CYCLOSPORINE

Product NDC
23155-839
11-digit product format
231550839
Labeler code
23155
Product ID
23155-839_15185077-eec3-40ca-a492-f500a05a045b
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
CYCLOSPORINE
Dosage form
CAPSULE, LIQUID FILLED
Route
ORAL
Labeler
Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.
Application
ANDA216046
Marketing category
ANDA
Marketing start
2022-11-30
Substance
CYCLOSPORINE
Active strength
100 mg/1
Pharmacologic classes
Calcineurin Inhibitor Immunosuppressant [EPC], Calcineurin Inhibitors [MoA], Cytochrome P450 3A4 Inhibitors [MoA], P-Glycoprotein Inhibitors [MoA]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 3 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A216046-001CYCLOSPORINECYCLOSPORINE25MGCAPSULE / ORALAB12022-08-02
A216046-002CYCLOSPORINECYCLOSPORINE50MGCAPSULE / ORALAB12022-08-02
A216046-003CYCLOSPORINECYCLOSPORINE100MGCAPSULE / ORALAB12022-08-02

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 3 matching rows.

Application-product, TE code table
Application-productTE code
A216046-001AB1
A216046-002AB1
A216046-003AB1

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 3 · 81 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02A216046-001CYCLOSPORINE25MGCAPSULE / ORALAB12022-08-02011fe1cb6892…
2026-02-19 14:30 UTC2026-02A216046-002CYCLOSPORINE50MGCAPSULE / ORALAB12022-08-02011fe1cb6892…
2026-02-19 14:30 UTC2026-02A216046-003CYCLOSPORINE100MGCAPSULE / ORALAB12022-08-02011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A216046-001CYCLOSPORINE25MGCAPSULE / ORALAB12022-08-0231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A216046-002CYCLOSPORINE50MGCAPSULE / ORALAB12022-08-0231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A216046-003CYCLOSPORINE100MGCAPSULE / ORALAB12022-08-0231067a03dcf5…
2025-08-23 18:47 UTC2025-08A216046-001CYCLOSPORINE25MGCAPSULE / ORALAB12022-08-026a471c1ec25d…
2025-08-23 18:47 UTC2025-08A216046-002CYCLOSPORINE50MGCAPSULE / ORALAB12022-08-026a471c1ec25d…
2025-08-23 18:47 UTC2025-08A216046-003CYCLOSPORINE100MGCAPSULE / ORALAB12022-08-026a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A216046-001CYCLOSPORINE25MGCAPSULE / ORALAB12022-08-02fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A216046-002CYCLOSPORINE50MGCAPSULE / ORALAB12022-08-02fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A216046-003CYCLOSPORINE100MGCAPSULE / ORALAB12022-08-02fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A216046-001CYCLOSPORINE25MGCAPSULE / ORALAB12022-08-02b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A216046-002CYCLOSPORINE50MGCAPSULE / ORALAB12022-08-02b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A216046-003CYCLOSPORINE100MGCAPSULE / ORALAB12022-08-02b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A216046-001CYCLOSPORINE25MGCAPSULE / ORALAB12022-08-0203ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A216046-002CYCLOSPORINE50MGCAPSULE / ORALAB12022-08-0203ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A216046-003CYCLOSPORINE100MGCAPSULE / ORALAB12022-08-0203ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A216046-001CYCLOSPORINE25MGCAPSULE / ORALAB12022-08-022680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A216046-002CYCLOSPORINE50MGCAPSULE / ORALAB12022-08-022680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A216046-003CYCLOSPORINE100MGCAPSULE / ORALAB12022-08-022680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A216046-001CYCLOSPORINE25MGCAPSULE / ORALAB12022-08-025bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A216046-002CYCLOSPORINE50MGCAPSULE / ORALAB12022-08-025bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A216046-003CYCLOSPORINE100MGCAPSULE / ORALAB12022-08-025bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A216046-001CYCLOSPORINE25MGCAPSULE / ORALAB12022-08-02d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A216046-002CYCLOSPORINE50MGCAPSULE / ORALAB12022-08-02d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A216046-003CYCLOSPORINE100MGCAPSULE / ORALAB12022-08-02d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A216046-001CYCLOSPORINE25MGCAPSULE / ORALAB12022-08-02d06236e962d9…
2024-10-29 15:01 UTC2024-10A216046-002CYCLOSPORINE50MGCAPSULE / ORALAB12022-08-02d06236e962d9…
2024-10-29 15:01 UTC2024-10A216046-003CYCLOSPORINE100MGCAPSULE / ORALAB12022-08-02d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A216046-001CYCLOSPORINE25MGCAPSULE / ORALAB12022-08-0279d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A216046-002CYCLOSPORINE50MGCAPSULE / ORALAB12022-08-0279d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A216046-003CYCLOSPORINE100MGCAPSULE / ORALAB12022-08-0279d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A216046-001CYCLOSPORINE25MGCAPSULE / ORALAB12022-08-02301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A216046-002CYCLOSPORINE50MGCAPSULE / ORALAB12022-08-02301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A216046-003CYCLOSPORINE100MGCAPSULE / ORALAB12022-08-02301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A216046-001CYCLOSPORINE25MGCAPSULE / ORALAB12022-08-021e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A216046-002CYCLOSPORINE50MGCAPSULE / ORALAB12022-08-021e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A216046-003CYCLOSPORINE100MGCAPSULE / ORALAB12022-08-021e350fbaab3a…
2024-05-31 18:47 UTC2024-05A216046-001CYCLOSPORINE25MGCAPSULE / ORALAB12022-08-028072bd15b7f6…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 3 · 81 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02A216046-001AB11011fe1cb6892…
2026-02-19 14:30 UTC2026-02A216046-002AB11011fe1cb6892…
2026-02-19 14:30 UTC2026-02A216046-003AB11011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A216046-001AB1131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A216046-002AB1131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A216046-003AB1131067a03dcf5…
2025-08-23 18:47 UTC2025-08A216046-001AB116a471c1ec25d…
2025-08-23 18:47 UTC2025-08A216046-002AB116a471c1ec25d…
2025-08-23 18:47 UTC2025-08A216046-003AB116a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A216046-001AB11fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A216046-002AB11fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A216046-003AB11fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A216046-001AB11b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A216046-002AB11b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A216046-003AB11b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A216046-001AB1103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A216046-002AB1103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A216046-003AB1103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A216046-001AB112680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A216046-002AB112680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A216046-003AB112680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A216046-001AB115bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A216046-002AB115bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A216046-003AB115bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A216046-001AB11d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A216046-002AB11d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A216046-003AB11d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A216046-001AB11d06236e962d9…
2024-10-29 15:01 UTC2024-10A216046-002AB11d06236e962d9…
2024-10-29 15:01 UTC2024-10A216046-003AB11d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A216046-001AB1179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A216046-002AB1179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A216046-003AB1179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A216046-001AB11301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A216046-002AB11301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A216046-003AB11301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A216046-001AB111e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A216046-002AB111e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A216046-003AB111e350fbaab3a…
2024-05-31 18:47 UTC2024-05A216046-001AB118072bd15b7f6…

Additional Listing Data#

Finished product
Yes
Brand name base
CYCLOSPORINE
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
CYCLOSPORINE100 mg/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
83HN0GTJ6DInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 3 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
241834Internal RxNorm lookup
835894Internal RxNorm lookup
835925Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1952d4c7-a40e-4924-b669-c41400774cb9Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
1be408a0-e15a-4092-b35e-4e294e65196fProduct name320240216
b3fdee3e-0c46-442f-aad5-aa71941d5621Product name120231023
78fb0708-fce5-decd-6611-5a9fbe3e3decProduct name320230327
54840517-000d-4fcb-b976-a6ddd102faa0Product name120220120
a5ba3bd0-8411-4005-ac3b-a41d8ee0633aProduct name120181029
b1c0d609-8b97-06ee-2cd0-5652a4b1d019Product name120140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
23155-839-11CYCLOSPORINE6 in 1 BLISTER PACKCAPSULE, LIQUID FILLED65
23155-839-30CYCLOSPORINE5 in 1 CARTONCAPSULE, LIQUID FILLED55

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
23155-839-11EA - Each23155-839e4e9c47e-a534-464c-a4e4-7b24cb953bc312023-01-09
23155-839-30EA - Each23155-83977e6745e-1524-4893-b992-4c4f6174593a12023-01-09

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
23155-839CYCLOSPORINE CAPSULE, LIQUID FILLED [HERITAGE PHARMACEUTICALS INC. D/B/A AVET PHARMACEUTICALS INC.]4Current NDC, Legacy NDC, 2 package rows20240322_1952d4c7-a40e-4924-b669-c41400774cb9.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
CYCLOSPORINECYCLOSPORINEHeritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.1952d4c7-a40e-4924-b669-c41400774cb92025-12-04Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 216046
application number: ANDA216046
ndc (product): 23155-839

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
241834cycloSPORINE, modified 100 MG Oral CapsulePSN1952d4c7-a40e-4924-b669-c41400774cb95
835894cycloSPORINE, modified 25 MG Oral CapsulePSN1952d4c7-a40e-4924-b669-c41400774cb95
835925cycloSPORINE, modified 50 MG Oral CapsulePSN1952d4c7-a40e-4924-b669-c41400774cb95
241834cyclosporine, modified 100 MG Oral CapsuleSCD1952d4c7-a40e-4924-b669-c41400774cb95
835894cyclosporine, modified 25 MG Oral CapsuleSCD1952d4c7-a40e-4924-b669-c41400774cb95
835925cyclosporine, modified 50 MG Oral CapsuleSCD1952d4c7-a40e-4924-b669-c41400774cb95

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
23155-839-11231550839116 in 1 BLISTER PACKHistorical
23155-839-30231550839305 BLISTER PACK in 1 CARTON (23155-839-30) / 6 CAPSULE, LIQUID FILLED in 1 BLISTER PACK (23155-839-11) 5 blister pack2022-11-300000-00-00NoNoCurrent