FDA.reportPublic FDA data

diphenhydramine hydrochloride 20 MG/ML Topical Spray

RxCUI
1050080
RxNorm name
diphenhydramine hydrochloride 20 MG/ML Topical Spray
Display name
diphenhydrAMINE (Topical)
Full name
diphenhydramine hydrochloride 20 MG/ML Topical Spray
Term type
SCD
Status
Active
Strength
2%
Dose form
Spray
Route
Topical
Updated
2026-07-19 06:50:54

RxNorm Status History#

Status
Active
Source
RXNORM
Current
YES
Release start
012011
Active start
012011
Multiple ingredient
NO
Branded
NO

Ingredients And Strength#

Ingredient, Strength, Base table
IngredientStrengthBaseBasis of strength
diphenhydramine hydrochloride20 MG / 1 MLdiphenhydraminediphenhydramine hydrochloride

Dose Form Concepts#

Dose form, RxCUI table
Dose formRxCUI
Topical Spray346165

Derived Ingredient Concepts#

Ingredient, RxCUI table
IngredientRxCUI
diphenhydramine3498

Source Vocabulary Codes#

Code type, Value, Category table
Code typeValueCategory
PRESCRIBABLEYATTRIBUTES
RXNAV_STRdiphenhydrAMINE hydrochloride 20 MG/ML Topical SprayNAMES
RxNorm Namediphenhydramine hydrochloride 20 MG/ML Topical SprayNAMES
RxNorm Synonymdiphenhydramine HCl 2 % Topical SprayNAMES
TTYSCDATTRIBUTES
SPL_SET_ID03feaaef-7401-d464-e063-6294a90a2b2dCODES
SPL_SET_ID47434af6-0fdd-9615-e063-6394a90ab9e8CODES
SPL_SET_ID4f4c801b-d894-4fa3-b024-6ca41a5f2a95CODES
SPL_SET_IDa373b2c3-5c58-4b64-9358-bdf42dfce08cCODES
RxCUI1050080CODES
MMSL_CODEBD4781CODES
MMSL_CODECD4781CODES

FDA NDC Products And Packages#

Package NDC, Product NDC, Name table
Package NDCProduct NDCNameLabelerApplication
42961-218-0142961-218Xpect Extra Strength Itch Relief Diphenhydramine HydrochlorideCintas CorporationM017
61010-8300-161010-8300Itch Relief diphenhydramine hydrochlorideSafetec of America, Inc.M017
79903-217-2579903-217Itch Relief Diphenhydramine HClWal-Mart Stores, Inc.M017
81522-751-2581522-751Itch Relief Diphenhydramine HClFSA Store Inc.M017

Drugs@FDA Applications#

Application, NDC, Name table
ApplicationNDCNameMarketing categoryLabeler
M01742961-218Xpect Extra Strength Itch Relief Diphenhydramine HydrochlorideOTC MONOGRAPH DRUGCintas Corporation

RxNav Current And Historical NDCs#

NDC11, Source, Active table
NDC11SourceActive
42961021801rxnav_ndcsyes
49348036630rxnav_ndcsyes
61010830001rxnav_ndcsyes
79903021725rxnav_ndcsyes
81522075125rxnav_ndcsyes
83926010210rxnav_ndcsyes
12547017004rxnav_historical_indirect
37205033816rxnav_historical
50428422290rxnav_historical
51879016306rxnav_historical
59898081010rxnav_historical
81522072601rxnav_historical

DailyMed RxNorm Mappings#

Set ID, RxNorm string, TTY table
Set IDRxNorm stringTTYSPL versionLabelEffective
03feaaef-7401-d464-e063-6294a90a2b2ddiphenhydrAMINE HCl 2 % Topical SprayPSN6Equate Itch Relief Pump Spray20260127
03feaaef-7401-d464-e063-6294a90a2b2ddiphenhydramine HCl 2 % Topical SpraySY6Equate Itch Relief Pump Spray20260127
03feaaef-7401-d464-e063-6294a90a2b2ddiphenhydramine hydrochloride 20 MG/ML Topical SpraySCD6Equate Itch Relief Pump Spray20260127
a373b2c3-5c58-4b64-9358-bdf42dfce08cdiphenhydrAMINE HCl 2 % Topical SprayPSN4Xpect Extra Strength Itch Relief20250924
a373b2c3-5c58-4b64-9358-bdf42dfce08cdiphenhydramine HCl 2 % Topical SpraySY4Xpect Extra Strength Itch Relief20250924
a373b2c3-5c58-4b64-9358-bdf42dfce08cdiphenhydramine hydrochloride 20 MG/ML Topical SpraySCD4Xpect Extra Strength Itch Relief20250924
92ed55fa-6713-43be-be55-6ba77f052c5ddiphenhydrAMINE HCl 2 % Topical SprayPSN4Respond ITCH RELIEF SPRAY Itch Relief Spray20150903
92ed55fa-6713-43be-be55-6ba77f052c5ddiphenhydramine hydrochloride 20 MG/ML Topical SpraySCD4Respond ITCH RELIEF SPRAY Itch Relief Spray20150903
92ed55fa-6713-43be-be55-6ba77f052c5ddiphenhydramine HCl 2 % Topical SpraySY4Respond ITCH RELIEF SPRAY Itch Relief Spray20150903
4f4c801b-d894-4fa3-b024-6ca41a5f2a95diphenhydramine HCl 2 % Topical SpraySY361010-8300, Itch Relief Spray20240204
4f4c801b-d894-4fa3-b024-6ca41a5f2a95diphenhydrAMINE HCl 2 % Topical SprayPSN361010-8300, Itch Relief Spray20240204
4f4c801b-d894-4fa3-b024-6ca41a5f2a95diphenhydramine hydrochloride 20 MG/ML Topical SpraySCD361010-8300, Itch Relief Spray20240204
fdcec01b-e4fe-4440-b6e1-572a13c49661diphenhydramine HCl 2 % Topical SpraySY3Xpect First Aid ITCH RELIEF SPRAY Itch Relief Spray20130513
fdcec01b-e4fe-4440-b6e1-572a13c49661diphenhydrAMINE HCl 2 % Topical SprayPSN3Xpect First Aid ITCH RELIEF SPRAY Itch Relief Spray20130513
fdcec01b-e4fe-4440-b6e1-572a13c49661diphenhydramine hydrochloride 20 MG/ML Topical SpraySCD3Xpect First Aid ITCH RELIEF SPRAY Itch Relief Spray20130513
2204e135-6a23-68a2-e063-6394a90ac019diphenhydramine HCl 2 % Topical SpraySY2Itch Eraser Spray20251118
2204e135-6a23-68a2-e063-6394a90ac019diphenhydramine hydrochloride 20 MG/ML Topical SpraySCD2Itch Eraser Spray20251118
2204e135-6a23-68a2-e063-6394a90ac019diphenhydrAMINE HCl 2 % Topical SprayPSN2Itch Eraser Spray20251118
afd7e738-9cf3-7937-e053-2995a90a55bcdiphenhydramine HCl 2 % Topical SpraySY2The Itch Eraser Spray20230119
afd7e738-9cf3-7937-e053-2995a90a55bcdiphenhydrAMINE HCl 2 % Topical SprayPSN2The Itch Eraser Spray20230119
afd7e738-9cf3-7937-e053-2995a90a55bcdiphenhydramine hydrochloride 20 MG/ML Topical SpraySCD2The Itch Eraser Spray20230119
47434af6-0fdd-9615-e063-6394a90ab9e8diphenhydrAMINE HCl 2 % Topical SprayPSN1Carring Mill Itch Relief Pump Spray20251231
47434af6-0fdd-9615-e063-6394a90ab9e8diphenhydramine hydrochloride 20 MG/ML Topical SpraySCD1Carring Mill Itch Relief Pump Spray20251231
47434af6-0fdd-9615-e063-6394a90ab9e8diphenhydramine HCl 2 % Topical SpraySY1Carring Mill Itch Relief Pump Spray20251231

DailyMed Labels#

Set ID, Title, Manufacturer table
Set IDTitleManufacturerEffective
03feaaef-7401-d464-e063-6294a90a2b2dEquate Itch Relief Pump SprayWal-Mart Stores, Inc.20260127
47434af6-0fdd-9615-e063-6394a90ab9e8Carring Mill Itch Relief Pump SprayFSA Store Inc.20251231
03feaaef-7401-d464-e063-6294a90a2b2dEquate Itch Relief Pump SprayWal-Mart Stores, Inc.20251029
a373b2c3-5c58-4b64-9358-bdf42dfce08cXpect Extra Strength Itch ReliefCintas Corporation | Safetec of America, Inc20250924
03feaaef-7401-d464-e063-6294a90a2b2dEquate Itch Relief Pump SprayWal-Mart Stores, Inc.20241220
4f4c801b-d894-4fa3-b024-6ca41a5f2a9561010-8300, Itch Relief SpraySafetec of America, Inc.20240204

Drug Classes#

Source, Class ID, Class table
SourceClass IDClassTypeRelationshipDrug concept
ATCR06AAAminoalkyl ethersATC1-4diphenhydramine
ATCD04AAAntihistamines for topical useATC1-4diphenhydramine
FDASPLN0000175587Histamine-1 Receptor AntagonistEPChas_epcdiphenhydramine
FDASPLN0000000190Histamine H1 Receptor AntagonistsMOAhas_moadiphenhydramine
MEDRTD004155DiphenhydramineCHEMhas_ingredientdiphenhydramine hydrochloride
MEDRTD004155DiphenhydramineCHEMhas_ingredientdiphenhydramine
MEDRTD001008Anxiety DisordersDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD001008Anxiety DisordersDISEASEmay_treatdiphenhydramine
MEDRTD004342Drug HypersensitivityDISEASEci_withdiphenhydramine hydrochloride
MEDRTD004342Drug HypersensitivityDISEASEci_withdiphenhydramine
MEDRTD007231Infant, NewbornDISEASEci_withdiphenhydramine hydrochloride
MEDRTD007231Infant, NewbornDISEASEci_withdiphenhydramine
MEDRTD007234Infant, PrematureDISEASEci_withdiphenhydramine hydrochloride
MEDRTD007234Infant, PrematureDISEASEci_withdiphenhydramine
MEDRTD007774LactationDISEASEci_withdiphenhydramine hydrochloride
MEDRTD007774LactationDISEASEci_withdiphenhydramine
MEDRTD009041Motion SicknessDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD009041Motion SicknessDISEASEmay_treatdiphenhydramine
MEDRTD009325NauseaDISEASEmay_treatdiphenhydramine
MEDRTD009325NauseaDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD012221Rhinitis, Allergic, PerennialDISEASEmay_treatdiphenhydramine
MEDRTD012221Rhinitis, Allergic, PerennialDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD007319Sleep Initiation and Maintenance DisordersDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD007319Sleep Initiation and Maintenance DisordersDISEASEmay_treatdiphenhydramine
MEDRTD012912SneezingDISEASEmay_treatdiphenhydramine
MEDRTD012912SneezingDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD013224Status AsthmaticusDISEASEci_withdiphenhydramine
MEDRTD013224Status AsthmaticusDISEASEci_withdiphenhydramine hydrochloride
MEDRTD014581UrticariaDISEASEmay_treatdiphenhydramine hydrochloride
MEDRTD014581UrticariaDISEASEmay_treatdiphenhydramine
MEDRTN0000000190Histamine H1 Receptor AntagonistsMOAhas_moadiphenhydramine hydrochloride
MEDRTN0000000190Histamine H1 Receptor AntagonistsMOAhas_moadiphenhydramine

Properties#

Category, Property, Value table
CategoryPropertyValue
ATTRIBUTESAVAILABLE_STRENGTH20 MG/ML
ATTRIBUTESGENERAL_CARDINALITYSINGLE
ATTRIBUTESHUMAN_DRUGUS
ATTRIBUTESPRESCRIBABLEY
ATTRIBUTESRXNAV_HUMAN_DRUGUS
ATTRIBUTESSCHEDULE0
ATTRIBUTESTTYSCD
CODESMMSL_CODEBD4781
CODESMMSL_CODECD4781
CODESRxCUI1050080
CODESSPL_SET_ID03feaaef-7401-d464-e063-6294a90a2b2d
CODESSPL_SET_ID47434af6-0fdd-9615-e063-6394a90ab9e8
CODESSPL_SET_ID4f4c801b-d894-4fa3-b024-6ca41a5f2a95
CODESSPL_SET_IDa373b2c3-5c58-4b64-9358-bdf42dfce08c
CODESVUID4002565
NAMESPrescribable SynonymdiphenhydrAMINE HCl 2 % Topical Spray
NAMESRXNAV_STRdiphenhydrAMINE hydrochloride 20 MG/ML Topical Spray
NAMESRxNorm Namediphenhydramine hydrochloride 20 MG/ML Topical Spray
NAMESRxNorm Synonymdiphenhydramine HCl 2 % Topical Spray
NAMESTallman SynonymdiphenhydrAMINE HCl 2 % Topical Spray
NAMESTallman SynonymdiphenhydrAMINE hydrochloride 20 MG/ML Topical Spray
SOURCESSourceGold Standard Alchemy
SOURCESSourceMetathesaurus FDA Structured Product Labels
SOURCESSourceMultum MediSource Lexicon
SOURCESSourceNational Drug Data File Plus Source Vocabulary
SOURCESSourceVeterans Health Administration National Drug File