DIFFERIN

Product NDC: 0299-5918
11-digit product format: 002995918
Labeler code: 0299
Product ID: 0299-5918_cc125ed9-1ac8-491e-8eba-bd55426fc825
Type: HUMAN PRESCRIPTION DRUG
Nonproprietary name: adapalene
Dosage form: GEL
Route: TOPICAL
Labeler: Galderma Laboratories, L.P.
Application: NDA021753
Marketing category: NDA
Marketing start: 2009-09-15
Marketing end: 2027-02-01
Substance: ADAPALENE
Active strength: 3 mg/g
Pharmacologic classes: Retinoid [EPC], Retinoids [CS]
NDC exclude flag: No
Current FDA listing: Yes

NDC auxiliary status#

These records are reproduced from FDA’s unfinished, excluded, and compounder listings. They describe what appeared in the source files; a missing record does not establish a regulatory status. View all current auxiliary records, including entries without an NDC. · View the auxiliary file history.

Current NDC status page 1 of 1 · 3 matching rows.

Dataset, Scope, Product NDC table
Dataset	Scope	Product NDC	Package NDC	Code	Status	Source date
excluded package	package	0299-5918	0299-5918-02	D	Discontinued by firm	2026-08-11
excluded package	package	0299-5918	0299-5918-15	D	Discontinued by firm	2026-08-11
excluded package	package	0299-5918	0299-5918-45	D	Discontinued by firm	2026-08-11

Observed NDC auxiliary status history#

This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.

Historic NDC status page 1 of 1 · 36 matching rows.

View current auxiliary records. · View the auxiliary file history.

Captured / source date, Package NDC, Snapshot table
Captured / source date	Package NDC	Snapshot	Source SHA-256
2025-12-14 17:58 UTC · source 2025-12-05	0299-5918-02	`d630ba8d3edf…`	`732f749b63fb…`
2025-12-14 17:58 UTC · source 2025-12-05	0299-5918-45	`d630ba8d3edf…`	`732f749b63fb…`
2025-12-14 17:58 UTC · source 2025-12-05	0299-5918-15	`d630ba8d3edf…`	`732f749b63fb…`
2025-08-27 00:01 UTC · source 2025-08-26	0299-5918-02	`f5e01cc5f278…`	`a2eaf40c39c3…`
2025-08-27 00:01 UTC · source 2025-08-26	0299-5918-45	`f5e01cc5f278…`	`a2eaf40c39c3…`
2025-08-27 00:01 UTC · source 2025-08-26	0299-5918-15	`f5e01cc5f278…`	`a2eaf40c39c3…`
2025-04-01 02:39 UTC · source 2025-03-31	0299-5918-02	`2ef7874e63bc…`	`57b86245f4fa…`
2025-04-01 02:39 UTC · source 2025-03-31	0299-5918-45	`2ef7874e63bc…`	`57b86245f4fa…`
2025-04-01 02:39 UTC · source 2025-03-31	0299-5918-15	`2ef7874e63bc…`	`57b86245f4fa…`
2025-03-28 20:22 UTC · source 2025-03-28	0299-5918-02	`a1b67e2a42f9…`	`c4cf2c586c0d…`
2025-03-28 20:22 UTC · source 2025-03-28	0299-5918-45	`a1b67e2a42f9…`	`c4cf2c586c0d…`
2025-03-28 20:22 UTC · source 2025-03-28	0299-5918-15	`a1b67e2a42f9…`	`c4cf2c586c0d…`
2025-03-22 03:12 UTC · source 2025-03-21	0299-5918-02	`cfe11265f3b6…`	`090c488252e2…`
2025-03-22 03:12 UTC · source 2025-03-21	0299-5918-45	`cfe11265f3b6…`	`090c488252e2…`
2025-03-22 03:12 UTC · source 2025-03-21	0299-5918-15	`cfe11265f3b6…`	`090c488252e2…`
2025-03-10 12:48 UTC · source 2025-03-10	0299-5918-02	`cdf11ea48f46…`	`ba0047e9e063…`
2025-03-10 12:48 UTC · source 2025-03-10	0299-5918-45	`cdf11ea48f46…`	`ba0047e9e063…`
2025-03-10 12:48 UTC · source 2025-03-10	0299-5918-15	`cdf11ea48f46…`	`ba0047e9e063…`
2025-02-02 03:52 UTC · source 2025-01-31	0299-5918-02	`302b2466d912…`	`e7b80fea0513…`
2025-02-02 03:52 UTC · source 2025-01-31	0299-5918-45	`302b2466d912…`	`e7b80fea0513…`
2025-02-02 03:52 UTC · source 2025-01-31	0299-5918-15	`302b2466d912…`	`e7b80fea0513…`
2025-01-20 13:05 UTC · source 2025-01-20	0299-5918-02	`ed331223b511…`	`672a5bd82f5f…`
2025-01-20 13:05 UTC · source 2025-01-20	0299-5918-45	`ed331223b511…`	`672a5bd82f5f…`
2025-01-20 13:05 UTC · source 2025-01-20	0299-5918-15	`ed331223b511…`	`672a5bd82f5f…`
2025-01-11 03:41 UTC · source 2025-01-10	0299-5918-02	`0efc9e666f02…`	`f202fb6c5f17…`
2025-01-11 03:41 UTC · source 2025-01-10	0299-5918-45	`0efc9e666f02…`	`f202fb6c5f17…`
2025-01-11 03:41 UTC · source 2025-01-10	0299-5918-15	`0efc9e666f02…`	`f202fb6c5f17…`
2024-11-09 02:27 UTC · source 2024-11-08	0299-5918-02	`ad56d346431e…`	`cc804d4bbf1e…`
2024-11-09 02:27 UTC · source 2024-11-08	0299-5918-45	`ad56d346431e…`	`cc804d4bbf1e…`
2024-11-09 02:27 UTC · source 2024-11-08	0299-5918-15	`ad56d346431e…`	`cc804d4bbf1e…`
2024-10-04 04:10 UTC · source 2024-10-03	0299-5918-02	`367a005e9d99…`	`383a685ebd0f…`
2024-10-04 04:10 UTC · source 2024-10-03	0299-5918-45	`367a005e9d99…`	`383a685ebd0f…`
2024-10-04 04:10 UTC · source 2024-10-03	0299-5918-15	`367a005e9d99…`	`383a685ebd0f…`
2024-07-10 04:00 UTC · source 2024-07-09	0299-5918-02	`557ba5c1ecfa…`	`9c80585c8c6e…`
2024-07-10 04:00 UTC · source 2024-07-09	0299-5918-45	`557ba5c1ecfa…`	`9c80585c8c6e…`
2024-07-10 04:00 UTC · source 2024-07-09	0299-5918-15	`557ba5c1ecfa…`	`9c80585c8c6e…`

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-product	Trade name	Ingredient	Strength	Dosage form / route	TE codes	RLD / RS	Approval date
N021753-001	DIFFERIN	ADAPALENE	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-product	TE code
N021753-001	AB

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 41 observed states.

Captured, Edition, Application-product table
Captured	Edition	Application-product	Trade name	Strength	Dosage form / route	Product TE source text	RLD / RS	Approval date	Source SHA-256
2026-02-19 14:30 UTC	2026-02	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`011fe1cb6892…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`31067a03dcf5…`
2025-08-23 18:47 UTC	2025-08	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`6a471c1ec25d…`
2025-03-22 03:13 UTC · 3 captures of this ZIP	2025-03	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`fd3edfee7708…`
2025-02-26 10:13 UTC · 3 captures of this ZIP	2025-02	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`b8a1b40f171c…`
2025-01-19 17:59 UTC · 7 captures of this ZIP	2025-01	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`03ed91905a0d…`
2024-12-13 21:23 UTC · 2 captures of this ZIP	2024-12	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`2680178bc6a6…`
2024-09-14 05:58 UTC · 2 captures of this ZIP	2024-09	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`5bbf6a4d5a75…`
2024-11-08 22:44 UTC · 3 captures of this ZIP	2024-11	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`d8e5a09893c0…`
2024-10-29 15:01 UTC	2024-10	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`d06236e962d9…`
2024-08-13 05:28 UTC · 3 captures of this ZIP	2024-08	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`79d66fd596c7…`
2024-07-13 05:37 UTC · 2 captures of this ZIP	2024-07	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`301d65b070ca…`
2024-06-18 03:08 UTC · 5 captures of this ZIP	2024-06	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`1e350fbaab3a…`
2024-05-31 18:47 UTC	2024-05	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`8072bd15b7f6…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`5c6f7cd8ea54…`
2022-04-08 23:34 UTC	2022-04	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`5d02ea3f76ae…`
2022-04-04 05:41 UTC	2022-04	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`4b0b4de00fa7…`
2019-12-13 00:20 UTC	2019-12	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`74a2ff9319b5…`
2022-03-09 01:35 UTC	2022-03	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`bb7c543d1eb4…`
2021-12-28 21:50 UTC	2021-12	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`782e0a99824c…`
2021-05-05 16:15 UTC · 3 captures of this ZIP	2021-05	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`87673890dc5c…`
2021-03-12 10:30 UTC	2021-03	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`5aa47cf7b7d7…`
2020-12-22 03:56 UTC	2020-12	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`8869cabd3fbd…`
2020-11-12 02:37 UTC	2020-11	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`c0c555d07b60…`
2019-12-14 00:12 UTC	2019-12	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`3f01610625f2…`
2019-09-15 20:21 UTC	2019-09	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`b00525d2431f…`
2019-07-19 19:46 UTC	2019-07	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`ea99ee380514…`
2024-03-16 18:09 UTC · 4 captures of this ZIP	2024-03	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`6a51e52b5d6a…`
2024-02-18 07:12 UTC	2024-02	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`1c564ffb4f44…`
2023-12-20 04:57 UTC	2023-12	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`ea1830bbd6c7…`
2023-11-28 05:40 UTC · 2 captures of this ZIP	2023-11	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`a72a2bbeb626…`
2023-10-25 00:34 UTC · 2 captures of this ZIP	2023-10	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`9b2671bbb829…`
2023-07-15 15:27 UTC · 2 captures of this ZIP	2023-07	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`a67488948f0b…`
2023-06-13 01:57 UTC · 3 captures of this ZIP	2023-06	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`3f0d92c62455…`
2023-05-13 08:27 UTC	2023-05	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`053a50430f4f…`
2023-01-26 05:58 UTC	2023-01	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`3bdfa0b2c4d7…`
2022-11-12 20:34 UTC · 5 captures of this ZIP	2022-11	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`3a93d1ddd44b…`
2022-10-28 04:53 UTC	2022-10	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`f41ea6bd6efb…`
2022-09-29 23:25 UTC	2022-09	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`e64feba35796…`
2022-07-09 03:26 UTC · 3 captures of this ZIP	2022-07	N021753-001	DIFFERIN	0.3%	GEL / TOPICAL	AB	RLD, RS	2007-06-19	`cb3db0bc1861…`

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 2 · 41 observed states.

Captured, Edition, Application-product table
Captured	Edition	Application-product	TE code	Order	Source SHA-256
2026-02-19 14:30 UTC	2026-02	N021753-001	AB	1	`011fe1cb6892…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N021753-001	AB	1	`31067a03dcf5…`
2025-08-23 18:47 UTC	2025-08	N021753-001	AB	1	`6a471c1ec25d…`
2025-03-22 03:13 UTC · 3 captures of this ZIP	2025-03	N021753-001	AB	1	`fd3edfee7708…`
2025-02-26 10:13 UTC · 3 captures of this ZIP	2025-02	N021753-001	AB	1	`b8a1b40f171c…`
2025-01-19 17:59 UTC · 7 captures of this ZIP	2025-01	N021753-001	AB	1	`03ed91905a0d…`
2024-12-13 21:23 UTC · 2 captures of this ZIP	2024-12	N021753-001	AB	1	`2680178bc6a6…`
2024-09-14 05:58 UTC · 2 captures of this ZIP	2024-09	N021753-001	AB	1	`5bbf6a4d5a75…`
2024-11-08 22:44 UTC · 3 captures of this ZIP	2024-11	N021753-001	AB	1	`d8e5a09893c0…`
2024-10-29 15:01 UTC	2024-10	N021753-001	AB	1	`d06236e962d9…`
2024-08-13 05:28 UTC · 3 captures of this ZIP	2024-08	N021753-001	AB	1	`79d66fd596c7…`
2024-07-13 05:37 UTC · 2 captures of this ZIP	2024-07	N021753-001	AB	1	`301d65b070ca…`
2024-06-18 03:08 UTC · 5 captures of this ZIP	2024-06	N021753-001	AB	1	`1e350fbaab3a…`
2024-05-31 18:47 UTC	2024-05	N021753-001	AB	1	`8072bd15b7f6…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N021753-001	AB	1	`5c6f7cd8ea54…`
2022-04-08 23:34 UTC	2022-04	N021753-001	AB	1	`5d02ea3f76ae…`
2022-04-04 05:41 UTC	2022-04	N021753-001	AB	1	`4b0b4de00fa7…`
2019-12-13 00:20 UTC	2019-12	N021753-001	AB	1	`74a2ff9319b5…`
2022-03-09 01:35 UTC	2022-03	N021753-001	AB	1	`bb7c543d1eb4…`
2021-12-28 21:50 UTC	2021-12	N021753-001	AB	1	`782e0a99824c…`
2021-05-05 16:15 UTC · 3 captures of this ZIP	2021-05	N021753-001	AB	1	`87673890dc5c…`
2021-03-12 10:30 UTC	2021-03	N021753-001	AB	1	`5aa47cf7b7d7…`
2020-12-22 03:56 UTC	2020-12	N021753-001	AB	1	`8869cabd3fbd…`
2020-11-12 02:37 UTC	2020-11	N021753-001	AB	1	`c0c555d07b60…`
2019-12-14 00:12 UTC	2019-12	N021753-001	AB	1	`3f01610625f2…`
2019-09-15 20:21 UTC	2019-09	N021753-001	AB	1	`b00525d2431f…`
2019-07-19 19:46 UTC	2019-07	N021753-001	AB	1	`ea99ee380514…`
2024-03-16 18:09 UTC · 4 captures of this ZIP	2024-03	N021753-001	AB	1	`6a51e52b5d6a…`
2024-02-18 07:12 UTC	2024-02	N021753-001	AB	1	`1c564ffb4f44…`
2023-12-20 04:57 UTC	2023-12	N021753-001	AB	1	`ea1830bbd6c7…`
2023-11-28 05:40 UTC · 2 captures of this ZIP	2023-11	N021753-001	AB	1	`a72a2bbeb626…`
2023-10-25 00:34 UTC · 2 captures of this ZIP	2023-10	N021753-001	AB	1	`9b2671bbb829…`
2023-07-15 15:27 UTC · 2 captures of this ZIP	2023-07	N021753-001	AB	1	`a67488948f0b…`
2023-06-13 01:57 UTC · 3 captures of this ZIP	2023-06	N021753-001	AB	1	`3f0d92c62455…`
2023-05-13 08:27 UTC	2023-05	N021753-001	AB	1	`053a50430f4f…`
2023-01-26 05:58 UTC	2023-01	N021753-001	AB	1	`3bdfa0b2c4d7…`
2022-11-12 20:34 UTC · 5 captures of this ZIP	2022-11	N021753-001	AB	1	`3a93d1ddd44b…`
2022-10-28 04:53 UTC	2022-10	N021753-001	AB	1	`f41ea6bd6efb…`
2022-09-29 23:25 UTC	2022-09	N021753-001	AB	1	`e64feba35796…`
2022-07-09 03:26 UTC · 3 captures of this ZIP	2022-07	N021753-001	AB	1	`cb3db0bc1861…`

Observed Orange Book patent history#

Patent history page 1 of 5 · 170 observed states.

Captured, Edition, Application-product table
Captured	Edition	Application-product	Patent	Expiration	Use code	Coverage / status	Submission date	Source SHA-256
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N021753-001	7579377	2025-02-23	U-818			`31067a03dcf5…`
2025-08-23 18:47 UTC	2025-08	N021753-001	7579377	2025-02-23	U-818			`6a471c1ec25d…`
2025-03-22 03:13 UTC · 3 captures of this ZIP	2025-03	N021753-001	7579377	2025-02-23	U-818			`fd3edfee7708…`
2025-02-26 10:13 UTC · 3 captures of this ZIP	2025-02	N021753-001	7579377	2025-02-23	U-818			`b8a1b40f171c…`
2025-01-19 17:59 UTC · 7 captures of this ZIP	2025-01	N021753-001	7737181	2024-08-29		Drug product		`03ed91905a0d…`
2025-01-19 17:59 UTC · 7 captures of this ZIP	2025-01	N021753-001	7579377	2025-02-23	U-818			`03ed91905a0d…`
2024-12-13 21:23 UTC · 2 captures of this ZIP	2024-12	N021753-001	7737181	2024-08-29		Drug product		`2680178bc6a6…`
2024-12-13 21:23 UTC · 2 captures of this ZIP	2024-12	N021753-001	7579377	2025-02-23	U-818			`2680178bc6a6…`
2024-09-14 05:58 UTC · 2 captures of this ZIP	2024-09	N021753-001	7737181	2024-08-29		Drug product		`5bbf6a4d5a75…`
2024-09-14 05:58 UTC · 2 captures of this ZIP	2024-09	N021753-001	7579377	2025-02-23	U-818			`5bbf6a4d5a75…`
2024-11-08 22:44 UTC · 3 captures of this ZIP	2024-11	N021753-001	7737181	2024-08-29		Drug product		`d8e5a09893c0…`
2024-11-08 22:44 UTC · 3 captures of this ZIP	2024-11	N021753-001	7579377	2025-02-23	U-818			`d8e5a09893c0…`
2024-10-29 15:01 UTC	2024-10	N021753-001	7737181	2024-08-29		Drug product		`d06236e962d9…`
2024-10-29 15:01 UTC	2024-10	N021753-001	7579377	2025-02-23	U-818			`d06236e962d9…`
2024-08-13 05:28 UTC · 3 captures of this ZIP	2024-08	N021753-001	7737181	2024-08-29		Drug product		`79d66fd596c7…`
2024-08-13 05:28 UTC · 3 captures of this ZIP	2024-08	N021753-001	7579377	2025-02-23	U-818			`79d66fd596c7…`
2024-07-13 05:37 UTC · 2 captures of this ZIP	2024-07	N021753-001	7737181	2024-08-29		Drug product		`301d65b070ca…`
2024-07-13 05:37 UTC · 2 captures of this ZIP	2024-07	N021753-001	7579377	2025-02-23	U-818			`301d65b070ca…`
2024-06-18 03:08 UTC · 5 captures of this ZIP	2024-06	N021753-001	7737181	2024-08-29		Drug product		`1e350fbaab3a…`
2024-06-18 03:08 UTC · 5 captures of this ZIP	2024-06	N021753-001	7579377	2025-02-23	U-818			`1e350fbaab3a…`
2024-05-31 18:47 UTC	2024-05	N021753-001	7737181	2024-08-29		Drug product		`8072bd15b7f6…`
2024-05-31 18:47 UTC	2024-05	N021753-001	7579377	2025-02-23	U-818			`8072bd15b7f6…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N021753-001	7834060	2023-03-12	U-1078		2010-11-19	`5c6f7cd8ea54…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N021753-001	7838558	2023-03-12		Drug product	2010-11-30	`5c6f7cd8ea54…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N021753-001	7868044	2023-03-12	U-1078		2011-01-12	`5c6f7cd8ea54…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N021753-001	8703820	2023-03-12	U-1078		2014-05-21	`5c6f7cd8ea54…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N021753-001	7737181	2024-08-29		Drug product		`5c6f7cd8ea54…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N021753-001	7579377	2025-02-23	U-818			`5c6f7cd8ea54…`
2022-04-08 23:34 UTC	2022-04	N021753-001	7834060	2023-03-12	U-1078		2010-11-19	`5d02ea3f76ae…`
2022-04-08 23:34 UTC	2022-04	N021753-001	7838558	2023-03-12		Drug product	2010-11-30	`5d02ea3f76ae…`
2022-04-08 23:34 UTC	2022-04	N021753-001	7868044	2023-03-12	U-1078		2011-01-12	`5d02ea3f76ae…`
2022-04-08 23:34 UTC	2022-04	N021753-001	8703820	2023-03-12	U-1078		2014-05-21	`5d02ea3f76ae…`
2022-04-08 23:34 UTC	2022-04	N021753-001	7737181	2024-08-29		Drug product		`5d02ea3f76ae…`
2022-04-08 23:34 UTC	2022-04	N021753-001	7579377	2025-02-23	U-818			`5d02ea3f76ae…`
2022-04-04 05:41 UTC	2022-04	N021753-001	7834060	2023-03-12	U-1078		2010-11-19	`4b0b4de00fa7…`
2022-04-04 05:41 UTC	2022-04	N021753-001	7838558	2023-03-12		Drug product	2010-11-30	`4b0b4de00fa7…`
2022-04-04 05:41 UTC	2022-04	N021753-001	7868044	2023-03-12	U-1078		2011-01-12	`4b0b4de00fa7…`
2022-04-04 05:41 UTC	2022-04	N021753-001	8703820	2023-03-12	U-1078		2014-05-21	`4b0b4de00fa7…`
2022-04-04 05:41 UTC	2022-04	N021753-001	7737181	2024-08-29		Drug product		`4b0b4de00fa7…`
2022-04-04 05:41 UTC	2022-04	N021753-001	7579377	2025-02-23	U-818			`4b0b4de00fa7…`

Additional Listing Data#

Finished product: Yes
Brand name base: DIFFERIN

Active Ingredients#

Ingredient, Strength table
Ingredient	Strength
ADAPALENE	3 mg/g

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
1L4806J2QF	Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
722111	Internal RxNorm lookup
722113	Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
a0031324-92a6-4c11-90e2-c2818f7278ec	Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product concept	Relation	Version	Effective
a46239a7-5963-4008-8cbb-6b9000f497eb	Product name	1	20250721
d9d61457-6a5a-41fc-b418-e5479a2904b7	Product name	2	20230303
91d0a1ed-5d14-5017-c7aa-3602ee038695	Product name	3	20210111
3f45980c-c196-47e5-0e5e-48b7c57327c5	Product name	5	20200428
5c3dfd42-8936-4261-a420-cfcbbf3030aa	Product name	2	20161206
08f39758-2d46-8afe-73ca-39fe69052a2b	Product name	1	20140508
8ae7bcde-1dd2-b073-852b-f464987f7427	Product name	1	20140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	SPL version
0299-5918-02	DIFFERIN	2 g in 1 TUBE	GEL	2	12
0299-5918-15	DIFFERIN	1 in 1 CARTON	GEL	1	12
0299-5918-15	DIFFERIN	15 g in 1 TUBE	GEL	15	12
0299-5918-25	DIFFERIN	1 in 1 CARTON	GEL	1	12
0299-5918-25	DIFFERIN	45 g in 1 BOTTLE, PUMP	GEL	45	12
0299-5918-45	DIFFERIN	1 in 1 CARTON	GEL	1	12
0299-5918-45	DIFFERIN	45 g in 1 TUBE	GEL	45	12

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDC	Billing unit	Product NDC	DailyMed indexing SPL	SPL version	Effective
0299-5918-25	GM - Gram	0299-5918	27ec8349-9bed-432a-afe3-d801b2331539	1	2013-02-13
0299-5918-45	GM - Gram	0299-5918	3fdd8c1a-9bc0-4af0-9503-2165de1c206b	1	2012-07-24

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
Ingredient	Type	UNII	DailyMed label	SPL version
Adapalene	ACTIVE INGREDIENT	1L4806J2QF	DIFFERIN (ADAPALENE) GEL [GALDERMA LABORATORIES, L.P.]	8
ADAPALENE	ACTIVE MOIETY	1L4806J2QF	DIFFERIN (ADAPALENE) GEL [GALDERMA LABORATORIES, L.P.]	8
Carbomer Homopolymer Type C	INACTIVE INGREDIENT	4Q93RCW27E	DIFFERIN (ADAPALENE) GEL [GALDERMA LABORATORIES, L.P.]	8
Edetate Disodium	INACTIVE INGREDIENT	7FLD91C86K	DIFFERIN (ADAPALENE) GEL [GALDERMA LABORATORIES, L.P.]	8
Hydrochloric Acid	INACTIVE INGREDIENT	QTT17582CB	DIFFERIN (ADAPALENE) GEL [GALDERMA LABORATORIES, L.P.]	8
Methylparaben	INACTIVE INGREDIENT	A2I8C7HI9T	DIFFERIN (ADAPALENE) GEL [GALDERMA LABORATORIES, L.P.]	8
Poloxamer 124	INACTIVE INGREDIENT	1S66E28KXA	DIFFERIN (ADAPALENE) GEL [GALDERMA LABORATORIES, L.P.]	8
Propylene Glycol	INACTIVE INGREDIENT	6DC9Q167V3	DIFFERIN (ADAPALENE) GEL [GALDERMA LABORATORIES, L.P.]	8
Sodium Hydroxide	INACTIVE INGREDIENT	55X04QC32I	DIFFERIN (ADAPALENE) GEL [GALDERMA LABORATORIES, L.P.]	8
Water	INACTIVE INGREDIENT	059QF0KO0R	DIFFERIN (ADAPALENE) GEL [GALDERMA LABORATORIES, L.P.]	8
Adapalene	ACTIVE INGREDIENT	1L4806J2QF	DIFFERIN (ADAPALENE) GEL [PHYSICIANS TOTAL CARE, INC.]	2
ADAPALENE	ACTIVE MOIETY	1L4806J2QF	DIFFERIN (ADAPALENE) GEL [PHYSICIANS TOTAL CARE, INC.]	2
Carbomer Homopolymer Type C	INACTIVE INGREDIENT	4Q93RCW27E	DIFFERIN (ADAPALENE) GEL [PHYSICIANS TOTAL CARE, INC.]	2
Edetate Disodium	INACTIVE INGREDIENT	7FLD91C86K	DIFFERIN (ADAPALENE) GEL [PHYSICIANS TOTAL CARE, INC.]	2
Hydrochloric Acid	INACTIVE INGREDIENT	QTT17582CB	DIFFERIN (ADAPALENE) GEL [PHYSICIANS TOTAL CARE, INC.]	2
Methylparaben	INACTIVE INGREDIENT	A2I8C7HI9T	DIFFERIN (ADAPALENE) GEL [PHYSICIANS TOTAL CARE, INC.]	2
Poloxamer 124	INACTIVE INGREDIENT	1S66E28KXA	DIFFERIN (ADAPALENE) GEL [PHYSICIANS TOTAL CARE, INC.]	2
Propylene Glycol	INACTIVE INGREDIENT	6DC9Q167V3	DIFFERIN (ADAPALENE) GEL [PHYSICIANS TOTAL CARE, INC.]	2
Sodium Hydroxide	INACTIVE INGREDIENT	55X04QC32I	DIFFERIN (ADAPALENE) GEL [PHYSICIANS TOTAL CARE, INC.]	2
Water	INACTIVE INGREDIENT	059QF0KO0R	DIFFERIN (ADAPALENE) GEL [PHYSICIANS TOTAL CARE, INC.]	2

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
0299-5918	DIFFERIN (ADAPALENE) GEL [GALDERMA LABORATORIES, L.P.]	12	Current NDC, Legacy NDC, 7 package rows	20240113_a0031324-92a6-4c11-90e2-c2818f7278ec.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 2 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
DIFFERIN	ADAPALENE	Galderma Laboratories, L.P.	a0031324-92a6-4c11-90e2-c2818f7278ec	2023-12-27	Warnings, Adverse reactions	Exact identifier application applno (NDA): 021753 application number: NDA021753 ndc (product): 0299-5918
ADAPALENE	ADAPALENE	Mayne Pharma Commercial LLC.	9a0d9a0d-a9f3-4eb9-be76-166ef182d13a	2022-11-28	Warnings, Adverse reactions	Exact identifier application applno (NDA): 021753 application number: NDA021753

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
1L4806J2QF	ADAPALENE	106685-40-9	ADAPALENE

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUI	RxNorm string	TTY	DailyMed	SPL version
722111	adapalene 0.3 % Topical Gel	PSN	a0031324-92a6-4c11-90e2-c2818f7278ec	12
722113	Differin 0.3 % Topical Gel	PSN	a0031324-92a6-4c11-90e2-c2818f7278ec	12
722113	adapalene 0.003 MG/MG Topical Gel [Differin]	SBD	a0031324-92a6-4c11-90e2-c2818f7278ec	12
722111	adapalene 0.003 MG/MG Topical Gel	SCD	a0031324-92a6-4c11-90e2-c2818f7278ec	12
722111	adapalene 0.3 % Topical Gel	SY	a0031324-92a6-4c11-90e2-c2818f7278ec	12
722113	Differin 0.003 MG/MG Topical Gel	SY	a0031324-92a6-4c11-90e2-c2818f7278ec	12
722113	Differin 0.3 % Topical Gel	SY	a0031324-92a6-4c11-90e2-c2818f7278ec	12
722113	Differin 3 MG per GM Topical Gel	SY	a0031324-92a6-4c11-90e2-c2818f7278ec	12
722111	adapalene 0.3 % Topical Gel	PSN	5183ead4-9735-4535-b4f1-8dcb417eef02	2
722113	Differin 0.3 % Topical Gel	PSN	5183ead4-9735-4535-b4f1-8dcb417eef02	2
722113	adapalene 0.003 MG/MG Topical Gel [Differin]	SBD	5183ead4-9735-4535-b4f1-8dcb417eef02	2
722111	adapalene 0.003 MG/MG Topical Gel	SCD	5183ead4-9735-4535-b4f1-8dcb417eef02	2
722111	adapalene 0.3 % Topical Gel	SY	5183ead4-9735-4535-b4f1-8dcb417eef02	2
722113	Differin 0.003 MG/MG Topical Gel	SY	5183ead4-9735-4535-b4f1-8dcb417eef02	2
722113	Differin 0.3 % Topical Gel	SY	5183ead4-9735-4535-b4f1-8dcb417eef02	2
722113	Differin 3 MG per GM Topical Gel	SY	5183ead4-9735-4535-b4f1-8dcb417eef02	2

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Units	Marketing start	Marketing end	Sample	Exclude flag	Status
0299-5918-02	00299591802	2 g in 1 TUBE (0299-5918-02)	2 g	2009-09-15	0000-00-00	No	No	Current
0299-5918-15	00299591815	1 TUBE in 1 CARTON (0299-5918-15) > 15 g in 1 TUBE	1 tube	2009-09-15	0000-00-00	No	No	Current
0299-5918-25	00299591825	1 BOTTLE, PUMP in 1 CARTON (0299-5918-25) / 45 g in 1 BOTTLE, PUMP		2009-09-15	2027-02-01	No	No	Current
0299-5918-45	00299591845	1 TUBE in 1 CARTON (0299-5918-45) > 45 g in 1 TUBE	1 tube	2009-09-15	0000-00-00	No	No	Current

Title, Manufacturer, Effective date table
Title	Manufacturer	Effective date	Type	Version
DIFFERIN	Galderma Laboratories, L.P. \| G Production Inc.	2023-12-27	HUMAN PRESCRIPTION DRUG LABEL	12
DIFFERIN	Physicians Total Care, Inc.	2012-03-07	HUMAN PRESCRIPTION DRUG LABEL	2