DRONTAL PLUS TASTE TABS

PA104396X

CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Drontal Plus Taste Tabs (praziquantel/pyrantel pamoate/febantel) Broad Spectrum Chewable Anthelmintic Tablets for Dogs are available in three tablet sizes. Each size is scored for convenient oral administration.

Each Drontal Plus Taste Tabs Tablet for Puppies and Small Dogs contains 22.7 mg praziquantel, 22.7 mg pyrantel base as pyrantel pamoate and 113.4 mg febantel.

Each Drontal Plus Taste Tabs Tablet for Medium Sized Dogs contains 68.0 mg praziquantel, 68.0 mg pyrantel base as pyrantel pamoate and 340.2 mg febantel.

Each Drontal Plus Taste Tabs Tablet for Large Dogs contains 136.0 mg praziquantel, 136.0 mg pyrantel base as pyrantel pamoate, and 680.4 mg febantel.

Drontal Plus Taste Tabs Tablets contain three active ingredients having different modes of action and spectra of activity. Praziquantel is active against cestodes (tapeworms). Praziquantel is absorbed, metabolized in the liver and excreted in the bile. Upon entering the digestive tract from the bile, cestocidal activity is exhibited.¹ Following exposure to praziquantel, the tapeworm loses its ability to resist digestion by the mammalian host. Because of this, whole tapeworms, including the scolices, are very rarely passed after administration of praziquantel. In many instances only disintegrated and partially digested pieces of tapeworms will be seen in the stool. The majority of tapeworms are digested and are not found in the feces.

Pyrantel pamoate is active against hookworms and ascarids. Pyrantel pamoate acts on the cholinergic receptors of the nematode resulting in spastic paralysis. Peristaltic action of the intestinal tract then eliminates the parasite.²

Febantel is active against nematode parasites including whipworms. Febantel is rapidly absorbed and metabolized in the animal. Available information suggests that the parasite's energy metabolism is blocked, leading to energy exchange breakdown and inhibited glucose uptake.

Laboratory efficacy and clinical studies conducted with Drontal Plus Anthelmintic Tablets demonstrate that each of the three active ingredients act independently without interference. The combined tablet formulation provides a wide spectrum of activity against the indicated species of intestinal helminths.

Drontal Plus (praziquantel/pyrantel pamoate/febantel) Taste Tabs Broad Spectrum Chewable Anthelmintic Tablets are indicated for removal of Tapeworms (Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus, and removal and control of Echinococcus multilocularis) and for removal of Hookworms (Ancylostoma caninum, Uncinaria stenocephala), Ascarids (Toxocara canis, Toxascaris leonina), and Whipworms (Trichuris vulpis) in dogs.

DO NOT USE IN PREGNANT ANIMALS. Dogs treated with elevated levels (6 consecutive days with 3 times the labeled dosage rate) of the combination of febantel and praziquantel in early pregnancy demonstrated an increased incidence of abortion and fetal abnormalities.⁸ The effects of Drontal Plus Anthelmintic Tablets on pregnant animals have not been determined.

There are no known contraindications against the use of praziquantel or pyrantel pamoate in dogs.

Strict hygienic precautions should be taken when handling dogs or feces suspected of harboring E. multilocularis. Infected dogs treated for the first time with Drontal Plus Taste Tabs Tablets and dogs treated at intervals greater than 28 days may shed eggs in the feces after treatment. The animal should be held in the clinic during this interval and all feces should be incinerated or autoclaved. If these procedures are not possible, the eggs can be destroyed by soaking the feces in a sodium hypochlorite (bleach) solution of 3.75% or greater.⁷ All areas where the animal was maintained or in contact with should be thoroughly cleaned with sodium hypochlorite and allowed to dry completely before reuse.

KEEP OUT OF REACH OF CHILDREN.

None of the 103 dogs treated with Drontal Plus Anthelmintic Tablets in the clinical field studies exhibited drug-related side effects. Of the 40 dogs treated with Drontal Plus Taste Tabs Tablets in laboratory studies, two dogs exhibited vomiting, one puppy exhibited bloody/mucoid stool and one puppy exhibited watery/profuse stool.

For product questions, to report adverse reactions, or for a copy of the Safety Data Sheet (SDS), call Elanco Product & Veterinary Support at 888-545-5973. For additional information about reporting adverse drug experiences for animal drugs, contact FDA at 1-888-FDA-VETS or www.fda.gov/reportanimalae.

Controlled safety evaluations have been conducted in dogs with Drontal Plus (praziquantel/pyrantel pamoate/febantel) Anthelmintic Tablets. Dogs receiving up to 5 times the label dosage (35 mg praziquantel, 35 mg pyrantel pamoate and 179 mg febantel per kg of body weight) for 3 consecutive days (3 times the label duration) showed clinical signs of vomition and non-formed stools. One dog receiving a 3 times labeled dose had elevated SGPT, SGOT, CPK and GGT readings (outside of normal range) at 6 days post-treatment. No additional findings were noted in hematology/clinical chemistry parameters nor were there any treatment-related histological lesions. Vomition was the only side effect observed when dogs received a single treatment of 61 mg praziquantel, 61 mg pyrantel pamoate and 305 mg febantel/kg with one dog having an elevated SGPT reading (outside of normal range) at 24 hours post-treatment which had returned to normal by 7 days.

Drontal Plus Taste Tabs Tablets should be stored at or below 77 °F (25 °C).

Un-blistered whole or partial tablets should be stored in a tightly sealed container.

Drontal Plus Taste Tabs Tablets are available in three tablet sizes:

40 tabs/box for Puppies and Small Dogs

40 tabs/box for Medium Sized Dogs

30 tabs /box for Large Dogs

1. 1.Andrews P. 1976. Pharmacokinetic Studies with DRONCIT in Animals Using a Biological Assay. Veterinary Medical Review. 2:154-165.
2. 2.Campbell WC. 1986. The Chemotherapy of Parasitic Infections. J. Parasit. 72(1):45-61.
3. 3.Hildreth MB Johnson MD and Kazacos KR. 1991. A Zoonosis of Increasing Concern in the United States. Compendium for Cont. Ed. 13(5): 727-740.
4. 4.Lieby PD Carney WP and Woods CE. 1970. Studies on Sylvatic Echinococcosis, III. Host Occurrence and Geographic Distribution of Echinococcus multilocularis in the North Central United States. J. Parasit. 56(6): 1141-1150.
5. 5.Georgi JR and Georgi ME. 1990. Parasitology for Veterinarians. W.B. Saunders Co. 118-138.
6. 6.Soulsby EJL. 1982. Helminths, Arthropods and Protozoa of Domesticated Animals. 7th Edition. Lea & Febiger. 118-138.
7. 7.Craig PS and McPharson CNL. 1988. Sodium Hypochlorite as an Ovicide for Echinococcus. Ann Trop Med. and Parasit. 82(2): 211-213.
8. 8.Freedom of Information Summary (FOI) NADA 133-953 Vercom Paste (febantel and praziquantel).

Patent information at
www.elancopatents.com
November 2025
PA104396X

Drontal, Taste Tabs, Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates.

© 2025 Elanco or its affiliates

Manufactured for:
Elanco US Inc
Indianapolis, IN 46221 U.S.A.
Approved by FDA under NADA # 141-007

Elanco™

40 Taste Tabs (4 strips of 10 Tablets)

Taste Tabs^TM
Drontal^TM Plus
(praziquantel/pyrantel pamoate/febantel)

Broad Spectrum Chewable Anthelmintic
For Puppies and Small Dogs (2-25 lbs.)

CAUTION: Federal law restricts this drug to
use by or on the order of a licensed veterinarian.

Elanco™

Manufactured for:
Elanco US Inc.
Indianapolis, IN 46221 U.S.A.
Approved by FDA under NADA # 141-007

Each Drontal Plus Taste Tabs Tablet contains:
22.7 mg praziquantel, 22.7 mg pyrantel base
as pyrantel pamoate, and 113.4 mg febantel

WARNING: KEEP OUT OF REACH OF CHILDREN

40 Taste Tabs (4 strips of 10 Tablets)

Taste Tabs^TM
Drontal^TM Plus
(praziquantel/pyrantel pamoate/febantel)

Broad Spectrum Chewable Anthelmintic
For Medium Sized Dogs (26-60 lbs.)

CAUTION: Federal law restricts this drug to
use by or on the order of a licensed veterinarian.

Elanco™

Manufactured for:
Elanco US Inc.
Indianapolis, IN 46221 U.S.A
Approved by FDA under NADA # 141-007

Each Drontal Plus Taste Tabs Tablet contains:
68.0 mg praziquantel, 68.0 mg pyrantel base
as pyrantel pamoate, and 340.2 mg febantel

WARNING: KEEP OUT OF REACH OF CHILDREN

30 Taste Tabs (3 strips of 10 Tablets)

Taste Tabs^TM
Drontal^TM Plus
(praziquantel/pyrantel pamoate/febantel)

Broad Spectrum Chewable Anthelmintic
For Large Dogs (45 lbs. and greater)

CAUTION: Federal law restricts this drug to use by
or on the order of a licensed veterinarian.

Elanco™

Manufactured for:
Elanco US Inc
Indianapolis, IN 46221 U.S.A.
Approved by FDA under NADA # 141-007

Each Drontal Plus Taste Tabs Tablet contains:
136.0 mg praziquantel, 136.0 mg pyrantel base
as pyrantel pamoate, and 680.4 mg febantel

WARNING: KEEP OUT OF REACH OF CHILDREN