diphenhydramine hydrochloride 1.67 MG/ML Oral Solution [Zzzquil]

RxCUI: 1248356
RxNorm name: diphenhydramine hydrochloride 1.67 MG/ML Oral Solution [Zzzquil]
Display name: ZZZQUIL (Oral Liquid)
Full name: diphenhydramine hydrochloride 1.67 MG/ML Oral Solution [Zzzquil]
Term type: SBD
Status: Active
Strength: 50 mg/30ml
Dose form: Sol
Route: Oral Liquid
Updated: 2026-07-25 06:55:11

RxNorm Status History#

Status: Active
Source: RXNORM
Current: YES
Release start: 042012
Active start: 042012
Multiple ingredient: NO
Branded: YES

Ingredients And Strength#

Ingredient, Strength, Base table
Ingredient	Strength	Base	Basis of strength
diphenhydramine hydrochloride	1.67 MG / 1 ML	diphenhydramine	diphenhydramine hydrochloride

Dose Form Concepts#

Dose form, RxCUI table
Dose form	RxCUI
Oral Solution	316968

Derived Ingredient Concepts#

Ingredient, RxCUI table
Ingredient	RxCUI
diphenhydramine	3498

Source Vocabulary Codes#

Code type, Values, Count table
Code type	Values	Count	Category
PRESCRIBABLE	Y	1	ATTRIBUTES
RXNAV_STR	Zzzquil 1.67 MG/ML Oral Solution	1	NAMES
RxNorm Name	diphenhydramine hydrochloride 1.67 MG/ML Oral Solution [Zzzquil]	1	NAMES
RxNorm Synonym	2 linked values Zzzquil 1.67 MG/ML Oral Solution Zzzquil 50 MG per 30 ML Oral Solution	2	NAMES
TTY	SBD	1	ATTRIBUTES
SPL_SET_ID	4 linked values 1be2f00b-5bdd-82e7-e063-6394a90ab9a5 1d608c94-1651-f318-e063-6294a90aa11e 01906eed-78ee-f2a1-e063-6294a90a809b e441c952-cd48-4159-ada2-271ca7541600	4	CODES
RxCUI	1248356	1	CODES
MMSL_CODE	BD28147	1	CODES

FDA NDC Products And Packages#

Package NDC, Product NDC, Name table
Package NDC	Product NDC	Name	Labeler	Application
37000-500-01	37000-500	ZzzQuil DIPHENHYDRAMINE HYDROCHLORIDE	The Procter & Gamble Manufacturing Company	M010
37000-500-06	37000-500	ZzzQuil DIPHENHYDRAMINE HYDROCHLORIDE	The Procter & Gamble Manufacturing Company	M010
37000-500-08	37000-500	ZzzQuil DIPHENHYDRAMINE HYDROCHLORIDE	The Procter & Gamble Manufacturing Company	M010
37000-500-12	37000-500	ZzzQuil DIPHENHYDRAMINE HYDROCHLORIDE	The Procter & Gamble Manufacturing Company	M010
37000-500-24	37000-500	ZzzQuil DIPHENHYDRAMINE HYDROCHLORIDE	The Procter & Gamble Manufacturing Company	M010
37000-500-36	37000-500	ZzzQuil DIPHENHYDRAMINE HYDROCHLORIDE	The Procter & Gamble Manufacturing Company	M010
69423-795-12	69423-795	VICKS ZzzQuil Diphenhydramine Hydrochloride	The Procter & Gamble Manufacturing Company	M010
84126-316-04	84126-316	ZzzQuil DIPHENHYDRAMINE HYDROCHLORIDE	The Procter & Gamble Manufacturing Company	M010

Drugs@FDA Applications#

Application, NDC, Name table
Application	NDC	Name	Marketing category	Labeler
M010	37000-500	ZzzQuil DIPHENHYDRAMINE HYDROCHLORIDE	OTC MONOGRAPH DRUG	The Procter & Gamble Manufacturing Company

RxNav Current And Historical NDCs#

RxNav current and historical NDC rows page 1 of 1 · 27 matching rows.

NDC11, Source, Active table
NDC11	Source	Active
23900001396	rxnav_ndcs	yes
23900001398	rxnav_ndcs	yes
23900001531	rxnav_ndcs	yes
23900001619	rxnav_ndcs	yes
23900003855	rxnav_ndcs	yes
23900003856	rxnav_ndcs	yes
23900003858	rxnav_ndcs	yes
23900003859	rxnav_ndcs	yes
37000043012	rxnav_ndcs	yes
37000043106	rxnav_ndcs	yes
37000043112	rxnav_ndcs	yes
37000043124	rxnav_ndcs	yes
37000050001	rxnav_ndcs	yes
37000050006	rxnav_ndcs	yes
37000050008	rxnav_ndcs	yes
37000050012	rxnav_ndcs	yes
37000050024	rxnav_ndcs	yes
37000050036	rxnav_ndcs	yes
69423079512	rxnav_ndcs	yes
84126031604	rxnav_ndcs	yes
37000043024	rxnav_historical
37000050004	rxnav_historical
37000093006	rxnav_historical
37000093012	rxnav_historical
37000093024	rxnav_historical
69423096512	rxnav_historical
69423097904	rxnav_historical

UNII Substances#

UNII substance links page 1 of 1 · 0 matching rows.

No records found.

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 2 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
VICKS ZzzQuil NIGHTTIME SLEEP-AID Diphenhydramine HCl FREE OF	DIPHENHYDRAMINE HYDROCHLORIDE	The Procter & Gamble Manufacturing Company	01906eed-78ee-f2a1-e063-6294a90a809b	2026-09-08	Warnings	Exact identifier ndc (package): 69423-795-12 ndc (product): 69423-795 ndc11 (package): 69423079512 rxcui: 1248356
Vicks ZzzQuil Nighttime Sleep-Aid	DIPHENHYDRAMINE HYDROCHLORIDE	The Procter & Gamble Manufacturing Company	1be2f00b-5bdd-82e7-e063-6394a90ab9a5	2026-04-06	Warnings	Exact identifier ndc (package): 37000-500-12 ndc (package): 37000-500-24 ndc11 (package): 37000050012 ndc11 (package): 37000050024 rxcui: 1248356

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

DailyMed RxNorm Mappings#

unique DailyMed labels mapped to this RxNorm concept page 1 of 1 · 5 matching rows.

Set ID, RxNorm mappings, Terms table
Set ID	RxNorm mappings	Terms	SPL version	Label	Effective
e441c952-cd48-4159-ada2-271ca7541600	ZzzQuil NIGHTTIME SLEEP-AID 50 MG in 30 mL Oral Solution [PSN] · diphenhydramine hydrochloride 1.67 MG/ML Oral Solution [Zzzquil] [SBD] · Zzzquil 1.67 MG/ML Oral Solution [SY] · Zzzquil 50 MG per 30 ML Oral Solution [SY]	4	21	ZzzQuil™ NIGHTTIME SLEEP-AID WARMING BERRY	20260220
dd1ab38a-afe6-07ea-e053-2995a90ad98f	ZzzQuil NIGHTTIME SLEEP-AID 50 MG in 30 mL Oral Solution [PSN] · diphenhydramine hydrochloride 1.67 MG/ML Oral Solution [Zzzquil] [SBD] · Zzzquil 1.67 MG/ML Oral Solution [SY] · Zzzquil 50 MG per 30 ML Oral Solution [SY]	4	10	ZzzQuil™ NIGHTTIME SLEEP-AID	20241010
01906eed-78ee-f2a1-e063-6294a90a809b	ZzzQuil NIGHTTIME SLEEP-AID 50 MG in 30 mL Oral Solution [PSN] · diphenhydramine hydrochloride 1.67 MG/ML Oral Solution [Zzzquil] [SBD] · Zzzquil 1.67 MG/ML Oral Solution [SY] · Zzzquil 50 MG per 30 ML Oral Solution [SY]	4	7	Vicks ZzzQuil™ Nighttime Sleep-Aid Diphenhydramine HCl FREE OF	20251003
1be2f00b-5bdd-82e7-e063-6394a90ab9a5	ZzzQuil NIGHTTIME SLEEP-AID 50 MG in 30 mL Oral Solution [PSN] · diphenhydramine hydrochloride 1.67 MG/ML Oral Solution [Zzzquil] [SBD] · Zzzquil 1.67 MG/ML Oral Solution [SY] · Zzzquil 50 MG per 30 ML Oral Solution [SY]	4	3	Vicks ZzzQuil™ Nighttime Sleep-Aid Warming Berry Liquid WITH ZzzQuil Sleep Nasal Strips CONVENIENCE KIT	20260406
1d608c94-1651-f318-e063-6294a90aa11e	ZzzQuil NIGHTTIME SLEEP-AID 50 MG in 30 mL Oral Solution [PSN] · diphenhydramine hydrochloride 1.67 MG/ML Oral Solution [Zzzquil] [SBD] · Zzzquil 1.67 MG/ML Oral Solution [SY] · Zzzquil 50 MG per 30 ML Oral Solution [SY]	4	3	ZzzQuil™ NIGHTTIME SLEEP-AID	20260305

Recently Linked DailyMed Labels#

Set ID, Title, Manufacturer table
Set ID	Title	Manufacturer	Effective
1d608c94-1651-f318-e063-6294a90aa11e	ZzzQuil™ NIGHTTIME SLEEP-AID	The Procter & Gamble Manufacturing Company	20261005
e441c952-cd48-4159-ada2-271ca7541600	ZzzQuil™ NIGHTTIME SLEEP-AID WARMING BERRY	The Procter & Gamble Manufacturing Company	20261002
01906eed-78ee-f2a1-e063-6294a90a809b	Vicks ZzzQuil™ Nighttime Sleep-Aid Diphenhydramine HCl FREE OF	The Procter & Gamble Manufacturing Company	20260908
1be2f00b-5bdd-82e7-e063-6394a90ab9a5	Vicks ZzzQuil™ Nighttime Sleep-Aid Warming Berry Liquid WITH ZzzQuil Sleep Nasal Strips CONVENIENCE KIT	The Procter & Gamble Manufacturing Company	20260406
1d608c94-1651-f318-e063-6294a90aa11e	ZzzQuil™ NIGHTTIME SLEEP-AID	The Procter & Gamble Manufacturing Company	20260305
e441c952-cd48-4159-ada2-271ca7541600	ZzzQuil™ NIGHTTIME SLEEP-AID WARMING BERRY	The Procter & Gamble Manufacturing Company	20260220
01906eed-78ee-f2a1-e063-6294a90a809b	Vicks ZzzQuil™ Nighttime Sleep-Aid Diphenhydramine HCl FREE OF	The Procter & Gamble Manufacturing Company	20251003
1be2f00b-5bdd-82e7-e063-6394a90ab9a5	Vicks ZzzQuil™ Nighttime Sleep-Aid Warming Berry Liquid WITH ZzzQuil Sleep Nasal Strips CONVENIENCE KIT	The Procter & Gamble Manufacturing Company	20251003
1d608c94-1651-f318-e063-6294a90aa11e	ZzzQuil™ NIGHTTIME SLEEP-AID	The Procter & Gamble Manufacturing Company	20251003
e441c952-cd48-4159-ada2-271ca7541600	ZzzQuil™ NIGHTTIME SLEEP-AID WARMING BERRY	The Procter & Gamble Manufacturing Company	20251001
dd1ab38a-afe6-07ea-e053-2995a90ad98f	ZzzQuil™ NIGHTTIME SLEEP-AID	The Procter & Gamble Manufacturing Company	20241010
29bf8bed-1efe-4514-9dc9-b7087a1785d8	ZzzQuil™ Nighttime Sleep-Aid	The Procter & Gamble Manufacturing Company	20231018
d2a50e5a-170f-5530-e053-2a95a90a2f16	Vicks ZzzQuil™ Nighttime Sleep-Aid Diphenhydramine HCl FREE OF	The Procter & Gamble Manufacturing Company	20230728
7b0cc06d-c1bd-415b-953f-6f89adbb2e59	ZzzQuil™ Alcohol Free Nighttime Sleep-Aid	The Procter & Gamble Manufacturing Company	20230209
8dbbef23-8746-935e-e053-2a95a90af25c	ZzzQuil™ Soothing Berry Flavor	The Procter & Gamble Manufacturing Company	20220729
7c7ff596-24c8-4894-a0c7-9df5bfc3aec6		National Council for Prescription Drug Programs	20130303

Drug Classes#

Source, Class ID, Class table
Source	Class ID	Class	Type	Relationship	Drug concept
ATC	R06AA	Aminoalkyl ethers	ATC1-4		diphenhydramine
ATC	D04AA	Antihistamines for topical use	ATC1-4		diphenhydramine
FDASPL	N0000175587	Histamine-1 Receptor Antagonist	EPC	has_epc	diphenhydramine
FDASPL	N0000000190	Histamine H1 Receptor Antagonists	MOA	has_moa	diphenhydramine
MEDRT	D004155	Diphenhydramine	CHEM	has_ingredient	diphenhydramine hydrochloride
MEDRT	D004155	Diphenhydramine	CHEM	has_ingredient	diphenhydramine
MEDRT	D001008	Anxiety Disorders	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D001008	Anxiety Disorders	DISEASE	may_treat	diphenhydramine
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	diphenhydramine hydrochloride
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	diphenhydramine
MEDRT	D007231	Infant, Newborn	DISEASE	ci_with	diphenhydramine hydrochloride
MEDRT	D007231	Infant, Newborn	DISEASE	ci_with	diphenhydramine
MEDRT	D007234	Infant, Premature	DISEASE	ci_with	diphenhydramine hydrochloride
MEDRT	D007234	Infant, Premature	DISEASE	ci_with	diphenhydramine
MEDRT	D007774	Lactation	DISEASE	ci_with	diphenhydramine hydrochloride
MEDRT	D007774	Lactation	DISEASE	ci_with	diphenhydramine
MEDRT	D009041	Motion Sickness	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D009041	Motion Sickness	DISEASE	may_treat	diphenhydramine
MEDRT	D009325	Nausea	DISEASE	may_treat	diphenhydramine
MEDRT	D009325	Nausea	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D012221	Rhinitis, Allergic, Perennial	DISEASE	may_treat	diphenhydramine
MEDRT	D012221	Rhinitis, Allergic, Perennial	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D007319	Sleep Initiation and Maintenance Disorders	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D007319	Sleep Initiation and Maintenance Disorders	DISEASE	may_treat	diphenhydramine
MEDRT	D012912	Sneezing	DISEASE	may_treat	diphenhydramine
MEDRT	D012912	Sneezing	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D013224	Status Asthmaticus	DISEASE	ci_with	diphenhydramine
MEDRT	D013224	Status Asthmaticus	DISEASE	ci_with	diphenhydramine hydrochloride
MEDRT	D014581	Urticaria	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D014581	Urticaria	DISEASE	may_treat	diphenhydramine
MEDRT	N0000000190	Histamine H1 Receptor Antagonists	MOA	has_moa	diphenhydramine hydrochloride
MEDRT	N0000000190	Histamine H1 Receptor Antagonists	MOA	has_moa	diphenhydramine

Group, Type, Concept table
Group	Type	Concept	Source
BN	BN	Zzzquil	rxnav_allrelated
DF	DF	Oral Solution	rxnav_allrelated
DFG	DFG	Oral Liquid Product	rxnav_allrelated
DFG	DFG	Oral Product	rxnav_allrelated
IN	IN	diphenhydramine	rxnav_allrelated
PIN	PIN	diphenhydramine hydrochloride	rxnav_allrelated
SBD	SBD	diphenhydramine hydrochloride 1.67 MG/ML Oral Solution [Zzzquil]	rxnav_allrelated
SBDC	SBDC	diphenhydramine hydrochloride 1.67 MG/ML [Zzzquil]	rxnav_allrelated
SBDF	SBDF	diphenhydramine Oral Solution [Zzzquil]	rxnav_allrelated
SBDFP	SBDFP	diphenhydramine hydrochloride Oral Solution [Zzzquil]	rxnav_allrelated
SBDG	SBDG	Zzzquil Oral Liquid Product	rxnav_allrelated
SBDG	SBDG	Zzzquil Oral Product	rxnav_allrelated
SCD	SCD	diphenhydramine hydrochloride 1.67 MG/ML Oral Solution	rxnav_allrelated
SCDC	SCDC	diphenhydramine hydrochloride 1.67 MG/ML	rxnav_allrelated
SCDF	SCDF	diphenhydramine Oral Solution	rxnav_allrelated
SCDFP	SCDFP	diphenhydramine hydrochloride Oral Solution	rxnav_allrelated
SCDG	SCDG	diphenhydramine Oral Liquid Product	rxnav_allrelated
SCDG	SCDG	diphenhydramine Oral Product	rxnav_allrelated
SCDGP	SCDGP	diphenhydramine hydrochloride Oral Liquid Product	rxnav_allrelated
SCDGP	SCDGP	diphenhydramine hydrochloride Oral Product	rxnav_allrelated

Properties#

Category, Property, Value table
Category	Property	Value
ATTRIBUTES	AVAILABLE_STRENGTH	1.67 MG/ML
ATTRIBUTES	GENERAL_CARDINALITY	SINGLE
ATTRIBUTES	HUMAN_DRUG	US
ATTRIBUTES	RXNAV_HUMAN_DRUG	US
ATTRIBUTES	SCHEDULE	0
NAMES	Prescribable Synonym	ZzzQuil NIGHTTIME SLEEP-AID 50 MG in 30 mL Oral Solution
NAMES	Tallman Synonym	diphenhydrAMINE hydrochloride 1.67 MG/ML Oral Solution [Zzzquil]
SOURCES	Source	Gold Standard Alchemy
SOURCES	Source	Metathesaurus FDA Structured Product Labels
SOURCES	Source	Micromedex RED BOOK
SOURCES	Source	Multum MediSource Lexicon