponsor
ZYDUS LIFESCIENCES

Application Products#

Product, Drug, Ingredient table
ProductDrugIngredientFormStrengthReference drugReference standard
001ZITUVIMET XRMETFORMIN HYDROCHLORIDE; SITAGLIPTINTABLET, EXTENDED RELEASE;ORAL500MG;50MGYesNo
002ZITUVIMET XRMETFORMIN HYDROCHLORIDE; SITAGLIPTINTABLET, EXTENDED RELEASE;ORAL1GM;50MGYesNo
003ZITUVIMET XRMETFORMIN HYDROCHLORIDE; SITAGLIPTINTABLET, EXTENDED RELEASE;ORAL1GM;100MGYesYes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 3 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
N216778-001ZITUVIMET XRMETFORMIN HYDROCHLORIDE; SITAGLIPTIN500MG;50MGTABLET, EXTENDED RELEASE / ORALRLD2024-07-18
N216778-002ZITUVIMET XRMETFORMIN HYDROCHLORIDE; SITAGLIPTIN1GM;50MGTABLET, EXTENDED RELEASE / ORALRLD2024-07-18
N216778-003ZITUVIMET XRMETFORMIN HYDROCHLORIDE; SITAGLIPTIN1GM;100MGTABLET, EXTENDED RELEASE / ORALRLD, RS2024-07-18

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02N216778-001ZITUVIMET XR500MG;50MGTABLET, EXTENDED RELEASE / ORALRLD2024-07-18011fe1cb6892…
2026-02-19 14:30 UTC2026-02N216778-002ZITUVIMET XR1GM;50MGTABLET, EXTENDED RELEASE / ORALRLD2024-07-18011fe1cb6892…
2026-02-19 14:30 UTC2026-02N216778-003ZITUVIMET XR1GM;100MGTABLET, EXTENDED RELEASE / ORALRLD, RS2024-07-18011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N216778-001ZITUVIMET XR500MG;50MGTABLET, EXTENDED RELEASE / ORALRLD2024-07-1831067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N216778-002ZITUVIMET XR1GM;50MGTABLET, EXTENDED RELEASE / ORALRLD2024-07-1831067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N216778-003ZITUVIMET XR1GM;100MGTABLET, EXTENDED RELEASE / ORALRLD, RS2024-07-1831067a03dcf5…
2025-08-23 18:47 UTC2025-08N216778-001ZITUVIMET XR500MG;50MGTABLET, EXTENDED RELEASE / ORALRLD2024-07-186a471c1ec25d…
2025-08-23 18:47 UTC2025-08N216778-002ZITUVIMET XR1GM;50MGTABLET, EXTENDED RELEASE / ORALRLD2024-07-186a471c1ec25d…
2025-08-23 18:47 UTC2025-08N216778-003ZITUVIMET XR1GM;100MGTABLET, EXTENDED RELEASE / ORALRLD, RS2024-07-186a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N216778-001ZITUVIMET XR500MG;50MGTABLET, EXTENDED RELEASE / ORALRLD2024-07-18fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N216778-002ZITUVIMET XR1GM;50MGTABLET, EXTENDED RELEASE / ORALRLD2024-07-18fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N216778-003ZITUVIMET XR1GM;100MGTABLET, EXTENDED RELEASE / ORALRLD, RS2024-07-18fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N216778-001ZITUVIMET XR500MG;50MGTABLET, EXTENDED RELEASE / ORALRLD2024-07-18b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N216778-002ZITUVIMET XR1GM;50MGTABLET, EXTENDED RELEASE / ORALRLD2024-07-18b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N216778-003ZITUVIMET XR1GM;100MGTABLET, EXTENDED RELEASE / ORALRLD, RS2024-07-18b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N216778-001ZITUVIMET XR500MG;50MGTABLET, EXTENDED RELEASE / ORALRLD2024-07-1803ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N216778-002ZITUVIMET XR1GM;50MGTABLET, EXTENDED RELEASE / ORALRLD2024-07-1803ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N216778-003ZITUVIMET XR1GM;100MGTABLET, EXTENDED RELEASE / ORALRLD, RS2024-07-1803ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N216778-001ZITUVIMET XR500MG;50MGTABLET, EXTENDED RELEASE / ORALRLD2024-07-182680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N216778-002ZITUVIMET XR1GM;50MGTABLET, EXTENDED RELEASE / ORALRLD2024-07-182680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N216778-003ZITUVIMET XR1GM;100MGTABLET, EXTENDED RELEASE / ORALRLD, RS2024-07-182680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N216778-001ZITUVIMET XR500MG;50MGTABLET, EXTENDED RELEASE / ORALRLD2024-07-185bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N216778-002ZITUVIMET XR1GM;50MGTABLET, EXTENDED RELEASE / ORALRLD2024-07-185bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N216778-003ZITUVIMET XR1GM;100MGTABLET, EXTENDED RELEASE / ORALRLD, RS2024-07-185bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N216778-001ZITUVIMET XR500MG;50MGTABLET, EXTENDED RELEASE / ORALRLD2024-07-18d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N216778-002ZITUVIMET XR1GM;50MGTABLET, EXTENDED RELEASE / ORALRLD2024-07-18d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N216778-003ZITUVIMET XR1GM;100MGTABLET, EXTENDED RELEASE / ORALRLD, RS2024-07-18d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N216778-001ZITUVIMET XR500MG;50MGTABLET, EXTENDED RELEASE / ORALRLD2024-07-18d06236e962d9…
2024-10-29 15:01 UTC2024-10N216778-002ZITUVIMET XR1GM;50MGTABLET, EXTENDED RELEASE / ORALRLD2024-07-18d06236e962d9…
2024-10-29 15:01 UTC2024-10N216778-003ZITUVIMET XR1GM;100MGTABLET, EXTENDED RELEASE / ORALRLD, RS2024-07-18d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N216778-001ZITUVIMET XR500MG;50MGTABLET, EXTENDED RELEASE / ORALRLD2024-07-1879d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N216778-002ZITUVIMET XR1GM;50MGTABLET, EXTENDED RELEASE / ORALRLD2024-07-1879d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N216778-003ZITUVIMET XR1GM;100MGTABLET, EXTENDED RELEASE / ORALRLD, RS2024-07-1879d66fd596c7…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06N216778-001ZITUVIMET XR500MG;50MGTABLET, EXTENDED RELEASE / ORALRLD2024-07-18a50c72e98297…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06N216778-002ZITUVIMET XR1GM;50MGTABLET, EXTENDED RELEASE / ORALRLD2024-07-18a50c72e98297…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06N216778-003ZITUVIMET XR1GM;100MGTABLET, EXTENDED RELEASE / ORALRLD, RS2024-07-18a50c72e98297…

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 4 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
ZITUVIMET XRSITAGLIPTIN AND METFORMIN HYDROCHLORIDEZydus Lifesciences Limited4bade493-499e-434a-97a0-26ca689176232026-01-05Exact identifier
application applno (NDA): 216778
application number: NDA216778
ZITUVIMET XRSITAGLIPTIN AND METFORMIN HYDROCHLORIDEZydus Pharmaceuticals USA Inc.2f635b36-e86a-4e53-8eaf-589917b5f3422025-07-16Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (NDA): 216778
application number: NDA216778
Sitagliptin and Metformin HydrochlorideSITAGLIPTIN AND METFORMIN HYDROCHLORIDEZydus Pharmaceuticals USA Inc.d3a728a0-decb-4340-8ee4-c5e27c13eb192024-08-31Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (NDA): 216778
application number: NDA216778
Sitagliptin and Metformin HydrochlorideSITAGLIPTIN AND METFORMIN HYDROCHLORIDEZydus Lifesciences Limiteda07fa1d9-7171-4f2a-ab34-f8fa410364a62024-08-24Exact identifier
application applno (NDA): 216778
application number: NDA216778

Documents#

Document, Submission type, Date table
DocumentSubmission typeDate
82214ORIG 2025-05-21
82198ORIG 2025-05-19
79142ORIG 2024-07-22
79141ORIG 2024-07-22