FDA.reportPublic FDA data

Signature Care Pain Relief

Product NDC
21130-111
11-digit product format
211300111
Labeler code
21130
Product ID
21130-111_c77c6d49-4bd8-4359-872c-4cc13aecb583
Type
HUMAN OTC DRUG
Nonproprietary name
Acetaminophen
Dosage form
TABLET
Route
ORAL
Labeler
Safeway
Application
M013
Marketing category
OTC MONOGRAPH DRUG
Marketing start
2015-09-01
Substance
ACETAMINOPHEN
Active strength
500 mg/1
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

NDC auxiliary status#

These records are reproduced from FDA’s unfinished, excluded, and compounder listings. They describe what appeared in the source files; a missing record does not establish a regulatory status. View all current auxiliary records, including entries without an NDC. · View the auxiliary file history.

Current NDC status page 1 of 1 · 2 matching rows.

Dataset, Scope, Product NDC table
DatasetScopeProduct NDCPackage NDCCodeStatusReporting periodSource date
excluded packagepackage21130-11121130-111-62DDiscontinued by firm2026-10-12
excluded packagepackage21130-11121130-111-90DDiscontinued by firm2026-10-12

Observed NDC auxiliary status history#

This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.

Historic NDC status page 1 of 1 · 8 matching rows.

View current auxiliary records. · View the auxiliary file history.

Captured / source date, Package NDC, Snapshot table
Captured / source datePackage NDCSnapshotSource SHA-256
2025-12-14 17:58 UTC · source 2025-12-0521130-111-90d630ba8d3edf…732f749b63fb…
2025-12-14 17:58 UTC · source 2025-12-0521130-111-62d630ba8d3edf…732f749b63fb…
2025-08-27 00:01 UTC · source 2025-08-2621130-111-90f5e01cc5f278…a2eaf40c39c3…
2025-08-27 00:01 UTC · source 2025-08-2621130-111-62f5e01cc5f278…a2eaf40c39c3…
2025-04-01 02:39 UTC · source 2025-03-3121130-111-902ef7874e63bc…57b86245f4fa…
2025-03-28 20:22 UTC · source 2025-03-2821130-111-90a1b67e2a42f9…c4cf2c586c0d…
2025-03-22 03:12 UTC · source 2025-03-2121130-111-90cfe11265f3b6…090c488252e2…
2025-03-10 12:48 UTC · source 2025-03-1021130-111-90cdf11ea48f46…ba0047e9e063…

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

Additional Listing Data#

Finished product
Yes
Brand name base
Signature Care Pain Relief
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
ACETAMINOPHEN500 mg/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
362O9ITL9DInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
198440Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
917bcd06-6dc6-42b3-80b4-c6746b347261Available on FDA.report

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
21130-111-62Signature Care Pain Relief1 in 1 CARTONTABLET15
21130-111-62Signature Care Pain Relief24 in 1 BOTTLETABLET245
21130-111-71Signature Care Pain Relief50 in 1 BOTTLETABLET505
21130-111-71Signature Care Pain Relief1 in 1 CARTONTABLET15
21130-111-78Signature Care Pain Relief100 in 1 BOTTLETABLET1005
21130-111-78Signature Care Pain Relief1 in 1 CARTONTABLET15
21130-111-85Signature Care Pain Relief1 in 1 CARTONTABLET15
21130-111-85Signature Care Pain Relief250 in 1 BOTTLETABLET2505
21130-111-90Signature Care Pain Relief500 in 1 BOTTLETABLET5005

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
IngredientTypeUNIIDailyMed labelSPL versionUploaded
ACETAMINOPHENACTIVE INGREDIENT362O9ITL9DSIGNATURE CARE PAIN RELIEF (ACETAMINOPHEN) TABLET [SAFEWAY]1
ACETAMINOPHENACTIVE MOIETY362O9ITL9DSIGNATURE CARE PAIN RELIEF (ACETAMINOPHEN) TABLET [SAFEWAY]1
CARNAUBA WAXINACTIVE INGREDIENTR12CBM0EIZSIGNATURE CARE PAIN RELIEF (ACETAMINOPHEN) TABLET [SAFEWAY]1
CROSCARMELLOSE SODIUMINACTIVE INGREDIENTM28OL1HH48SIGNATURE CARE PAIN RELIEF (ACETAMINOPHEN) TABLET [SAFEWAY]1
HYPROMELLOSESINACTIVE INGREDIENT3NXW29V3WOSIGNATURE CARE PAIN RELIEF (ACETAMINOPHEN) TABLET [SAFEWAY]1
POLYETHYLENE GLYCOLSINACTIVE INGREDIENT3WJQ0SDW1ASIGNATURE CARE PAIN RELIEF (ACETAMINOPHEN) TABLET [SAFEWAY]1
POVIDONESINACTIVE INGREDIENTFZ989GH94ESIGNATURE CARE PAIN RELIEF (ACETAMINOPHEN) TABLET [SAFEWAY]1
STARCH, CORNINACTIVE INGREDIENTO8232NY3SJSIGNATURE CARE PAIN RELIEF (ACETAMINOPHEN) TABLET [SAFEWAY]1
STEARIC ACIDINACTIVE INGREDIENT4ELV7Z65APSIGNATURE CARE PAIN RELIEF (ACETAMINOPHEN) TABLET [SAFEWAY]1

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
21130-111SIGNATURE CARE PAIN RELIEF (ACETAMINOPHEN) TABLET [SAFEWAY]5Current NDC, Legacy NDC, 9 package rows20240924_917bcd06-6dc6-42b3-80b4-c6746b347261.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 7 of 79 · 1,579 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
INFANTS PAIN AND FEVERACETAMINOPHENAmazon.com Services LLC112076c4-cac2-45ab-9c77-5573edae71802026-07-10WarningsExact identifier
application number: M013
AspirinASPIRINWal-Mart Stores Inc8ae16aa2-54bc-4c1a-aa36-93524199a67b2026-07-09WarningsExact identifier
application number: M013
AcetaminophenACETAMINOPHENWildman Business Group943c8f49-e65e-40bc-b364-3274df4d21a22026-07-09WarningsExact identifier
application number: M013
Aspirin Regular StrengthASPIRINFOODHOLD U.S.A., LLC9e09b4fb-e015-45ea-8b1c-27faf65572aa2026-07-09WarningsExact identifier
application number: M013
Tension Headache ReliefACETAMINOPHEN, CAFFEINEWalgreen Companyf13fb7e9-50ea-4e2c-a442-38b1b5b315d72026-07-09WarningsExact identifier
application number: M013
Acetaminophen 500 Pyrilamine Maleate 15 and Caffeine 60ACETAMINOPHEN 500MG PYRILAMINE MALEATE 15MG AND CAFFEINE 60MG TABLETSHealth Pharma USA LLC34eb8a9b-d0ee-13e8-e063-6294a90a2fef2026-07-08WarningsExact identifier
application number: M013
Acetaminophen 250 mg Aspirin 250 mg Caffeine 65 mgACETAMINOPHEN 250 MG ASPIRIN 250 MG CAFFEINE 65 MGHealth Pharma USA LLC3590d417-272b-ae4d-e063-6394a90a5dc62026-07-08WarningsExact identifier
application number: M013
GOODMEDS EXTRA STRENGTH PAIN RELIEF ACETAMINOPHENACETAMINOPHENCabinet Health P.B.C.88884253-5a79-4ac1-b8ce-03966d8b509d2026-07-08WarningsExact identifier
application number: M013
AcetaminophenACETAMINOPHENHealth Pharma USA LLC671adabe-5f82-4599-a133-3f67ccb340792026-07-07WarningsExact identifier
application number: M013
Pain Reliever PlusACETAMINOPHEN, ASPIRIN, CAFFEINERugby Laboratoriesc3df1652-96a8-6043-e053-2995a90a2d262026-07-07WarningsExact identifier
application number: M013
Rapidol AspirinASPIRINPharmadel LLC00d9ab0d-ff25-784f-e063-6294a90a84972026-07-06WarningsExact identifier
application number: M013
AspirinASPIRINTrifecta Pharmaceuticals USA LLC227cefca-acc4-41d0-e063-6394a90a35b92026-07-06WarningsExact identifier
application number: M013
Extra Strength Pain AidACETAMINOPHEN, ASPIRIN, CAFFEINEHi-Tech Nutaceuticals, LLCa39e4b99-700d-0f5c-e053-2a95a90a6bd32026-07-06WarningsExact identifier
application number: M013
Nighttime Sleep AidACETAMINOPHEN, DIPHENHYDRAMINEHi-Tech Nutraceuticals, LLCa39e2bd6-3d0a-642b-e053-2995a90a42a02026-07-06WarningsExact identifier
application number: M013
Extra Strength AcetaminophenACETAMINOPHENHi-Tech Nutraceuticals, LLCa36be487-7a36-550f-e053-2a95a90a95c12026-07-06WarningsExact identifier
application number: M013
AcetaminophenACETAMINOPHENHi-Tech Nutraceuticals, LLCa39c524e-c131-d7fb-e053-2995a90a785b2026-07-06WarningsExact identifier
application number: M013
PAIN RELIEVERASPIRIN 81 MGHealth Pharma USA, LLCd60aed37-3a9e-46d1-e053-2995a90a1d1f2026-07-06WarningsExact identifier
application number: M013
Tylenol PM Extra StrengthACETAMINOPHEN AND DIPHENHYDRAMINE HYDROCHLORIDESelect Consumer Group55d0dceb-c9a9-778e-e063-6294a90a2ad72026-07-04WarningsExact identifier
application number: M013
Bayer Genuine AspirinASPIRINSelect Consumer Group3ca776c2-47ed-5107-e063-6394a90ac5df2026-07-03WarningsExact identifier
application number: M013
AspirinASPIRINRugby Laboratoriesf7ca9f4a-f8ef-46d2-9536-b69541e6653d2026-07-02WarningsExact identifier
application number: M013

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
198440acetaminophen 500 MG Oral TabletPSN917bcd06-6dc6-42b3-80b4-c6746b3472615
198440acetaminophen 500 MG Oral TabletSCD917bcd06-6dc6-42b3-80b4-c6746b3472615
198440APAP 500 MG Oral TabletSY917bcd06-6dc6-42b3-80b4-c6746b3472615

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
21130-111-62211300111621 BOTTLE in 1 CARTON (21130-111-62) > 24 TABLET in 1 BOTTLE1 bottle2015-09-010000-00-00NoNoCurrent
21130-111-71211300111711 BOTTLE in 1 CARTON (21130-111-71) / 50 TABLET in 1 BOTTLE1 bottle2015-09-010000-00-00NoNoCurrent
21130-111-78211300111781 BOTTLE in 1 CARTON (21130-111-78) / 100 TABLET in 1 BOTTLE1 bottle2015-09-010000-00-00NoNoCurrent
21130-111-85211300111851 BOTTLE in 1 CARTON (21130-111-85) / 250 TABLET in 1 BOTTLE1 bottle2015-09-010000-00-00NoNoCurrent
21130-111-9021130011190500 TABLET in 1 BOTTLE (21130-111-90) 500 tablet2015-09-010000-00-00NoNoCurrent