Quest Plus by is a Animal medication manufactured, distributed, or labeled by Zoetis Inc.. Drug facts, warnings, and ingredients follow.
QUEST PLUS Gel (moxidectin/praziquantel) when administered at the recommended dose level of
0.4 mg moxidectin/kg and 2.5 mg praziquantel/kg (2.2 lb) body weight is effective in the treatment and control of the following stages of gastrointestinal parasites in horses and ponies:
Strongylus vulgaris – (adults and L4/L5 arterial stages)
Strongylus edentatus – (adults and tissue stages)
Triodontophorus brevicauda – (adults)
Triodontophorus serratus – (adults)
Cylicostephanus spp., including
Cylicocyclus spp., including
Undifferentiated lumenal larvae
Late L3 and L4 mucosal cyathostome larvae
Parascarisequorum – (adults and L4 larval stages)
Oxyuris equi – (adults and L4 larval stages)
Trichostrongylus axei– (adults)
Large-mouth stomach worms:
Habronema muscae– (adults)
Horse stomach bots:
Gasterophilus intestinalis– (2nd and 3rd instars)
Gasterophilus nasalis– (3rd instars)
Anoplocephala perfoliata – (adults)
One administration of the recommended dose rate of QUEST PLUS Gel also suppresses strongyle egg
production through 84 days
Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. For best
control of parasites, all horses and ponies should be included in a strategic treatment program, with
particular attention given to high performance animals. In foals, initial treatment is recommended at
6 months of age, after which they should be included in a recurrent treatment program. Because
QUEST PLUS Gel provides eff ective control of the mucosal stages of small strongyles (encysted
cyathostomes) and tapeworms, it is useful in reducing the frequency of treatment required for successful
strategic equine parasite control. A veterinarian can assist in preparing the best program for your needs.
QUEST PLUS Gel when used at the recommended dose rate suppresses strongyle egg production
through 84 days following a single oral administration. This residual strongyle control reduces
pasture contamination and provides a period of protection from reinfection for horses and ponies
maintained on the same pasture.
QUEST PLUS Gel contains two active pharmaceutical ingredients, moxidectin and praziquantel.
Moxidectin acts by interfering with chloride channel-mediated neurotransmission in the parasite.
This results in paralysis and elimination of the parasite. Moxidectin is safe for use in horses and ponies
because it does not have the same injurious eff ect on the mammalian nervous system. Praziquantel
increases the tapeworm’s membrane permeability to calcium and other cations causing severe
contraction and paralysis of the tapeworm’s muscles.
This spastic paralysis results in the inability of tapeworms to attach to the host’s intestinal wall.
Detached tapeworms are either destroyed by the host’s immune defense system or passed in the feces.
QUEST PLUS Gel is specially formulated as a palatable gel which is easily administered to horses
and ponies. QUEST PLUS Gel is packaged in ready-to-use SURE-DIAL® syringes. The syringe is
calibrated in 50-pound increments, up to 1500 pounds. This enables the administration of the
recommended dose level by choosing a setting consistent with the animal’s weight.
Since the dose is based on the weight of the animal, you need to use a scale or weight tape to fi nd
each animal’s weight before treating with QUEST PLUS Gel. Once the weight is known, set the dose
for each horse or pony as follows.
1. Hold the syringe with the capped end pointing to the left and so that you can see the
weight measurements and tick marks (small black lines). Each tick mark relates to 50 lb
of body weight.
2. Turn the white dial ring until the left side of the ring lines up with the weight of the animal.
1. Make sure there is no feed in the animal’s mouth.
2. Remove the cap from the end of the syringe. Save the cap for reuse.
3. Place the tip of the syringe inside the animal’s mouth at the space between the teeth.
4. Gently push the plunger until it stops, depositing the gel on the back of the tongue.
5. Remove the syringe from the animal’s mouth and raise the animal’s head slightly to make
sure it swallows the gel.
6. Replace the syringe cap.
If the first animal you treat weighs less than 1500 lb, there will be gel left in the syringe. You can use
this gel to treat other horses or ponies. To set the next dose, add the weight of the animal you want
to treat to the dose setting already on the syringe. For example, if the syringe was first used to treat
a 250 lb animal, the white dial ring is set on 250 lb. To treat a 500 lb animal next, move the white dial
ring to the 750 lb marking (250+500=750). You need more than one syringe to treat horses weighing
more than 1500 lb.
QUEST PLUS Gel can be safely administered at the recommended dose to horses and ponies of all
breeds at least 6 months of age and older. Transient ataxia, incoordination, lethargy, depression and
droopy lips and eyelids may be seen when very young or debilitated animals are treated. In these
instances, supportive care may be advisable. QUEST PLUS Gel is safe for use in breeding, pregnant,
and lactating mares. In a reproductive safety study, 10 mares received QUEST PLUS Gel at three times
the recommended dosage, and 10 mares received tap water (control). Mares were dosed at least
once a month from breeding through 30 days post-foaling, with increased frequency (every 2 weeks)
around breeding. Nine out of 10 QUEST PLUS Gel treated mares became pregnant, and gave birth
to live foals. Ten control mares became pregnant, and 8 out of the 10 mares gave birth to live foals.
One QUEST PLUS Gel treated mare had episodes of depression, decreased appetite, and diarrhea
shortly after receiving 5 of the 17 (29%) doses. The same mare had one episode of colic shortly
after one administration of QUEST PLUS Gel. This mare’s colic, depression, decreased appetite, and
diarrhea all resolved without treatment. Another QUEST PLUS Gel treated mare had an abnormal
reproductive cycle (prolonged time to ovulation) following foal heat (at least 39 days). This mare
became pregnant on the fi rst breeding and gave birth to a female foal that was normal at birth;
however, the foal developed an enlarged clitoris by Day 30 post-foaling.
To report adverse drug reactions or to obtain a copy of the Safety Data Sheet (SDS) call 1-888-963-8471.
Not for use in humans. Keep this and all drugs out of the reach of children. Do not ingest. If swallowed, induce vomiting. Wash hands and contaminated skin with soap and water. If accidental contact with eyes occurs, flush repeatedly with water. If irritation or any other symptom attributable to exposure to this product persists, consult your physician.
QUEST PLUS Gel is available in one syringe applicator size.
Each SURE-DIAL® syringe contains 0.5 oz (14.0 g) of QUEST PLUS Gel which is suffi cient to treat a
single horse weighing up to 1500 lb, or two or more lighter animals with a combined body weight
of up to 1500 lb.
0.5 oz (14.0 g) syringe - 20 mg moxidectin and 125 mg praziquantel per mL
Store at or below 77°F (25°C). Avoid freezing. If frozen, thaw completely before use. Store partiallyused
syringes with the cap tightly secured.
moxidectin and praziquantel gel
|Labeler - Zoetis Inc. (828851555)|
Registration | Serial
78209005 2942954 Dead/Cancelled
Wyeth Holdings Corporation