Indications and uses
helps prevent and reduce plaque and gingivitis helps control plaque bacteria that contribute to the development of gingivitis and bleeding gums
Crest Pro-Health Multi-Protection
- Manufacturer
- The Procter & Gamble Manufacturing Company
- Effective date
- 2026-01-08
- Label type
- HUMAN OTC DRUG LABEL
- Version
- 14
- Source
- monthly-update
- Hydrated at
- 2026-06-03 17:51:55
Label at a glance#
ProductCrest Pro-Health Multi-Protection Refreshing Clean Mint
Active ingredientCETYLPYRIDINIUM CHLORIDE
Label structure10 sections
Dosage and administration
use after your normal brushing and flossing routine; rinse toothpaste from mouth prior to use adults and children 6 yrs. & older: Rinse for 30 seconds with 20 mL (4 teaspoonfuls) twice a day do not swallow children 6 years to under 12 years of age: supervise use children under 6 years of age: do not use
Label contents#
Full prescribing information#
SPL UNCLASSIFIED SECTION
Drug Facts
Active ingredient
Cetylpyridinium chloride 0.07%
Purpose
Antigingivitis/Antiplaque
Uses
- helps prevent and reduce plaque and gingivitis
- helps control plaque bacteria that contribute to the development of gingivitis and bleeding gums
Warnings
OTC - ASK DOCTOR SECTION
Ask a dentist if symptoms persist or condition worsens after regular use.
OTC - KEEP OUT OF REACH OF CHILDREN SECTION
Keep out of reach of children under 6 years of age. If more than used for rinsing is accidentally swallowed, get medical help or contact a Poison Control Center right away.
Directions
- use after your normal brushing and flossing routine; rinse toothpaste from mouth prior to use
- adults and children 6 yrs. & older: Rinse for 30 seconds with 20 mL (4 teaspoonfuls) twice a day
- do not swallow
- children 6 years to under 12 years of age: supervise use
- children under 6 years of age: do not use
Inactive ingredients
water, glycerin, flavor, poloxamer 407, methylparaben, sodium saccharin, propylparaben, blue 1
Questions?
1–800–285–9139
SPL UNCLASSIFIED SECTION
Dist. by Procter & Gamble,
Cincinnati OH 45202
PRINCIPAL DISPLAY PANEL - 500mL Bottle Label
ALCOHOL FREE
Crest®
PRO-HEALTH®
CPC ANTIGINGIVITIS/ANTIPLAQUE ORAL RINSE
CLEAN MINT
MULTI-PROTECTION
99% GERM KILL
- Reduces Plaque Bacteria
- HELPS PREVENT GINGIVITIS
- FRESHENS BREATH
500 mL (16.9 FL OZ)
91986694
DailyMed RxNorm Mappings#
| RxCUI | RxNorm string | TTY | SPL version |
|---|---|---|---|
| 1100924 | cetylpyridinium chloride 0.07 % Oral Rinse | PSN | 14 |
| 1251371 | Crest Pro-Health 0.07 % Oral Rinse | PSN | 14 |
| 1251371 | cetylpyridinium chloride 0.7 MG/ML Mouthwash [Crest Mouthwash] | SBD | 14 |
| 1100924 | cetylpyridinium chloride 0.7 MG/ML Mouthwash | SCD | 14 |
| 1100924 | cetylpyridinium chloride 0.07 % Oral Rinse | SY | 14 |
| 1251371 | Crest 0.07 % Mouthwash | SY | 14 |
FDA-Initiated Inactive NDC Indexing#
DailyMed Package Descriptions#
| Package NDC | Product | Description | Form | Quantity | Strength | SPL version |
|---|---|---|---|---|---|---|
| 37000-451-01 | Crest Pro-Health Multi-ProtectionRefreshing Clean Mint | 36 mL in 1 BOTTLE, PLASTIC | RINSE | 36 | 14 | |
| 37000-451-02 | Crest Pro-Health Multi-ProtectionRefreshing Clean Mint | 100 mL in 1 BOTTLE, PLASTIC | RINSE | 100 | 14 | |
| 37000-451-03 | Crest Pro-Health Multi-ProtectionRefreshing Clean Mint | 250 mL in 1 BOTTLE, PLASTIC | RINSE | 250 | 14 | |
| 37000-451-04 | Crest Pro-Health Multi-ProtectionRefreshing Clean Mint | 500 mL in 1 BOTTLE, PLASTIC | RINSE | 500 | 14 | |
| 37000-451-05 | Crest Pro-Health Multi-ProtectionRefreshing Clean Mint | 1000 mL in 1 BOTTLE, PLASTIC | RINSE | 1000 | 14 | |
| 37000-451-06 | Crest Pro-Health Multi-ProtectionRefreshing Clean Mint | 1500 mL in 1 BOTTLE, PLASTIC | RINSE | 1500 | 14 | |
| 37000-451-10 | Crest Pro-Health Multi-ProtectionRefreshing Clean Mint | 2 in 1 PACKAGE | RINSE | 2 | 14 | |
| 37000-451-10 | Crest Pro-Health Multi-ProtectionRefreshing Clean Mint | 1000 mL in 1 BOTTLE | RINSE | 1000 | 14 | |
| 37000-451-11 | Crest Pro-Health Multi-ProtectionRefreshing Clean Mint | 3 in 1 CELLO PACK | RINSE | 3 | 14 | |
| 37000-451-11 | Crest Pro-Health Multi-ProtectionRefreshing Clean Mint | 1000 mL in 1 BOTTLE, PLASTIC | RINSE | 1000 | 14 |
DailyMed Socrata Ingredients#
| Ingredient | Type | UNII | SPL version | Uploaded |
|---|---|---|---|---|
| Cetylpyridinium chloride | ACTIVE INGREDIENT | D9OM4SK49P | 1 | |
| Cetylpyridinium | ACTIVE MOIETY | CUB7JI0JV3 | 1 | |
| FD&C blue no. 1 | INACTIVE INGREDIENT | H3R47K3TBD | 1 | |
| glycerin | INACTIVE INGREDIENT | PDC6A3C0OX | 1 | |
| methylparaben | INACTIVE INGREDIENT | A2I8C7HI9T | 1 | |
| poloxamer 407 | INACTIVE INGREDIENT | TUF2IVW3M2 | 1 | |
| propylparaben | INACTIVE INGREDIENT | Z8IX2SC1OH | 1 | |
| saccharin sodium dihydrate | INACTIVE INGREDIENT | SB8ZUX40TY | 1 | |
| water | INACTIVE INGREDIENT | 059QF0KO0R | 1 |
Products#
Every source-derived product name is available through these pages.
- Crest Pro-Health Multi-Protection Refreshing Clean Mint
- Cetylpyridinium chloride
- WATER
- GLYCERIN
- POLOXAMER 407
- METHYLPARABEN
- SACCHARIN SODIUM
- PROPYLPARABEN
- FD&C BLUE NO. 1
- CETYLPYRIDINIUM
NDC Codes#
| Product NDC | Package NDC |
|---|---|
| 37000-451 | 37000-451-01, 37000-451-03, 37000-451-04, 37000-451-05, 37000-451-06, 37000-451-10, 37000-451-02, 37000-451-11 |
Ingredients#
Every source-derived ingredient row is available through these pages.
| Name | UNII | Kind |
|---|---|---|
| WATER | 059QF0KO0R | IACT |
| GLYCERIN | PDC6A3C0OX | IACT |
| POLOXAMER 407 | TUF2IVW3M2 | IACT |
| METHYLPARABEN | A2I8C7HI9T | IACT |
| SACCHARIN SODIUM | SB8ZUX40TY | IACT |
| PROPYLPARABEN | Z8IX2SC1OH | IACT |
| FD&C BLUE NO. 1 | H3R47K3TBD | IACT |
| CETYLPYRIDINIUM CHLORIDE | D9OM4SK49P | ACTIB |
Source Document#
Older Hydrated Versions#
| Version | Effective date | Source | Hydrated |
|---|---|---|---|
| 13 | 2025-12-18 | full-release | 2026-06-01 01:26:30 |
Inactive ingredient matches#
Inactive Ingredient Database values describe FDA-listed use contexts. The match method and ambiguity count are shown because ingredient names, routes, and dosage forms are not always unique. Browse recovered IID releases and source provenance.
| DailyMed ingredient | IID ingredient | UNII | Dosage form / route | Potency | Maximum daily exposure | Match |
|---|---|---|---|---|---|---|
| glycerin | GLYCERIN | PDC6A3C0OX | DROPS / ORAL | 300 mg/1ml | ||
| FD&C blue no. 1 | FD&C BLUE NO. 1 | H3R47K3TBD | TABLET, EXTENDED RELEASE / ORAL | 4 mg | ||
| propylparaben | PROPYLPARABEN | Z8IX2SC1OH | CAPSULE, EXTENDED RELEASE / ORAL | 0.22 mg | ||
| poloxamer 407 | POLOXAMER 407 | TUF2IVW3M2 | POWDER, FOR SUSPENSION / ORAL | 0.01 mg | ||
| FD&C blue no. 1 | FD&C BLUE NO. 1 | H3R47K3TBD | CAPSULE, COATED PELLETS / ORAL | NA | ||
| methylparaben | METHYLPARABEN | A2I8C7HI9T | TABLET, CHEWABLE / ORAL | 1.28 mg | ||
| glycerin | GLYCERIN | PDC6A3C0OX | ELIXIR / ORAL | 5621 mg | ||
| FD&C blue no. 1 | FD&C BLUE NO. 1 | H3R47K3TBD | TABLET, FILM COATED / ORAL | 0.16 mg | ||
| FD&C blue no. 1 | FD&C BLUE NO. 1 | H3R47K3TBD | POWDER, FOR SOLUTION / ORAL | 0.04 mg/5ml | ||
| saccharin sodium dihydrate | SACCHARIN SODIUM | SB8ZUX40TY | CONCENTRATE / ORAL | 6 mg | ||
| FD&C blue no. 1 | FD&C BLUE NO. 1 | H3R47K3TBD | CAPSULE, COATED PELLETS / ORAL | NA | ||
| saccharin sodium dihydrate | SACCHARIN SODIUM | SB8ZUX40TY | SYRUP / ORAL | 24 mg | ||
| propylparaben | PROPYLPARABEN | Z8IX2SC1OH | TABLET / ORAL | 0.2 mg | ||
| methylparaben | METHYLPARABEN | A2I8C7HI9T | SUSPENSION / ORAL | 388 mg | ||
| poloxamer 407 | POLOXAMER 407 | TUF2IVW3M2 | TABLET / ORAL | 495 mg | ||
| FD&C blue no. 1 | FD&C BLUE NO. 1 | H3R47K3TBD | CAPSULE, DELAYED RELEASE PELLETS / ORAL | 0.01 mg | ||
| methylparaben | METHYLPARABEN | A2I8C7HI9T | CONCENTRATE / ORAL | 12 mg | ||
| methylparaben | METHYLPARABEN | A2I8C7HI9T | DROPS / ORAL | 1 mg/1ml | ||
| FD&C blue no. 1 | FD&C BLUE NO. 1 | H3R47K3TBD | CAPSULE, DELAYED RELEASE / ORAL | 2 mg | ||
| glycerin | GLYCERIN | PDC6A3C0OX | DROPS / ORAL | 300 mg/1ml | ||
| FD&C blue no. 1 | FD&C BLUE NO. 1 | H3R47K3TBD | CAPSULE, COATED, EXTENDED RELEASE / ORAL | NA | ||
| FD&C blue no. 1 | FD&C BLUE NO. 1 | H3R47K3TBD | ELIXIR / ORAL | NA | ||
| saccharin sodium dihydrate | SACCHARIN SODIUM | SB8ZUX40TY | ELIXIR / ORAL | 15 mg/5ml | ||
| methylparaben | METHYLPARABEN | A2I8C7HI9T | CONCENTRATE / ORAL | 12 mg | ||
| FD&C blue no. 1 | FD&C BLUE NO. 1 | H3R47K3TBD | LIQUID / ORAL | NA | ||
| FD&C blue no. 1 | FD&C BLUE NO. 1 | H3R47K3TBD | SYRUP / ORAL | 0.05 mg/5ml | ||
| propylparaben | PROPYLPARABEN | Z8IX2SC1OH | LIQUID / ORAL | 2 mg | ||
| propylparaben | PROPYLPARABEN | Z8IX2SC1OH | SOLUTION / ORAL | 100 mg | ||
| saccharin sodium dihydrate | SACCHARIN SODIUM | SB8ZUX40TY | TABLET / ORAL | 43 mg | ||
| poloxamer 407 | POLOXAMER 407 | TUF2IVW3M2 | CAPSULE / ORAL | 468 mg | ||
| glycerin | GLYCERIN | PDC6A3C0OX | TABLET, EXTENDED RELEASE / ORAL | 7 mg | ||
| propylparaben | PROPYLPARABEN | Z8IX2SC1OH | CONCENTRATE / ORAL | 2.5 mg/5ml | ||
| FD&C blue no. 1 | FD&C BLUE NO. 1 | H3R47K3TBD | POWDER, FOR SOLUTION / ORAL | 0.04 mg/5ml | ||
| saccharin sodium dihydrate | SACCHARIN SODIUM | SB8ZUX40TY | TABLET, FILM COATED / ORAL | 2 mg | ||
| methylparaben | METHYLPARABEN | A2I8C7HI9T | SUSPENSION, EXTENDED RELEASE / ORAL | 40 mg | ||
| propylparaben | PROPYLPARABEN | Z8IX2SC1OH | CAPSULE / ORAL | 1 mg | ||
| methylparaben | METHYLPARABEN | A2I8C7HI9T | CAPSULE / ORAL | 7 mg | ||
| FD&C blue no. 1 | FD&C BLUE NO. 1 | H3R47K3TBD | CAPSULE, EXTENDED RELEASE / ORAL | 1 mg | ||
| saccharin sodium dihydrate | SACCHARIN SODIUM | SB8ZUX40TY | CAPSULE / ORAL | 24 mg | ||
| propylparaben | PROPYLPARABEN | Z8IX2SC1OH | ELIXIR / ORAL | 200 mg | ||
| FD&C blue no. 1 | FD&C BLUE NO. 1 | H3R47K3TBD | SUSPENSION / ORAL | 1 mg | ||
| FD&C blue no. 1 | FD&C BLUE NO. 1 | H3R47K3TBD | LIQUID / ORAL | NA | ||
| FD&C blue no. 1 | FD&C BLUE NO. 1 | H3R47K3TBD | LIQUID / ORAL | NA | ||
| saccharin sodium dihydrate | SACCHARIN SODIUM | SB8ZUX40TY | PASTE / ORAL | 3 mg | ||
| saccharin sodium dihydrate | SACCHARIN SODIUM | SB8ZUX40TY | POWDER, FOR SUSPENSION / ORAL | 85 mg | ||
| glycerin | GLYCERIN | PDC6A3C0OX | ELIXIR / ORAL | 5621 mg | ||
| glycerin | GLYCERIN | PDC6A3C0OX | SUSPENSION, EXTENDED RELEASE / ORAL | 2000 mg | ||
| methylparaben | METHYLPARABEN | A2I8C7HI9T | ELIXIR / ORAL | 800 mg | ||
| methylparaben | METHYLPARABEN | A2I8C7HI9T | CAPSULE / ORAL | 7 mg | ||
| glycerin | GLYCERIN | PDC6A3C0OX | CAPSULE, COATED / ORAL | 14.21 mg | ||
| propylparaben | PROPYLPARABEN | Z8IX2SC1OH | CAPSULE / ORAL | 1 mg | ||
| FD&C blue no. 1 | FD&C BLUE NO. 1 | H3R47K3TBD | LIQUID / ORAL | NA | ||
| FD&C blue no. 1 | FD&C BLUE NO. 1 | H3R47K3TBD | TABLET, COATED / ORAL | 0.52 mg | ||
| FD&C blue no. 1 | FD&C BLUE NO. 1 | H3R47K3TBD | CAPSULE, LIQUID FILLED / ORAL | 0.08 mg | ||
| glycerin | GLYCERIN | PDC6A3C0OX | TABLET, FILM COATED / ORAL | 1.55 mg | ||
| propylparaben | PROPYLPARABEN | Z8IX2SC1OH | CAPSULE, EXTENDED RELEASE / ORAL | 0.22 mg | ||
| FD&C blue no. 1 | FD&C BLUE NO. 1 | H3R47K3TBD | FILM, SOLUBLE / ORAL | 0.04 mg | ||
| saccharin sodium dihydrate | SACCHARIN SODIUM | SB8ZUX40TY | ELIXIR / ORAL | 15 mg/5ml | ||
| methylparaben | METHYLPARABEN | A2I8C7HI9T | POWDER, FOR SUSPENSION / ORAL | 75 mg | ||
| saccharin sodium dihydrate | SACCHARIN SODIUM | SB8ZUX40TY | SOLUTION / ORAL | 665 mg |
openFDA label cross-check#
OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.
| Brand | Generic | Manufacturer | SPL set ID | Effective date | Available safety fields | Join |
|---|---|---|---|---|---|---|
| Crest Pro-Health Multi-Protection Refreshing Clean Mint | CETYLPYRIDINIUM CHLORIDE | The Procter & Gamble Manufacturing Company | 8867d791-7e93-4f39-aaaf-bfbee8296fd9 | 2026-01-08 | Warnings | 37000-451-04 37000-451-11 37000-451-03 37000-451-02 37000-451-05 37000-451-06 37000-451-01 37000-451-10 37000-451 37000045103 37000045105 37000045111 37000045106 37000045110 37000045104 37000045101 37000045102 47e4e758-d6de-4e88-e063-6394a90ac40e 8867d791-7e93-4f39-aaaf-bfbee8296fd9 |
Reported adverse events (FAERS/openFDA)#
Adverse event summaries are temporarily unavailable. Other product information remains available.