diphenhydramine hydrochloride 2.5 MG/ML Oral Solution [Benadryl]

RxCUI: 1049908
RxNorm name: diphenhydramine hydrochloride 2.5 MG/ML Oral Solution [Benadryl]
Display name: BENADRYL (Oral Liquid)
Full name: diphenhydramine hydrochloride 2.5 MG/ML Oral Solution [Benadryl]
Term type: SBD
Status: Active
Strength: 12.5 mg/5ml
Dose form: Sol
Route: Oral Liquid
Updated: 2026-07-25 06:53:11

RxNorm Status History#

Status: Active
Source: RXNORM
Current: YES
Release start: 012011
Active start: 012011
Multiple ingredient: NO
Branded: YES

Ingredients And Strength#

Ingredient, Strength, Base table
Ingredient	Strength	Base	Basis of strength
diphenhydramine hydrochloride	2.5 MG / 1 ML	diphenhydramine	diphenhydramine hydrochloride

Dose Form Concepts#

Dose form, RxCUI table
Dose form	RxCUI
Oral Solution	316968

Derived Ingredient Concepts#

Ingredient, RxCUI table
Ingredient	RxCUI
diphenhydramine	3498

Source Vocabulary Codes#

Code type, Values, Count table
Code type	Values	Count	Category
PRESCRIBABLE	Y	1	ATTRIBUTES
RXNAV_STR	Benadryl 2.5 MG/ML Oral Solution	1	NAMES
RxNorm Name	diphenhydramine hydrochloride 2.5 MG/ML Oral Solution [Benadryl]	1	NAMES
RxNorm Synonym	2 linked values Benadryl 2.5 MG/ML Oral Solution Benadryl Children's Allergy 12.5 MG per 5 ML Oral Solution	2	NAMES
TTY	SBD	1	ATTRIBUTES
SPL_SET_ID	3 linked values 10d478ff-ddc6-45da-87ff-cfe1b2b07a8e 224ba2a3-1a93-29c8-e063-6394a90a9bef fc9181b9-c92d-493e-8d7c-4a4239c6c092	3	CODES
RxCUI	1049908	1	CODES
MMSL_CODE	BD3420	1	CODES

FDA NDC Products And Packages#

Package NDC, Product NDC, Name table
Package NDC	Product NDC	Name	Labeler	Application
50580-534-04	50580-534	Childrens Benadryl ALLERGY Diphenhydramine hydrochloride	Kenvue Brands LLC	M012
50580-534-08	50580-534	Childrens Benadryl ALLERGY Diphenhydramine hydrochloride	Kenvue Brands LLC	M012
50580-534-18	50580-534	Childrens Benadryl ALLERGY Diphenhydramine hydrochloride	Kenvue Brands LLC	M012
50580-535-01	50580-535	Childrens Benadryl DYE-FREE ALLERGY Diphenhydramine hydrochloride	Kenvue Brands LLC	M012
50580-535-02	50580-535	Childrens Benadryl DYE-FREE ALLERGY Diphenhydramine hydrochloride	Kenvue Brands LLC	M012
50580-535-08	50580-535	Childrens Benadryl DYE-FREE ALLERGY Diphenhydramine hydrochloride	Kenvue Brands LLC	M012
50580-573-04	50580-573	BENADRYL Allergy Diphenhydramine hydrochloride	Kenvue Brands LLC	M012

Drugs@FDA Applications#

Application, NDC, Name table
Application	NDC	Name	Marketing category	Labeler
M012	50580-534	Childrens Benadryl ALLERGY Diphenhydramine hydrochloride	OTC MONOGRAPH DRUG	Kenvue Brands LLC

RxNav Current And Historical NDCs#

RxNav current and historical NDC rows page 1 of 1 · 21 matching rows.

NDC11, Source, Active table
NDC11	Source	Active
50580053404	rxnav_ndcs	yes
50580053408	rxnav_ndcs	yes
50580053416	rxnav_ndcs	yes
50580053418	rxnav_ndcs	yes
50580053501	rxnav_ndcs	yes
50580053502	rxnav_ndcs	yes
50580053504	rxnav_ndcs	yes
50580053508	rxnav_ndcs	yes
50580057304	rxnav_ndcs	yes
00045053402	rxnav_historical
00071233317	rxnav_historical
00501204910	rxnav_historical
00501205004	rxnav_historical
00501205008	rxnav_historical
00501205304	rxnav_historical
12547017055	rxnav_historical
12547017137	rxnav_historical
12547017540	rxnav_historical
21695057404	rxnav_historical
35058053501	rxnav_historical
50580033410	rxnav_historical

UNII Substances#

UNII substance links page 1 of 1 · 0 matching rows.

No records found.

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 3 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
Childrens Benadryl ALLERGY	DIPHENHYDRAMINE HYDROCHLORIDE	Kenvue Brands LLC	fc9181b9-c92d-493e-8d7c-4a4239c6c092	2026-07-24	Warnings	Exact identifier ndc (package): 50580-534-04 ndc (package): 50580-534-08 ndc (package): 50580-534-18 ndc (product): 50580-534 ndc11 (package): 50580053408 ndc11 (package): 50580053404 ndc11 (package): 50580053418 ndc11 (package): 50580053416 rxcui: 1049908
BENADRYL Allergy	DIPHENHYDRAMINE HYDROCHLORIDE	Kenvue Brands LLC	224ba2a3-1a93-29c8-e063-6394a90a9bef	2025-01-30	Warnings	Exact identifier ndc (package): 50580-573-04 ndc (product): 50580-573 ndc11 (package): 50580057304 rxcui: 1049908
Childrens Benadryl DYE-FREE ALLERGY	DIPHENHYDRAMINE HYDROCHLORIDE	Kenvue Brands LLC	10d478ff-ddc6-45da-87ff-cfe1b2b07a8e	2024-11-27	Warnings	Exact identifier ndc (package): 50580-535-02 ndc (package): 50580-535-08 ndc (package): 50580-535-01 ndc (product): 50580-535 ndc11 (package): 50580053508 ndc11 (package): 50580053501 ndc11 (package): 50580053502 rxcui: 1049908

DailyMed RxNorm Mappings#

unique DailyMed labels mapped to this RxNorm concept page 1 of 1 · 3 matching rows.

Set ID, RxNorm mappings, Terms table
Set ID	RxNorm mappings	Terms	SPL version	Label	Effective
fc9181b9-c92d-493e-8d7c-4a4239c6c092	Benadryl Children's Allergy 12.5 MG in 5 mL Oral Solution [PSN] · diphenhydramine hydrochloride 2.5 MG/ML Oral Solution [Benadryl] [SBD] · Benadryl 2.5 MG/ML Oral Solution [SY] · Benadryl Children's Allergy 12.5 MG per 5 ML Oral Solution [SY]	4	13	Children's Benadryl ® ALLERGY	20250513
10d478ff-ddc6-45da-87ff-cfe1b2b07a8e	Benadryl Children's Allergy 12.5 MG in 5 mL Oral Solution [PSN] · diphenhydramine hydrochloride 2.5 MG/ML Oral Solution [Benadryl] [SBD] · Benadryl 2.5 MG/ML Oral Solution [SY] · Benadryl Children's Allergy 12.5 MG per 5 ML Oral Solution [SY]	4	10	Children's Benadryl ® DYE-FREE ALLERGY	20241127
224ba2a3-1a93-29c8-e063-6394a90a9bef	Benadryl Children's Allergy 12.5 MG in 5 mL Oral Solution [PSN] · diphenhydramine hydrochloride 2.5 MG/ML Oral Solution [Benadryl] [SBD] · Benadryl 2.5 MG/ML Oral Solution [SY] · Benadryl Children's Allergy 12.5 MG per 5 ML Oral Solution [SY]	4	3	BENADRYL Allergy Oral Solution	20250130

Recently Linked DailyMed Labels#

Set ID, Title, Manufacturer table
Set ID	Title	Manufacturer	Effective
fc9181b9-c92d-493e-8d7c-4a4239c6c092	Children's Benadryl ® ALLERGY	Kenvue Brands LLC	20260724
fc9181b9-c92d-493e-8d7c-4a4239c6c092	Children's Benadryl ® ALLERGY	Kenvue Brands LLC	20250513
224ba2a3-1a93-29c8-e063-6394a90a9bef	BENADRYL Allergy Oral Solution	Kenvue Brands LLC	20250130
10d478ff-ddc6-45da-87ff-cfe1b2b07a8e	Children's Benadryl ® DYE-FREE ALLERGY	Kenvue Brands LLC	20241127
8dc7767c-f723-441f-968d-1619c1aaeb0d		National Council for Prescription Drug Programs	20120724
d77ec339-aeee-4272-bab3-be49e308437a		National Council for Prescription Drug Programs	20120724

Drug Classes#

Source, Class ID, Class table
Source	Class ID	Class	Type	Relationship	Drug concept
ATC	R06AA	Aminoalkyl ethers	ATC1-4		diphenhydramine
ATC	D04AA	Antihistamines for topical use	ATC1-4		diphenhydramine
FDASPL	N0000175587	Histamine-1 Receptor Antagonist	EPC	has_epc	diphenhydramine
FDASPL	N0000000190	Histamine H1 Receptor Antagonists	MOA	has_moa	diphenhydramine
MEDRT	D004155	Diphenhydramine	CHEM	has_ingredient	diphenhydramine hydrochloride
MEDRT	D004155	Diphenhydramine	CHEM	has_ingredient	diphenhydramine
MEDRT	D001008	Anxiety Disorders	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D001008	Anxiety Disorders	DISEASE	may_treat	diphenhydramine
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	diphenhydramine hydrochloride
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	diphenhydramine
MEDRT	D007231	Infant, Newborn	DISEASE	ci_with	diphenhydramine hydrochloride
MEDRT	D007231	Infant, Newborn	DISEASE	ci_with	diphenhydramine
MEDRT	D007234	Infant, Premature	DISEASE	ci_with	diphenhydramine hydrochloride
MEDRT	D007234	Infant, Premature	DISEASE	ci_with	diphenhydramine
MEDRT	D007774	Lactation	DISEASE	ci_with	diphenhydramine hydrochloride
MEDRT	D007774	Lactation	DISEASE	ci_with	diphenhydramine
MEDRT	D009041	Motion Sickness	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D009041	Motion Sickness	DISEASE	may_treat	diphenhydramine
MEDRT	D009325	Nausea	DISEASE	may_treat	diphenhydramine
MEDRT	D009325	Nausea	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D012221	Rhinitis, Allergic, Perennial	DISEASE	may_treat	diphenhydramine
MEDRT	D012221	Rhinitis, Allergic, Perennial	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D007319	Sleep Initiation and Maintenance Disorders	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D007319	Sleep Initiation and Maintenance Disorders	DISEASE	may_treat	diphenhydramine
MEDRT	D012912	Sneezing	DISEASE	may_treat	diphenhydramine
MEDRT	D012912	Sneezing	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D013224	Status Asthmaticus	DISEASE	ci_with	diphenhydramine
MEDRT	D013224	Status Asthmaticus	DISEASE	ci_with	diphenhydramine hydrochloride
MEDRT	D014581	Urticaria	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D014581	Urticaria	DISEASE	may_treat	diphenhydramine
MEDRT	N0000000190	Histamine H1 Receptor Antagonists	MOA	has_moa	diphenhydramine hydrochloride
MEDRT	N0000000190	Histamine H1 Receptor Antagonists	MOA	has_moa	diphenhydramine

Group, Type, Concept table
Group	Type	Concept	Source
BN	BN	Benadryl	rxnav_allrelated
DF	DF	Oral Solution	rxnav_allrelated
DFG	DFG	Oral Liquid Product	rxnav_allrelated
DFG	DFG	Oral Product	rxnav_allrelated
GPCK	GPCK	{1 (dextromethorphan hydrobromide 1 MG/ML / guaifenesin 20 MG/ML Oral Solution) / 1 (diphenhydramine hydrochloride 2.5 MG/ML Oral Solution) } Pack	rxnav_allrelated
IN	IN	diphenhydramine	rxnav_allrelated
PIN	PIN	diphenhydramine hydrochloride	rxnav_allrelated
SBD	SBD	diphenhydramine hydrochloride 2.5 MG/ML Oral Solution [Benadryl]	rxnav_allrelated
SBDC	SBDC	diphenhydramine hydrochloride 2.5 MG/ML [Benadryl]	rxnav_allrelated
SBDF	SBDF	diphenhydramine Oral Solution [Benadryl]	rxnav_allrelated
SBDFP	SBDFP	diphenhydramine hydrochloride Oral Solution [Benadryl]	rxnav_allrelated
SBDG	SBDG	Benadryl Oral Liquid Product	rxnav_allrelated
SBDG	SBDG	Benadryl Oral Product	rxnav_allrelated
SCD	SCD	diphenhydramine hydrochloride 2.5 MG/ML Oral Solution	rxnav_allrelated
SCDC	SCDC	diphenhydramine hydrochloride 2.5 MG/ML	rxnav_allrelated
SCDF	SCDF	diphenhydramine Oral Solution	rxnav_allrelated
SCDFP	SCDFP	diphenhydramine hydrochloride Oral Solution	rxnav_allrelated
SCDG	SCDG	diphenhydramine Oral Liquid Product	rxnav_allrelated
SCDG	SCDG	diphenhydramine Oral Product	rxnav_allrelated
SCDGP	SCDGP	diphenhydramine hydrochloride Oral Liquid Product	rxnav_allrelated
SCDGP	SCDGP	diphenhydramine hydrochloride Oral Product	rxnav_allrelated

Properties#

Category, Property, Value table
Category	Property	Value
ATTRIBUTES	AVAILABLE_STRENGTH	2.5 MG/ML
ATTRIBUTES	GENERAL_CARDINALITY	SINGLE
ATTRIBUTES	HUMAN_DRUG	US
ATTRIBUTES	RXNAV_HUMAN_DRUG	US
ATTRIBUTES	SCHEDULE	0
NAMES	Prescribable Synonym	Benadryl Children's Allergy 12.5 MG in 5 mL Oral Solution
NAMES	Tallman Synonym	diphenhydrAMINE hydrochloride 2.5 MG/ML Oral Solution [Benadryl]
SOURCES	Source	Gold Standard Alchemy
SOURCES	Source	Metathesaurus FDA Structured Product Labels
SOURCES	Source	Micromedex RED BOOK
SOURCES	Source	Multum MediSource Lexicon