{1 (aspirin 325 MG / dextromethorphan hydrobromide 10 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) / 1 (aspirin 500 MG / dextromethorphan hydrobromide 10 MG / doxylamine succinate 6.25 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) } Pack
- RxCUI
- 1730187
- RxNorm name
- {1 (aspirin 325 MG / dextromethorphan hydrobromide 10 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) / 1 (aspirin 500 MG / dextromethorphan hydrobromide 10 MG / doxylamine succinate 6.25 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) } Pack
- Display name
- Aspirin/Dextromethorphan/Doxylamine/Phenylephrine (Pack)
- Full name
- {1 (aspirin 325 MG / dextromethorphan hydrobromide 10 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) / 1 (aspirin 500 MG / dextromethorphan hydrobromide 10 MG / doxylamine succinate 6.25 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) } Pack
- Term type
- GPCK
- Status
- Active
- Strength
- mixed
- Dose form
- Pack
- Route
- Pack
- Updated
- 2026-10-21 00:31:01
RxNorm Status History#
- Status
- Active
- Source
- RXNORM
- Current
- YES
- Release start
- 022016
- Active start
- 022016
- Multiple ingredient
- YES
- Branded
- NO
Ingredients And Strength#
| Ingredient | Strength | Base | Basis of strength |
|---|---|---|---|
| aspirin | 325 MG / 1 EACH | aspirin | aspirin |
| aspirin | 500 MG / 1 EACH | aspirin | aspirin |
| dextromethorphan hydrobromide | 10 MG / 1 EACH | dextromethorphan | dextromethorphan hydrobromide |
| doxylamine succinate | 6.25 MG / 1 EACH | doxylamine | doxylamine succinate |
| phenylephrine bitartrate | 7.8 MG / 1 EACH | phenylephrine | phenylephrine bitartrate |
Dose Form Concepts#
| Dose form | RxCUI |
|---|---|
| Pack | 746839 |
Derived Ingredient Concepts#
| Ingredient | RxCUI |
|---|---|
| aspirin | 1191 |
| dextromethorphan | 3289 |
| doxylamine | 3642 |
| phenylephrine | 8163 |
Source Vocabulary Codes#
FDA NDC Products And Packages#
| Package NDC | Product NDC | Name | Labeler | Application |
|---|---|---|---|---|
| 0280-0025-01 | 0280-0025 | Alka-Seltzer Plus Severe Cold PowerFast Fizz aspirin, dextromethorphan hydrobromide, phenylephrine bitartrate, doxylamine succinate | Bayer HealthCare LLC. | M012 |
| 0280-1550-20 | 0280-1550 | Alka-Seltzer Plus Cold Day and Night Aspirin, Dextromethorphan hydrobromide, Phenylephrine bitartrate, Doxylamine succinate | Bayer HealthCare LLC. | M012 |
Drugs@FDA Applications#
UNII Substances#
No records found.
openFDA label cross-check#
OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.
| Brand | Generic | Manufacturer | SPL set ID | Effective date | Available safety fields | Join |
|---|---|---|---|---|---|---|
| Alka-Seltzer Plus Severe Cold PowerFast Fizz | ASPIRIN, DEXTROMETHORPHAN HYDROBROMIDE, PHENYLEPHRINE BITARTRATE, DOXYLAMINE SUCCINATE | Bayer HealthCare LLC. | a37c9d9d-52db-23ff-e053-2995a90a8f76 | 2025-12-04 | Warnings | 0280-0025-01 0280-0025 00280002501 1730187 |
| Alka-Seltzer Plus Cold Day and Night | ASPIRIN, DEXTROMETHORPHAN HYDROBROMIDE, PHENYLEPHRINE BITARTRATE, DOXYLAMINE SUCCINATE | Bayer HealthCare LLC. | 75894849-a0ba-57be-e053-2a91aa0a049a | 2025-12-04 | Warnings | 0280-1550-20 0280-1550 00280155020 1730187 |
Reported adverse events (FAERS/openFDA)#
Adverse event summaries are temporarily unavailable. Other product information remains available.
DailyMed RxNorm Mappings#
| Set ID | RxNorm mappings | Terms | SPL version | Label | Effective |
|---|---|---|---|---|---|
| 75894849-a0ba-57be-e053-2a91aa0a049a | {1 (aspirin 325 MG / dextromethorphan hydrobromide 10 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) / 1 (aspirin 500 MG / dextromethorphan hydrobromide 10 MG / doxylamine succinate 6.25 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) } Pack [GPCK] · 1 daytime (aspirin 325 MG / dextromethorphan HBr 10 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) / 1 nighttime (aspirin 500 MG / dextromethorphan HBr 10 MG / doxylamine succinate 6.25 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) Pack [PSN] · 1 daytime (aspirin 325 MG / dextromethorphan HBr 10 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) / 1 nighttime (aspirin 500 MG / dextromethorphan HBr 10 MG / doxylamine succinate 6.25 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) Pack [SY] | 3 | 6 | Alka-Seltzer Plus® Cold Day & Night Effervescent Tablets | 20251204 |
| a37c9d9d-52db-23ff-e053-2995a90a8f76 | {1 (aspirin 325 MG / dextromethorphan hydrobromide 10 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) / 1 (aspirin 500 MG / dextromethorphan hydrobromide 10 MG / doxylamine succinate 6.25 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) } Pack [GPCK] · 1 daytime (aspirin 325 MG / dextromethorphan HBr 10 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) / 1 nighttime (aspirin 500 MG / dextromethorphan HBr 10 MG / doxylamine succinate 6.25 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) Pack [PSN] · 1 daytime (aspirin 325 MG / dextromethorphan HBr 10 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) / 1 nighttime (aspirin 500 MG / dextromethorphan HBr 10 MG / doxylamine succinate 6.25 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) Pack [SY] | 3 | 4 | Alksa-Seltzer Plus Severe Cold PowerFast Fizz Day and Night Effervescent Tablets UI 1614458 & 1614460 | 20251204 |
Recently Linked DailyMed Labels#
| Set ID | Title | Manufacturer | Effective |
|---|---|---|---|
| 75894849-a0ba-57be-e053-2a91aa0a049a | Alka-Seltzer Plus® Cold Day & Night Effervescent Tablets | Bayer HealthCare LLC. | 20251204 |
| a37c9d9d-52db-23ff-e053-2995a90a8f76 | Alksa-Seltzer Plus Severe Cold PowerFast Fizz Day and Night Effervescent Tablets UI 1614458 & 1614460 | Bayer HealthCare LLC. | 20251204 |
| 5319b7c6-1fd1-1ca5-e054-00144ff8d46c | Alka-Seltzer Plus® Multi-Symptom Cold Day & Night Effervescent Tablets | Bayer HealthCare LLC. | 20200220 |
Drug Classes#
| Source | Class ID | Class | Type | Relationship | Drug concept |
|---|---|---|---|---|---|
| ATC | C01CA | Adrenergic and dopaminergic agents | ATC1-4 | phenylephrine | |
| ATC | R06AA | Aminoalkyl ethers | ATC1-4 | doxylamine | |
| ATC | R05DA | Opium alkaloids and derivatives | ATC1-4 | dextromethorphan | |
| ATC | A01AD | Other agents for local oral treatment | ATC1-4 | aspirin | |
| ATC | C05AX | Other agents for treatment of hemorrhoids and anal fissures for topical use | ATC1-4 | phenylephrine | |
| ATC | B01AC | Platelet aggregation inhibitors excl. heparin | ATC1-4 | aspirin | |
| ATC | N02BA | Salicylic acid and derivatives | ATC1-4 | aspirin | |
| ATC | R01BA | Sympathomimetics | ATC1-4 | phenylephrine | |
| ATC | S01FB | Sympathomimetics excl. antiglaucoma preparations | ATC1-4 | phenylephrine | |
| ATC | S01GA | Sympathomimetics used as decongestants | ATC1-4 | phenylephrine | |
| ATC | R01AB | Sympathomimetics, combinations excl. corticosteroids | ATC1-4 | phenylephrine | |
| ATC | R01AA | Sympathomimetics, plain | ATC1-4 | phenylephrine | |
| FDASPL | N0000186105 | alpha-1 Adrenergic Agonist | EPC | has_epc | phenylephrine |
| FDASPL | N0000175750 | Antihistamine | EPC | has_epc | doxylamine |
| FDASPL | N0000175722 | Nonsteroidal Anti-inflammatory Drug | EPC | has_epc | aspirin |
| FDASPL | N0000175578 | Platelet Aggregation Inhibitor | EPC | has_epc | aspirin |
| FDASPL | N0000182149 | Sigma-1 Agonist | EPC | has_epc | dextromethorphan |
| FDASPL | N0000181821 | Uncompetitive N-methyl-D-aspartate Receptor Antagonist | EPC | has_epc | dextromethorphan |
| FDASPL | N0000000207 | Histamine Receptor Antagonists | MOA | has_moa | doxylamine |
| FDASPL | N0000182147 | Sigma-1 Receptor Agonists | MOA | has_moa | dextromethorphan |
| FDASPL | N0000181819 | Uncompetitive NMDA Receptor Antagonists | MOA | has_moa | dextromethorphan |
| MEDRT | D001241 | Aspirin | CHEM | has_ingredient | aspirin |
| MEDRT | D003915 | Dextromethorphan | CHEM | has_ingredient | dextromethorphan hydrobromide |
| MEDRT | D003915 | Dextromethorphan | CHEM | has_ingredient | dextromethorphan |
| MEDRT | D004319 | Doxylamine | CHEM | has_ingredient | doxylamine succinate |
| MEDRT | D004319 | Doxylamine | CHEM | has_ingredient | doxylamine |
| MEDRT | D010656 | Phenylephrine | CHEM | has_ingredient | phenylephrine |
| MEDRT | D013447 | Sulfites | CHEM | ci_chemclass | phenylephrine bitartrate |
| MEDRT | D013447 | Sulfites | CHEM | ci_chemclass | phenylephrine |
| MEDRT | D001172 | Arthritis, Rheumatoid | DISEASE | may_treat | aspirin |
| MEDRT | D001778 | Blood Coagulation Disorders | DISEASE | ci_with | aspirin |
| MEDRT | D001791 | Blood Platelet Disorders | DISEASE | ci_with | aspirin |
| MEDRT | D002544 | Cerebral Infarction | DISEASE | may_prevent | aspirin |
| MEDRT | D002644 | Chickenpox | DISEASE | ci_with | aspirin |
| MEDRT | D002675 | Child, Preschool | DISEASE | ci_with | aspirin |
| MEDRT | D003371 | Cough | DISEASE | may_prevent | dextromethorphan |
| MEDRT | D003371 | Cough | DISEASE | may_treat | dextromethorphan |
| MEDRT | D003371 | Cough | DISEASE | may_treat | dextromethorphan hydrobromide |
| MEDRT | D003371 | Cough | DISEASE | may_prevent | dextromethorphan hydrobromide |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | doxylamine |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | dextromethorphan |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | aspirin |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | phenylephrine |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | doxylamine succinate |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | dextromethorphan hydrobromide |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | phenylephrine bitartrate |
| MEDRT | D005334 | Fever | DISEASE | may_treat | aspirin |
| MEDRT | D005401 | Fissure in Ano | DISEASE | may_treat | phenylephrine |
| MEDRT | D005401 | Fissure in Ano | DISEASE | may_treat | phenylephrine bitartrate |
| MEDRT | D005902 | Glaucoma, Open-Angle | DISEASE | may_treat | phenylephrine bitartrate |
| MEDRT | D005902 | Glaucoma, Open-Angle | DISEASE | may_treat | phenylephrine |
| MEDRT | D006073 | Gout | DISEASE | may_treat | aspirin |
| MEDRT | D006261 | Headache | DISEASE | may_treat | doxylamine |
| MEDRT | D006261 | Headache | DISEASE | may_treat | doxylamine succinate |
| MEDRT | D006396 | Hematemesis | DISEASE | ci_with | aspirin |
| MEDRT | D006474 | Hemorrhagic Disorders | DISEASE | ci_with | aspirin |
| MEDRT | D006484 | Hemorrhoids | DISEASE | may_treat | phenylephrine |
| MEDRT | D006484 | Hemorrhoids | DISEASE | may_treat | phenylephrine bitartrate |
| MEDRT | D006973 | Hypertension | DISEASE | ci_with | phenylephrine |
| MEDRT | D006973 | Hypertension | DISEASE | ci_with | phenylephrine bitartrate |
| MEDRT | D007022 | Hypotension | DISEASE | may_treat | phenylephrine bitartrate |
| MEDRT | D007022 | Hypotension | DISEASE | may_treat | phenylephrine |
| MEDRT | D007223 | Infant | DISEASE | ci_with | aspirin |
| MEDRT | D007249 | Inflammation | DISEASE | may_treat | aspirin |
| MEDRT | D002546 | Ischemic Attack, Transient | DISEASE | may_prevent | aspirin |
| MEDRT | D008551 | Melena | DISEASE | ci_with | aspirin |
| MEDRT | D015878 | Mydriasis | DISEASE | induces | phenylephrine bitartrate |
| MEDRT | D015878 | Mydriasis | DISEASE | induces | phenylephrine |
| MEDRT | D009203 | Myocardial Infarction | DISEASE | may_prevent | aspirin |
| MEDRT | D009298 | Nasal Polyps | DISEASE | ci_with | aspirin |
| MEDRT | D010003 | Osteoarthritis | DISEASE | may_treat | aspirin |
| MEDRT | D010146 | Pain | DISEASE | may_treat | aspirin |
| MEDRT | D010146 | Pain | DISEASE | may_prevent | aspirin |
| MEDRT | D011225 | Pre-Eclampsia | DISEASE | may_prevent | aspirin |
| MEDRT | D011263 | Pregnancy Trimester, Third | DISEASE | ci_with | aspirin |
| MEDRT | D011538 | Pruritus Ani | DISEASE | may_treat | phenylephrine |
| MEDRT | D011538 | Pruritus Ani | DISEASE | may_treat | phenylephrine bitartrate |
| MEDRT | D012213 | Rheumatic Fever | DISEASE | may_treat | aspirin |
| MEDRT | D012221 | Rhinitis, Allergic, Perennial | DISEASE | may_treat | doxylamine |
| MEDRT | D012221 | Rhinitis, Allergic, Perennial | DISEASE | may_treat | doxylamine succinate |
| MEDRT | D012223 | Rhinitis, Vasomotor | DISEASE | may_treat | phenylephrine |
| MEDRT | D012223 | Rhinitis, Vasomotor | DISEASE | may_treat | phenylephrine bitartrate |
| MEDRT | D012772 | Shock, Septic | DISEASE | may_treat | phenylephrine |
| MEDRT | D012772 | Shock, Septic | DISEASE | may_treat | phenylephrine bitartrate |
| MEDRT | D007319 | Sleep Initiation and Maintenance Disorders | DISEASE | may_treat | doxylamine succinate |
| MEDRT | D007319 | Sleep Initiation and Maintenance Disorders | DISEASE | may_treat | doxylamine |
| MEDRT | D013617 | Tachycardia, Supraventricular | DISEASE | may_treat | phenylephrine |
| MEDRT | D013617 | Tachycardia, Supraventricular | DISEASE | may_treat | phenylephrine bitartrate |
| MEDRT | D017180 | Tachycardia, Ventricular | DISEASE | ci_with | phenylephrine bitartrate |
| MEDRT | D017180 | Tachycardia, Ventricular | DISEASE | ci_with | phenylephrine |
| MEDRT | N0000000209 | Adrenergic alpha-Agonists | MOA | has_moa | phenylephrine bitartrate |
| MEDRT | N0000000209 | Adrenergic alpha-Agonists | MOA | has_moa | phenylephrine |
| MEDRT | N0000000160 | Cyclooxygenase Inhibitors | MOA | has_moa | aspirin |
| MEDRT | N0000000190 | Histamine H1 Receptor Antagonists | MOA | has_moa | doxylamine succinate |
| MEDRT | N0000000190 | Histamine H1 Receptor Antagonists | MOA | has_moa | doxylamine |
| MEDRT | N0000000184 | Monoamine Oxidase Inhibitors | MOA | ci_moa | dextromethorphan |
| MEDRT | N0000000184 | Monoamine Oxidase Inhibitors | MOA | ci_moa | dextromethorphan hydrobromide |
| MEDRT | N0000000109 | Serotonin Uptake Inhibitors | MOA | has_moa | dextromethorphan |
| MEDRT | N0000000109 | Serotonin Uptake Inhibitors | MOA | has_moa | dextromethorphan hydrobromide |
| MEDRT | N0000182147 | Sigma-1 Receptor Agonists | MOA | has_moa | dextromethorphan |
| MEDRT | N0000182147 | Sigma-1 Receptor Agonists | MOA | has_moa | dextromethorphan hydrobromide |
| MEDRT | N0000181819 | Uncompetitive NMDA Receptor Antagonists | MOA | has_moa | dextromethorphan hydrobromide |
| MEDRT | N0000181819 | Uncompetitive NMDA Receptor Antagonists | MOA | has_moa | dextromethorphan |
| MEDRT | N0000008371 | Conjunctival Arterial Vasoconstriction | PE | has_pe | phenylephrine bitartrate |
| MEDRT | N0000008371 | Conjunctival Arterial Vasoconstriction | PE | has_pe | phenylephrine |
| MEDRT | N0000008657 | Decreased Histamine Activity | PE | has_pe | doxylamine |
| MEDRT | N0000008657 | Decreased Histamine Activity | PE | has_pe | doxylamine succinate |
| MEDRT | N0000008701 | Decreased Medullary Respiratory Drive | PE | has_pe | dextromethorphan |
| MEDRT | N0000008701 | Decreased Medullary Respiratory Drive | PE | has_pe | dextromethorphan hydrobromide |
| MEDRT | N0000008896 | Decreased Nasal and Sinus Secretions | PE | has_pe | phenylephrine |
| MEDRT | N0000008896 | Decreased Nasal and Sinus Secretions | PE | has_pe | phenylephrine bitartrate |
| MEDRT | N0000008831 | Decreased Platelet Activating Factor Production | PE | has_pe | aspirin |
| MEDRT | N0000008832 | Decreased Platelet Aggregation | PE | has_pe | aspirin |
| MEDRT | N0000008836 | Decreased Prostaglandin Production | PE | has_pe | aspirin |
| MEDRT | N0000009006 | Decreased Thromboxane Production | PE | has_pe | aspirin |
| MEDRT | N0000000026 | Hepatic Metabolism | PK | has_pk | aspirin |
| MEDRT | N0000000042 | Renal Excretion | PK | has_pk | aspirin |
Properties#
| Category | Property | Value |
|---|---|---|
| ATTRIBUTES | GENERAL_CARDINALITY | MULTI |
| ATTRIBUTES | HUMAN_DRUG | US |
| NAMES | Prescribable Synonym | 1 daytime (aspirin 325 MG / dextromethorphan HBr 10 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) / 1 nighttime (aspirin 500 MG / dextromethorphan HBr 10 MG / doxylamine succinate 6.25 MG / phenylephrine bitartrate 7.8 MG Effervescent Oral Tablet) Pack |
| SOURCES | Source | Gold Standard Alchemy |
| SOURCES | Source | Metathesaurus FDA Structured Product Labels |
| SOURCES | Source | National Drug Data File Plus Source Vocabulary |