ZzzQuil

Product NDC: 37000-500
Requested package NDC: 37000-500-12
11-digit product format: 370000500
Labeler code: 37000
Product ID: 37000-500_4b456ea0-a1c4-e3f2-e063-6294a90ae679
Type: HUMAN OTC DRUG
Nonproprietary name: DIPHENHYDRAMINE HYDROCHLORIDE
Dosage form: LIQUID
Route: ORAL
Labeler: The Procter & Gamble Manufacturing Company
Application: M010
Marketing category: OTC MONOGRAPH DRUG
Marketing start: 2011-12-08
Substance: DIPHENHYDRAMINE HYDROCHLORIDE
Active strength: 50 mg/30mL
Pharmacologic classes: Histamine H1 Receptor Antagonists [MoA], Histamine-1 Receptor Antagonist [EPC]
NDC exclude flag: No
Listing certified through: 2027-12-31
Current FDA listing: Yes

Additional Listing Data#

Finished product: Yes
Brand name base: ZzzQuil
Brand name suffix: Nighttime Sleep-Aid
Listing expiration: 2027-12-31

Active Ingredients#

Ingredient, Strength table
Ingredient	Strength
DIPHENHYDRAMINE HYDROCHLORIDE	50 mg/30mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
TC2D6JAD40	Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
1248354	Internal RxNorm lookup
1248356	Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
e441c952-cd48-4159-ada2-271ca7541600	Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product concept	Relation	Version	Effective
0e2e0f88-b076-afe1-4bdd-32bca4375bec	Product name	3	20250127
c6f86816-7da6-43ea-8c25-ac9758311cc5	Product name	1	20220118
252e11b6-1a9a-4283-a242-df2c129c496d	Product name	3	20170717
3e48c9c4-918d-5d23-2f0b-d2398b06be54	Product name	1	20140508
6084a4f4-5437-c9a5-caec-5361ee075a59	Product name	1	20140508
865c72dd-0d94-daac-f728-ddd4ded2a79e	Product name	1	20140508
90c5639a-61b0-88d6-ddcf-21888e94869a	Product name	1	20140508
9514609b-a2a9-f8ec-6ba6-3f8e5ee89877	Product name	1	20140508

FDA-Initiated Inactive NDC Indexing#

NDC, Effective, Related label table
NDC	Effective	Related label
37000-500-01	2024-01-30	ZzzQuil™ NIGHTTIME SLEEP-AID WARMING BERRY
37000-500-06	2024-01-30	ZzzQuil™ NIGHTTIME SLEEP-AID WARMING BERRY
37000-500-08	2024-01-30	ZzzQuil™ NIGHTTIME SLEEP-AID WARMING BERRY
37000-500-12	2024-01-30	ZzzQuil™ NIGHTTIME SLEEP-AID WARMING BERRY
37000-500-24	2024-01-30	ZzzQuil™ NIGHTTIME SLEEP-AID WARMING BERRY
37000-500-36	2024-01-30	ZzzQuil™ NIGHTTIME SLEEP-AID WARMING BERRY
37000-500-06	2021-02-12	ZzzQuil™ NIGHTTIME SLEEP-AID WARMING BERRY
37000-500-12	2021-02-12	ZzzQuil™ NIGHTTIME SLEEP-AID WARMING BERRY
37000-500-24	2021-02-12	ZzzQuil™ NIGHTTIME SLEEP-AID WARMING BERRY
37000-500-36	2021-02-12	ZzzQuil™ NIGHTTIME SLEEP-AID WARMING BERRY
37000-500-06	2021-01-29	ZzzQuil™ NIGHTTIME SLEEP-AID WARMING BERRY
37000-500-12	2021-01-29	ZzzQuil™ NIGHTTIME SLEEP-AID WARMING BERRY
37000-500-24	2021-01-29	ZzzQuil™ NIGHTTIME SLEEP-AID WARMING BERRY
37000-500-36	2021-01-29	ZzzQuil™ NIGHTTIME SLEEP-AID WARMING BERRY

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	Strength	SPL version
37000-500-01	ZzzQuilNighttime Sleep-Aid	30 mL in 1 BOTTLE, PLASTIC	LIQUID	30		21
37000-500-06	ZzzQuilNighttime Sleep-Aid	177 mL in 1 BOTTLE, PLASTIC	LIQUID	177		21
37000-500-08	ZzzQuilNighttime Sleep-Aid	30 mL in 1 BOTTLE, PLASTIC	LIQUID	30		21
37000-500-08	ZzzQuilNighttime Sleep-Aid	8 in 1 PACKAGE, COMBINATION	LIQUID	8		21
37000-500-12	ZzzQuilNighttime Sleep-Aid	354 mL in 1 BOTTLE, PLASTIC	LIQUID	354		21
37000-500-24	ZzzQuilNighttime Sleep-Aid	2 in 1 PACKAGE, COMBINATION	LIQUID	2		21
37000-500-36	ZzzQuilNighttime Sleep-Aid	3 in 1 PACKAGE, COMBINATION	LIQUID	3		21
37000-500-12	Vicks ZzzQuilNighttime Sleep-Aid	354 mL in 1 BOTTLE, PLASTIC	LIQUID	354 mL	50 mg in 30mL	3
37000-500-24	Vicks ZzzQuilNighttime Sleep-Aid	2 in 1 PACKAGE, COMBINATION	LIQUID		50 mg in 30mL	3

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDC	Billing unit	Product NDC	DailyMed indexing SPL	SPL version	Effective
37000-500-06	ML - Milliliter	37000-500	7c7ff596-24c8-4894-a0c7-9df5bfc3aec6	1	2013-03-03
37000-500-12	ML - Milliliter	37000-500	e0b24d7c-6a0a-4407-a48b-cca3d0d3b8a1	1	2016-06-14
37000-500-24	ML - Milliliter	37000-500	8581da31-ba83-4caa-828e-148ce4cb05a9	1	2017-06-15
37000-500-36	ML - Milliliter	37000-500	48fae6c1-97bf-4d14-aac0-8989228fd3d8	1	2017-06-15

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
Ingredient	Type	UNII	DailyMed label	SPL version
DIPHENHYDRAMINE HYDROCHLORIDE	ACTIVE INGREDIENT	TC2D6JAD40	ZZZQUIL NIGHTTIME SLEEP-AID (DIPHENHYDRAMINE HYDROCHLORIDE) LIQUID [PROCTER & GAMBLE MANUFACRUING COMPANY]	3
DIPHENHYDRAMINE	ACTIVE MOIETY	8GTS82S83M	ZZZQUIL NIGHTTIME SLEEP-AID (DIPHENHYDRAMINE HYDROCHLORIDE) LIQUID [PROCTER & GAMBLE MANUFACRUING COMPANY]	3
ALCOHOL	INACTIVE INGREDIENT	3K9958V90M	ZZZQUIL NIGHTTIME SLEEP-AID (DIPHENHYDRAMINE HYDROCHLORIDE) LIQUID [PROCTER & GAMBLE MANUFACRUING COMPANY]	3
CITRIC ACID MONOHYDRATE	INACTIVE INGREDIENT	2968PHW8QP	ZZZQUIL NIGHTTIME SLEEP-AID (DIPHENHYDRAMINE HYDROCHLORIDE) LIQUID [PROCTER & GAMBLE MANUFACRUING COMPANY]	3
FD&C BLUE NO. 1	INACTIVE INGREDIENT	H3R47K3TBD	ZZZQUIL NIGHTTIME SLEEP-AID (DIPHENHYDRAMINE HYDROCHLORIDE) LIQUID [PROCTER & GAMBLE MANUFACRUING COMPANY]	3
FD&C RED NO. 40	INACTIVE INGREDIENT	WZB9127XOA	ZZZQUIL NIGHTTIME SLEEP-AID (DIPHENHYDRAMINE HYDROCHLORIDE) LIQUID [PROCTER & GAMBLE MANUFACRUING COMPANY]	3
HIGH FRUCTOSE CORN SYRUP	INACTIVE INGREDIENT	XY6UN3QB6S	ZZZQUIL NIGHTTIME SLEEP-AID (DIPHENHYDRAMINE HYDROCHLORIDE) LIQUID [PROCTER & GAMBLE MANUFACRUING COMPANY]	3
POLYOXYL 40 STEARATE	INACTIVE INGREDIENT	13A4J4NH9I	ZZZQUIL NIGHTTIME SLEEP-AID (DIPHENHYDRAMINE HYDROCHLORIDE) LIQUID [PROCTER & GAMBLE MANUFACRUING COMPANY]	3
PROPYLENE GLYCOL	INACTIVE INGREDIENT	6DC9Q167V3	ZZZQUIL NIGHTTIME SLEEP-AID (DIPHENHYDRAMINE HYDROCHLORIDE) LIQUID [PROCTER & GAMBLE MANUFACRUING COMPANY]	3
SACCHARIN SODIUM	INACTIVE INGREDIENT	SB8ZUX40TY	ZZZQUIL NIGHTTIME SLEEP-AID (DIPHENHYDRAMINE HYDROCHLORIDE) LIQUID [PROCTER & GAMBLE MANUFACRUING COMPANY]	3
SODIUM BENZOATE	INACTIVE INGREDIENT	OJ245FE5EU	ZZZQUIL NIGHTTIME SLEEP-AID (DIPHENHYDRAMINE HYDROCHLORIDE) LIQUID [PROCTER & GAMBLE MANUFACRUING COMPANY]	3
TRISODIUM CITRATE DIHYDRATE	INACTIVE INGREDIENT	B22547B95K	ZZZQUIL NIGHTTIME SLEEP-AID (DIPHENHYDRAMINE HYDROCHLORIDE) LIQUID [PROCTER & GAMBLE MANUFACRUING COMPANY]	3
WATER	INACTIVE INGREDIENT	059QF0KO0R	ZZZQUIL NIGHTTIME SLEEP-AID (DIPHENHYDRAMINE HYDROCHLORIDE) LIQUID [PROCTER & GAMBLE MANUFACRUING COMPANY]	3

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
37000-500	ZZZQUIL NIGHTTIME SLEEP-AID (DIPHENHYDRAMINE HYDROCHLORIDE) LIQUID [THE PROCTER & GAMBLE MANUFACTURING COMPANY]	17	Current NDC, Legacy NDC, 7 package rows	20241012_e441c952-cd48-4159-ada2-271ca7541600.zip
37000-500	VICKS ZZZQUIL NIGHTTIME SLEEP-AID (DIPHENHYDRAMINE HYDROCHLORIDE) KIT [THE PROCTER & GAMBLE MANUFACTURING COMPANY]	1	Current NDC, Legacy NDC	20240715_1be2f00b-5bdd-82e7-e063-6394a90ab9a5.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 14 · 263 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
Wal Som Nighttime Sleep Aid	DIPHENHYDRAMINE HCL	Walgreens	ff475a69-dbb2-40a9-b7f4-9c7b7e975d19	2026-07-23	Warnings	Exact identifier application number: M010
Sleep Aid	DIPHENHYDRAMINE HCL	TARGET Corporation	336ac29d-db24-44da-a299-5a4793ae8f6a	2026-07-21	Warnings	Exact identifier application number: M010
Best Choice Childrens Allergy Relief Bubblegum flavor	DIPHENHYDRAMINE HCL	BEST CHOICE (VALU MERCHANDISERS COMPANY)	9bf2d698-8394-46c3-b7a9-e99ab6bb88e4	2026-07-17	Warnings	Exact identifier application number: M010
ADWE dye-free childrens allergy	DIPHENHYDRAMINE HYDROCHLORIDE	RARITAN PHARMACEUTICALS INC	ea3a51af-3025-497f-8cd7-e99391b0d06f	2026-07-17	Warnings	Exact identifier application number: M010
nighttime sleep aid	DIPHENHYDRAMINE HCL	Amazon.com Services LLC	a8056e5f-e9d8-4555-9212-bf1fa3c15439	2026-07-16	Warnings	Exact identifier application number: M010
Sleep Aid	DIPHENHYDRAMINE HCL	Amerisource Bergen	147adc14-ca7c-45f5-9925-ea569edbfe96	2026-07-09	Warnings	Exact identifier application number: M010
Nighttime Sleep Aid	DIPHENHYDRAMINE HCL 25 MG	Health Pharma USA LLC	d659f747-9790-8bd6-e053-2995a90ae793	2026-07-07	Warnings	Exact identifier application number: M010
Pharbedryl	DIPHENHYDRAMINE HCL	St. Mary's Medical Park Pharmacy	3ef18965-bafb-cc19-e063-6394a90af17d	2026-06-29	Warnings	Exact identifier application number: M010
CalmCo Sleep Aid	DIPHENHYDRAMINE HCL	CalmCo LLC	552d0e50-a58c-8e47-e063-6394a90a8f7b	2026-06-26	Warnings	Exact identifier application number: M010
Vicks ZzzQuil Night Pain	DIPHENHYDRAMINE HYDROCHLORIDE AND ACETAMINOPHEN	The Procter & Gamble Manufacturing Company	a7cf8e2e-7aac-a1fa-e053-2a95a90a561a	2026-06-26	Warnings	Exact identifier application number: M010
Nighttime Sleep Aid	DIPHENHYDRAMINE HCL	Bi-Mart	1b40e794-089f-4546-8f8d-ba7016cd4e7f	2026-06-22	Warnings	Exact identifier application number: M010
Sleep-Aid	DIPHENHYDRAMINE HCL	Rite Aid Corporation	1a5668df-2bbc-4724-af39-19d30a8920f3	2026-06-22	Warnings	Exact identifier application number: M010
Sleep Aid Night Time	DIPHENHYDRAMINE HCL	DOLGENCORP, LLC	9f1e2e1f-d3e8-4c8a-9e3e-c2ab9e4c79e8	2026-06-16	Warnings	Exact identifier application number: M010
Sleep Aid	DIPHENHYDRAMINE HCL	Topco Associates, LLC	57a81e24-ef0d-4143-b266-71e2d4be7617	2026-06-16	Warnings	Exact identifier application number: M010
Nighttime Sleep Aid	DIPHENHYDRAMINE HCL	CVS Pharmacy	3710254e-6c3c-4044-9694-59703274cd0f	2026-06-15	Warnings	Exact identifier application number: M010
Sleep Aid Nighttime	DIPHENHYDRAMINE HCL	Wal-Mart Stores Inc	cfddfdeb-701f-452d-876d-8003e6fcefe3	2026-06-15	Warnings	Exact identifier application number: M010
Nighttime Sleep Aid	DIPHENHYDRAMINE HCL	Family Dollar Services Inc	2d63400b-43ae-4dd2-b917-3f65e02366b4	2026-06-08	Warnings	Exact identifier application number: M010
Mantra	MANTRA SLEEP AID WILD CHERRY	MOREMED INC.	316d11fe-a173-a1dd-e063-6394a90af499	2026-05-21	Warnings	Exact identifier application number: M010
Nighttime Sleep Aid	DIPHENHYDRAMINE HCL	TOPCO ASSOCIATES LLC	9558cc42-d27d-42af-b0a7-44cad025165d	2026-05-21	Warnings	Exact identifier application number: M010
Sleep Aid NightTime	DIPHENHYDRAMINE HCL	Wal-Mart Stores Inc	dac2a0b9-f851-467b-a39f-3560d42c96e2	2026-05-20	Warnings	Exact identifier application number: M010

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
TC2D6JAD40	DIPHENHYDRAMINE HYDROCHLORIDE	147-24-0	DIPHENHYDRAMINE HYDROCHLORIDE

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUI	RxNorm string	TTY	DailyMed	SPL version
1248354	diphenhydrAMINE HCl 50 MG in 30 mL Oral Solution	PSN	e441c952-cd48-4159-ada2-271ca7541600	21
1248356	ZzzQuil NIGHTTIME SLEEP-AID 50 MG in 30 mL Oral Solution	PSN	e441c952-cd48-4159-ada2-271ca7541600	21
1248356	diphenhydramine hydrochloride 1.67 MG/ML Oral Solution [Zzzquil]	SBD	e441c952-cd48-4159-ada2-271ca7541600	21
1248354	diphenhydramine hydrochloride 1.67 MG/ML Oral Solution	SCD	e441c952-cd48-4159-ada2-271ca7541600	21
1248354	diphenhydramine HCl 1.667 MG/ML Oral Solution	SY	e441c952-cd48-4159-ada2-271ca7541600	21
1248354	diphenhydramine HCl 50 MG per 30 ML Oral Solution	SY	e441c952-cd48-4159-ada2-271ca7541600	21
1248356	Zzzquil 1.67 MG/ML Oral Solution	SY	e441c952-cd48-4159-ada2-271ca7541600	21
1248356	Zzzquil 50 MG per 30 ML Oral Solution	SY	e441c952-cd48-4159-ada2-271ca7541600	21
1248354	diphenhydrAMINE HCl 50 MG in 30 mL Oral Solution	PSN	1be2f00b-5bdd-82e7-e063-6394a90ab9a5	3
1248356	ZzzQuil NIGHTTIME SLEEP-AID 50 MG in 30 mL Oral Solution	PSN	1be2f00b-5bdd-82e7-e063-6394a90ab9a5	3
1248356	diphenhydramine hydrochloride 1.67 MG/ML Oral Solution [Zzzquil]	SBD	1be2f00b-5bdd-82e7-e063-6394a90ab9a5	3
1248354	diphenhydramine hydrochloride 1.67 MG/ML Oral Solution	SCD	1be2f00b-5bdd-82e7-e063-6394a90ab9a5	3
1248354	diphenhydramine HCl 1.667 MG/ML Oral Solution	SY	1be2f00b-5bdd-82e7-e063-6394a90ab9a5	3
1248354	diphenhydramine HCl 50 MG per 30 ML Oral Solution	SY	1be2f00b-5bdd-82e7-e063-6394a90ab9a5	3
1248356	Zzzquil 1.67 MG/ML Oral Solution	SY	1be2f00b-5bdd-82e7-e063-6394a90ab9a5	3
1248356	Zzzquil 50 MG per 30 ML Oral Solution	SY	1be2f00b-5bdd-82e7-e063-6394a90ab9a5	3

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Units	Marketing start	Marketing end	Sample	Exclude flag	Status
37000-500-12	37000050012	354 mL in 1 BOTTLE, PLASTIC (37000-500-12)	354 ml	2011-12-08	0000-00-00	No	No	Current

Title, Manufacturer, Effective date table
Title	Manufacturer	Effective date	Type	Version
Vicks ZzzQuil Nighttime Sleep-Aid	The Procter & Gamble Manufacturing Company	2026-04-06	HUMAN OTC DRUG LABEL	3
ZzzQuil™ NIGHTTIME SLEEP-AID WARMING BERRY	The Procter & Gamble Manufacturing Company	2026-02-20	HUMAN OTC DRUG LABEL	21