Alka-Seltzer Plus Severe Cough Mucus and Congestion
- Product NDC
- 0280-0505
- 11-digit product format
- 002800505
- Labeler code
- 0280
- Product ID
- 0280-0505_45266194-8eb1-21f4-e063-6294a90af1dc
- Type
- HUMAN OTC DRUG
- Nonproprietary name
- Alka-Seltzer Plus Severe Cough Mucus and Congestion
- Dosage form
- CAPSULE, LIQUID FILLED
- Route
- ORAL
- Labeler
- Bayer HealthCare LLC.
- Application
- M012
- Marketing category
- OTC MONOGRAPH DRUG
- Marketing start
- 2015-01-07
- Substance
- PHENYLEPHRINE HYDROCHLORIDE; ACETAMINOPHEN; GUAIFENESIN; DEXTROMETHORPHAN HYDROBROMIDE
- Active strength
- 5; 250; 200; 10 mg/1; mg/1; mg/1; mg/1
- Pharmacologic classes
- Adrenergic alpha1-Agonists [MoA], Decreased Respiratory Secretion Viscosity [PE], Expectorant [EPC], Increased Respiratory Secretions [PE], Sigma-1 Agonist [EPC], Sigma-1 Receptor Agonists [MoA], Uncompetitive N-methyl-D-aspartate Receptor Antagonist [EPC], Uncompetitive NMDA Receptor Antagonists [MoA], alpha-1 Adrenergic Agonist [EPC]
- NDC exclude flag
- No
- Listing certified through
- 2026-12-31
- Current FDA listing
- Yes
Reported adverse events (FAERS/openFDA)#
Adverse event summaries are temporarily unavailable. Other product information remains available.
Additional Listing Data#
- Finished product
- Yes
- Brand name base
- Alka-Seltzer Plus Severe Cough Mucus and Congestion
- Brand name suffix
- Liquid Gels
- Listing expiration
- 2026-12-31
Active Ingredients#
| Ingredient | Strength |
|---|---|
| PHENYLEPHRINE HYDROCHLORIDE | 5 mg/1 |
| ACETAMINOPHEN | 250 mg/1 |
| GUAIFENESIN | 200 mg/1 |
| DEXTROMETHORPHAN HYDROBROMIDE | 10 mg/1 |
Harmonized UNII identifiers#
| Identifier | FDA.report destination |
|---|---|
| 04JA59TNSJ | Internal UNII lookup |
| 362O9ITL9D | Internal UNII lookup |
| 495W7451VQ | Internal UNII lookup |
| 9D2RTI9KYH | Internal UNII lookup |
Harmonized RxCUI identifiers#
| Identifier | FDA.report destination |
|---|---|
| 1432488 | Internal RxNorm lookup |
Harmonized SPL set identifiers#
| Identifier | FDA.report destination |
|---|---|
| 0c120569-622d-3a23-e054-00144ff88e88 | Available on FDA.report |
DailyMed Product Concepts#
DailyMed Package Descriptions#
| Package NDC | Product | Description | Form | Quantity | Strength | SPL version |
|---|---|---|---|---|---|---|
| 0280-0505-20 | Alka-Seltzer Plus Severe Cough Mucus and CongestionLiquid Gels | 2 in 1 CARTON | CAPSULE, LIQUID FILLED | 2 | 8 | |
| 0280-0505-20 | Alka-Seltzer Plus Severe Cough Mucus and CongestionLiquid Gels | 20 in 1 BLISTER PACK | CAPSULE, LIQUID FILLED | 20 | 8 |
DailyMed Billing Units#
| Package NDC | Billing unit | Product NDC | DailyMed indexing SPL | SPL version | Effective |
|---|---|---|---|---|---|
| 0280-0505-20 | EA - Each | 0280-0505 | 8ea7a7fc-a2ac-494d-b781-d53a2a33533b | 1 | 2019-09-05 |
DailyMed Socrata Ingredients#
DailyMed Dashboard NDC Coverage#
| NDC | Dashboard title | SPL version | Validation | Dashboard ZIP |
|---|---|---|---|---|
| 0280-0505 | ALKA-SELTZER PLUS SEVERE COUGH MUCUS AND CONGESTION LIQUID GELS (ALKA-SELTZER PLUS SEVERE COUGH MUCUS AND CONGESTION) CAPSULE, LIQUID FILLED [BAYER HEALTHCARE LLC.] | 7 | Current NDC, Legacy NDC, 2 package rows | 20231205_0c120569-622d-3a23-e054-00144ff88e88.zip |
openFDA label cross-check#
OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.
| Brand | Generic | Manufacturer | SPL set ID | Effective date | Available safety fields | Join |
|---|---|---|---|---|---|---|
| Daytime and Nighttime | ACETAMINOPHEN, GUAIFENESIN, DEXTROMETHORPHAN HBR, DOXYLAMINE SUCCINATE | CVS HEALTH CORP | 43da4211-3bb3-0a8e-e063-6294a90a4fcd | 2026-03-16 | Warnings | M012 |
| Severe Cold and Flu | ACETAMINOPHEN, DEXTROMETHORPHAN HBR, DOXYLAMINE SUCCINATE, PHENYLEPHRINE HCL | HyVee Inc | 96d8b6d1-8a51-41a4-80d3-fab61492b3cc | 2026-03-14 | Warnings | M012 |
| MAXIMUM STRENGTH COLD AND FLU | ACETAMINOPHEN,DEXTROMETHORPHAN HYDROBROMIDE,GUAIFENESIN,PHENYLEPHRINE HYDROCHLORIDE | CVS Pharmacy, Inc | c0b36e4d-3667-58f6-e053-2a95a90afad7 | 2026-03-14 | Warnings | M012 |
| Cold and Flu | ACETAMINOPHEN, DEXTROMETHORPHAN HBR, DOXYLAMINE SUCCINATE | HyVee Inc | a16a85c2-e1fd-4d1a-a650-271ae430eb4f | 2026-03-14 | Warnings | M012 |
| Childrens Allergy Relief | DIPHENHYDRAMINE HCL | Kroger Company | ab12c975-2085-4365-9c4b-0be573a260c4 | 2026-03-13 | Warnings | M012 |
| Daytime Cold and Flu Non drowsy | ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, PHENYLEPHRINE HYDROCHLORIDE | EQUATE (Wal-Mart Stores, Inc.) (see also WAL-MART INC) | db0f0164-3cbd-49b0-91ef-2e5218b09c3f | 2026-03-12 | Warnings | M012 |
| Allergy Relief Complete | DIPHENHYDRAMINE HCL | WinCo Foods, LLC | 88e3e51a-c9a5-43f9-b9d7-97509c607df1 | 2026-03-12 | Warnings | M012 |
| Mucinex Fast-Max Kickstart Severe Cold and Flu and Mucinex Fast-Max Recharge Nighttime Cold and Flu | ACETAMINOPHEN, DEXTROMETHORPHAN HBR, GUAIFENESIN, PHENYLEPHRINE HCL, AND TRIPROLIDINE HCL | RB Health (US) LLC | 4cc490a6-a27a-a25b-e063-6294a90a3a95 | 2026-03-11 | Warnings | M012 |
| Mucus Relief Cold, Flu and Sore Throat | ACETAMINOPHEN, DEXTROMETHORPHAN HBR, GUAIFENESIN, PHENYLEPHRINE HCL | TOPCO ASSOCIATES LLC | 6207ef50-4f28-4dbc-9a52-f44dd53d2a4f | 2026-03-11 | Warnings | M012 |
| severe cold and flu | ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, GUAIFENESIN, PHENYLEPHRINE HYDROCHLORIDE | CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED | c17a10a3-6b8f-4734-8f00-1f4c5c729725 | 2026-03-11 | Warnings | M012 |
| Allergy Relief | DIPHENHYDRAMINE HCL | Strategic Sourcing Services LLC | ba6d69ff-b392-4f21-b3d7-00d8ec5dee32 | 2026-03-11 | Warnings | M012 |
| Sudafed PE Sinus Pressure Plus Pain | ACETAMINOPHEN AND PHENYLEPHRINE HYDROCHLORIDE | Sportpharm LLC | 67428f4b-28be-4682-a9a9-781bf85089ff | 2026-03-10 | Warnings | M012 |
| Allergy Relief | DIPHENHYDRAMINE HYDROCHLORIDE | HEB | 40091b98-b4c7-4a3b-e063-6294a90abd5d | 2026-03-10 | Warnings | M012 |
| Allergy | CHLORPHENIRAMINE MALEATE | United Natural Foods, Inc. dba UNFI | 0aa4ac07-bd02-46b2-9cf0-0643e0e1a2da | 2026-03-10 | Warnings | M012 |
| Allergy Relief | CHLORPHENIRAMINE MALEATE | Topco Associates, LLC | 35305aa9-4fc1-4cda-b6f0-89df64f9eeff | 2026-03-10 | Warnings | M012 |
| nasal decongestant | OXYMETAZOLINE HYDROCHLORIDE | Safeway | 03332596-2c37-4771-b13b-ab766e616866 | 2026-03-10 | Warnings | M012 |
| Sinus Pressure and Congestion Relief Maximum Strength | PSEUDOEPHEDRINE HCL | Rite Aid Corporation | d86140ab-1117-4d14-a380-f5cc375775a1 | 2026-03-10 | Warnings | M012 |
| Allergy Relief | DIPHENHYDRAMINE HCL | AMERISOURCE BERGEN | 4c9cca86-41bf-1635-e063-6294a90a17fb | 2026-03-09 | Warnings | M012 |
| sinus pressure and pain and cough | ACETAMINOPHEN, DEXTROMETHORPHAN HBR, GUAIFENESIN, PHENYLEPHRINE HCL | Target Corporation | 488588f3-62d3-4248-937a-1c200792b5f1 | 2026-03-09 | Warnings | M012 |
| Daytime Nighttime Cold and Flu | ACETAMINOPHEN, DEXTROMETHORPHAN HBR, PHENYLEPHRINE HCI, ACETAMINOPHEN, DEXTROMETHORPHAN HBR, DOXYLAMINE SUCCINATE | Grocery Outlet, Inc. | 447a8753-96bd-676a-e063-6394a90a48f2 | 2026-03-06 | Warnings | M012 |
DailyMed RxNorm Mappings#
| RxCUI | RxNorm string | TTY | DailyMed | SPL version |
|---|---|---|---|---|
| 1432488 | acetaminophen 250 MG / dextromethorphan HBr 10 MG / guaiFENesin 200 MG / phenylephrine HCl 5 MG Oral Capsule | PSN | 0c120569-622d-3a23-e054-00144ff88e88 | 8 |
| 1432488 | acetaminophen 250 MG / dextromethorphan hydrobromide 10 MG / guaifenesin 200 MG / phenylephrine hydrochloride 5 MG Oral Capsule | SCD | 0c120569-622d-3a23-e054-00144ff88e88 | 8 |
| 1432488 | APAP 250 MG / Dextromethorphan Hydrobromide 10 MG / Guaifenesin 200 MG / Phenylephrine Hydrochloride 5 MG Oral Capsule | SY | 0c120569-622d-3a23-e054-00144ff88e88 | 8 |
Packages#
| Package NDC | 11-digit format | Description | Units | Marketing start | Marketing end | Sample | Exclude flag | Status |
|---|---|---|---|---|---|---|---|---|
| 0280-0505-20 | 00280050520 | 2 BLISTER PACK in 1 CARTON (0280-0505-20) / 20 CAPSULE, LIQUID FILLED in 1 BLISTER PACK | 2 blister pack | 2015-01-07 | 0000-00-00 | No | No | Current |