Indications and uses
temporarily relieves these symptoms due to a cold or flu: minor aches and pains headache cough sore throat runny nose sneezing nasal and sinus congestion temporarily reduces fever
temporarily relieves these symptoms due to a cold or flu: minor aches and pains headache cough sore throat runny nose sneezing nasal and sinus congestion temporarily reduces fever
do not take more than the recommended dose adults and children 12 years and over: take 2 tablets fully dissolved in 4 oz of water every 4 hours. Do not exceed 8 tablets in 24 hours or as directed by a doctor. children under 12 years: do not use
each tablet contains: potassium 80 mg; sodium 356 mg store at room temperature. Avoid excessive heat.
Drug Facts
| Active ingredients (in each tablet) | Purposes |
|---|---|
| Acetaminophen 250 mg | Pain reliever/fever reducer |
| Chlorpheniramine maleate 2 mg | Antihistamine |
| Dextromethorphan hydrobromide 10 mg | Cough suppressant |
| Phenylephrine hydrochloride 5 mg | Nasal decongestant |
This product contains acetaminophen. Severe liver damage may occur if you take
Acetaminophen may cause severe skin or severe allergic reactions. Symptoms may include:
If a skin or general allergic reaction occurs, stop use and seek medical help right away.
If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly.
Do not use to sedate children.
If pregnant or breast-feeding, ask a health professional before use.
Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
anhydrous citric acid, calcium silicate, dimethicone, FD&C red #40, FD&C yellow #6, flavors, magnesium stearate, maltodextrin, mannitol, potassium bicarbonate, povidone, sodium bicarbonate, sucralose
1-800-986-0369 (Mon-Fri 9AM – 5PM EST)
Alka-
Seltzer
PLUS®
ACETAMINOPHEN / Pain Reliever-Fever Reducer
Chlorpheniramine Maleate / Antihistamine
Dextromethorphan HBr / Cough Suppressant
Phenylephrine Hydrochloride / Nasal Decongestant
SEVERE
Cold
& Flu
CITRUS
• Fever & Body Ache • Cough • Nasal Congestion
• Runny Nose • Sore Throat
BAYER
POWER FAST FiZZ™
2
EFFERVESCENT
Tablets
Single-Pack

| RxCUI | RxNorm string | TTY | SPL version |
|---|---|---|---|
| 1536477 | acetaminophen 250 MG / chlorpheniramine maleate 2 MG / dextromethorphan HBr 10 MG / phenylephrine HCl 5 MG Effervescent Oral Tablet | PSN | 2 |
| 1536477 | acetaminophen 250 MG / chlorpheniramine maleate 2 MG / dextromethorphan hydrobromide 10 MG / phenylephrine hydrochloride 5 MG Effervescent Oral Tablet | SCD | 2 |
| 1536477 | APAP 250 MG / Chlorpheniramine Maleate 2 MG / Dextromethorphan Hydrobromide 10 MG / Phenylephrine Hydrochloride 5 MG Effervescent Oral Tablet | SY | 2 |
| Class | Version | Type | Effective |
|---|---|---|---|
| CHLORPHENIRAMINE Pharmacologic Class Indexing | 3 | Indexing - Pharmacologic Class | 20180813 |
| DEXTROMETHORPHAN Pharmacologic Class Indexing | 2 | Indexing - Pharmacologic Class | 20180813 |
| PHENYLEPHRINE Pharmacologic Class Indexing | 2 | Indexing - Pharmacologic Class | 20180813 |
| NDC | Effective | Action | Document | Indexing SPL | Related label |
|---|---|---|---|---|---|
| 52904-830-04 | 2024-01-30 | C162847 | 48780-1 | 1030e365-3531-111a-e063-dadaa90a10e2 | Alka Seltzer Plus ® Severe Cold and Flu |
| 52904-830-05 | 2024-01-30 | C162847 | 48780-1 | 1030e365-3531-111a-e063-dadaa90a10e2 | Alka Seltzer Plus ® Severe Cold and Flu |
| 52904-830-20 | 2024-01-30 | C162847 | 48780-1 | 1030e365-3531-111a-e063-dadaa90a10e2 | Alka Seltzer Plus ® Severe Cold and Flu |
| 52904-830-25 | 2024-01-30 | C162847 | 48780-1 | 1030e365-3531-111a-e063-dadaa90a10e2 | Alka Seltzer Plus ® Severe Cold and Flu |
| 52904-830-30 | 2024-01-30 | C162847 | 48780-1 | 1030e365-3531-111a-e063-dadaa90a10e2 | Alka Seltzer Plus ® Severe Cold and Flu |
| Package NDC | Product | Description | Form | Quantity | Strength | SPL version |
|---|---|---|---|---|---|---|
| 52904-830-04 | Alka Seltzer Plus Severe Cold and Flu PowerFast Fizz | 2 in 1 POUCH | TABLET, EFFERVESCENT | 2 | 2 | |
| 52904-830-04 | Alka Seltzer Plus Severe Cold and Flu PowerFast Fizz | 1 in 1 BLISTER PACK | TABLET, EFFERVESCENT | 1 | 2 | |
| 52904-830-05 | Alka Seltzer Plus Severe Cold and Flu PowerFast Fizz | 2 in 1 BLISTER PACK | TABLET, EFFERVESCENT | 2 | 2 | |
| 52904-830-05 | Alka Seltzer Plus Severe Cold and Flu PowerFast Fizz | 2 in 1 POUCH | TABLET, EFFERVESCENT | 2 | 2 | |
| 52904-830-20 | Alka Seltzer Plus Severe Cold and Flu PowerFast Fizz | 2 in 1 POUCH | TABLET, EFFERVESCENT | 2 | 2 | |
| 52904-830-20 | Alka Seltzer Plus Severe Cold and Flu PowerFast Fizz | 20 in 1 CARTON | TABLET, EFFERVESCENT | 20 | 2 | |
| 52904-830-25 | Alka Seltzer Plus Severe Cold and Flu PowerFast Fizz | 2 in 1 POUCH | TABLET, EFFERVESCENT | 2 | 2 | |
| 52904-830-25 | Alka Seltzer Plus Severe Cold and Flu PowerFast Fizz | 25 in 1 CARTON | TABLET, EFFERVESCENT | 25 | 2 | |
| 52904-830-30 | Alka Seltzer Plus Severe Cold and Flu PowerFast Fizz | 30 in 1 CARTON | TABLET, EFFERVESCENT | 30 | 2 | |
| 52904-830-30 | Alka Seltzer Plus Severe Cold and Flu PowerFast Fizz | 2 in 1 POUCH | TABLET, EFFERVESCENT | 2 | 2 |
| NDC | Dashboard title | SPL version | Validation | Dashboard ZIP |
|---|---|---|---|---|
| 52904-830 | ALKA SELTZER PLUS SEVERE COLD AND FLU POWERFAST FIZZ (CHLORPHENIRAMINE MALEATE, ACETAMINOPHEN, PHENYLEPHRINE HYDROCHLORIDE, DEXTROMETHORPHAN HYDROBROMIDE TABLET, EFFERVESCENT) TABLET, EFFERVESCENT [SELECT CORPORATION] | 2 | Legacy NDC, 10 package rows | 20220514_00c4b91d-2edf-4090-9de3-7eac35d7428c.zip |
Every source-derived product name is available through these pages.
| Product NDC | Package NDC |
|---|---|
| 52904-830 | 52904-830-04, 52904-830-05, 52904-830-20, 52904-830-25, 52904-830-30 |
| 0280-0022 |
Every source-derived ingredient row is available through these pages.
| Name | UNII | Kind |
|---|---|---|
| Acetaminophen | 362O9ITL9D | ACTIB |
| Dextromethorphan hydrobromide | 9D2RTI9KYH | ACTIB |
| Phenylephrine hydrochloride | 04JA59TNSJ | ACTIB |
| Chlorpheniramine maleate | V1Q0O9OJ9Z | ACTIB |
| acesulfame potassium | 23OV73Q5G9 | IACT |
| anhydrous citric acid | XF417D3PSL | IACT |
| FD&C red no. 40 | WZB9127XOA | IACT |
| magnesium stearate | 70097M6I30 | IACT |
| maltodextrin | 7CVR7L4A2D | IACT |
| mannitol | 3OWL53L36A | IACT |
| saccharin sodium | SB8ZUX40TY | IACT |
| sodium bicarbonate | 8MDF5V39QO | IACT |
OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.
| Brand | Generic | Manufacturer | SPL set ID | Effective date | Available safety fields | Join |
|---|---|---|---|---|---|---|
| eda1d1c6-b5f4-4b40-89c5-ee0c44a78ee3 | 00c4b91d-2edf-4090-9de3-7eac35d7428c | 2022-05-12 | Warnings | eda1d1c6-b5f4-4b40-89c5-ee0c44a78ee3 00c4b91d-2edf-4090-9de3-7eac35d7428c |
Adverse event summaries are temporarily unavailable. Other product information remains available.