CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER n

Product NDC: 58411-237
Requested package NDC: 58411-237-10
11-digit product format: 584110237
Labeler code: 58411
Product ID: 58411-237_7df47be5-ab9d-5b67-e053-2a91aa0a6956
Type: HUMAN OTC DRUG
Nonproprietary name: AVOBENZONE, OCTINOXATE, and OCTOCRYLENE
Dosage form: CREAM
Route: TOPICAL
Labeler: SHISEIDO AMERICAS CORPORATION
Application: part352
Marketing category: OTC MONOGRAPH NOT FINAL
Marketing start: 2014-10-01
Marketing end: 0000-00-00
Substance: AVOBENZONE; OCTINOXATE; OCTOCRYLENE
Active strength: 518 mg/20mL; mg/20mL; mg/20mL
NDC exclude flag: No
Listing certified through: 2020-12-31
Current FDA listing: Historical FDA.report record

NDC auxiliary status#

These records are reproduced from FDA’s unfinished, excluded, and compounder listings. They describe what appeared in the source files; a missing record does not establish a regulatory status. View all current auxiliary records, including entries without an NDC. · View the auxiliary file history.

Current NDC status page 1 of 1 · 1 matching rows.

Dataset, Scope, Product NDC table
Dataset	Scope	Product NDC	Package NDC	Code	Status	Reporting period	Source date
excluded package	package	58411-237	58411-237-10	D	Discontinued by firm		2026-10-16

Observed NDC auxiliary status history#

This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.

Historic NDC status page 1 of 1 · 9 matching rows.

View current auxiliary records. · View the auxiliary file history.

Captured / source date, Snapshot, Source SHA-256 table
Captured / source date	Snapshot	Source SHA-256
2025-12-14 17:58 UTC · source 2025-12-05	`d630ba8d3edf…`	`732f749b63fb…`
2025-08-27 00:01 UTC · source 2025-08-26	`f5e01cc5f278…`	`a2eaf40c39c3…`
2025-04-01 02:39 UTC · source 2025-03-31	`2ef7874e63bc…`	`57b86245f4fa…`
2025-03-28 20:22 UTC · source 2025-03-28	`a1b67e2a42f9…`	`c4cf2c586c0d…`
2025-03-22 03:12 UTC · source 2025-03-21	`cfe11265f3b6…`	`090c488252e2…`
2025-03-10 12:48 UTC · source 2025-03-10	`cdf11ea48f46…`	`ba0047e9e063…`
2025-02-02 03:52 UTC · source 2025-01-31	`302b2466d912…`	`e7b80fea0513…`
2025-01-20 13:05 UTC · source 2025-01-20	`ed331223b511…`	`672a5bd82f5f…`
2025-01-11 03:41 UTC · source 2025-01-10	`0efc9e666f02…`	`f202fb6c5f17…`

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
Ingredient	Type	UNII	DailyMed label	SPL version
AVOBENZONE	ACTIVE INGREDIENT	G63QQF2NOX	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
OCTINOXATE	ACTIVE INGREDIENT	4Y5P7MUD51	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
OCTOCRYLENE	ACTIVE INGREDIENT	5A68WGF6WM	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
AVOBENZONE	ACTIVE MOIETY	G63QQF2NOX	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
OCTINOXATE	ACTIVE MOIETY	4Y5P7MUD51	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
OCTOCRYLENE	ACTIVE MOIETY	5A68WGF6WM	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
.ALPHA.-TOCOPHEROL	INACTIVE INGREDIENT	H4N855PNZ1	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
.ALPHA.-TOCOPHEROL ACETATE, DL-	INACTIVE INGREDIENT	WR1WPI7EW8	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
ALCOHOL	INACTIVE INGREDIENT	3K9958V90M	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
BEHENETH-20	INACTIVE INGREDIENT	BJ4GP2IFLN	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
BUPLEURUM FALCATUM ROOT	INACTIVE INGREDIENT	X04E310LUY	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
BUTYLATED HYDROXYTOLUENE	INACTIVE INGREDIENT	1P9D0Z171K	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
BUTYLENE GLYCOL	INACTIVE INGREDIENT	3XUS85K0RA	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
CARBOXYMETHYLCELLULOSE SODIUM	INACTIVE INGREDIENT	K679OBS311	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
CHINESE CINNAMON	INACTIVE INGREDIENT	WS4CQ062KM	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
CITRIC ACID MONOHYDRATE	INACTIVE INGREDIENT	2968PHW8QP	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
DIGLYCINE	INACTIVE INGREDIENT	10525P22U0	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
DIMETHICONE	INACTIVE INGREDIENT	92RU3N3Y1O	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
DIPHENYLSILOXY PHENYL TRIMETHICONE	INACTIVE INGREDIENT	I445L28B12	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
DIPROPYLENE GLYCOL	INACTIVE INGREDIENT	E107L85C40	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
DOCOSANOL	INACTIVE INGREDIENT	9G1OE216XY	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
EDETATE DISODIUM	INACTIVE INGREDIENT	7FLD91C86K	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
FERRIC OXIDE RED	INACTIVE INGREDIENT	1K09F3G675	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
FERRIC OXIDE YELLOW	INACTIVE INGREDIENT	EX438O2MRT	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
GINKGO	INACTIVE INGREDIENT	19FUJ2C58T	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
GLYCERIN	INACTIVE INGREDIENT	PDC6A3C0OX	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
GREEN TEA LEAF	INACTIVE INGREDIENT	W2ZU1RY8B0	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
HYALURONATE SODIUM	INACTIVE INGREDIENT	YSE9PPT4TH	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
HYDROGENATED PALM OIL	INACTIVE INGREDIENT	257THB963H	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
HYDROGENATED POLYDECENE (550 MW)	INACTIVE INGREDIENT	U333RI6EB7	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
ISODODECANE	INACTIVE INGREDIENT	A8289P68Y2	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
ISOSTEARIC ACID	INACTIVE INGREDIENT	X33R8U0062	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
LAURYL BETAINE	INACTIVE INGREDIENT	Y4P927Q133	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
METHYL AMINOMETHYLCYCLOHEXANE CARBOXAMIDE HYDROCHLORIDE	INACTIVE INGREDIENT	ZV6O50F5CP	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
NUPHAR JAPONICA ROOT	INACTIVE INGREDIENT	3OPM78C6RQ	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
PALM KERNEL OIL	INACTIVE INGREDIENT	B0S90M0233	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
PALM OIL	INACTIVE INGREDIENT	5QUO05548Z	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
PEG-10 DIMETHICONE (600 CST)	INACTIVE INGREDIENT	8PR7V1SVM0	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
PEG/PPG-14/7 DIMETHYL ETHER	INACTIVE INGREDIENT	6DNW9T7YT2	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
PHENOXYETHANOL	INACTIVE INGREDIENT	HIE492ZZ3T	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
POTASSIUM HYDROXIDE	INACTIVE INGREDIENT	WZH3C48M4T	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
PPG-17	INACTIVE INGREDIENT	OV0Q322E0U	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
SILICON DIOXIDE	INACTIVE INGREDIENT	ETJ7Z6XBU4	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
SODIUM ACETYLATED HYALURONATE	INACTIVE INGREDIENT	WN66R7GL93	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
SODIUM BENZOATE	INACTIVE INGREDIENT	OJ245FE5EU	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
SODIUM POLYMETAPHOSPHATE	INACTIVE INGREDIENT	P1BM4ZH95L	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
STEARYL ALCOHOL	INACTIVE INGREDIENT	2KR89I4H1Y	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
TRIETHYLHEXANOIN	INACTIVE INGREDIENT	7K3W1BIU6K	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
WATER	INACTIVE INGREDIENT	059QF0KO0R	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
XANTHAN GUM	INACTIVE INGREDIENT	TTV12P4NEE	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1
XYLITOL	INACTIVE INGREDIENT	VCQ006KQ1E	CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER N (AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE) CREAM [SHISEIDO AMERICAS CORPORATION]	1

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
G63QQF2NOX	AVOBENZONE	70356-09-1	AVOBENZONE
4Y5P7MUD51	OCTINOXATE	83834-59-7	OCTINOXATE
5A68WGF6WM	OCTOCRYLENE	6197-30-4	OCTOCRYLENE

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Units	Marketing start	Marketing end	Sample	Exclude flag	Status
58411-237-10	58411023710	1 BOTTLE in 1 CARTON (58411-237-10) > 20 mL in 1 BOTTLE	1 bottle	2014-10-01	0000-00-00	No	No	Current

Title, Manufacturer, Effective date table
Title	Manufacturer	Effective date	Type	Version
CLÉ DE PEAU BEAUTÉ SYNACTIF DAYTIME MOISTURIZER n	SHISEIDO AMERICAS CORPORATION \| SHISEIDO AMERICA INC.	2018-12-26	HUMAN OTC DRUG LABEL	2

CLE DE PEAU BEAUTE SYNACTIF DAYTIME MOISTURIZER n

NDC auxiliary status#

Observed NDC auxiliary status history#

Reported adverse events (FAERS/openFDA)#

DailyMed Socrata Ingredients#

Related Records#

Related UNII Ingredients#

Packages#

Related DailyMed Labels#