EXAPRIN PLUS- aspirin, acetaminophen, caffeine tablet, film coated

Exaprin Plus by

Drug Labeling and Warnings

Exaprin Plus by is a Otc medication manufactured, distributed, or labeled by HART Health, LNK International, Inc.. Drug facts, warnings, and ingredients follow.

Drug Details [pdf]

Active ingredients (in each caplet)

Acetaminophen 250 mg
Aspirin 250 mg (*nonsteroidal anti-inflammatory drug)
Caffeine 65 mg

Purpose

Pain reliever
Pain reliever
Pain reliever aid

Uses

temporarily relieves minor aches and pains due to:

• headache
• muscular aches
• minor arthritis pain
• backache
• common cold
• menstrual cramps
• toothache
• temporarily reduces fever

Warning

Reye’s syndrome: Children and teenagers should not use this medicine for chicken pox or flu symptoms before a doctor is consulted about Reye's syndrome, a rare but serious illness reported to be associated with asprin.

Allergy alert: Aspirin may cause a severe allergic reaction which may include:

• hives
• facial swelling
• asthma (wheezing)
• shock

Allergy alert: Acetaminophen may cause severe skin reactions which may include:

• rash
• blisters
• skin reddening

Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take:

• with other drugs containing acetaminophen
• more than 4,000 mg of acetaminophen in 24 hours
• 3 or more alcoholic drinks every day while using this product

Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding.

The chance is higher if you:

• are age 60 or older
• have had stomach ulcers or bleeding problems
• take more or for a longer time than directed
• take a blood thinning (anticoagulant) or steroid drug
• have 3 or more alcoholic drinks every day while using this product
• take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others)

Do not use

• if you have ever had an allergic reaction to any other pain reliever/fever reducer
• with any other drug containing acetaminophen (prescription or nonprescription).

Ask a doctor before use if

• you have asthma, high blood pressure, heart disease, liver cirrhosis, or kidney disease
• you are taking a diuretic
• you have a history of stomach problems, such as heartburn
• stomach bleeding warning applies you

Ask a doctor or pharmacist before use if you

• take any drug for diabetes, gout, or arthritis
• take any drug containing an NSAID
• you do not know if other drugs you are taking contain acetaminophen

Stop use and ask a doctor if

• an allergic reaction occurs, seek medical help right away
• new symptoms occur
• redness or swelling is present
• ringing in the ears or loss of hearing occurs
• fever gets worse or lasts more than 3 days
• pain gets worse or lasts more than 10 days
• you have any of the following signs of stomach bleeding: feel faint, vomit blood, have bloody or black stools, or stomach pain that does not get better.

These could be signs of a serious condition

If pregnant or breast-feeding,

ask a health professional before use. It is especially important not to use aspirin at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.

Keep out of reach of children.

Overdose warning

taking more than the recommended dose (overdose) may cause liver damage. Quick medical attention is critical for adult as well as for children even if you do not notice any signs or symptoms. In case of overdose, get medical help or contact a Poison Control Center right away. 1-800-222-1222

Directions

do not take more than directed

Adults and children 12 years of age and over:

• take 2 caplets with water every 6 hours while symptoms persist
• do not take more than 8 caplets in 24 hours unless directed by a doctor.

Children under 12 years of age: ask a doctor

Other information

• caplets enclosed in a sealed packet
• do not use if packet is torn, cut, or open
• store at 59° to 86°F (15°-30°C)
• avoid excessive heat and humidity

Inactive ingredients

corn starch, crospovidone, hypromellose, microcrystalline cellulose, povidone, propylene glycol, sodium lauryl sulfate, sodium starch glycolate, stearic acid, titanium dioxide

PRINCIPAL DISPLAY PANEL

INGREDIENTS AND APPEARANCE

EXAPRIN PLUS 
aspirin, acetaminophen, caffeine tablet, film coated

Product Information
Product Type	HUMAN OTC DRUG	Item Code (Source)	NDC: 50332-0144
Route of Administration	ORAL

Active Ingredient/Active Moiety
Ingredient Name	Basis of Strength	Strength
ACETAMINOPHEN (UNII: 362O9ITL9D) (ACETAMINOPHEN - UNII:362O9ITL9D)	ACETAMINOPHEN	250 mg
ASPIRIN (UNII: R16CO5Y76E) (ASPIRIN - UNII:R16CO5Y76E)	ASPIRIN	250 mg
CAFFEINE (UNII: 3G6A5W338E) (CAFFEINE - UNII:3G6A5W338E)	CAFFEINE	65 mg

Inactive Ingredients
Ingredient Name	Strength
CROSPOVIDONE (UNII: 2S7830E561)
HYPROMELLOSES (UNII: 3NXW29V3WO)
MICROCRYSTALLINE CELLULOSE (UNII: OP1R32D61U)
POVIDONE (UNII: FZ989GH94E)
PROPYLENE GLYCOL (UNII: 6DC9Q167V3)
SODIUM LAURYL SULFATE (UNII: 368GB5141J)
STEARIC ACID (UNII: 4ELV7Z65AP)
TITANIUM DIOXIDE (UNII: 15FIX9V2JP)

Product Characteristics
Color	white	Score	2 pieces
Shape	OVAL	Size	17mm
Flavor		Imprint Code	44;334
Contains

Packaging
#	Item Code	Package Description	Marketing Start Date	Marketing End Date
1	NDC: 50332-0144-4	40 in 1 BOX	08/04/2025
1		2 in 1 PACKET; Type 0: Not a Combination Product
2	NDC: 50332-0144-7	100 in 1 BOX	08/04/2025
2		2 in 1 PACKET; Type 0: Not a Combination Product

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
OTC Monograph Drug	M013	08/04/2025

Labeler - HART Health (069560969)

Registrant - HART Health (069560969)

Establishment
Name	Address	ID/FEI	Business Operations
LNK International, Inc.		832867837	manufacture(50332-0144)