diphenhydramine hydrochloride 2.5 MG/ML / phenylephrine hydrochloride 1 MG/ML Oral Solution [Benadryl-D Allergy and Sinus]

RxCUI: 1086723
RxNorm name: diphenhydramine hydrochloride 2.5 MG/ML / phenylephrine hydrochloride 1 MG/ML Oral Solution [Benadryl-D Allergy and Sinus]
Display name: BENADRYL-D ALLERGY AND SINUS (Oral Liquid)
Full name: diphenhydramine hydrochloride 2.5 MG/ML / phenylephrine hydrochloride 1 MG/ML Oral Solution [Benadryl-D Allergy and Sinus]
Term type: SBD
Status: Active
Strength: 12.5-5 mg/5ml
Dose form: Sol
Route: Oral Liquid
Updated: 2026-07-25 06:53:39

RxNorm Status History#

Status: Active
Source: RXNORM
Current: YES
Release start: 022011
Active start: 022011
Multiple ingredient: YES
Branded: YES

Ingredients And Strength#

Ingredient, Strength, Base table
Ingredient	Strength	Base	Basis of strength
diphenhydramine hydrochloride	2.5 MG / 1 ML	diphenhydramine	diphenhydramine hydrochloride
phenylephrine hydrochloride	1 MG / 1 ML	phenylephrine	phenylephrine hydrochloride

Dose Form Concepts#

Dose form, RxCUI table
Dose form	RxCUI
Oral Solution	316968

Derived Ingredient Concepts#

Ingredient, RxCUI table
Ingredient	RxCUI
diphenhydramine	3498
phenylephrine	8163

Source Vocabulary Codes#

Code type, Value, Category table
Code type	Value	Category
PRESCRIBABLE	Y	ATTRIBUTES
RXNAV_STR	Benadryl Children's Allergy Plus Congestion 12.5 MG / 5 MG per 5 ML Oral Solution	NAMES
RxNorm Name	diphenhydramine hydrochloride 2.5 MG/ML / phenylephrine hydrochloride 1 MG/ML Oral Solution [Benadryl-D Allergy and Sinus]	NAMES
RxNorm Synonym	Benadryl Children's Allergy Plus Congestion 12.5 MG / 5 MG per 5 ML Oral Solution	NAMES
RxNorm Synonym	Benadryl-D Allergy and Sinus (diphenhydramine hydrochloride 12.5 MG/ML / phenylephrine hydrochloride 5 MG) per 5 ML Oral Solution	NAMES
TTY	SBD	ATTRIBUTES
SPL_SET_ID	b8b75904-3806-4258-89c1-d6ff486ed41c	CODES
RxCUI	1086723	CODES
MMSL_CODE	BD24663	CODES

FDA NDC Products And Packages#

Package NDC, Product NDC, Name table
Package NDC	Product NDC	Name	Labeler	Application
50580-341-01	50580-341	Childrens Benadryl Allergy Plus Congestion Diphenhydramine hydrochloride and Phenylephrine hydrochloride	Kenvue Brands LLC	M012

Drugs@FDA Applications#

Application, NDC, Name table
Application	NDC	Name	Marketing category	Labeler
M012	50580-341	Childrens Benadryl Allergy Plus Congestion Diphenhydramine hydrochloride and Phenylephrine hydrochloride	OTC MONOGRAPH DRUG	Kenvue Brands LLC

RxNav Current And Historical NDCs#

NDC11, Source, Active table
NDC11	Source	Active
50580034101	rxnav_ndcs	yes
50580078104	rxnav_historical

DailyMed RxNorm Mappings#

Set ID, RxNorm string, TTY table
Set ID	RxNorm string	TTY	SPL version	Label	Effective
b8b75904-3806-4258-89c1-d6ff486ed41c	Benadryl-D Children's Allergy & Sinus 12.5 MG / 5 MG in 5 mL Oral Solution	PSN	9	Childrens Benadryl Allergy Plus Congestion	20241108
b8b75904-3806-4258-89c1-d6ff486ed41c	Benadryl-D Allergy and Sinus (diphenhydramine hydrochloride 12.5 MG/ML / phenylephrine hydrochloride 5 MG) per 5 ML Oral Solution	SY	9	Childrens Benadryl Allergy Plus Congestion	20241108
b8b75904-3806-4258-89c1-d6ff486ed41c	Benadryl Children's Allergy Plus Congestion 12.5 MG / 5 MG per 5 ML Oral Solution	SY	9	Childrens Benadryl Allergy Plus Congestion	20241108
b8b75904-3806-4258-89c1-d6ff486ed41c	diphenhydramine hydrochloride 2.5 MG/ML / phenylephrine hydrochloride 1 MG/ML Oral Solution [Benadryl-D Allergy and Sinus]	SBD	9	Childrens Benadryl Allergy Plus Congestion	20241108

DailyMed Labels#

Set ID, Title, Manufacturer table
Set ID	Title	Manufacturer	Effective
b8b75904-3806-4258-89c1-d6ff486ed41c	Childrens Benadryl Allergy Plus Congestion	Kenvue Brands LLC	20241108

Drug Classes#

Source, Class ID, Class table
Source	Class ID	Class	Type	Relationship	Drug concept
ATC	C01CA	Adrenergic and dopaminergic agents	ATC1-4		phenylephrine
ATC	R06AA	Aminoalkyl ethers	ATC1-4		diphenhydramine
ATC	D04AA	Antihistamines for topical use	ATC1-4		diphenhydramine
ATC	C05AX	Other agents for treatment of hemorrhoids and anal fissures for topical use	ATC1-4		phenylephrine
ATC	R01BA	Sympathomimetics	ATC1-4		phenylephrine
ATC	S01FB	Sympathomimetics excl. antiglaucoma preparations	ATC1-4		phenylephrine
ATC	S01GA	Sympathomimetics used as decongestants	ATC1-4		phenylephrine
ATC	R01AB	Sympathomimetics, combinations excl. corticosteroids	ATC1-4		phenylephrine
ATC	R01AA	Sympathomimetics, plain	ATC1-4		phenylephrine
FDASPL	N0000186105	alpha-1 Adrenergic Agonist	EPC	has_epc	phenylephrine
FDASPL	N0000175587	Histamine-1 Receptor Antagonist	EPC	has_epc	diphenhydramine
FDASPL	N0000000190	Histamine H1 Receptor Antagonists	MOA	has_moa	diphenhydramine
MEDRT	D004155	Diphenhydramine	CHEM	has_ingredient	diphenhydramine
MEDRT	D004155	Diphenhydramine	CHEM	has_ingredient	diphenhydramine hydrochloride
MEDRT	D010656	Phenylephrine	CHEM	has_ingredient	phenylephrine hydrochloride
MEDRT	D010656	Phenylephrine	CHEM	has_ingredient	phenylephrine
MEDRT	D013447	Sulfites	CHEM	ci_chemclass	phenylephrine hydrochloride
MEDRT	D013447	Sulfites	CHEM	ci_chemclass	phenylephrine
MEDRT	D001008	Anxiety Disorders	DISEASE	may_treat	diphenhydramine
MEDRT	D001008	Anxiety Disorders	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	phenylephrine
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	diphenhydramine
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	diphenhydramine hydrochloride
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	phenylephrine hydrochloride
MEDRT	D005401	Fissure in Ano	DISEASE	may_treat	phenylephrine hydrochloride
MEDRT	D005401	Fissure in Ano	DISEASE	may_treat	phenylephrine
MEDRT	D005902	Glaucoma, Open-Angle	DISEASE	may_treat	phenylephrine
MEDRT	D005902	Glaucoma, Open-Angle	DISEASE	may_treat	phenylephrine hydrochloride
MEDRT	D006484	Hemorrhoids	DISEASE	may_treat	phenylephrine hydrochloride
MEDRT	D006484	Hemorrhoids	DISEASE	may_treat	phenylephrine
MEDRT	D006973	Hypertension	DISEASE	ci_with	phenylephrine hydrochloride
MEDRT	D006973	Hypertension	DISEASE	ci_with	phenylephrine
MEDRT	D007022	Hypotension	DISEASE	may_treat	phenylephrine hydrochloride
MEDRT	D007022	Hypotension	DISEASE	may_treat	phenylephrine
MEDRT	D007231	Infant, Newborn	DISEASE	ci_with	diphenhydramine hydrochloride
MEDRT	D007231	Infant, Newborn	DISEASE	ci_with	diphenhydramine
MEDRT	D007234	Infant, Premature	DISEASE	ci_with	diphenhydramine hydrochloride
MEDRT	D007234	Infant, Premature	DISEASE	ci_with	diphenhydramine
MEDRT	D007774	Lactation	DISEASE	ci_with	diphenhydramine hydrochloride
MEDRT	D007774	Lactation	DISEASE	ci_with	diphenhydramine
MEDRT	D009041	Motion Sickness	DISEASE	may_treat	diphenhydramine
MEDRT	D009041	Motion Sickness	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D015878	Mydriasis	DISEASE	induces	phenylephrine hydrochloride
MEDRT	D015878	Mydriasis	DISEASE	induces	phenylephrine
MEDRT	D009325	Nausea	DISEASE	may_treat	diphenhydramine
MEDRT	D009325	Nausea	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D011538	Pruritus Ani	DISEASE	may_treat	phenylephrine hydrochloride
MEDRT	D011538	Pruritus Ani	DISEASE	may_treat	phenylephrine
MEDRT	D012221	Rhinitis, Allergic, Perennial	DISEASE	may_treat	diphenhydramine
MEDRT	D012221	Rhinitis, Allergic, Perennial	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D012223	Rhinitis, Vasomotor	DISEASE	may_treat	phenylephrine
MEDRT	D012223	Rhinitis, Vasomotor	DISEASE	may_treat	phenylephrine hydrochloride
MEDRT	D012772	Shock, Septic	DISEASE	may_treat	phenylephrine
MEDRT	D012772	Shock, Septic	DISEASE	may_treat	phenylephrine hydrochloride
MEDRT	D007319	Sleep Initiation and Maintenance Disorders	DISEASE	may_treat	diphenhydramine
MEDRT	D007319	Sleep Initiation and Maintenance Disorders	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D012912	Sneezing	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D012912	Sneezing	DISEASE	may_treat	diphenhydramine
MEDRT	D013224	Status Asthmaticus	DISEASE	ci_with	diphenhydramine hydrochloride
MEDRT	D013224	Status Asthmaticus	DISEASE	ci_with	diphenhydramine
MEDRT	D013617	Tachycardia, Supraventricular	DISEASE	may_treat	phenylephrine hydrochloride
MEDRT	D013617	Tachycardia, Supraventricular	DISEASE	may_treat	phenylephrine
MEDRT	D017180	Tachycardia, Ventricular	DISEASE	ci_with	phenylephrine hydrochloride
MEDRT	D017180	Tachycardia, Ventricular	DISEASE	ci_with	phenylephrine
MEDRT	D014581	Urticaria	DISEASE	may_treat	diphenhydramine
MEDRT	D014581	Urticaria	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	N0000000209	Adrenergic alpha-Agonists	MOA	has_moa	phenylephrine hydrochloride
MEDRT	N0000000209	Adrenergic alpha-Agonists	MOA	has_moa	phenylephrine
MEDRT	N0000000190	Histamine H1 Receptor Antagonists	MOA	has_moa	diphenhydramine hydrochloride
MEDRT	N0000000190	Histamine H1 Receptor Antagonists	MOA	has_moa	diphenhydramine
MEDRT	N0000008371	Conjunctival Arterial Vasoconstriction	PE	has_pe	phenylephrine
MEDRT	N0000008371	Conjunctival Arterial Vasoconstriction	PE	has_pe	phenylephrine hydrochloride
MEDRT	N0000008896	Decreased Nasal and Sinus Secretions	PE	has_pe	phenylephrine
MEDRT	N0000008896	Decreased Nasal and Sinus Secretions	PE	has_pe	phenylephrine hydrochloride

Group, Type, Concept table
Group	Type	Concept	Source
BN	BN	Benadryl-D Allergy and Sinus	rxnav_allrelated
DF	DF	Oral Solution	rxnav_allrelated
DFG	DFG	Oral Liquid Product	rxnav_allrelated
DFG	DFG	Oral Product	rxnav_allrelated
IN	IN	diphenhydramine	rxnav_allrelated
IN	IN	phenylephrine	rxnav_allrelated
MIN	MIN	diphenhydramine / phenylephrine	rxnav_allrelated
PIN	PIN	diphenhydramine hydrochloride	rxnav_allrelated
PIN	PIN	phenylephrine hydrochloride	rxnav_allrelated
SBD	SBD	diphenhydramine hydrochloride 2.5 MG/ML / phenylephrine hydrochloride 1 MG/ML Oral Solution [Benadryl-D Allergy and Sinus]	rxnav_allrelated
SBDC	SBDC	diphenhydramine hydrochloride 2.5 MG/ML / phenylephrine hydrochloride 1 MG/ML [Benadryl-D Allergy and Sinus]	rxnav_allrelated
SBDF	SBDF	diphenhydramine / phenylephrine Oral Solution [Benadryl-D Allergy and Sinus]	rxnav_allrelated
SBDFP	SBDFP	diphenhydramine hydrochloride / phenylephrine hydrochloride Oral Solution [Benadryl-D Allergy and Sinus]	rxnav_allrelated
SBDG	SBDG	Benadryl-D Allergy and Sinus Oral Liquid Product	rxnav_allrelated
SBDG	SBDG	Benadryl-D Allergy and Sinus Oral Product	rxnav_allrelated
SCD	SCD	diphenhydramine hydrochloride 2.5 MG/ML / phenylephrine hydrochloride 1 MG/ML Oral Solution	rxnav_allrelated
SCDC	SCDC	diphenhydramine hydrochloride 2.5 MG/ML	rxnav_allrelated
SCDC	SCDC	phenylephrine hydrochloride 1 MG/ML	rxnav_allrelated
SCDF	SCDF	diphenhydramine / phenylephrine Oral Solution	rxnav_allrelated
SCDFP	SCDFP	diphenhydramine hydrochloride / phenylephrine hydrochloride Oral Solution	rxnav_allrelated
SCDG	SCDG	diphenhydramine / phenylephrine Oral Liquid Product	rxnav_allrelated
SCDG	SCDG	diphenhydramine / phenylephrine Oral Product	rxnav_allrelated
SCDGP	SCDGP	diphenhydramine hydrochloride / phenylephrine hydrochloride Oral Liquid Product	rxnav_allrelated
SCDGP	SCDGP	diphenhydramine hydrochloride / phenylephrine hydrochloride Oral Product	rxnav_allrelated

Properties#

Category, Property, Value table
Category	Property	Value
ATTRIBUTES	AVAILABLE_STRENGTH	2.5 MG/ML / 1 MG/ML
ATTRIBUTES	GENERAL_CARDINALITY	MULTI
ATTRIBUTES	HUMAN_DRUG	US
ATTRIBUTES	PRESCRIBABLE	Y
ATTRIBUTES	RXNAV_HUMAN_DRUG	US
ATTRIBUTES	TTY	SBD
CODES	MMSL_CODE	BD24663
CODES	RxCUI	1086723
CODES	SPL_SET_ID	b8b75904-3806-4258-89c1-d6ff486ed41c
NAMES	Prescribable Synonym	Benadryl-D Children's Allergy & Sinus 12.5 MG / 5 MG in 5 mL Oral Solution
NAMES	RXNAV_STR	Benadryl Children's Allergy Plus Congestion 12.5 MG / 5 MG per 5 ML Oral Solution
NAMES	RxNorm Name	diphenhydramine hydrochloride 2.5 MG/ML / phenylephrine hydrochloride 1 MG/ML Oral Solution [Benadryl-D Allergy and Sinus]
NAMES	RxNorm Synonym	Benadryl Children's Allergy Plus Congestion 12.5 MG / 5 MG per 5 ML Oral Solution
NAMES	RxNorm Synonym	Benadryl-D Allergy and Sinus (diphenhydramine hydrochloride 12.5 MG/ML / phenylephrine hydrochloride 5 MG) per 5 ML Oral Solution
NAMES	Tallman Synonym	Benadryl-D Allergy and Sinus (diphenhydrAMINE hydrochloride 12.5 MG/ML / phenylephrine hydrochloride 5 MG) per 5 ML Oral Solution
NAMES	Tallman Synonym	diphenhydrAMINE hydrochloride 2.5 MG/ML / phenylephrine hydrochloride 1 MG/ML Oral Solution [Benadryl-D Allergy and Sinus]
SOURCES	Source	Gold Standard Alchemy
SOURCES	Source	Metathesaurus FDA Structured Product Labels
SOURCES	Source	Micromedex RED BOOK

diphenhydramine hydrochloride 2.5 MG/ML / phenylephrine hydrochloride 1 MG/ML Oral Solution [Benadryl-D Allergy and Sinus]

RxNorm Status History#

Ingredients And Strength#

Dose Form Concepts#

Derived Ingredient Concepts#

Source Vocabulary Codes#

FDA NDC Products And Packages#

Drugs@FDA Applications#

RxNav Current And Historical NDCs#

DailyMed RxNorm Mappings#

DailyMed Labels#

Drug Classes#

Related Concepts#

Properties#