Bupivacaine

Product NDC
57884-3252
11-digit product format
578843252
Labeler code
57884
Product ID
57884-3252_1c5d9dbb-0d16-6893-e063-6394a90ad989
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Bupivacaine
Dosage form
INJECTION, SUSPENSION, LIPOSOMAL
Route
INFILTRATION
Labeler
Jiangsu Hengrui Pharmaceuticals Co., Ltd.
Application
ANDA214348
Marketing category
ANDA
Marketing start
2024-07-01
Substance
BUPIVACAINE
Active strength
13.3 mg/mL
Pharmacologic classes
Amide Local Anesthetic [EPC], Amides [CS], Local Anesthesia [PE]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 42.

Orange Book products#

Current product rows page 1 of 1 · 2 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A214348-001BUPIVACAINE LIPOSOMEBUPIVACAINE133MG/10ML (13.3MG/ML)INJECTABLE, LIPOSOMAL / INJECTION2024-07-01
A214348-002BUPIVACAINE LIPOSOMEBUPIVACAINE266MG/20ML (13.3MG/ML)INJECTABLE, LIPOSOMAL / INJECTION2024-07-01

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-08-18 06:07:402026-07A214348-001BUPIVACAINE LIPOSOME133MG/10ML (13.3MG/ML)INJECTABLE, LIPOSOMAL / INJECTION2024-07-01caaa826d4ba7…
2026-08-18 06:07:402026-07A214348-002BUPIVACAINE LIPOSOME266MG/20ML (13.3MG/ML)INJECTABLE, LIPOSOMAL / INJECTION2024-07-01caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A214348-001BUPIVACAINE LIPOSOME133MG/10ML (13.3MG/ML)INJECTABLE, LIPOSOMAL / INJECTION2024-07-01011fe1cb6892…
2026-02-19 14:30 UTC2026-02A214348-002BUPIVACAINE LIPOSOME266MG/20ML (13.3MG/ML)INJECTABLE, LIPOSOMAL / INJECTION2024-07-01011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A214348-001BUPIVACAINE LIPOSOME133MG/10ML (13.3MG/ML)INJECTABLE, LIPOSOMAL / INJECTION2024-07-0131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A214348-002BUPIVACAINE LIPOSOME266MG/20ML (13.3MG/ML)INJECTABLE, LIPOSOMAL / INJECTION2024-07-0131067a03dcf5…
2025-08-23 18:47 UTC2025-08A214348-001BUPIVACAINE LIPOSOME133MG/10ML (13.3MG/ML)INJECTABLE, LIPOSOMAL / INJECTIONAP2024-07-016a471c1ec25d…
2025-08-23 18:47 UTC2025-08A214348-002BUPIVACAINE LIPOSOME266MG/20ML (13.3MG/ML)INJECTABLE, LIPOSOMAL / INJECTIONAP2024-07-016a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A214348-001BUPIVACAINE LIPOSOME133MG/10ML (13.3MG/ML)INJECTABLE, LIPOSOMAL / INJECTIONAP2024-07-01fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A214348-002BUPIVACAINE LIPOSOME266MG/20ML (13.3MG/ML)INJECTABLE, LIPOSOMAL / INJECTIONAP2024-07-01fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A214348-001BUPIVACAINE LIPOSOME133MG/10ML (13.3MG/ML)INJECTABLE, LIPOSOMAL / INJECTIONAP2024-07-01b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A214348-002BUPIVACAINE LIPOSOME266MG/20ML (13.3MG/ML)INJECTABLE, LIPOSOMAL / INJECTIONAP2024-07-01b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A214348-001BUPIVACAINE LIPOSOME133MG/10ML (13.3MG/ML)INJECTABLE, LIPOSOMAL / INJECTIONAP2024-07-0103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A214348-002BUPIVACAINE LIPOSOME266MG/20ML (13.3MG/ML)INJECTABLE, LIPOSOMAL / INJECTIONAP2024-07-0103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A214348-001BUPIVACAINE LIPOSOME133MG/10ML (13.3MG/ML)INJECTABLE, LIPOSOMAL / INJECTIONAP2024-07-012680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A214348-002BUPIVACAINE LIPOSOME266MG/20ML (13.3MG/ML)INJECTABLE, LIPOSOMAL / INJECTIONAP2024-07-012680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A214348-001BUPIVACAINE LIPOSOME133MG/10ML (13.3MG/ML)INJECTABLE, LIPOSOMAL / INJECTIONAP2024-07-015bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A214348-002BUPIVACAINE LIPOSOME266MG/20ML (13.3MG/ML)INJECTABLE, LIPOSOMAL / INJECTIONAP2024-07-015bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A214348-001BUPIVACAINE LIPOSOME133MG/10ML (13.3MG/ML)INJECTABLE, LIPOSOMAL / INJECTIONAP2024-07-01d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A214348-002BUPIVACAINE LIPOSOME266MG/20ML (13.3MG/ML)INJECTABLE, LIPOSOMAL / INJECTIONAP2024-07-01d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A214348-001BUPIVACAINE LIPOSOME133MG/10ML (13.3MG/ML)INJECTABLE, LIPOSOMAL / INJECTIONAP2024-07-01d06236e962d9…
2024-10-29 15:01 UTC2024-10A214348-002BUPIVACAINE LIPOSOME266MG/20ML (13.3MG/ML)INJECTABLE, LIPOSOMAL / INJECTIONAP2024-07-01d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A214348-001BUPIVACAINE LIPOSOME133MG/10ML (13.3MG/ML)INJECTABLE, LIPOSOMAL / INJECTIONAP2024-07-0179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A214348-002BUPIVACAINE LIPOSOME266MG/20ML (13.3MG/ML)INJECTABLE, LIPOSOMAL / INJECTIONAP2024-07-0179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A214348-001BUPIVACAINE LIPOSOME133MG/10ML (13.3MG/ML)INJECTABLE, LIPOSOMAL / INJECTIONAP2024-07-01301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A214348-002BUPIVACAINE LIPOSOME266MG/20ML (13.3MG/ML)INJECTABLE, LIPOSOMAL / INJECTIONAP2024-07-01301d65b070ca…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A214348-001BUPIVACAINE LIPOSOME133MG/10ML (13.3MG/ML)INJECTABLE, LIPOSOMAL / INJECTION2024-07-01a50c72e98297…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A214348-002BUPIVACAINE LIPOSOME266MG/20ML (13.3MG/ML)INJECTABLE, LIPOSOMAL / INJECTION2024-07-01a50c72e98297…

Observed Orange Book normalized TE history#

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2025-08-23 18:47 UTC2025-08A214348-001AP16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A214348-002AP16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A214348-001AP1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A214348-002AP1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A214348-001AP1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A214348-002AP1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A214348-001AP103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A214348-002AP103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A214348-001AP12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A214348-002AP12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A214348-001AP15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A214348-002AP15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A214348-001AP1d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A214348-002AP1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A214348-001AP1d06236e962d9…
2024-10-29 15:01 UTC2024-10A214348-002AP1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A214348-001AP179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A214348-002AP179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A214348-001AP1301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A214348-002AP1301d65b070ca…

Additional Listing Data#

Finished product
Yes
Brand name base
Bupivacaine
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
BUPIVACAINE13.3 mg/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
Y8335394ROInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1191508Internal RxNorm lookup
1745061Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
0af296bb-1599-4b35-b66b-994924d3e898Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
cbf85893-59ef-423f-87d4-a573c000a8b9Product name820250731
5dad6767-dcd1-b0da-8727-7f3f7bc3a435Product name220250303
e3a99641-4540-4894-9108-00cab3c57b7eProduct name120211207
5da98533-f072-406b-9e1b-6ac19eca9926Product name120210622
306b993e-3140-4823-ad5e-88b708f9d2acProduct name120210510
a831e694-3663-4a83-82be-6c309429f750Product name220200608

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
57884-3252-1Bupivacaine20 mL in 1 VIALINJECTION, SUSPENSION, LIPOSOMAL204
57884-3252-1Bupivacaine10 in 1 CARTONINJECTION, SUSPENSION, LIPOSOMAL104

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
57884-3252BUPIVACAINE INJECTION, SUSPENSION, LIPOSOMAL [JIANGSU HENGRUI PHARMACEUTICALS CO., LTD.]4Current NDC, 2 package rows20240711_0af296bb-1599-4b35-b66b-994924d3e898.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
BupivacaineBUPIVACAINEJiangsu Hengrui Pharmaceuticals Co., Ltd.0af296bb-1599-4b35-b66b-994924d3e8982024-07-09Warnings, Adverse reactionsExact identifier
application applno (ANDA): 214348
application number: ANDA214348
ndc (product): 57884-3252

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
1745061BUPivacaine liposome 1.3 % in 10 ML InjectionPSN0af296bb-1599-4b35-b66b-994924d3e8984
1191508BUPivacaine liposome 1.3 % in 20 ML InjectionPSN0af296bb-1599-4b35-b66b-994924d3e8984
174506110 ML bupivacaine liposome 13.3 MG/ML InjectionSCD0af296bb-1599-4b35-b66b-994924d3e8984
119150820 ML bupivacaine liposome 13.3 MG/ML InjectionSCD0af296bb-1599-4b35-b66b-994924d3e8984
1191508bupivacaine liposome 1.3 % in 20 ML InjectionSY0af296bb-1599-4b35-b66b-994924d3e8984
1745061bupivacaine liposome 133 MG per 10 ML InjectionSY0af296bb-1599-4b35-b66b-994924d3e8984
1191508bupivacaine liposome 266 MG per 20 ML InjectionSY0af296bb-1599-4b35-b66b-994924d3e8984

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startSampleExclude flagStatus
57884-3252-15788432520110 VIAL in 1 CARTON (57884-3252-1) / 20 mL in 1 VIAL10 vial2024-07-01NoNoCurrent