diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG [Aleve PM]
- RxCUI
- 1550959
- RxNorm name
- diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG [Aleve PM]
- Term type
- SBDC
- Status
- Active
- Updated
- 2026-10-13 14:25:08
RxNorm Status History#
- Status
- Active
- Source
- RXNORM
- Current
- YES
- Release start
- 112014
- Active start
- 112014
- Multiple ingredient
- YES
- Branded
- YES
Ingredients And Strength#
Ingredient, Strength, Base table| Ingredient | Strength | Base | Basis of strength |
|---|
| 25 MG / 1 EACH | diphenhydramine | |
| 220 MG / 1 EACH | naproxen | |
Derived Ingredient Concepts#
RxNav Current And Historical NDCs#
RxNav current and historical NDC rows page 1 of 1 · 0 matching rows.
No records found.
UNII Substances#
UNII substance links page 1 of 1 · 0 matching rows.
No records found.
Reported adverse events (FAERS/openFDA)#
Adverse event summaries are temporarily unavailable. Other product information remains available.
DailyMed RxNorm Mappings#
unique DailyMed labels mapped to this RxNorm concept page 1 of 1 · 0 matching rows.
No records found.
Drug Classes#
Source, Class ID, Class table| Source | Class ID | Class | Type | Relationship | Drug concept |
|---|
| ATC | R06AA | Aminoalkyl ethers | ATC1-4 | | diphenhydramine |
| ATC | D04AA | Antihistamines for topical use | ATC1-4 | | diphenhydramine |
| ATC | M02AA | Antiinflammatory preparations, non-steroids for topical use | ATC1-4 | | naproxen |
| ATC | G02CC | Antiinflammatory products for vaginal administration | ATC1-4 | | naproxen |
| ATC | M01AE | Propionic acid derivatives | ATC1-4 | | diphenhydramine / naproxen |
| ATC | M01AE | Propionic acid derivatives | ATC1-4 | | naproxen |
| FDASPL | N0000175587 | Histamine-1 Receptor Antagonist | EPC | has_epc | diphenhydramine |
| FDASPL | N0000175722 | Nonsteroidal Anti-inflammatory Drug | EPC | has_epc | naproxen |
| FDASPL | N0000000160 | Cyclooxygenase Inhibitors | MOA | has_moa | naproxen |
| FDASPL | N0000000190 | Histamine H1 Receptor Antagonists | MOA | has_moa | diphenhydramine |
| MEDRT | D004155 | Diphenhydramine | CHEM | has_ingredient | diphenhydramine hydrochloride |
| MEDRT | D004155 | Diphenhydramine | CHEM | has_ingredient | diphenhydramine |
| MEDRT | D009288 | Naproxen | CHEM | has_ingredient | naproxen |
| MEDRT | D009288 | Naproxen | CHEM | has_ingredient | naproxen sodium |
| MEDRT | D001008 | Anxiety Disorders | DISEASE | may_treat | diphenhydramine |
| MEDRT | D001008 | Anxiety Disorders | DISEASE | may_treat | diphenhydramine hydrochloride |
| MEDRT | D001171 | Arthritis, Juvenile | DISEASE | may_treat | naproxen |
| MEDRT | D001171 | Arthritis, Juvenile | DISEASE | may_treat | naproxen sodium |
| MEDRT | D001172 | Arthritis, Rheumatoid | DISEASE | may_treat | naproxen sodium |
| MEDRT | D001172 | Arthritis, Rheumatoid | DISEASE | may_treat | naproxen |
| MEDRT | D001416 | Back Pain | DISEASE | may_treat | naproxen sodium |
| MEDRT | D001416 | Back Pain | DISEASE | may_treat | naproxen |
| MEDRT | D002062 | Bursitis | DISEASE | may_treat | naproxen |
| MEDRT | D002062 | Bursitis | DISEASE | may_treat | naproxen sodium |
| MEDRT | D003139 | Common Cold | DISEASE | may_treat | naproxen sodium |
| MEDRT | D003139 | Common Cold | DISEASE | may_treat | naproxen |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | diphenhydramine hydrochloride |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | naproxen sodium |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | naproxen |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | diphenhydramine |
| MEDRT | D004412 | Dysmenorrhea | DISEASE | may_treat | naproxen sodium |
| MEDRT | D004412 | Dysmenorrhea | DISEASE | may_treat | naproxen |
| MEDRT | D005334 | Fever | DISEASE | may_treat | naproxen sodium |
| MEDRT | D005334 | Fever | DISEASE | may_treat | naproxen |
| MEDRT | D006073 | Gout | DISEASE | may_treat | naproxen sodium |
| MEDRT | D006073 | Gout | DISEASE | may_treat | naproxen |
| MEDRT | D006261 | Headache | DISEASE | may_treat | naproxen |
| MEDRT | D006261 | Headache | DISEASE | may_treat | naproxen sodium |
| MEDRT | D007231 | Infant, Newborn | DISEASE | ci_with | diphenhydramine |
| MEDRT | D007231 | Infant, Newborn | DISEASE | ci_with | diphenhydramine hydrochloride |
| MEDRT | D007234 | Infant, Premature | DISEASE | ci_with | diphenhydramine hydrochloride |
| MEDRT | D007234 | Infant, Premature | DISEASE | ci_with | diphenhydramine |
| MEDRT | D007249 | Inflammation | DISEASE | may_treat | naproxen |
| MEDRT | D007249 | Inflammation | DISEASE | may_treat | naproxen sodium |
| MEDRT | D007774 | Lactation | DISEASE | ci_with | diphenhydramine hydrochloride |
| MEDRT | D007774 | Lactation | DISEASE | ci_with | diphenhydramine |
| MEDRT | D009041 | Motion Sickness | DISEASE | may_treat | diphenhydramine |
| MEDRT | D009041 | Motion Sickness | DISEASE | may_treat | diphenhydramine hydrochloride |
| MEDRT | D009325 | Nausea | DISEASE | may_treat | diphenhydramine |
| MEDRT | D009325 | Nausea | DISEASE | may_treat | diphenhydramine hydrochloride |
| MEDRT | D010003 | Osteoarthritis | DISEASE | may_treat | naproxen sodium |
| MEDRT | D010003 | Osteoarthritis | DISEASE | may_treat | naproxen |
| MEDRT | D010146 | Pain | DISEASE | may_prevent | naproxen sodium |
| MEDRT | D010146 | Pain | DISEASE | may_prevent | naproxen |
| MEDRT | D011263 | Pregnancy Trimester, Third | DISEASE | ci_with | naproxen |
| MEDRT | D011263 | Pregnancy Trimester, Third | DISEASE | ci_with | naproxen sodium |
| MEDRT | D012221 | Rhinitis, Allergic, Perennial | DISEASE | may_treat | diphenhydramine |
| MEDRT | D012221 | Rhinitis, Allergic, Perennial | DISEASE | may_treat | diphenhydramine hydrochloride |
| MEDRT | D007319 | Sleep Initiation and Maintenance Disorders | DISEASE | may_treat | diphenhydramine hydrochloride |
| MEDRT | D007319 | Sleep Initiation and Maintenance Disorders | DISEASE | may_treat | diphenhydramine |
| MEDRT | D012912 | Sneezing | DISEASE | may_treat | diphenhydramine hydrochloride |
| MEDRT | D012912 | Sneezing | DISEASE | may_treat | diphenhydramine |
| MEDRT | D013167 | Spondylitis, Ankylosing | DISEASE | may_treat | naproxen |
| MEDRT | D013167 | Spondylitis, Ankylosing | DISEASE | may_treat | naproxen sodium |
| MEDRT | D013224 | Status Asthmaticus | DISEASE | ci_with | diphenhydramine hydrochloride |
| MEDRT | D013224 | Status Asthmaticus | DISEASE | ci_with | diphenhydramine |
| MEDRT | D014098 | Toothache | DISEASE | may_treat | naproxen |
| MEDRT | D014098 | Toothache | DISEASE | may_treat | naproxen sodium |
| MEDRT | D014581 | Urticaria | DISEASE | may_treat | diphenhydramine |
| MEDRT | D014581 | Urticaria | DISEASE | may_treat | diphenhydramine hydrochloride |
| MEDRT | N0000000160 | Cyclooxygenase Inhibitors | MOA | has_moa | naproxen sodium |
| MEDRT | N0000000160 | Cyclooxygenase Inhibitors | MOA | has_moa | naproxen |
| MEDRT | N0000000190 | Histamine H1 Receptor Antagonists | MOA | has_moa | diphenhydramine |
| MEDRT | N0000000190 | Histamine H1 Receptor Antagonists | MOA | has_moa | diphenhydramine hydrochloride |
| MEDRT | N0000008831 | Decreased Platelet Activating Factor Production | PE | has_pe | naproxen sodium |
| MEDRT | N0000008831 | Decreased Platelet Activating Factor Production | PE | has_pe | naproxen |
| MEDRT | N0000008836 | Decreased Prostaglandin Production | PE | has_pe | naproxen sodium |
| MEDRT | N0000008836 | Decreased Prostaglandin Production | PE | has_pe | naproxen |
| MEDRT | N0000009006 | Decreased Thromboxane Production | PE | has_pe | naproxen sodium |
| MEDRT | N0000009006 | Decreased Thromboxane Production | PE | has_pe | naproxen |
| MEDRT | N0000000042 | Renal Excretion | PK | has_pk | naproxen |
| MEDRT | N0000000042 | Renal Excretion | PK | has_pk | naproxen sodium |
Properties#
Category, Property, Value table| Category | Property | Value |
|---|
| ATTRIBUTES | GENERAL_CARDINALITY | MULTI |
| ATTRIBUTES | RXNAV_HUMAN_DRUG | US |
| NAMES | Tallman Synonym | diphenhydrAMINE hydrochloride 25 MG / naproxen sodium 220 MG [Aleve PM] |