diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet

RxCUI: 1550957
RxNorm name: diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet
Display name: diphenhydrAMINE/Naproxen (Oral Pill)
Full name: diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet
Term type: SCD
Status: Active
Strength: 25-220 mg
Dose form: Tab
Route: Oral Pill
Updated: 2026-10-13 14:25:01

RxNorm Status History#

Status: Active
Source: RXNORM
Current: YES
Release start: 112014
Active start: 112014
Multiple ingredient: YES
Branded: NO

Ingredients And Strength#

Ingredient, Strength, Base table
Ingredient	Strength	Base	Basis of strength
diphenhydramine hydrochloride	25 MG / 1 EACH	diphenhydramine	diphenhydramine hydrochloride
naproxen sodium	220 MG / 1 EACH	naproxen	naproxen sodium

Dose Form Concepts#

Dose form, RxCUI table
Dose form	RxCUI
Oral Tablet	317541

Derived Ingredient Concepts#

Ingredient, RxCUI table
Ingredient	RxCUI
diphenhydramine	3498
naproxen	7258

Source Vocabulary Codes#

Code type, Values, Count table
Code type	Values	Count	Category
PRESCRIBABLE	Y	1	ATTRIBUTES
RXNAV_STR	diphenhydrAMINE hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet	1	NAMES
RxNorm Name	diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet	1	NAMES
TTY	SCD	1	ATTRIBUTES
SPL_SET_ID	19 linked values 0d59780a-ef22-4b67-8b42-9795dbec8db0 03a331d8-c957-4949-894f-51d9bd15e0d0 6c2c087c-e36d-4971-b977-d3cab6d6edee 7beed9e7-816b-494b-93fa-9caf10aa3834 34d635f8-9703-4c29-92a5-85d3b47c4c93 43e4ed28-b1be-4548-86ac-f40f9f83f04e 60cb7b6e-f2d2-48ca-8db7-7124717735d5 4281faf5-7182-404f-9f53-3d9ea0354a18 16547905-59c0-4936-82e1-2d9f5935d8dd a20f193e-4e64-400a-b605-df08026cb80b bdac694e-ab2a-376d-e053-2a95a90a9467 c0769941-bcf2-4237-b70c-a79089ad5335 caca14cf-95f2-4c60-8bba-2154b8f353a3 d5dafdd0-968d-4ee6-9461-1f72d3255240 ed0f3275-f156-13a3-e053-2a95a90a2ce8 ed7bfa3f-4972-4ab6-9f0c-0873a11571a9 f548aa3d-b35e-458a-9815-3595a451ab78 fe810c0e-ab42-5a8a-e053-6394a90affe4 fe82699d-fdc2-038e-e053-6294a90a606c	19	CODES
RxCUI	1550957	1	CODES
MMSL_CODE	2 linked values BD30191 CD30191	2	CODES

FDA NDC Products And Packages#

Package NDC, Product NDC, Name table
Package NDC	Product NDC	Name	Labeler	Application
0113-8264-06	0113-8264	good sense naproxen sodium diphenhydramine hydrochloride, naproxen sodium	L. Perrigo Company	ANDA208499
0113-8264-60	0113-8264	good sense naproxen sodium diphenhydramine hydrochloride, naproxen sodium	L. Perrigo Company	ANDA208499
0113-8264-71	0113-8264	good sense naproxen sodium diphenhydramine hydrochloride, naproxen sodium	L. Perrigo Company	ANDA208499
0363-2264-27	0363-2264	ALL NIGHT PAIN RELIEF PM diphenhydramine hydrochloride, naproxen sodium	Walgreen Company	ANDA208499
11673-687-27	11673-687	up and up naproxen sodium pm diphenhydramine hydrochloride, naproxen sodium	Target Corporation	ANDA208499
11673-819-08	11673-819	Naproxen Sodium and Diphenhydramine HCL Naproxen Sodium and Diphenhydramine HCL	TARGET CORPORATION	ANDA213663
21130-639-71	21130-639	NAPROXEN SODIUM PM diphenhydramine hydrochloride, naproxen sodium	Safeway	ANDA208499
21130-814-05	21130-814	Naproxen Sodium Diphenhydramine Hydrochloride Naproxen Sodium Diphenhydramine Hydrochloride	SAFEWAY	ANDA213663
30142-753-27	30142-753	naproxen sodium pm diphenhydramine hydrochloride, naproxen sodium	Kroger Company	ANDA208499
36800-264-27	36800-264	topcare all night pain relief pm diphenhydramine hydrochloride, naproxen sodium	Topco Associates LLC	ANDA208499
36800-264-60	36800-264	topcare all night pain relief pm diphenhydramine hydrochloride, naproxen sodium	Topco Associates LLC	ANDA208499
37808-264-27	37808-264	naproxen sodium pm diphenhydramine hydrochloride, naproxen sodium	H E B	ANDA208499
37808-264-60	37808-264	naproxen sodium pm diphenhydramine hydrochloride, naproxen sodium	H E B	ANDA208499
41163-593-71	41163-593	equaline naproxen sodium pm diphenhydramine hydrochloride, naproxen sodium	United Natural Foods, Inc. dba UNFI	ANDA208499
41250-526-27	41250-526	naproxen sodium pm diphenhydramine hydrochloride, naproxen sodium	Meijer Distribution Inc	ANDA208499
41520-264-27	41520-264	careone naproxen sodium pm diphenhydramine hydrochloride, naproxen sodium	American Sales Company	ANDA208499
41520-264-60	41520-264	careone naproxen sodium pm diphenhydramine hydrochloride, naproxen sodium	American Sales Company	ANDA208499
55910-858-27	55910-858	dg health naproxen sodium pm diphenhydramine hydrochloride, naproxen sodium	Dolgencorp Inc	ANDA208499
62207-814-38	62207-814	Naproxen Sodium and Diphenhydramine HCl Naproxen Sodium and Diphenhydramine HCl	Granules India Ltd	ANDA213663
62207-814-39	62207-814	Naproxen Sodium and Diphenhydramine HCl Naproxen Sodium and Diphenhydramine HCl	Granules India Ltd	ANDA213663
62207-814-47	62207-814	Naproxen Sodium and Diphenhydramine HCl Naproxen Sodium and Diphenhydramine HCl	Granules India Ltd	ANDA213663
62207-814-95	62207-814	Naproxen Sodium and Diphenhydramine HCl Naproxen Sodium and Diphenhydramine HCl	Granules India Ltd	ANDA213663
69238-1422-2	69238-1422	Naproxen Sodium and Diphenhydramine HCl Naproxen Sodium and Diphenhydramine	Amneal Pharmaceuticals NY LLC	ANDA209726
69238-1422-4	69238-1422	Naproxen Sodium and Diphenhydramine HCl Naproxen Sodium and Diphenhydramine	Amneal Pharmaceuticals NY LLC	ANDA209726
69238-1422-6	69238-1422	Naproxen Sodium and Diphenhydramine HCl Naproxen Sodium and Diphenhydramine	Amneal Pharmaceuticals NY LLC	ANDA209726
69238-1422-8	69238-1422	Naproxen Sodium and Diphenhydramine HCl Naproxen Sodium and Diphenhydramine	Amneal Pharmaceuticals NY LLC	ANDA209726
69842-328-02	69842-328	Naproxen Sodium Diphenhydramine HCl Naproxen Sodium Diphenhydramine HCl	CVS PHARMACY, INC	ANDA213663
70677-0064-1	70677-0064	Naproxen Sodium PM Naproxen Sodium	Strategic Sourcing Services LLC	ANDA209726
72288-310-06	72288-310	basic care naproxen sodium pm diphenhydramine hydrochloride, naproxen sodium	Amazon.com Services LLC	ANDA208499
79903-204-20	79903-204	Naproxen Sodium Diphenhydramine HCL Naproxen Sodium Diphenhydramine HCL	Walmart	ANDA213663

Drugs@FDA Applications#

Application, NDC, Name table
Application	NDC	Name	Marketing category	Labeler
ANDA208499	0113-8264	good sense naproxen sodium diphenhydramine hydrochloride, naproxen sodium	ANDA	L. Perrigo Company
ANDA213663	11673-819	Naproxen Sodium and Diphenhydramine HCL Naproxen Sodium and Diphenhydramine HCL	ANDA	TARGET CORPORATION
ANDA209726	69238-1422	Naproxen Sodium and Diphenhydramine HCl Naproxen Sodium and Diphenhydramine	ANDA	Amneal Pharmaceuticals NY LLC

RxNav Current And Historical NDCs#

RxNav current and historical NDC rows page 1 of 1 · 57 matching rows.

NDC11, Source, Active table
NDC11	Source	Active
00113826400	rxnav_ndcs	yes
00113826406	rxnav_ndcs	yes
00113826458	rxnav_ndcs	yes
00113826460	rxnav_ndcs	yes
00113826471	rxnav_ndcs	yes
00363084480	rxnav_ndcs	yes
00363226427	rxnav_ndcs	yes
00363226480	rxnav_ndcs	yes
11673068727	rxnav_ndcs	yes
11673081908	rxnav_ndcs	yes
21130063971	rxnav_ndcs	yes
21130081405	rxnav_ndcs	yes
30142075327	rxnav_ndcs	yes
36800026427	rxnav_ndcs	yes
36800026460	rxnav_ndcs	yes
37808026427	rxnav_ndcs	yes
37808026460	rxnav_ndcs	yes
41163059358	rxnav_ndcs	yes
41163059371	rxnav_ndcs	yes
41250052627	rxnav_ndcs	yes
41250052660	rxnav_ndcs	yes
41520026427	rxnav_ndcs	yes
41520026460	rxnav_ndcs	yes
55910085827	rxnav_ndcs	yes
55910085858	rxnav_ndcs	yes
55910085860	rxnav_ndcs	yes
62207081438	rxnav_ndcs	yes
62207081439	rxnav_ndcs	yes
62207081447	rxnav_ndcs	yes
62207081495	rxnav_ndcs	yes
69238142202	rxnav_ndcs	yes
69238142204	rxnav_ndcs	yes
69238142206	rxnav_ndcs	yes
69238142208	rxnav_ndcs	yes
69842032802	rxnav_ndcs	yes
69842032808	rxnav_ndcs	yes
70677006401	rxnav_ndcs	yes
72288031006	rxnav_ndcs	yes
79903020420	rxnav_ndcs	yes
00113726406	rxnav_historical
00363976608	rxnav_historical
11822067024	rxnav_historical
11822067026	rxnav_historical
21130080858	rxnav_historical
21130080871	rxnav_historical
30142038360	rxnav_historical
45963022012	rxnav_historical
45963022020	rxnav_historical
45963022023	rxnav_historical
45963022024	rxnav_historical
45963022040	rxnav_historical
49035072760	rxnav_historical
55315084420	rxnav_historical
55910085420	rxnav_historical
55910085440	rxnav_historical
62011039601	rxnav_historical
63868041120	rxnav_historical

UNII Substances#

UNII substance links page 1 of 1 · 0 matching rows.

No records found.

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 19 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
naproxen sodium pm	DIPHENHYDRAMINE HYDROCHLORIDE, NAPROXEN SODIUM	Meijer Distribution Inc	34d635f8-9703-4c29-92a5-85d3b47c4c93	2026-07-07	Warnings	Exact identifier ndc (package): 41250-526-27 ndc (product): 41250-526 ndc11 (package): 41250052660 ndc11 (package): 41250052627 rxcui: 1550957
good sense naproxen sodium	DIPHENHYDRAMINE HYDROCHLORIDE, NAPROXEN SODIUM	L. Perrigo Company	f548aa3d-b35e-458a-9815-3595a451ab78	2026-05-11	Warnings	Exact identifier ndc (package): 0113-8264-06 ndc (package): 0113-8264-71 ndc (package): 0113-8264-60 ndc (product): 0113-8264 ndc11 (package): 00113826471 ndc11 (package): 00113826400 ndc11 (package): 00113826406 ndc11 (package): 00113826458 ndc11 (package): 00113826460 rxcui: 1550957
ALL NIGHT PAIN RELIEF PM	DIPHENHYDRAMINE HYDROCHLORIDE, NAPROXEN SODIUM	Walgreen Company	43e4ed28-b1be-4548-86ac-f40f9f83f04e	2026-04-27	Warnings	Exact identifier ndc (package): 0363-2264-27 ndc (product): 0363-2264 ndc11 (package): 00363226480 ndc11 (package): 00363226427 rxcui: 1550957
naproxen sodium pm	DIPHENHYDRAMINE HYDROCHLORIDE, NAPROXEN SODIUM	H E B	4281faf5-7182-404f-9f53-3d9ea0354a18	2026-02-12	Warnings	Exact identifier ndc (package): 37808-264-27 ndc (package): 37808-264-60 ndc (product): 37808-264 ndc11 (package): 37808026460 ndc11 (package): 37808026427 rxcui: 1550957
Naproxen Sodium Diphenhydramine HCL	NAPROXEN SODIUM DIPHENHYDRAMINE HCL	Walmart	fe810c0e-ab42-5a8a-e053-6394a90affe4	2025-12-19	Warnings	Exact identifier ndc (package): 79903-204-20 ndc (product): 79903-204 ndc11 (package): 79903020420 rxcui: 1550957
Naproxen Sodium and Diphenhydramine HCL	NAPROXEN SODIUM AND DIPHENHYDRAMINE HCL	TARGET CORPORATION	fe82699d-fdc2-038e-e053-6294a90a606c	2025-12-19	Warnings	Exact identifier ndc (package): 11673-819-08 ndc (product): 11673-819 ndc11 (package): 11673081908 rxcui: 1550957
Naproxen Sodium Diphenhydramine HCl	NAPROXEN SODIUM DIPHENHYDRAMINE HCL	CVS PHARMACY, INC	bdac694e-ab2a-376d-e053-2a95a90a9467	2025-12-19	Warnings	Exact identifier ndc (package): 69842-328-02 ndc (product): 69842-328 ndc11 (package): 69842032808 ndc11 (package): 69842032802 rxcui: 1550957
Naproxen Sodium Diphenhydramine Hydrochloride	NAPROXEN SODIUM DIPHENHYDRAMINE HYDROCHLORIDE	SAFEWAY	ed0f3275-f156-13a3-e053-2a95a90a2ce8	2025-12-18	Warnings	Exact identifier ndc (package): 21130-814-05 ndc (product): 21130-814 ndc11 (package): 21130081405 rxcui: 1550957
topcare all night pain relief pm	DIPHENHYDRAMINE HYDROCHLORIDE, NAPROXEN SODIUM	Topco Associates LLC	a20f193e-4e64-400a-b605-df08026cb80b	2025-12-11	Warnings	Exact identifier ndc (package): 36800-264-27 ndc (package): 36800-264-60 ndc (product): 36800-264 ndc11 (package): 36800026427 ndc11 (package): 36800026460 rxcui: 1550957
Aleve PM	DIPHENHYDRAMINE HYDROCHLORIDE AND NAPROXEN SODIUM	Bayer HealthCare LLC.	82891458-ab0d-459a-8602-dcebd22c3010	2025-12-04	Warnings	Exact identifier rxcui: 1550957
up and up naproxen sodium pm	DIPHENHYDRAMINE HYDROCHLORIDE, NAPROXEN SODIUM	Target Corporation	c0769941-bcf2-4237-b70c-a79089ad5335	2025-11-05	Warnings	Exact identifier ndc (package): 11673-687-27 ndc (product): 11673-687 ndc11 (package): 11673068727 rxcui: 1550957
dg health naproxen sodium pm	DIPHENHYDRAMINE HYDROCHLORIDE, NAPROXEN SODIUM	Dolgencorp Inc	6c2c087c-e36d-4971-b977-d3cab6d6edee	2025-11-05	Warnings	Exact identifier ndc (package): 55910-858-27 ndc (product): 55910-858 ndc11 (package): 55910085860 ndc11 (package): 55910085827 ndc11 (package): 55910085858 rxcui: 1550957
Naproxen Sodium PM	NAPROXEN SODIUM	Strategic Sourcing Services LLC	03a331d8-c957-4949-894f-51d9bd15e0d0	2025-08-20	Warnings	Exact identifier ndc (package): 70677-0064-1 ndc (product): 70677-0064 ndc11 (package): 70677006401 rxcui: 1550957
naproxen sodium pm	DIPHENHYDRAMINE HYDROCHLORIDE, NAPROXEN SODIUM	Kroger Company	d5dafdd0-968d-4ee6-9461-1f72d3255240	2025-07-10	Warnings	Exact identifier ndc (package): 30142-753-27 ndc (product): 30142-753 ndc11 (package): 30142075327 rxcui: 1550957
NAPROXEN SODIUM PM	DIPHENHYDRAMINE HYDROCHLORIDE, NAPROXEN SODIUM	Safeway	60cb7b6e-f2d2-48ca-8db7-7124717735d5	2025-07-09	Warnings	Exact identifier ndc (package): 21130-639-71 ndc (product): 21130-639 ndc11 (package): 21130063971 rxcui: 1550957
equaline naproxen sodium pm	DIPHENHYDRAMINE HYDROCHLORIDE, NAPROXEN SODIUM	United Natural Foods, Inc. dba UNFI	ed7bfa3f-4972-4ab6-9f0c-0873a11571a9	2025-06-04	Warnings	Exact identifier ndc (package): 41163-593-71 ndc (product): 41163-593 ndc11 (package): 41163059371 ndc11 (package): 41163059358 rxcui: 1550957
basic care naproxen sodium pm	DIPHENHYDRAMINE HYDROCHLORIDE, NAPROXEN SODIUM	Amazon.com Services LLC	7beed9e7-816b-494b-93fa-9caf10aa3834	2024-01-24	Warnings	Exact identifier ndc (package): 72288-310-06 ndc (product): 72288-310 ndc11 (package): 72288031006 rxcui: 1550957
Naproxen Sodium and Diphenhydramine HCl	NAPROXEN SODIUM AND DIPHENHYDRAMINE	Amneal Pharmaceuticals NY LLC	caca14cf-95f2-4c60-8bba-2154b8f353a3	2023-12-30	Warnings	Exact identifier ndc (package): 69238-1422-2 ndc (package): 69238-1422-6 ndc (package): 69238-1422-8 ndc (package): 69238-1422-4 ndc (product): 69238-1422 ndc11 (package): 69238142204 ndc11 (package): 69238142206 ndc11 (package): 69238142202 ndc11 (package): 69238142208 rxcui: 1550957
careone naproxen sodium pm	DIPHENHYDRAMINE HYDROCHLORIDE, NAPROXEN SODIUM	American Sales Company	16547905-59c0-4936-82e1-2d9f5935d8dd	2023-12-11	Warnings	Exact identifier ndc (package): 41520-264-60 ndc (package): 41520-264-27 ndc (product): 41520-264 ndc11 (package): 41520026460 ndc11 (package): 41520026427 rxcui: 1550957

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

DailyMed RxNorm Mappings#

unique DailyMed labels mapped to this RxNorm concept page 1 of 1 · 22 matching rows.

Set ID, RxNorm mappings, Terms table
Set ID	RxNorm mappings	Terms	SPL version	Label	Effective
82891458-ab0d-459a-8602-dcebd22c3010	diphenhydrAMINE HCl 25 MG / naproxen sodium 220 MG Oral Tablet [PSN] · diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet [SCD]	2	16	Aleve ® PM	20251204
f548aa3d-b35e-458a-9815-3595a451ab78	diphenhydrAMINE HCl 25 MG / naproxen sodium 220 MG Oral Tablet [PSN] · diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet [SCD]	2	7	Perrigo Naproxen Sodium PM Drug Facts	20260511
bdac694e-ab2a-376d-e053-2a95a90a9467	diphenhydrAMINE HCl 25 MG / naproxen sodium 220 MG Oral Tablet [PSN] · diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet [SCD]	2	7	NAPROXEN SODIUM PM Naproxen Sodium & Diphenhydramine HCl Tablets 220mg/25mg (NSAID) Pain Reliever/Nighttime sleep aid Sleep aid plus 12 hours pain relieving	20251219
fe810c0e-ab42-5a8a-e053-6394a90affe4	diphenhydrAMINE HCl 25 MG / naproxen sodium 220 MG Oral Tablet [PSN] · diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet [SCD]	2	6	All Night Pain Relief Naproxen Sodium and Diphenhydramine HCL Tablets, 220mg/25mg (NSAID) Pain Reliever/Nightitme Sleep-aid Sleep Aid plus 12-hours pain relieving	20251219
fe82699d-fdc2-038e-e053-6294a90a606c	diphenhydrAMINE HCl 25 MG / naproxen sodium 220 MG Oral Tablet [PSN] · diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet [SCD]	2	6	Naproxen Sodium PM 220mg Naproxen Sodium/ 25mg Diphenhydramine HCL Tablets Pain reliever (NSAID)/Nighttime sleep-aid Sleep aid plus 12 hours pain relieving	20251219
a20f193e-4e64-400a-b605-df08026cb80b	diphenhydrAMINE HCl 25 MG / naproxen sodium 220 MG Oral Tablet [PSN] · diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet [SCD]	2	6	Topco Associates LLC. All Night Pain Relief PM Drug Facts	20251211
ed7bfa3f-4972-4ab6-9f0c-0873a11571a9	diphenhydrAMINE HCl 25 MG / naproxen sodium 220 MG Oral Tablet [PSN] · diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet [SCD]	2	6	SuperValu Inc. Naproxen Sodium PM Drug Facts	20250604
caca14cf-95f2-4c60-8bba-2154b8f353a3	diphenhydrAMINE HCl 25 MG / naproxen sodium 220 MG Oral Tablet [PSN] · diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet [SCD]	2	6	Naproxen Sodium and Diphenhydramine HCl Tablets	20231230
4281faf5-7182-404f-9f53-3d9ea0354a18	diphenhydrAMINE HCl 25 MG / naproxen sodium 220 MG Oral Tablet [PSN] · diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet [SCD]	2	5	HEB Naproxen Sodium PM Drug Facts	20260212
ed0f3275-f156-13a3-e053-2a95a90a2ce8	diphenhydrAMINE HCl 25 MG / naproxen sodium 220 MG Oral Tablet [PSN] · diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet [SCD]	2	5	Pain Relief PM Naproxen Sodium and Diphenhydramine HCL Tablets 220mg/25mg (NSAID)** Pain Reliever/Nighttime sleep-aid SLEEP AID PLUS 12 HOURS PAIN RELIEVING	20251218
0d59780a-ef22-4b67-8b42-9795dbec8db0	diphenhydrAMINE HCl 25 MG / naproxen sodium 220 MG Oral Tablet [PSN] · diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet [SCD]	2	5	Naproxen Sodium and Diphenhydramaine HCl Tablets	20250801
6c2c087c-e36d-4971-b977-d3cab6d6edee	diphenhydrAMINE HCl 25 MG / naproxen sodium 220 MG Oral Tablet [PSN] · diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet [SCD]	2	4	Dolgencorp, LLC Naproxen Sodium PM Drug Facts	20251105
c0769941-bcf2-4237-b70c-a79089ad5335	diphenhydrAMINE HCl 25 MG / naproxen sodium 220 MG Oral Tablet [PSN] · diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet [SCD]	2	4	Target Corporation Naproxen Sodium PM Drug Facts	20251105
03a331d8-c957-4949-894f-51d9bd15e0d0	diphenhydrAMINE HCl 25 MG / naproxen sodium 220 MG Oral Tablet [PSN] · diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet [SCD]	2	4	Drug Facts	20250820
7aadfdd4-f8f5-4b7a-a388-1889c3d7d8ba	diphenhydrAMINE HCl 25 MG / naproxen sodium 220 MG Oral Tablet [PSN] · diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet [SCD]	2	4	Drug Facts	20250820
d5dafdd0-968d-4ee6-9461-1f72d3255240	diphenhydrAMINE HCl 25 MG / naproxen sodium 220 MG Oral Tablet [PSN] · diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet [SCD]	2	4	Kroger Co. Naproxen Sodium PM Drug Facts	20250710
16547905-59c0-4936-82e1-2d9f5935d8dd	diphenhydrAMINE HCl 25 MG / naproxen sodium 220 MG Oral Tablet [PSN] · diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet [SCD]	2	4	American Sales Company Naproxen Sodium PM Drug Facts	20231211
34d635f8-9703-4c29-92a5-85d3b47c4c93	diphenhydrAMINE HCl 25 MG / naproxen sodium 220 MG Oral Tablet [PSN] · diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet [SCD]	2	4	Meijer Distribution, Inc. Naproxen Sodium PM Drug Facts	20231115
4d27516d-7d84-485d-af1d-9c20c0702e85	diphenhydrAMINE HCl 25 MG / naproxen sodium 220 MG Oral Tablet [PSN] · diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet [SCD]	2	4	Kroger Co. Naproxen Sodium PM Drug Facts	20231115
7beed9e7-816b-494b-93fa-9caf10aa3834	diphenhydrAMINE HCl 25 MG / naproxen sodium 220 MG Oral Tablet [PSN] · diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet [SCD]	2	3	Amazon Naproxen Sodium Pm Drug Facts	20240124
43e4ed28-b1be-4548-86ac-f40f9f83f04e	diphenhydrAMINE HCl 25 MG / naproxen sodium 220 MG Oral Tablet [PSN] · diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet [SCD]	2	2	Walgreen Co. All Night Pain Relief PM Drug Facts	20260427
60cb7b6e-f2d2-48ca-8db7-7124717735d5	diphenhydrAMINE HCl 25 MG / naproxen sodium 220 MG Oral Tablet [PSN] · diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet [SCD]	2	2	Better Living Brands LLC NAPROXEN SODIUM PM Drug Facts	20250709

Recently Linked DailyMed Labels#

Set ID, Title, Manufacturer table
Set ID	Title	Manufacturer	Effective
0d59780a-ef22-4b67-8b42-9795dbec8db0	Naproxen Sodium and Diphenhydramaine HCl Tablets	Granules India Ltd	20261007
34d635f8-9703-4c29-92a5-85d3b47c4c93	Meijer Distribution, Inc. Naproxen Sodium PM Drug Facts	Meijer Distribution Inc	20260707
f548aa3d-b35e-458a-9815-3595a451ab78	Perrigo Naproxen Sodium PM Drug Facts	L. Perrigo Company	20260511
43e4ed28-b1be-4548-86ac-f40f9f83f04e	Walgreen Co. All Night Pain Relief PM Drug Facts	Walgreen Company	20260427
4281faf5-7182-404f-9f53-3d9ea0354a18	HEB Naproxen Sodium PM Drug Facts	H E B	20260212
bdac694e-ab2a-376d-e053-2a95a90a9467	NAPROXEN SODIUM PM Naproxen Sodium & Diphenhydramine HCl Tablets 220mg/25mg (NSAID) Pain Reliever/Nighttime sleep aid Sleep aid plus 12 hours pain relieving	CVS PHARMACY, INC	20251219
fe82699d-fdc2-038e-e053-6294a90a606c	Naproxen Sodium PM 220mg Naproxen Sodium/ 25mg Diphenhydramine HCL Tablets Pain reliever (NSAID)/Nighttime sleep-aid Sleep aid plus 12 hours pain relieving	TARGET CORPORATION	20251219
fe810c0e-ab42-5a8a-e053-6394a90affe4	All Night Pain Relief Naproxen Sodium and Diphenhydramine HCL Tablets, 220mg/25mg (NSAID) Pain Reliever/Nightitme Sleep-aid Sleep Aid plus 12-hours pain relieving	Walmart	20251219
ed0f3275-f156-13a3-e053-2a95a90a2ce8	Pain Relief PM Naproxen Sodium and Diphenhydramine HCL Tablets 220mg/25mg (NSAID)** Pain Reliever/Nighttime sleep-aid SLEEP AID PLUS 12 HOURS PAIN RELIEVING	SAFEWAY	20251218
fe82699d-fdc2-038e-e053-6294a90a606c	Naproxen Sodium PM 220mg Naproxen Sodium/ 25mg Diphenhydramine HCL Tablets Pain reliever (NSAID)/Nighttime sleep-aid Sleep aid plus 12 hours pain relieving	TARGET CORPORATION	20251212
a20f193e-4e64-400a-b605-df08026cb80b	Topco Associates LLC. All Night Pain Relief PM Drug Facts	Topco Associates LLC	20251211
bdac694e-ab2a-376d-e053-2a95a90a9467	NAPROXEN SODIUM PM Naproxen Sodium & Diphenhydramine HCl Tablets 220mg/25mg (NSAID) Pain Reliever/Nighttime sleep aid Sleep aid plus 12 hours pain relieving	CVS PHARMACY, INC	20251211
c0769941-bcf2-4237-b70c-a79089ad5335	Target Corporation Naproxen Sodium PM Drug Facts	Target Corporation	20251105
6c2c087c-e36d-4971-b977-d3cab6d6edee	Dolgencorp, LLC Naproxen Sodium PM Drug Facts	Dolgencorp Inc	20251105
f548aa3d-b35e-458a-9815-3595a451ab78	Perrigo Naproxen Sodium PM Drug Facts	L. Perrigo Company	20250827
03a331d8-c957-4949-894f-51d9bd15e0d0	Drug Facts	Strategic Sourcing Services LLC	20250820
7aadfdd4-f8f5-4b7a-a388-1889c3d7d8ba	Drug Facts	Strategic Sourcing Services LLC	20250820
0d59780a-ef22-4b67-8b42-9795dbec8db0	Naproxen Sodium and Diphenhydramaine HCl Tablets	Granules India Ltd	20250801
d5dafdd0-968d-4ee6-9461-1f72d3255240	Kroger Co. Naproxen Sodium PM Drug Facts	Kroger Company	20250710
60cb7b6e-f2d2-48ca-8db7-7124717735d5	Better Living Brands LLC NAPROXEN SODIUM PM Drug Facts	Safeway	20250709
ed7bfa3f-4972-4ab6-9f0c-0873a11571a9	SuperValu Inc. Naproxen Sodium PM Drug Facts	United Natural Foods, Inc. dba UNFI	20250604
12ab219a-051c-4e54-98e1-32cb3689586e	Drug Facts	Walgreens	20250507
ae48d1aa-2528-4e66-ad78-f2f10df42325	Better Living Brands LLC Naproxen Sodium PM Drug Facts	Safeway	20250204
2a766b70-e845-42bd-afb6-b4040ed334b0	Wal-Mart All Night Pain Relief Drug Facts	Wal-Mart Stores Inc	20240905
6c2c087c-e36d-4971-b977-d3cab6d6edee	Dolgencorp, LLC Naproxen Sodium PM Drug Facts	Dolgencorp Inc	20240307
bf8ff5f8-ac9e-5fe7-e053-2995a90a0e74	NAPROXEN SODIUM PM Naproxen Sodium & Diphenhydramine HCl Tablets 220mg/25mg (NSAID) Pain Reliever/Nighttime sleep aid Sleep aid plus 12 hours pain relieving	WALGREEN CO.	20240131
7beed9e7-816b-494b-93fa-9caf10aa3834	Amazon Naproxen Sodium Pm Drug Facts	Amazon.com Services LLC	20240124
caca14cf-95f2-4c60-8bba-2154b8f353a3	Naproxen Sodium and Diphenhydramine HCl Tablets	Amneal Pharmaceuticals NY LLC \| Amneal Pharmaceuticals Private Limited	20231230
16547905-59c0-4936-82e1-2d9f5935d8dd	American Sales Company Naproxen Sodium PM Drug Facts	American Sales Company	20231211
326d9260-6bb9-46fd-bafc-5235c2c025b0	Drug Facts	Freds Inc	20231128
4d27516d-7d84-485d-af1d-9c20c0702e85	Kroger Co. Naproxen Sodium PM Drug Facts	Kroger Company	20231115
34d635f8-9703-4c29-92a5-85d3b47c4c93	Meijer Distribution, Inc. Naproxen Sodium PM Drug Facts	Meijer Distribution Inc	20231115
c0769941-bcf2-4237-b70c-a79089ad5335	Target Corporation Naproxen Sodium PM Drug Facts	Target Corporation	20230928
f58c4937-3310-4651-83f3-66fe423742a2	Drug Facts	QUALITY CHOICE (Chain Drug Marketing Association)	20230504
a16d1925-c01e-4a00-ba01-e9d699b65e7d	Drug Facts	Dolgencorp, Inc. (DOLLAR GENERAL & REXALL)	20221202
6431fba1-429b-43ab-9ac1-3e8d1669bffd	Amazon Naproxen Sodium PM Drug Facts	L. Perrigo Company	20200113
a7fa26f0-11df-4ddd-ae93-bf640372318b	Naproxen Sodium and Diphenhydramine Hydrochloride Tablets	Actavis Pharma, Inc.	20191202

Drug Classes#

Source, Class ID, Class table
Source	Class ID	Class	Type	Relationship	Drug concept
ATC	R06AA	Aminoalkyl ethers	ATC1-4		diphenhydramine
ATC	D04AA	Antihistamines for topical use	ATC1-4		diphenhydramine
ATC	M02AA	Antiinflammatory preparations, non-steroids for topical use	ATC1-4		naproxen
ATC	G02CC	Antiinflammatory products for vaginal administration	ATC1-4		naproxen
ATC	M01AE	Propionic acid derivatives	ATC1-4		diphenhydramine / naproxen
ATC	M01AE	Propionic acid derivatives	ATC1-4		naproxen
FDASPL	N0000175587	Histamine-1 Receptor Antagonist	EPC	has_epc	diphenhydramine
FDASPL	N0000175722	Nonsteroidal Anti-inflammatory Drug	EPC	has_epc	naproxen
FDASPL	N0000000160	Cyclooxygenase Inhibitors	MOA	has_moa	naproxen
FDASPL	N0000000190	Histamine H1 Receptor Antagonists	MOA	has_moa	diphenhydramine
MEDRT	D004155	Diphenhydramine	CHEM	has_ingredient	diphenhydramine hydrochloride
MEDRT	D004155	Diphenhydramine	CHEM	has_ingredient	diphenhydramine
MEDRT	D009288	Naproxen	CHEM	has_ingredient	naproxen
MEDRT	D009288	Naproxen	CHEM	has_ingredient	naproxen sodium
MEDRT	D001008	Anxiety Disorders	DISEASE	may_treat	diphenhydramine
MEDRT	D001008	Anxiety Disorders	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D001171	Arthritis, Juvenile	DISEASE	may_treat	naproxen
MEDRT	D001171	Arthritis, Juvenile	DISEASE	may_treat	naproxen sodium
MEDRT	D001172	Arthritis, Rheumatoid	DISEASE	may_treat	naproxen sodium
MEDRT	D001172	Arthritis, Rheumatoid	DISEASE	may_treat	naproxen
MEDRT	D001416	Back Pain	DISEASE	may_treat	naproxen sodium
MEDRT	D001416	Back Pain	DISEASE	may_treat	naproxen
MEDRT	D002062	Bursitis	DISEASE	may_treat	naproxen
MEDRT	D002062	Bursitis	DISEASE	may_treat	naproxen sodium
MEDRT	D003139	Common Cold	DISEASE	may_treat	naproxen sodium
MEDRT	D003139	Common Cold	DISEASE	may_treat	naproxen
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	diphenhydramine hydrochloride
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	naproxen sodium
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	naproxen
MEDRT	D004342	Drug Hypersensitivity	DISEASE	ci_with	diphenhydramine
MEDRT	D004412	Dysmenorrhea	DISEASE	may_treat	naproxen sodium
MEDRT	D004412	Dysmenorrhea	DISEASE	may_treat	naproxen
MEDRT	D005334	Fever	DISEASE	may_treat	naproxen sodium
MEDRT	D005334	Fever	DISEASE	may_treat	naproxen
MEDRT	D006073	Gout	DISEASE	may_treat	naproxen sodium
MEDRT	D006073	Gout	DISEASE	may_treat	naproxen
MEDRT	D006261	Headache	DISEASE	may_treat	naproxen
MEDRT	D006261	Headache	DISEASE	may_treat	naproxen sodium
MEDRT	D007231	Infant, Newborn	DISEASE	ci_with	diphenhydramine
MEDRT	D007231	Infant, Newborn	DISEASE	ci_with	diphenhydramine hydrochloride
MEDRT	D007234	Infant, Premature	DISEASE	ci_with	diphenhydramine hydrochloride
MEDRT	D007234	Infant, Premature	DISEASE	ci_with	diphenhydramine
MEDRT	D007249	Inflammation	DISEASE	may_treat	naproxen
MEDRT	D007249	Inflammation	DISEASE	may_treat	naproxen sodium
MEDRT	D007774	Lactation	DISEASE	ci_with	diphenhydramine hydrochloride
MEDRT	D007774	Lactation	DISEASE	ci_with	diphenhydramine
MEDRT	D009041	Motion Sickness	DISEASE	may_treat	diphenhydramine
MEDRT	D009041	Motion Sickness	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D009325	Nausea	DISEASE	may_treat	diphenhydramine
MEDRT	D009325	Nausea	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D010003	Osteoarthritis	DISEASE	may_treat	naproxen sodium
MEDRT	D010003	Osteoarthritis	DISEASE	may_treat	naproxen
MEDRT	D010146	Pain	DISEASE	may_prevent	naproxen sodium
MEDRT	D010146	Pain	DISEASE	may_prevent	naproxen
MEDRT	D011263	Pregnancy Trimester, Third	DISEASE	ci_with	naproxen
MEDRT	D011263	Pregnancy Trimester, Third	DISEASE	ci_with	naproxen sodium
MEDRT	D012221	Rhinitis, Allergic, Perennial	DISEASE	may_treat	diphenhydramine
MEDRT	D012221	Rhinitis, Allergic, Perennial	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D007319	Sleep Initiation and Maintenance Disorders	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D007319	Sleep Initiation and Maintenance Disorders	DISEASE	may_treat	diphenhydramine
MEDRT	D012912	Sneezing	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	D012912	Sneezing	DISEASE	may_treat	diphenhydramine
MEDRT	D013167	Spondylitis, Ankylosing	DISEASE	may_treat	naproxen
MEDRT	D013167	Spondylitis, Ankylosing	DISEASE	may_treat	naproxen sodium
MEDRT	D013224	Status Asthmaticus	DISEASE	ci_with	diphenhydramine hydrochloride
MEDRT	D013224	Status Asthmaticus	DISEASE	ci_with	diphenhydramine
MEDRT	D014098	Toothache	DISEASE	may_treat	naproxen
MEDRT	D014098	Toothache	DISEASE	may_treat	naproxen sodium
MEDRT	D014581	Urticaria	DISEASE	may_treat	diphenhydramine
MEDRT	D014581	Urticaria	DISEASE	may_treat	diphenhydramine hydrochloride
MEDRT	N0000000160	Cyclooxygenase Inhibitors	MOA	has_moa	naproxen sodium
MEDRT	N0000000160	Cyclooxygenase Inhibitors	MOA	has_moa	naproxen
MEDRT	N0000000190	Histamine H1 Receptor Antagonists	MOA	has_moa	diphenhydramine
MEDRT	N0000000190	Histamine H1 Receptor Antagonists	MOA	has_moa	diphenhydramine hydrochloride
MEDRT	N0000008831	Decreased Platelet Activating Factor Production	PE	has_pe	naproxen sodium
MEDRT	N0000008831	Decreased Platelet Activating Factor Production	PE	has_pe	naproxen
MEDRT	N0000008836	Decreased Prostaglandin Production	PE	has_pe	naproxen sodium
MEDRT	N0000008836	Decreased Prostaglandin Production	PE	has_pe	naproxen
MEDRT	N0000009006	Decreased Thromboxane Production	PE	has_pe	naproxen sodium
MEDRT	N0000009006	Decreased Thromboxane Production	PE	has_pe	naproxen
MEDRT	N0000000042	Renal Excretion	PK	has_pk	naproxen
MEDRT	N0000000042	Renal Excretion	PK	has_pk	naproxen sodium

Group, Type, Concept table
Group	Type	Concept	Source
BN	BN	Aleve PM	rxnav_allrelated
DF	DF	Oral Tablet	rxnav_allrelated
DFG	DFG	Oral Product	rxnav_allrelated
DFG	DFG	Pill	rxnav_allrelated
IN	IN	diphenhydramine	rxnav_allrelated
IN	IN	naproxen	rxnav_allrelated
MIN	MIN	diphenhydramine / naproxen	rxnav_allrelated
PIN	PIN	diphenhydramine hydrochloride	rxnav_allrelated
PIN	PIN	naproxen sodium	rxnav_allrelated
SBD	SBD	diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet [Aleve PM]	rxnav_allrelated
SBDC	SBDC	diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG [Aleve PM]	rxnav_allrelated
SBDF	SBDF	diphenhydramine / naproxen Oral Tablet [Aleve PM]	rxnav_allrelated
SBDFP	SBDFP	diphenhydramine hydrochloride / naproxen sodium Oral Tablet [Aleve PM]	rxnav_allrelated
SBDG	SBDG	Aleve PM Oral Product	rxnav_allrelated
SBDG	SBDG	Aleve PM Pill	rxnav_allrelated
SCD	SCD	diphenhydramine hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet	rxnav_allrelated
SCDC	SCDC	diphenhydramine hydrochloride 25 MG	rxnav_allrelated
SCDC	SCDC	naproxen sodium 220 MG	rxnav_allrelated
SCDF	SCDF	diphenhydramine / naproxen Oral Tablet	rxnav_allrelated
SCDFP	SCDFP	diphenhydramine hydrochloride / naproxen sodium Oral Tablet	rxnav_allrelated
SCDG	SCDG	diphenhydramine / naproxen Oral Product	rxnav_allrelated
SCDG	SCDG	diphenhydramine / naproxen Pill	rxnav_allrelated
SCDGP	SCDGP	diphenhydramine hydrochloride / naproxen sodium Oral Product	rxnav_allrelated
SCDGP	SCDGP	diphenhydramine hydrochloride / naproxen sodium Pill	rxnav_allrelated

Properties#

Category, Property, Value table
Category	Property	Value
ATTRIBUTES	AVAILABLE_STRENGTH	25 MG / 220 MG
ATTRIBUTES	GENERAL_CARDINALITY	MULTI
ATTRIBUTES	HUMAN_DRUG	US
ATTRIBUTES	RXNAV_HUMAN_DRUG	US
ATTRIBUTES	SCHEDULE	0
CODES	ANDA	ANDA208499
CODES	ANDA	ANDA209726
CODES	ANDA	ANDA213663
CODES	VUID	4034092
NAMES	Prescribable Synonym	diphenhydrAMINE HCl 25 MG / naproxen sodium 220 MG Oral Tablet
NAMES	Tallman Synonym	diphenhydrAMINE hydrochloride 25 MG / naproxen sodium 220 MG Oral Tablet
SOURCES	Source	Gold Standard Alchemy
SOURCES	Source	Metathesaurus FDA Structured Product Labels
SOURCES	Source	Micromedex RED BOOK
SOURCES	Source	Multum MediSource Lexicon
SOURCES	Source	National Drug Data File Plus Source Vocabulary
SOURCES	Source	Veterans Health Administration National Drug File