Lofexidine hydrochloride

Product NDC
66993-345
11-digit product format
669930345
Labeler code
66993
Product ID
66993-345_b317fb7f-8a02-4d11-9d20-401644e5d6ef
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
lofexidine hydrochloride
Dosage form
TABLET, FILM COATED
Route
ORAL
Labeler
Prasco Laboratories
Application
NDA209229
Marketing category
NDA AUTHORIZED GENERIC
Marketing start
2024-08-29
Substance
LOFEXIDINE HYDROCHLORIDE
Active strength
.2 mg/1
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
N209229-001LUCEMYRALOFEXIDINE HYDROCHLORIDEEQ 0.18MG BASETABLET / ORALABRLD, RS2018-05-16

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-productTE code
N209229-001AB

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 41 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALABRLD, RS2018-05-16011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALABRLD, RS2018-05-1631067a03dcf5…
2025-08-23 18:47 UTC2025-08N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALABRLD, RS2018-05-166a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALABRLD, RS2018-05-16fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALABRLD, RS2018-05-16b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALABRLD, RS2018-05-1603ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALABRLD, RS2018-05-162680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALABRLD, RS2018-05-165bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALABRLD, RS2018-05-16d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALABRLD, RS2018-05-16d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALRLD, RS2018-05-1679d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALRLD, RS2018-05-16301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALRLD, RS2018-05-161e350fbaab3a…
2024-05-31 18:47 UTC2024-05N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALRLD, RS2018-05-168072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALRLD, RS2018-05-165c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALRLD, RS2018-05-165d02ea3f76ae…
2022-04-04 05:41 UTC2022-04N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALRLD, RS2018-05-164b0b4de00fa7…
2019-12-13 00:20 UTC2019-12N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALRLD, RS2018-05-1674a2ff9319b5…
2022-03-09 01:35 UTC2022-03N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALRLD, RS2018-05-16bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALRLD, RS2018-05-16782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALRLD, RS2018-05-1687673890dc5c…
2021-03-12 10:30 UTC2021-03N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALRLD, RS2018-05-165aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALRLD, RS2018-05-168869cabd3fbd…
2020-11-12 02:37 UTC2020-11N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALRLD, RS2018-05-16c0c555d07b60…
2019-12-14 00:12 UTC2019-12N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALRLD, RS2018-05-163f01610625f2…
2019-09-15 20:21 UTC2019-09N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALRLD, RS2018-05-16b00525d2431f…
2019-07-19 19:46 UTC2019-07N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALRLD, RS2018-05-16ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALRLD, RS2018-05-166a51e52b5d6a…
2024-02-18 07:12 UTC2024-02N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALRLD, RS2018-05-161c564ffb4f44…
2023-12-20 04:57 UTC2023-12N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALRLD, RS2018-05-16ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALRLD, RS2018-05-16a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALRLD, RS2018-05-169b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALRLD, RS2018-05-16a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALRLD, RS2018-05-163f0d92c62455…
2023-05-13 08:27 UTC2023-05N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALRLD, RS2018-05-16053a50430f4f…
2023-01-26 05:58 UTC2023-01N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALRLD, RS2018-05-163bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALRLD, RS2018-05-163a93d1ddd44b…
2022-10-28 04:53 UTC2022-10N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALRLD, RS2018-05-16f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALRLD, RS2018-05-16e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07N209229-001LUCEMYRAEQ 0.18MG BASETABLET / ORALRLD, RS2018-05-16cb3db0bc1861…

Observed Orange Book normalized TE history#

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02N209229-001AB1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N209229-001AB131067a03dcf5…
2025-08-23 18:47 UTC2025-08N209229-001AB16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N209229-001AB1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N209229-001AB1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N209229-001AB103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N209229-001AB12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N209229-001AB15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N209229-001AB1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N209229-001AB1d06236e962d9…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06N209229-001AB1a50c72e98297…

Observed Orange Book exclusivity history#

Captured, Edition, Application-product table
CapturedEditionApplication-productExclusivity codeExpirationSource SHA-256
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N209229-001NCE2023-05-165c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04N209229-001NCE2023-05-165d02ea3f76ae…
2022-04-04 05:41 UTC2022-04N209229-001NCE2023-05-164b0b4de00fa7…
2019-12-13 00:20 UTC2019-12N209229-001NCE2023-05-1674a2ff9319b5…
2022-03-09 01:35 UTC2022-03N209229-001NCE2023-05-16bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12N209229-001NCE2023-05-16782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N209229-001NCE2023-05-1687673890dc5c…
2021-03-12 10:30 UTC2021-03N209229-001NCE2023-05-165aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12N209229-001NCE2023-05-168869cabd3fbd…
2020-11-12 02:37 UTC2020-11N209229-001NCE2023-05-16c0c555d07b60…
2019-12-14 00:12 UTC2019-12N209229-001NCE2023-05-163f01610625f2…
2019-09-15 20:21 UTC2019-09N209229-001NCE2023-05-16b00525d2431f…
2019-07-19 19:46 UTC2019-07N209229-001NCE2023-05-16ea99ee380514…
2023-12-20 04:57 UTC2023-12N209229-001NCE2023-05-16ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11N209229-001NCE2023-05-16a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10N209229-001NCE2023-05-169b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07N209229-001NCE2023-05-16a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06N209229-001NCE2023-05-163f0d92c62455…
2023-05-13 08:27 UTC2023-05N209229-001NCE2023-05-16053a50430f4f…
2023-01-26 05:58 UTC2023-01N209229-001NCE2023-05-163bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11N209229-001NCE2023-05-163a93d1ddd44b…
2022-10-28 04:53 UTC2022-10N209229-001NCE2023-05-16f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09N209229-001NCE2023-05-16e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07N209229-001NCE2023-05-16cb3db0bc1861…

Additional Listing Data#

Finished product
Yes
Brand name base
Lofexidine hydrochloride
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
LOFEXIDINE HYDROCHLORIDE.2 mg/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
V47G1SDI1BInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
2046591Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
77367dfa-434f-4d61-95fe-f0f1628457d1Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
3e49fde7-51ed-4b66-8350-88f7c4d066d4Product name220250317

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
66993-345-37Lofexidine hydrochloride36 in 1 BOTTLETABLET, FILM COATED363
66993-345-37Lofexidine hydrochloride1 in 1 CARTONTABLET, FILM COATED13
66993-345-76Lofexidine hydrochloride1 in 1 CARTONTABLET, FILM COATED13
66993-345-76Lofexidine hydrochloride96 in 1 BOTTLETABLET, FILM COATED963

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
66993-345-37EA - Each66993-345407530f7-b7cf-41e9-a487-84f17ab34b6812024-09-09
66993-345-76EA - Each66993-345095de77c-d06e-46e7-b0b5-a3c80cd61da512024-09-09

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
66993-345LOFEXIDINE HYDROCHLORIDE TABLET, FILM COATED [PRASCO LABORATORIES]3Current NDC, 4 package rows20240921_77367dfa-434f-4d61-95fe-f0f1628457d1.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 2 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
LucemyraLOFEXIDINE HYDROCHLORIDEUSWM, LLCb748f308-ba71-4fd9-84ec-ec7e0f2108852026-07-15Warnings, Adverse reactionsExact identifier
application applno (NDA): 209229
application number: NDA209229
Lofexidine hydrochlorideLOFEXIDINE HYDROCHLORIDEPrasco Laboratories77367dfa-434f-4d61-95fe-f0f1628457d12023-08-01Warnings, Adverse reactionsExact identifier
application applno (NDA): 209229
application number: NDA209229
ndc (product): 66993-345

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
2046591lofexidine 0.18 MG Oral TabletPSN77367dfa-434f-4d61-95fe-f0f1628457d13
2046591lofexidine 0.18 MG Oral TabletSCD77367dfa-434f-4d61-95fe-f0f1628457d13
2046591lofexidine 0.18 MG (as lofexidine HCl 0.2 MG) Oral TabletSY77367dfa-434f-4d61-95fe-f0f1628457d13

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startSampleExclude flagStatus
66993-345-37669930345371 BOTTLE in 1 CARTON (66993-345-37) / 36 TABLET, FILM COATED in 1 BOTTLE1 bottle2024-08-29NoNoCurrent
66993-345-76669930345761 BOTTLE in 1 CARTON (66993-345-76) / 96 TABLET, FILM COATED in 1 BOTTLE1 bottle2024-08-29NoNoCurrent