Acyclovir

Product NDC
63323-325
11-digit product format
633230325
Labeler code
63323
Product ID
63323-325_5913c199-275d-40b3-a249-050106e058de
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
acyclovir
Dosage form
INJECTION, SOLUTION
Route
INTRAVENOUS
Labeler
Fresenius Kabi USA, LLC
Application
ANDA074930
Marketing category
ANDA
Marketing start
2000-10-17
Substance
ACYCLOVIR SODIUM
Active strength
50 mg/mL
Pharmacologic classes
DNA Polymerase Inhibitors [MoA], Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor [EPC], Herpes Zoster Virus Nucleoside Analog DNA Polymerase Inhibitor [EPC], Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor [EPC], Nucleoside Analog [EXT]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A074930-001ACYCLOVIR SODIUMACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-13

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-productTE code
A074930-001AP

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 41 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-13011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-1331067a03dcf5…
2025-08-23 18:47 UTC2025-08A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-136a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-13fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-13b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-1303ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-132680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-135bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-13d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-13d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-1379d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-13301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-131e350fbaab3a…
2024-05-31 18:47 UTC2024-05A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-138072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-135c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-135d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-134b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-1374a2ff9319b5…
2022-03-09 01:35 UTC2022-03A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-13bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-13782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-1387673890dc5c…
2021-03-12 10:30 UTC2021-03A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-135aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-138869cabd3fbd…
2020-11-12 02:37 UTC2020-11A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-13c0c555d07b60…
2019-12-14 00:12 UTC2019-12A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-133f01610625f2…
2019-09-15 20:21 UTC2019-09A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-13b00525d2431f…
2019-07-19 19:46 UTC2019-07A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-13ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-136a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-131c564ffb4f44…
2023-12-20 04:57 UTC2023-12A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-13ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-13a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-139b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-13a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-133f0d92c62455…
2023-05-13 08:27 UTC2023-05A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-13053a50430f4f…
2023-01-26 05:58 UTC2023-01A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-133bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-133a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-13f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-13e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07A074930-001ACYCLOVIR SODIUMEQ 50MG BASE/MLINJECTABLE / INJECTIONAPRS1998-05-13cb3db0bc1861…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 2 · 41 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02A074930-001AP1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A074930-001AP131067a03dcf5…
2025-08-23 18:47 UTC2025-08A074930-001AP16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A074930-001AP1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A074930-001AP1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A074930-001AP103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A074930-001AP12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A074930-001AP15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A074930-001AP1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A074930-001AP1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A074930-001AP179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A074930-001AP1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A074930-001AP11e350fbaab3a…
2024-05-31 18:47 UTC2024-05A074930-001AP18072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A074930-001AP15c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A074930-001AP15d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A074930-001AP14b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A074930-001AP174a2ff9319b5…
2022-03-09 01:35 UTC2022-03A074930-001AP1bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A074930-001AP1782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A074930-001AP187673890dc5c…
2021-03-12 10:30 UTC2021-03A074930-001AP15aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A074930-001AP18869cabd3fbd…
2020-11-12 02:37 UTC2020-11A074930-001AP1c0c555d07b60…
2019-12-14 00:12 UTC2019-12A074930-001AP13f01610625f2…
2019-09-15 20:21 UTC2019-09A074930-001AP1b00525d2431f…
2019-07-19 19:46 UTC2019-07A074930-001AP1ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A074930-001AP16a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A074930-001AP11c564ffb4f44…
2023-12-20 04:57 UTC2023-12A074930-001AP1ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A074930-001AP1a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A074930-001AP19b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A074930-001AP1a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A074930-001AP13f0d92c62455…
2023-05-13 08:27 UTC2023-05A074930-001AP1053a50430f4f…
2023-01-26 05:58 UTC2023-01A074930-001AP13bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A074930-001AP13a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A074930-001AP1f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A074930-001AP1e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07A074930-001AP1cb3db0bc1861…

Additional Listing Data#

Finished product
Yes
Brand name base
Acyclovir
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
ACYCLOVIR SODIUM50 mg/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
927L42J563Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1734932Internal RxNorm lookup
1734934Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
badf347b-eeee-4239-9c74-966f262925aaAvailable on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
33190c02-82e1-0a4d-d716-9ccd23588463Product name520250225
c367d1da-5a72-8966-6d11-1eb9a73ae758Product name320231115
5518bf13-db2f-2e9c-3679-e70ecf03752cProduct name920210614
27897900-0e40-497b-97e1-88057e68fe6cProduct name420200710
ca834e59-e669-229c-9288-0ccb76dc373eProduct name920200220
d7f95c49-d3e1-4bbc-a389-e9cd73f59a28Product name120190702
fb15b394-3715-4c87-a447-421489aa8739Product name320170727
7bdc4804-3832-c0df-e519-72b6d47c9792Product name120140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
63323-325-03Acyclovir10 mL in 1 VIAL, SINGLE-DOSEINJECTION, SOLUTION106
63323-325-09Acyclovir20 mL in 1 VIAL, SINGLE-DOSEINJECTION, SOLUTION206
63323-325-10Acyclovir10 in 1 TRAYINJECTION, SOLUTION106
63323-325-20Acyclovir10 in 1 TRAYINJECTION, SOLUTION106
63323-325-14Acyclovir10 in 1 TRAYINJECTION, SOLUTION105
63323-325-24Acyclovir10 in 1 TRAYINJECTION, SOLUTION105
63323-325-41Acyclovir10 mL in 1 VIAL, SINGLE-DOSEINJECTION, SOLUTION105
63323-325-43Acyclovir20 mL in 1 VIAL, SINGLE-DOSEINJECTION, SOLUTION205

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
63323-325-03ML - Milliliter63323-3251bcda4dc-94a0-4d23-bb80-4b692f5487b712021-03-02
63323-325-09ML - Milliliter63323-325d1804f35-cedc-45cc-a5ec-a8433bb6262a12021-03-02
63323-325-10ML - Milliliter63323-325461eaa84-2fb9-46cc-bcea-8ba3bfbfaa2e12012-07-24
63323-325-14ML - Milliliter63323-3251710765e-61d6-4a4e-9e3d-ee56f127e77c12014-07-02
63323-325-20ML - Milliliter63323-32586a2f8a4-7f32-4c51-b49b-7dcdbdc9edab12012-07-24
63323-325-24ML - Milliliter63323-3251ca846f9-f051-480d-8bd6-c6c67e7da56b12014-07-02
63323-325-41ML - Milliliter63323-32501d2e0ab-dc1f-438c-a6d5-7e7ba23e451112022-08-04

DailyMed Socrata Ingredients#

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
63323-325ACYCLOVIR (ACYCLOVIR) INJECTION, SOLUTION [FRESENIUS KABI USA, LLC ]6Current NDC, Legacy NDC, 4 package rows20240910_cb64dfab-52ee-4312-bc9c-c3d04efe9109.zip
63323-325ACYCLOVIR INJECTION, SOLUTION [FRESENIUS KABI USA, LLC ]5Current NDC, Legacy NDC, 4 package rows20240913_badf347b-eeee-4239-9c74-966f262925aa.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 2 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
AcyclovirACYCLOVIRFresenius Kabi USA, LLCbadf347b-eeee-4239-9c74-966f262925aa2024-06-30Warnings, Adverse reactionsExact identifier
application applno (ANDA): 074930
application number: ANDA074930
ndc (product): 63323-325
AcyclovirACYCLOVIRFresenius Kabi USA, LLCcb64dfab-52ee-4312-bc9c-c3d04efe91092024-06-27Warnings, Adverse reactionsExact identifier
application applno (ANDA): 074930
application number: ANDA074930
ndc (product): 63323-325

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
1734934acyclovir sodium 1000 MG in 20 ML InjectionPSNcb64dfab-52ee-4312-bc9c-c3d04efe91096
1734932acyclovir sodium 500 MG in 10 ML InjectionPSNcb64dfab-52ee-4312-bc9c-c3d04efe91096
173493210 ML acyclovir 50 MG/ML InjectionSCDcb64dfab-52ee-4312-bc9c-c3d04efe91096
173493420 ML acyclovir 50 MG/ML InjectionSCDcb64dfab-52ee-4312-bc9c-c3d04efe91096
173493210 ML acycycloguanosine 50 MG/ML InjectionSYcb64dfab-52ee-4312-bc9c-c3d04efe91096
173493420 ML acycycloguanosine 50 MG/ML InjectionSYcb64dfab-52ee-4312-bc9c-c3d04efe91096
1734934acyclovir 1000 MG per 20 ML InjectionSYcb64dfab-52ee-4312-bc9c-c3d04efe91096
1734932acyclovir 50 MG/ML (equivalent to acyclovir sodium 54.9 MG/ML) per 10 ML InjectionSYcb64dfab-52ee-4312-bc9c-c3d04efe91096
1734934acyclovir 50 MG/ML (equivalent to acyclovir sodium 54.9 MG/ML) per 20 ML InjectionSYcb64dfab-52ee-4312-bc9c-c3d04efe91096
1734932acyclovir 500 MG per 10 ML InjectionSYcb64dfab-52ee-4312-bc9c-c3d04efe91096
1734934acyclovir sodium 1000 MG in 20 ML InjectionPSNbadf347b-eeee-4239-9c74-966f262925aa5
1734932acyclovir sodium 500 MG in 10 ML InjectionPSNbadf347b-eeee-4239-9c74-966f262925aa5
173493210 ML acyclovir 50 MG/ML InjectionSCDbadf347b-eeee-4239-9c74-966f262925aa5
173493420 ML acyclovir 50 MG/ML InjectionSCDbadf347b-eeee-4239-9c74-966f262925aa5
173493210 ML acycycloguanosine 50 MG/ML InjectionSYbadf347b-eeee-4239-9c74-966f262925aa5
173493420 ML acycycloguanosine 50 MG/ML InjectionSYbadf347b-eeee-4239-9c74-966f262925aa5
1734934acyclovir 1000 MG per 20 ML InjectionSYbadf347b-eeee-4239-9c74-966f262925aa5
1734932acyclovir 50 MG/ML (equivalent to acyclovir sodium 54.9 MG/ML) per 10 ML InjectionSYbadf347b-eeee-4239-9c74-966f262925aa5
1734934acyclovir 50 MG/ML (equivalent to acyclovir sodium 54.9 MG/ML) per 20 ML InjectionSYbadf347b-eeee-4239-9c74-966f262925aa5
1734932acyclovir 500 MG per 10 ML InjectionSYbadf347b-eeee-4239-9c74-966f262925aa5

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
63323-325-036332303250310 mL in 1 VIAL, SINGLE-DOSE10 mlHistorical
63323-325-096332303250920 mL in 1 VIAL, SINGLE-DOSE20 mlHistorical
63323-325-106332303251010 VIAL, SINGLE-DOSE in 1 TRAY (63323-325-10) / 10 mL in 1 VIAL, SINGLE-DOSE (63323-325-03) 2000-10-170000-00-00NoNoCurrent
63323-325-146332303251410 VIAL, SINGLE-DOSE in 1 TRAY (63323-325-14) / 10 mL in 1 VIAL, SINGLE-DOSE (63323-325-41) 2000-10-170000-00-00NoNoCurrent
63323-325-206332303252010 VIAL, SINGLE-DOSE in 1 TRAY (63323-325-20) / 20 mL in 1 VIAL, SINGLE-DOSE (63323-325-09) 2000-10-170000-00-00NoNoCurrent
63323-325-246332303252410 VIAL, SINGLE-DOSE in 1 TRAY (63323-325-24) / 20 mL in 1 VIAL, SINGLE-DOSE (63323-325-43) 2000-10-170000-00-00NoNoCurrent
63323-325-416332303254110 mL in 1 VIAL, SINGLE-DOSE10 mlHistorical
63323-325-436332303254320 mL in 1 VIAL, SINGLE-DOSE20 mlHistorical