Home NDC 0299-5915 Differin
Product NDC 0299-5915
11-digit product format 002995915
Labeler code 0299
Product ID 0299-5915_e308ee59-596a-4f36-b4b7-85012575041d
Type HUMAN PRESCRIPTION DRUG
Nonproprietary name Adapalene
Dosage form CREAM
Route TOPICAL
Labeler GALDERMA LABORATORIES, L.P
Application NDA020748
Marketing category NDA
Marketing start 2009-11-24
Marketing end 2027-05-31
Substance ADAPALENE
Active strength 1 mg/g
Pharmacologic classes Retinoid [EPC], Retinoids [CS]
NDC exclude flag No
Current FDA listing Yes Source provenance: Browse the complete Orange Book source catalog · source snapshot 42 .
Orange Book products# Current product rows page 1 of 1 · 1 matching rows.
Application-product, Trade name, Ingredient table Application-product Trade name Ingredient Strength Dosage form / route TE codes RLD / RS Approval date N020748-001 DIFFERIN ADAPALENE 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26
Therapeutic equivalence codes# Current TE-code rows page 1 of 1 · 1 matching rows.
Application-product, TE code table Application-product TE code N020748-001 AB
Observed Orange Book product history# Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.
Product history page 1 of 2 · 42 observed states.
Captured, Edition, Application-product table Captured Edition Application-product Trade name Strength Dosage form / route Product TE source text RLD / RS Approval date Source SHA-256 2026-08-18 06:07:40 2026-07 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 caaa826d4ba7…2026-02-19 14:30 UTC 2026-02 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 011fe1cb6892…2025-12-14 10:44 UTC · 2 captures of this ZIP 2025-12 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 31067a03dcf5…2025-08-23 18:47 UTC 2025-08 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 6a471c1ec25d…2025-03-22 03:13 UTC · 3 captures of this ZIP 2025-03 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 fd3edfee7708…2025-02-26 10:13 UTC · 3 captures of this ZIP 2025-02 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 b8a1b40f171c…2025-01-19 17:59 UTC · 7 captures of this ZIP 2025-01 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 03ed91905a0d…2024-12-13 21:23 UTC · 2 captures of this ZIP 2024-12 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 2680178bc6a6…2024-09-14 05:58 UTC · 2 captures of this ZIP 2024-09 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 5bbf6a4d5a75…2024-11-08 22:44 UTC · 3 captures of this ZIP 2024-11 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 d8e5a09893c0…2024-10-29 15:01 UTC 2024-10 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 d06236e962d9…2024-08-13 05:28 UTC · 3 captures of this ZIP 2024-08 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 79d66fd596c7…2024-07-13 05:37 UTC · 2 captures of this ZIP 2024-07 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 301d65b070ca…2024-06-18 03:08 UTC · 5 captures of this ZIP 2024-06 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 1e350fbaab3a…2024-05-31 18:47 UTC 2024-05 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 8072bd15b7f6…2022-06-29 02:47 UTC · 2 captures of this ZIP 2022-06 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 5c6f7cd8ea54…2022-04-08 23:34 UTC 2022-04 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 5d02ea3f76ae…2022-04-04 05:41 UTC 2022-04 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 4b0b4de00fa7…2019-12-13 00:20 UTC 2019-12 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 74a2ff9319b5…2022-03-09 01:35 UTC 2022-03 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 bb7c543d1eb4…2021-12-28 21:50 UTC 2021-12 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 782e0a99824c…2021-05-05 16:15 UTC · 3 captures of this ZIP 2021-05 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 87673890dc5c…2021-03-12 10:30 UTC 2021-03 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 5aa47cf7b7d7…2020-12-22 03:56 UTC 2020-12 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 8869cabd3fbd…2020-11-12 02:37 UTC 2020-11 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 c0c555d07b60…2019-12-14 00:12 UTC 2019-12 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 3f01610625f2…2019-09-15 20:21 UTC 2019-09 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 b00525d2431f…2019-07-19 19:46 UTC 2019-07 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 ea99ee380514…2024-03-16 18:09 UTC · 4 captures of this ZIP 2024-03 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 6a51e52b5d6a…2024-02-18 07:12 UTC 2024-02 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 1c564ffb4f44…2023-12-20 04:57 UTC 2023-12 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 ea1830bbd6c7…2023-11-28 05:40 UTC · 2 captures of this ZIP 2023-11 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 a72a2bbeb626…2023-10-25 00:34 UTC · 2 captures of this ZIP 2023-10 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 9b2671bbb829…2023-07-15 15:27 UTC · 2 captures of this ZIP 2023-07 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 a67488948f0b…2023-06-13 01:57 UTC · 3 captures of this ZIP 2023-06 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 3f0d92c62455…2023-05-13 08:27 UTC 2023-05 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 053a50430f4f…2023-01-26 05:58 UTC 2023-01 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 3bdfa0b2c4d7…2022-11-12 20:34 UTC · 5 captures of this ZIP 2022-11 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 3a93d1ddd44b…2022-10-28 04:53 UTC 2022-10 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 f41ea6bd6efb…2022-09-29 23:25 UTC 2022-09 N020748-001 DIFFERIN 0.1% CREAM / TOPICAL AB RLD, RS 2000-05-26 e64feba35796…
Observed Orange Book normalized TE history# Normalized TE history page 1 of 2 · 42 observed states.
DailyMed Product Concepts# DailyMed Package Descriptions# Package NDC, Product, Description table Package NDC Product Description Form Quantity Strength SPL version 0299-5915-45 Differin 45 g in 1 TUBE CREAM 45 8 0299-5915-45 Differin 1 in 1 CARTON CREAM 1 8
DailyMed Socrata Ingredients# Ingredient, Type, UNII table Ingredient Type UNII DailyMed label SPL version Uploaded Adapalene ACTIVE INGREDIENT 1L4806J2QF DIFFERIN (ADAPALENE) CREAM [GALDERMA LABORATORIES, L.P] 3 Adapalene ACTIVE MOIETY 1L4806J2QF DIFFERIN (ADAPALENE) CREAM [GALDERMA LABORATORIES, L.P] 3 Edetate Disodium INACTIVE INGREDIENT 7FLD91C86K DIFFERIN (ADAPALENE) CREAM [GALDERMA LABORATORIES, L.P] 3 Glycerin INACTIVE INGREDIENT PDC6A3C0OX DIFFERIN (ADAPALENE) CREAM [GALDERMA LABORATORIES, L.P] 3 Methylparaben INACTIVE INGREDIENT A2I8C7HI9T DIFFERIN (ADAPALENE) CREAM [GALDERMA LABORATORIES, L.P] 3 Phenoxyethanol INACTIVE INGREDIENT HIE492ZZ3T DIFFERIN (ADAPALENE) CREAM [GALDERMA LABORATORIES, L.P] 3 Propylparaben INACTIVE INGREDIENT Z8IX2SC1OH DIFFERIN (ADAPALENE) CREAM [GALDERMA LABORATORIES, L.P] 3 Squalane INACTIVE INGREDIENT GW89575KF9 DIFFERIN (ADAPALENE) CREAM [GALDERMA LABORATORIES, L.P] 3 Trolamine INACTIVE INGREDIENT 9O3K93S3TK DIFFERIN (ADAPALENE) CREAM [GALDERMA LABORATORIES, L.P] 3 Water INACTIVE INGREDIENT 059QF0KO0R DIFFERIN (ADAPALENE) CREAM [GALDERMA LABORATORIES, L.P] 3 ADAPALENE ACTIVE INGREDIENT 1L4806J2QF DIFFERIN (ADAPALENE) CREAM [PHYSICIANS TOTAL CARE, INC.] 1 ADAPALENE ACTIVE MOIETY 1L4806J2QF DIFFERIN (ADAPALENE) CREAM [PHYSICIANS TOTAL CARE, INC.] 1 EDETATE DISODIUM INACTIVE INGREDIENT 7FLD91C86K DIFFERIN (ADAPALENE) CREAM [PHYSICIANS TOTAL CARE, INC.] 1 GLYCERIN INACTIVE INGREDIENT PDC6A3C0OX DIFFERIN (ADAPALENE) CREAM [PHYSICIANS TOTAL CARE, INC.] 1 METHYLPARABEN INACTIVE INGREDIENT A2I8C7HI9T DIFFERIN (ADAPALENE) CREAM [PHYSICIANS TOTAL CARE, INC.] 1 PHENOXYETHANOL INACTIVE INGREDIENT HIE492ZZ3T DIFFERIN (ADAPALENE) CREAM [PHYSICIANS TOTAL CARE, INC.] 1 SQUALANE INACTIVE INGREDIENT GW89575KF9 DIFFERIN (ADAPALENE) CREAM [PHYSICIANS TOTAL CARE, INC.] 1 TROLAMINE INACTIVE INGREDIENT 9O3K93S3TK DIFFERIN (ADAPALENE) CREAM [PHYSICIANS TOTAL CARE, INC.] 1 WATER INACTIVE INGREDIENT 059QF0KO0R DIFFERIN (ADAPALENE) CREAM [PHYSICIANS TOTAL CARE, INC.] 1
DailyMed Dashboard NDC Coverage# NDC, Dashboard title, SPL version table NDC Dashboard title SPL version Validation Dashboard ZIP 0299-5915 DIFFERIN (ADAPALENE) CREAM [GALDERMA LABORATORIES, L.P] 7 Current NDC, Legacy NDC, 2 package rows 20221209_ab4b2120-57fc-6c61-b239-37c21789c065.zip
openFDA label cross-check# OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.
Matched openFDA labels page 1 of 1 · 1 matching rows.
Brand, Generic, Manufacturer table Brand Generic Manufacturer SPL set ID Effective date Available safety fields Join Adapalene ADAPALENE Padagis Israel Pharmaceuticals Ltd 94cf9af1-afab-4064-a2ca-619b54218262 2023-07-25 Adverse reactions Exact identifier application applno (NDA): 020748 application number: NDA020748
DailyMed RxNorm Mappings# Packages# Package NDC, 11-digit format, Description table Package NDC 11-digit format Description Units Marketing start Marketing end Sample Exclude flag Status 0299-5915-45 00299591545 1 TUBE in 1 CARTON (0299-5915-45) / 45 g in 1 TUBE 1 tube 2009-11-24 2027-05-31 No No Current