Application 205435

Type
NDA
Sponsor
CUBIST PHARMS LLC

Application Products#

Product, Drug, Ingredient table
ProductDrugIngredientFormStrengthReference drugReference standard
001SIVEXTROTEDIZOLID PHOSPHATETABLET;ORAL200MGYesYes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 43.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
N205435-001SIVEXTROTEDIZOLID PHOSPHATE200MGTABLET / ORALRLD, RS2014-06-20

Orange Book patents#

Current patent rows page 1 of 1 · 7 matching rows.

Application-product, Patent, Expiration table
Application-productPatentExpirationUse codeCoverage / statusSubmission date
N205435-00184206762028-02-23U-282Drug substance, Drug product2014-07-03
N205435-00178163792028-06-20U-2507Drug substance, Drug product2014-07-03
N205435-001100659472030-02-03Drug product2019-04-09
N205435-001104428292030-02-03Drug substance2019-11-13
N205435-00196242502030-02-03U-2507Drug substance, Drug product2019-04-09
N205435-00199884062030-02-03Drug product2019-04-09
N205435-00184263892030-12-31U-282Drug substance, Drug product2014-07-03

Orange Book exclusivity#

Current exclusivity rows page 1 of 1 · 1 matching rows.

Application-product, Exclusivity code, Expiration table
Application-productExclusivity codeExpiration
N205435-001NPP2028-04-04

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 43 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-09-14 22:38:342026-08N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-2084e616aacf4f…
2026-08-18 06:07:402026-07N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-20caaa826d4ba7…
2026-02-19 14:30 UTC2026-02N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-20011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-2031067a03dcf5…
2025-08-23 18:47 UTC2025-08N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-206a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-20fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-20b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-2003ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-202680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-205bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-20d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-20d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-2079d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-20301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-201e350fbaab3a…
2024-05-31 18:47 UTC2024-05N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-208072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-205c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-205d02ea3f76ae…
2022-04-04 05:41 UTC2022-04N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-204b0b4de00fa7…
2019-12-13 00:20 UTC2019-12N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-2074a2ff9319b5…
2022-03-09 01:35 UTC2022-03N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-20bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-20782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-2087673890dc5c…
2021-03-12 10:30 UTC2021-03N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-205aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-208869cabd3fbd…
2020-11-12 02:37 UTC2020-11N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-20c0c555d07b60…
2019-12-14 00:12 UTC2019-12N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-203f01610625f2…
2019-09-15 20:21 UTC2019-09N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-20b00525d2431f…
2019-07-19 19:46 UTC2019-07N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-20ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-206a51e52b5d6a…
2024-02-18 07:12 UTC2024-02N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-201c564ffb4f44…
2023-12-20 04:57 UTC2023-12N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-20ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-20a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-209b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-20a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-203f0d92c62455…
2023-05-13 08:27 UTC2023-05N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-20053a50430f4f…
2023-01-26 05:58 UTC2023-01N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-203bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-203a93d1ddd44b…
2022-10-28 04:53 UTC2022-10N205435-001SIVEXTRO200MGTABLET / ORALRLD, RS2014-06-20f41ea6bd6efb…

Observed Orange Book patent history#

Patent history page 1 of 8 · 298 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productPatentExpirationUse codeCoverage / statusSubmission dateSource SHA-256
2026-09-14 22:38:342026-08N205435-00184206762028-02-23U-282Drug substance, Drug product2014-07-0384e616aacf4f…
2026-09-14 22:38:342026-08N205435-00178163792028-06-20U-2507Drug substance, Drug product2014-07-0384e616aacf4f…
2026-09-14 22:38:342026-08N205435-001100659472030-02-03Drug product2019-04-0984e616aacf4f…
2026-09-14 22:38:342026-08N205435-001104428292030-02-03Drug substance2019-11-1384e616aacf4f…
2026-09-14 22:38:342026-08N205435-00196242502030-02-03U-2507Drug substance, Drug product2019-04-0984e616aacf4f…
2026-09-14 22:38:342026-08N205435-00199884062030-02-03Drug product2019-04-0984e616aacf4f…
2026-09-14 22:38:342026-08N205435-00184263892030-12-31U-282Drug substance, Drug product2014-07-0384e616aacf4f…
2026-08-18 06:07:402026-07N205435-00184206762028-02-23U-282Drug substance, Drug product2014-07-03caaa826d4ba7…
2026-08-18 06:07:402026-07N205435-00178163792028-06-20U-2507Drug substance, Drug product2014-07-03caaa826d4ba7…
2026-08-18 06:07:402026-07N205435-001100659472030-02-03Drug product2019-04-09caaa826d4ba7…
2026-08-18 06:07:402026-07N205435-001104428292030-02-03Drug substance2019-11-13caaa826d4ba7…
2026-08-18 06:07:402026-07N205435-00196242502030-02-03U-2507Drug substance, Drug product2019-04-09caaa826d4ba7…
2026-08-18 06:07:402026-07N205435-00199884062030-02-03Drug product2019-04-09caaa826d4ba7…
2026-08-18 06:07:402026-07N205435-00184263892030-12-31U-282Drug substance, Drug product2014-07-03caaa826d4ba7…
2026-02-19 14:30 UTC2026-02N205435-00184206762028-02-23U-282Drug substance, Drug product2014-07-03011fe1cb6892…
2026-02-19 14:30 UTC2026-02N205435-00178163792028-06-20U-2507Drug substance, Drug product2014-07-03011fe1cb6892…
2026-02-19 14:30 UTC2026-02N205435-001100659472030-02-03Drug product2019-04-09011fe1cb6892…
2026-02-19 14:30 UTC2026-02N205435-001104428292030-02-03Drug substance2019-11-13011fe1cb6892…
2026-02-19 14:30 UTC2026-02N205435-00196242502030-02-03U-2507Drug substance, Drug product2019-04-09011fe1cb6892…
2026-02-19 14:30 UTC2026-02N205435-00199884062030-02-03Drug product2019-04-09011fe1cb6892…
2026-02-19 14:30 UTC2026-02N205435-00184263892030-12-31U-282Drug substance, Drug product2014-07-03011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N205435-00184206762028-02-23U-282Drug substance, Drug product2014-07-0331067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N205435-00178163792028-06-20U-2507Drug substance, Drug product2014-07-0331067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N205435-001100659472030-02-03Drug product2019-04-0931067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N205435-001104428292030-02-03Drug substance2019-11-1331067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N205435-00196242502030-02-03U-2507Drug substance, Drug product2019-04-0931067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N205435-00199884062030-02-03Drug product2019-04-0931067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N205435-00184263892030-12-31U-282Drug substance, Drug product2014-07-0331067a03dcf5…
2025-08-23 18:47 UTC2025-08N205435-00184206762028-02-23U-282Drug substance, Drug product2014-07-036a471c1ec25d…
2025-08-23 18:47 UTC2025-08N205435-00178163792028-06-20U-2507Drug substance, Drug product2014-07-036a471c1ec25d…
2025-08-23 18:47 UTC2025-08N205435-001100659472030-02-03Drug product2019-04-096a471c1ec25d…
2025-08-23 18:47 UTC2025-08N205435-001104428292030-02-03Drug substance2019-11-136a471c1ec25d…
2025-08-23 18:47 UTC2025-08N205435-00196242502030-02-03U-2507Drug substance, Drug product2019-04-096a471c1ec25d…
2025-08-23 18:47 UTC2025-08N205435-00199884062030-02-03Drug product2019-04-096a471c1ec25d…
2025-08-23 18:47 UTC2025-08N205435-00184263892030-12-31U-282Drug substance, Drug product2014-07-036a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N205435-00184206762028-02-23U-282Drug substance, Drug product2014-07-03fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N205435-00178163792028-06-20U-2507Drug substance, Drug product2014-07-03fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N205435-001100659472030-02-03Drug product2019-04-09fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N205435-001104428292030-02-03Drug substance2019-11-13fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N205435-00196242502030-02-03U-2507Drug substance, Drug product2019-04-09fd3edfee7708…

Observed Orange Book exclusivity history#

Exclusivity history page 1 of 3 · 96 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productExclusivity codeExpirationSource SHA-256
2026-09-14 22:38:342026-08N205435-001NPP2028-04-0484e616aacf4f…
2026-08-18 06:07:402026-07N205435-001NPP2028-04-04caaa826d4ba7…
2026-02-19 14:30 UTC2026-02N205435-001NPP2028-04-04011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N205435-001NPP2028-04-0431067a03dcf5…
2025-08-23 18:47 UTC2025-08N205435-001NPP2028-04-046a471c1ec25d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N205435-001NCE2019-06-2003ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N205435-001GAIN2024-06-2003ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N205435-001NCE2019-06-202680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N205435-001GAIN2024-06-202680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N205435-001NCE2019-06-205bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N205435-001GAIN2024-06-205bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N205435-001NCE2019-06-20d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N205435-001GAIN2024-06-20d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N205435-001NCE2019-06-20d06236e962d9…
2024-10-29 15:01 UTC2024-10N205435-001GAIN2024-06-20d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N205435-001NCE2019-06-2079d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N205435-001GAIN2024-06-2079d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N205435-001NCE2019-06-20301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N205435-001GAIN2024-06-20301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N205435-001NCE2019-06-201e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N205435-001GAIN2024-06-201e350fbaab3a…
2024-05-31 18:47 UTC2024-05N205435-001NCE2019-06-208072bd15b7f6…
2024-05-31 18:47 UTC2024-05N205435-001GAIN2024-06-208072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N205435-001NCE2019-06-205c6f7cd8ea54…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N205435-001NPP2023-06-195c6f7cd8ea54…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N205435-001GAIN2024-06-205c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04N205435-001NCE2019-06-205d02ea3f76ae…
2022-04-08 23:34 UTC2022-04N205435-001NPP2023-06-195d02ea3f76ae…
2022-04-08 23:34 UTC2022-04N205435-001GAIN2024-06-205d02ea3f76ae…
2022-04-04 05:41 UTC2022-04N205435-001NCE2019-06-204b0b4de00fa7…
2022-04-04 05:41 UTC2022-04N205435-001NPP2023-06-194b0b4de00fa7…
2022-04-04 05:41 UTC2022-04N205435-001GAIN2024-06-204b0b4de00fa7…
2019-12-13 00:20 UTC2019-12N205435-001NCE2019-06-2074a2ff9319b5…
2019-12-13 00:20 UTC2019-12N205435-001GAIN2024-06-2074a2ff9319b5…
2022-03-09 01:35 UTC2022-03N205435-001NCE2019-06-20bb7c543d1eb4…
2022-03-09 01:35 UTC2022-03N205435-001NPP2023-06-19bb7c543d1eb4…
2022-03-09 01:35 UTC2022-03N205435-001GAIN2024-06-20bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12N205435-001NCE2019-06-20782e0a99824c…
2021-12-28 21:50 UTC2021-12N205435-001NPP2023-06-19782e0a99824c…
2021-12-28 21:50 UTC2021-12N205435-001GAIN2024-06-20782e0a99824c…

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
SIVEXTROTEDIZOLID PHOSPHATEMerck Sharp & Dohme LLC75672079-589f-451a-bdbf-eaebcfcc80a92026-02-27Warnings, Adverse reactionsExact identifier
application applno (NDA): 205435
application number: NDA205435
ndc (product): 67919-041

NDC Listings For This Application#

NDC listings for this application page 1 of 1 · 15 matching rows.

NDC, Name, Nonproprietary name table
NDCNameNonproprietary nameLabelerMarketing categoryStatus
67919-041SIVEXTROtedizolid phosphateMerck Sharp & Dohme Corp.NDACurrent
67919-041SIVEXTROtedizolid phosphateMerck Sharp & Dohme Corp.NDACurrent
67919-041SIVEXTROtedizolid phosphateMerck Sharp & Dohme Corp.NDACurrent
67919-041SIVEXTROtedizolid phosphateMerck Sharp & Dohme LLCNDACurrent
67919-041SIVEXTROtedizolid phosphateMerck Sharp & Dohme LLCNDACurrent
67919-041SIVEXTROtedizolid phosphateMerck Sharp & Dohme LLCNDACurrent
67919-041SIVEXTROtedizolid phosphateMerck Sharp & Dohme Corp.NDACurrent
67919-041SIVEXTROtedizolid phosphateMerck Sharp & Dohme Corp.NDACurrent
67919-041SIVEXTROtedizolid phosphateMerck Sharp & Dohme Corp.NDACurrent
72000-310SIVEXTROtedizolid phosphateNabriva Therapeutics US, Inc.NDACurrent
72000-310SIVEXTROtedizolid phosphateNabriva Therapeutics US, Inc.NDACurrent
72000-310SIVEXTROtedizolid phosphateNabriva Therapeutics US, Inc.NDACurrent
72000-310SIVEXTROtedizolid phosphateNabriva Therapeutics US, Inc.NDACurrent
72000-310SIVEXTROtedizolid phosphateNabriva Therapeutics US, Inc.NDACurrent
72000-310SIVEXTROtedizolid phosphateNabriva Therapeutics US, Inc.NDACurrent

Documents#

Document, Submission type, Date table
DocumentSubmission typeDate
85275SUPPL 2026-03-06
85206SUPPL 2026-03-03
81884SUPPL 2025-04-08
81827SUPPL 2025-04-07
69354SUPPL2021-11-18
69346SUPPL2021-11-18
65028SUPPL2020-10-27
65015SUPPL2020-10-23
63675SUPPL2020-06-23
63660SUPPL2020-06-22
59958SUPPL2019-09-11
59960SUPPL2019-09-10
57932SUPPL2019-03-08
57922SUPPL2019-03-07
49477SUPPL2017-08-21
49475SUPPL2017-08-21
49433SUPPL2017-08-16
49430SUPPL2017-08-16
45802SUPPL2016-11-04
45737SUPPL2016-10-31
45408SUPPL2016-09-28
45282SUPPL2016-09-19
10448SUPPL2016-06-07
40469SUPPL2015-03-09
32676SUPPL2015-03-06
44918ORIG2014-07-16
22989ORIG2014-07-16
40468ORIG2014-06-23
32675ORIG2014-06-23