Home NDC 0299-5912 Differin
Product NDC 0299-5912
11-digit product format 002995912
Labeler code 0299
Product ID 0299-5912_676f04a0-99a9-484f-9d40-62f710ea7fe1
Type HUMAN PRESCRIPTION DRUG
Nonproprietary name adapalene
Dosage form LOTION
Route TOPICAL
Labeler Galderma Laboratories, L.P.
Application NDA022502
Marketing category NDA
Marketing start 2010-03-31
Marketing end 0000-00-00
Substance ADAPALENE
Active strength 0 g/100mL
Pharmacologic classes Retinoid [EPC], Retinoids [CS]
NDC exclude flag No
Listing certified through 2023-12-31
Current FDA listing Historical FDA.report record Source provenance: Browse the complete Orange Book source catalog · source snapshot 1 .
Orange Book products# Current product rows page 1 of 1 · 1 matching rows.
Application-product, Trade name, Ingredient table Application-product Trade name Ingredient Strength Dosage form / route TE codes RLD / RS Approval date N022502-001 DIFFERIN ADAPALENE 0.1% LOTION / TOPICAL RLD 2010-03-17
Orange Book patents# Current patent rows page 1 of 1 · 3 matching rows.
Application-product, Patent, Expiration table Application-product Patent Expiration Use code Coverage / status Submission date N022502-001 8435502 2026-09-15 U-1078 Drug product 2013-05-22 N022502-001 8709392 2026-09-15 U-1078 Drug product 2014-05-16 N022502-001 7998467 2028-05-31 U-1078 Drug product 2011-08-19
Observed Orange Book product history# Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.
Product history page 1 of 2 · 41 observed states.
Captured, Edition, Application-product table Captured Edition Application-product Trade name Strength Dosage form / route Product TE source text RLD / RS Approval date Source SHA-256 2026-02-19 14:30 UTC 2026-02 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD 2010-03-17 011fe1cb6892…2025-12-14 10:44 UTC · 2 captures of this ZIP 2025-12 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD 2010-03-17 31067a03dcf5…2025-08-23 18:47 UTC 2025-08 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD 2010-03-17 6a471c1ec25d…2025-03-22 03:13 UTC · 3 captures of this ZIP 2025-03 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD 2010-03-17 fd3edfee7708…2025-02-26 10:13 UTC · 3 captures of this ZIP 2025-02 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD 2010-03-17 b8a1b40f171c…2025-01-19 17:59 UTC · 7 captures of this ZIP 2025-01 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD 2010-03-17 03ed91905a0d…2024-12-13 21:23 UTC · 2 captures of this ZIP 2024-12 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD 2010-03-17 2680178bc6a6…2024-09-14 05:58 UTC · 2 captures of this ZIP 2024-09 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD 2010-03-17 5bbf6a4d5a75…2024-11-08 22:44 UTC · 3 captures of this ZIP 2024-11 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD 2010-03-17 d8e5a09893c0…2024-10-29 15:01 UTC 2024-10 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD 2010-03-17 d06236e962d9…2024-08-13 05:28 UTC · 3 captures of this ZIP 2024-08 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD 2010-03-17 79d66fd596c7…2024-07-13 05:37 UTC · 2 captures of this ZIP 2024-07 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD 2010-03-17 301d65b070ca…2024-06-18 03:08 UTC · 5 captures of this ZIP 2024-06 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD 2010-03-17 1e350fbaab3a…2024-05-31 18:47 UTC 2024-05 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD, RS 2010-03-17 8072bd15b7f6…2022-06-29 02:47 UTC · 2 captures of this ZIP 2022-06 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD, RS 2010-03-17 5c6f7cd8ea54…2022-04-08 23:34 UTC 2022-04 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD, RS 2010-03-17 5d02ea3f76ae…2022-04-04 05:41 UTC 2022-04 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD, RS 2010-03-17 4b0b4de00fa7…2019-12-13 00:20 UTC 2019-12 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD, RS 2010-03-17 74a2ff9319b5…2022-03-09 01:35 UTC 2022-03 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD, RS 2010-03-17 bb7c543d1eb4…2021-12-28 21:50 UTC 2021-12 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD, RS 2010-03-17 782e0a99824c…2021-05-05 16:15 UTC · 3 captures of this ZIP 2021-05 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD, RS 2010-03-17 87673890dc5c…2021-03-12 10:30 UTC 2021-03 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD, RS 2010-03-17 5aa47cf7b7d7…2020-12-22 03:56 UTC 2020-12 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD, RS 2010-03-17 8869cabd3fbd…2020-11-12 02:37 UTC 2020-11 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD, RS 2010-03-17 c0c555d07b60…2019-12-14 00:12 UTC 2019-12 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD, RS 2010-03-17 3f01610625f2…2019-09-15 20:21 UTC 2019-09 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD, RS 2010-03-17 b00525d2431f…2019-07-19 19:46 UTC 2019-07 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD, RS 2010-03-17 ea99ee380514…2024-03-16 18:09 UTC · 4 captures of this ZIP 2024-03 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD, RS 2010-03-17 6a51e52b5d6a…2024-02-18 07:12 UTC 2024-02 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD, RS 2010-03-17 1c564ffb4f44…2023-12-20 04:57 UTC 2023-12 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD, RS 2010-03-17 ea1830bbd6c7…2023-11-28 05:40 UTC · 2 captures of this ZIP 2023-11 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD, RS 2010-03-17 a72a2bbeb626…2023-10-25 00:34 UTC · 2 captures of this ZIP 2023-10 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD, RS 2010-03-17 9b2671bbb829…2023-07-15 15:27 UTC · 2 captures of this ZIP 2023-07 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD, RS 2010-03-17 a67488948f0b…2023-06-13 01:57 UTC · 3 captures of this ZIP 2023-06 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD, RS 2010-03-17 3f0d92c62455…2023-05-13 08:27 UTC 2023-05 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD, RS 2010-03-17 053a50430f4f…2023-01-26 05:58 UTC 2023-01 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD, RS 2010-03-17 3bdfa0b2c4d7…2022-11-12 20:34 UTC · 5 captures of this ZIP 2022-11 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD, RS 2010-03-17 3a93d1ddd44b…2022-10-28 04:53 UTC 2022-10 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD, RS 2010-03-17 f41ea6bd6efb…2022-09-29 23:25 UTC 2022-09 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD, RS 2010-03-17 e64feba35796…2022-07-09 03:26 UTC · 3 captures of this ZIP 2022-07 N022502-001 DIFFERIN 0.1% LOTION / TOPICAL RLD, RS 2010-03-17 cb3db0bc1861…
Observed Orange Book patent history# Patent history page 1 of 4 · 123 observed states.
Captured, Edition, Application-product table Captured Edition Application-product Patent Expiration Use code Coverage / status Submission date Source SHA-256 2026-02-19 14:30 UTC 2026-02 N022502-001 8435502 2026-09-15 U-1078 Drug product 2013-05-22 011fe1cb6892…2026-02-19 14:30 UTC 2026-02 N022502-001 8709392 2026-09-15 U-1078 Drug product 2014-05-16 011fe1cb6892…2026-02-19 14:30 UTC 2026-02 N022502-001 7998467 2028-05-31 U-1078 Drug product 2011-08-19 011fe1cb6892…2025-12-14 10:44 UTC · 2 captures of this ZIP 2025-12 N022502-001 8435502 2026-09-15 U-1078 Drug product 2013-05-22 31067a03dcf5…2025-12-14 10:44 UTC · 2 captures of this ZIP 2025-12 N022502-001 8709392 2026-09-15 U-1078 Drug product 2014-05-16 31067a03dcf5…2025-12-14 10:44 UTC · 2 captures of this ZIP 2025-12 N022502-001 7998467 2028-05-31 U-1078 Drug product 2011-08-19 31067a03dcf5…2025-08-23 18:47 UTC 2025-08 N022502-001 8435502 2026-09-15 U-1078 Drug product 2013-05-22 6a471c1ec25d…2025-08-23 18:47 UTC 2025-08 N022502-001 8709392 2026-09-15 U-1078 Drug product 2014-05-16 6a471c1ec25d…2025-08-23 18:47 UTC 2025-08 N022502-001 7998467 2028-05-31 U-1078 Drug product 2011-08-19 6a471c1ec25d…2025-03-22 03:13 UTC · 3 captures of this ZIP 2025-03 N022502-001 8435502 2026-09-15 U-1078 Drug product 2013-05-22 fd3edfee7708…2025-03-22 03:13 UTC · 3 captures of this ZIP 2025-03 N022502-001 8709392 2026-09-15 U-1078 Drug product 2014-05-16 fd3edfee7708…2025-03-22 03:13 UTC · 3 captures of this ZIP 2025-03 N022502-001 7998467 2028-05-31 U-1078 Drug product 2011-08-19 fd3edfee7708…2025-02-26 10:13 UTC · 3 captures of this ZIP 2025-02 N022502-001 8435502 2026-09-15 U-1078 Drug product 2013-05-22 b8a1b40f171c…2025-02-26 10:13 UTC · 3 captures of this ZIP 2025-02 N022502-001 8709392 2026-09-15 U-1078 Drug product 2014-05-16 b8a1b40f171c…2025-02-26 10:13 UTC · 3 captures of this ZIP 2025-02 N022502-001 7998467 2028-05-31 U-1078 Drug product 2011-08-19 b8a1b40f171c…2025-01-19 17:59 UTC · 7 captures of this ZIP 2025-01 N022502-001 8435502 2026-09-15 U-1078 Drug product 2013-05-22 03ed91905a0d…2025-01-19 17:59 UTC · 7 captures of this ZIP 2025-01 N022502-001 8709392 2026-09-15 U-1078 Drug product 2014-05-16 03ed91905a0d…2025-01-19 17:59 UTC · 7 captures of this ZIP 2025-01 N022502-001 7998467 2028-05-31 U-1078 Drug product 2011-08-19 03ed91905a0d…2024-12-13 21:23 UTC · 2 captures of this ZIP 2024-12 N022502-001 8435502 2026-09-15 U-1078 Drug product 2013-05-22 2680178bc6a6…2024-12-13 21:23 UTC · 2 captures of this ZIP 2024-12 N022502-001 8709392 2026-09-15 U-1078 Drug product 2014-05-16 2680178bc6a6…2024-12-13 21:23 UTC · 2 captures of this ZIP 2024-12 N022502-001 7998467 2028-05-31 U-1078 Drug product 2011-08-19 2680178bc6a6…2024-09-14 05:58 UTC · 2 captures of this ZIP 2024-09 N022502-001 8435502 2026-09-15 U-1078 Drug product 2013-05-22 5bbf6a4d5a75…2024-09-14 05:58 UTC · 2 captures of this ZIP 2024-09 N022502-001 8709392 2026-09-15 U-1078 Drug product 2014-05-16 5bbf6a4d5a75…2024-09-14 05:58 UTC · 2 captures of this ZIP 2024-09 N022502-001 7998467 2028-05-31 U-1078 Drug product 2011-08-19 5bbf6a4d5a75…2024-11-08 22:44 UTC · 3 captures of this ZIP 2024-11 N022502-001 8435502 2026-09-15 U-1078 Drug product 2013-05-22 d8e5a09893c0…2024-11-08 22:44 UTC · 3 captures of this ZIP 2024-11 N022502-001 8709392 2026-09-15 U-1078 Drug product 2014-05-16 d8e5a09893c0…2024-11-08 22:44 UTC · 3 captures of this ZIP 2024-11 N022502-001 7998467 2028-05-31 U-1078 Drug product 2011-08-19 d8e5a09893c0…2024-10-29 15:01 UTC 2024-10 N022502-001 8435502 2026-09-15 U-1078 Drug product 2013-05-22 d06236e962d9…2024-10-29 15:01 UTC 2024-10 N022502-001 8709392 2026-09-15 U-1078 Drug product 2014-05-16 d06236e962d9…2024-10-29 15:01 UTC 2024-10 N022502-001 7998467 2028-05-31 U-1078 Drug product 2011-08-19 d06236e962d9…2024-08-13 05:28 UTC · 3 captures of this ZIP 2024-08 N022502-001 8435502 2026-09-15 U-1078 Drug product 2013-05-22 79d66fd596c7…2024-08-13 05:28 UTC · 3 captures of this ZIP 2024-08 N022502-001 8709392 2026-09-15 U-1078 Drug product 2014-05-16 79d66fd596c7…2024-08-13 05:28 UTC · 3 captures of this ZIP 2024-08 N022502-001 7998467 2028-05-31 U-1078 Drug product 2011-08-19 79d66fd596c7…2024-07-13 05:37 UTC · 2 captures of this ZIP 2024-07 N022502-001 8435502 2026-09-15 U-1078 Drug product 2013-05-22 301d65b070ca…2024-07-13 05:37 UTC · 2 captures of this ZIP 2024-07 N022502-001 8709392 2026-09-15 U-1078 Drug product 2014-05-16 301d65b070ca…2024-07-13 05:37 UTC · 2 captures of this ZIP 2024-07 N022502-001 7998467 2028-05-31 U-1078 Drug product 2011-08-19 301d65b070ca…2024-06-18 03:08 UTC · 5 captures of this ZIP 2024-06 N022502-001 8435502 2026-09-15 U-1078 Drug product 2013-05-22 1e350fbaab3a…2024-06-18 03:08 UTC · 5 captures of this ZIP 2024-06 N022502-001 8709392 2026-09-15 U-1078 Drug product 2014-05-16 1e350fbaab3a…2024-06-18 03:08 UTC · 5 captures of this ZIP 2024-06 N022502-001 7998467 2028-05-31 U-1078 Drug product 2011-08-19 1e350fbaab3a…2024-05-31 18:47 UTC 2024-05 N022502-001 8435502 2026-09-15 U-1078 Drug product 2013-05-22 8072bd15b7f6…
DailyMed Product Concepts# DailyMed Socrata Ingredients# Ingredient, Type, UNII table Ingredient Type UNII DailyMed label SPL version Uploaded Adapalene ACTIVE INGREDIENT 1L4806J2QF DIFFERIN (ADAPALENE) LOTION [GALDERMA LABORATORIES, L.P.] 8 Adapalene ACTIVE MOIETY 1L4806J2QF DIFFERIN (ADAPALENE) LOTION [GALDERMA LABORATORIES, L.P.] 8 Carbomer Homopolymer Type A INACTIVE INGREDIENT F68VH75CJC DIFFERIN (ADAPALENE) LOTION [GALDERMA LABORATORIES, L.P.] 8 Edetate Disodium INACTIVE INGREDIENT 7FLD91C86K DIFFERIN (ADAPALENE) LOTION [GALDERMA LABORATORIES, L.P.] 8 Medium-chain Triglycerides INACTIVE INGREDIENT C9H2L21V7U DIFFERIN (ADAPALENE) LOTION [GALDERMA LABORATORIES, L.P.] 8 Methylparaben INACTIVE INGREDIENT A2I8C7HI9T DIFFERIN (ADAPALENE) LOTION [GALDERMA LABORATORIES, L.P.] 8 Phenoxyethanol INACTIVE INGREDIENT HIE492ZZ3T DIFFERIN (ADAPALENE) LOTION [GALDERMA LABORATORIES, L.P.] 8 Poloxamer 124 INACTIVE INGREDIENT 1S66E28KXA DIFFERIN (ADAPALENE) LOTION [GALDERMA LABORATORIES, L.P.] 8 POLYETHYLENE GLYCOL 1500 INACTIVE INGREDIENT 1212Z7S33A DIFFERIN (ADAPALENE) LOTION [GALDERMA LABORATORIES, L.P.] 8 POLYETHYLENE GLYCOL 300 INACTIVE INGREDIENT 5655G9Y8AQ DIFFERIN (ADAPALENE) LOTION [GALDERMA LABORATORIES, L.P.] 8 Propylene Glycol INACTIVE INGREDIENT 6DC9Q167V3 DIFFERIN (ADAPALENE) LOTION [GALDERMA LABORATORIES, L.P.] 8 Propylparaben INACTIVE INGREDIENT Z8IX2SC1OH DIFFERIN (ADAPALENE) LOTION [GALDERMA LABORATORIES, L.P.] 8 Sodium Hydroxide INACTIVE INGREDIENT 55X04QC32I DIFFERIN (ADAPALENE) LOTION [GALDERMA LABORATORIES, L.P.] 8 Stearyl Alcohol INACTIVE INGREDIENT 2KR89I4H1Y DIFFERIN (ADAPALENE) LOTION [GALDERMA LABORATORIES, L.P.] 8 Water INACTIVE INGREDIENT 059QF0KO0R DIFFERIN (ADAPALENE) LOTION [GALDERMA LABORATORIES, L.P.] 8 Adapalene ACTIVE INGREDIENT 1L4806J2QF DIFFERIN (ADAPALENE) LOTION [PHYSICIANS TOTAL CARE, INC.] 2 Adapalene ACTIVE MOIETY 1L4806J2QF DIFFERIN (ADAPALENE) LOTION [PHYSICIANS TOTAL CARE, INC.] 2 Carbomer Homopolymer Type A INACTIVE INGREDIENT F68VH75CJC DIFFERIN (ADAPALENE) LOTION [PHYSICIANS TOTAL CARE, INC.] 2 Edetate Disodium INACTIVE INGREDIENT 7FLD91C86K DIFFERIN (ADAPALENE) LOTION [PHYSICIANS TOTAL CARE, INC.] 2 Medium-chain Triglycerides INACTIVE INGREDIENT C9H2L21V7U DIFFERIN (ADAPALENE) LOTION [PHYSICIANS TOTAL CARE, INC.] 2 Methylparaben INACTIVE INGREDIENT A2I8C7HI9T DIFFERIN (ADAPALENE) LOTION [PHYSICIANS TOTAL CARE, INC.] 2 Phenoxyethanol INACTIVE INGREDIENT HIE492ZZ3T DIFFERIN (ADAPALENE) LOTION [PHYSICIANS TOTAL CARE, INC.] 2 Poloxamer 124 INACTIVE INGREDIENT 1S66E28KXA DIFFERIN (ADAPALENE) LOTION [PHYSICIANS TOTAL CARE, INC.] 2 Propylene Glycol INACTIVE INGREDIENT 6DC9Q167V3 DIFFERIN (ADAPALENE) LOTION [PHYSICIANS TOTAL CARE, INC.] 2 Propylparaben INACTIVE INGREDIENT Z8IX2SC1OH DIFFERIN (ADAPALENE) LOTION [PHYSICIANS TOTAL CARE, INC.] 2 Sodium Hydroxide INACTIVE INGREDIENT 55X04QC32I DIFFERIN (ADAPALENE) LOTION [PHYSICIANS TOTAL CARE, INC.] 2 Stearyl Alcohol INACTIVE INGREDIENT 2KR89I4H1Y DIFFERIN (ADAPALENE) LOTION [PHYSICIANS TOTAL CARE, INC.] 2 Water INACTIVE INGREDIENT 059QF0KO0R DIFFERIN (ADAPALENE) LOTION [PHYSICIANS TOTAL CARE, INC.] 2
DailyMed Dashboard NDC Coverage# NDC, Dashboard title, SPL version table NDC Dashboard title SPL version Validation Dashboard ZIP 0299-5912 DIFFERIN (ADAPALENE) LOTION [GALDERMA LABORATORIES, L.P.] 14 Legacy NDC 20241027_78b3c1f9-0fc2-4075-6cf0-454a492e6ae3.zip
DailyMed RxNorm Mappings# Packages# Package NDC, 11-digit format, Description table Package NDC 11-digit format Description Units Marketing start Marketing end Sample Exclude flag Status 0299-5912-01 00299591201 15 mL in 1 BOTTLE (0299-5912-01) 15 ml 2010-04-27 0000-00-00 No No Current 0299-5912-02 00299591202 1 BOTTLE, PUMP in 1 CARTON (0299-5912-02) > 59 mL in 1 BOTTLE, PUMP 2010-04-27 0000-00-00 No No Current