Indications and uses
temporarily relieves minor aches and pains due to: headache muscular aches minor arthritis pain backache common cold menstrual cramps toothache temporarily reduces fever
Exaprin Plus
- Manufacturer
- HART Health | LNK International, Inc.
- Effective date
- 2025-08-04
- Label type
- HUMAN OTC DRUG LABEL
- Version
- 1
- Source
- full-release
- Hydrated at
- 2026-06-01 01:14:05
Label at a glance#
ProductExaprin Plus
Active ingredientACETAMINOPHEN, ASPIRIN, CAFFEINE
Label structure8 sections
Dosage and administration
do not take more than directed Adults and children 12 years of age and over: take 2 caplets with water every 6 hours while symptoms persist do not take more than 8 caplets in 24 hours unless directed by a doctor. Children under 12 years of age: ask a doctor
Storage and handling
caplets enclosed in a sealed packet do not use if packet is torn, cut, or open store at 59° to 86°F (15°-30°C) avoid excessive heat and humidity
Contacts and useful links#
Label contents#
Full prescribing information#
Active ingredients (in each caplet)
Acetaminophen 250 mg
Aspirin 250 mg (*nonsteroidal anti-inflammatory drug)
Caffeine 65 mg
Purpose
Pain reliever
Pain reliever
Pain reliever aid
Uses
temporarily relieves minor aches and pains due to:
- headache
- muscular aches
- minor arthritis pain
- backache
- common cold
- menstrual cramps
- toothache
- temporarily reduces fever
Warning
Reye’s syndrome: Children and teenagers should not use this medicine for chicken pox or flu symptoms before a doctor is consulted about Reye's syndrome, a rare but serious illness reported to be associated with asprin.
Allergy alert: Aspirin may cause a severe allergic reaction which may include:
- hives
- facial swelling
- asthma (wheezing)
- shock
Allergy alert: Acetaminophen may cause severe skin reactions which may include:
- rash
- blisters
- skin reddening
Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take:
- with other drugs containing acetaminophen
- more than 4,000 mg of acetaminophen in 24 hours
- 3 or more alcoholic drinks every day while using this product
Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding.
The chance is higher if you:
- are age 60 or older
- have had stomach ulcers or bleeding problems
- take more or for a longer time than directed
- take a blood thinning (anticoagulant) or steroid drug
- have 3 or more alcoholic drinks every day while using this product
- take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others)
Do not use
- if you have ever had an allergic reaction to any other pain reliever/fever reducer
- with any other drug containing acetaminophen (prescription or nonprescription).
Ask a doctor before use if
- you have asthma, high blood pressure, heart disease, liver cirrhosis, or kidney disease
- you are taking a diuretic
- you have a history of stomach problems, such as heartburn
- stomach bleeding warning applies you
Ask a doctor or pharmacist before use if you
- take any drug for diabetes, gout, or arthritis
- take any drug containing an NSAID
- you do not know if other drugs you are taking contain acetaminophen
Stop use and ask a doctor if
- an allergic reaction occurs, seek medical help right away
- new symptoms occur
- redness or swelling is present
- ringing in the ears or loss of hearing occurs
- fever gets worse or lasts more than 3 days
- pain gets worse or lasts more than 10 days
- you have any of the following signs of stomach bleeding: feel faint, vomit blood, have bloody or black stools, or stomach pain that does not get better.
These could be signs of a serious condition
If pregnant or breast-feeding,
ask a health professional before use. It is especially important not to use aspirin at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.
Keep out of reach of children.
OVERDOSAGE SECTION
Overdose warning
taking more than the recommended dose (overdose) may cause liver damage. Quick medical attention is critical for adult as well as for children even if you do not notice any signs or symptoms. In case of overdose, get medical help or contact a Poison Control Center right away. 1-800-222-1222
Directions
do not take more than directed
Adults and children 12 years of age and over:
- take 2 caplets with water every 6 hours while symptoms persist
- do not take more than 8 caplets in 24 hours unless directed by a doctor.
Children under 12 years of age: ask a doctor
Other information
- caplets enclosed in a sealed packet
- do not use if packet is torn, cut, or open
- store at 59° to 86°F (15°-30°C)
- avoid excessive heat and humidity
Inactive ingredients
corn starch, crospovidone, hypromellose, microcrystalline cellulose, povidone, propylene glycol, sodium lauryl sulfate, sodium starch glycolate, stearic acid, titanium dioxide
PACKAGE LABEL.PRINCIPAL DISPLAY PANEL
DailyMed RxNorm Mappings#
| RxCUI | RxNorm string | TTY | SPL version |
|---|---|---|---|
| 308297 | acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG Oral Tablet | PSN | 1 |
| 2723568 | Exaprin Plus 250 MG / 250 MG / 65 MG Oral Tablet | PSN | 1 |
| 2723568 | acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG Oral Tablet [Exaprin Plus] | SBD | 1 |
| 308297 | acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG Oral Tablet | SCD | 1 |
| 308297 | APAP 250 MG / ASA 250 MG / caffeine 65 MG Oral Tablet | SY | 1 |
| 2723568 | APAP 250 MG / ASA 250 MG / caffeine 65 MG Oral Tablet [Exaprin Plus] | SY | 1 |
| 2723568 | Exaprin Plus (acetaminophen 250 MG / aspirin 250 MG / caffeine 65 MG) Oral Tablet | SY | 1 |
DailyMed Pharmacologic Classes#
| Class | Version | Type | Effective |
|---|---|---|---|
| ASPIRIN Pharmacologic Class Indexing | 3 | Indexing - Pharmacologic Class | 20191108 |
| CAFFEINE Pharmacologic Class Indexing | 2 | Indexing - Pharmacologic Class | 20180813 |
DailyMed Product Concepts#
Products#
Every source-derived product name is available through these pages.
- Exaprin Plus
- Aspirin, Acetaminophen, Caffeine
- CROSPOVIDONE
- HYPROMELLOSES
- MICROCRYSTALLINE CELLULOSE
- POVIDONE
- PROPYLENE GLYCOL
- SODIUM LAURYL SULFATE
- STEARIC ACID
- TITANIUM DIOXIDE
- ACETAMINOPHEN
- ASPIRIN
- CAFFEINE
NDC Codes#
| Product NDC | Package NDC |
|---|---|
| 50332-0144 | 50332-0144-4, 50332-0144-7 |
Ingredients#
Every source-derived ingredient row is available through these pages.
| Name | UNII | Kind |
|---|---|---|
| CROSPOVIDONE | 2S7830E561 | IACT |
| HYPROMELLOSES | 3NXW29V3WO | IACT |
| MICROCRYSTALLINE CELLULOSE | OP1R32D61U | IACT |
| POVIDONE | FZ989GH94E | IACT |
| PROPYLENE GLYCOL | 6DC9Q167V3 | IACT |
| SODIUM LAURYL SULFATE | 368GB5141J | IACT |
| STEARIC ACID | 4ELV7Z65AP | IACT |
| TITANIUM DIOXIDE | 15FIX9V2JP | IACT |
| ACETAMINOPHEN | 362O9ITL9D | ACTIB |
| ASPIRIN | R16CO5Y76E | ACTIB |
| CAFFEINE | 3G6A5W338E | ACTIB |
Source Document#
openFDA label cross-check#
OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.
| Brand | Generic | Manufacturer | SPL set ID | Effective date | Available safety fields | Join |
|---|---|---|---|---|---|---|
| Exaprin Plus | ASPIRIN, ACETAMINOPHEN, CAFFEINE | HART Health | 8a9ca680-e6cf-4ee4-8a5f-bd6d7470b848 | 2025-08-04 | Warnings | 50332-0144-7 50332-0144-4 50332-0144 50332014407 50332014404 c3b1d504-cbf3-4d95-aa12-ee5c70733b6c 8a9ca680-e6cf-4ee4-8a5f-bd6d7470b848 |
Reported adverse events (FAERS/openFDA)#
Adverse event summaries are temporarily unavailable. Other product information remains available.