Application 212273

Type
NDA
Sponsor
VERTEX PHARMS INC

Application Products#

Product, Drug, Ingredient table
ProductDrugIngredientFormStrengthReference drugReference standard
001TRIKAFTA (COPACKAGED)ELEXACAFTOR, IVACAFTOR, TEZACAFTOR; IVACAFTORTABLET, TABLET;ORAL100MG,75MG,50MG;N/A,150MG,N/AYesYes
002TRIKAFTA (COPACKAGED)ELEXACAFTOR, IVACAFTOR, TEZACAFTOR; IVACAFTORTABLET;ORAL50MG,37.5MG,25MG; 75MGYesNo

Source provenance: Browse the complete Orange Book source catalog · source snapshot 42.

Orange Book products#

Current product rows page 1 of 1 · 2 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
N212273-001TRIKAFTA (COPACKAGED)ELEXACAFTOR, IVACAFTOR, TEZACAFTOR; IVACAFTOR100MG,75MG,50MG; 150MGTABLET / ORALRLD, RS2019-10-21
N212273-002TRIKAFTA (COPACKAGED)ELEXACAFTOR, IVACAFTOR, TEZACAFTOR; IVACAFTOR50MG,37.5MG,25MG; 75MGTABLET / ORALRLD2021-06-08

Orange Book patents#

Current patent rows page 1 of 2 · 141 matching rows.

Application-product, Patent, Expiration table
Application-productPatentExpirationUse codeCoverage / statusSubmission date
N212273-00183544272026-07-06U-30292019-11-14
N212273-00183544272026-07-06U-31452019-11-14
N212273-00184102742026-12-28Drug product2019-11-14
N212273-00187542242026-12-28Drug substance, Drug product2019-11-14
N212273-00196701632026-12-28U-3031Drug product2019-11-14
N212273-00196701632026-12-28U-3155Drug product2019-11-14
N212273-00196701632026-12-28U-4078Drug product2019-11-14
N212273-00196701632026-12-28U-4477Drug product2019-11-14
N212273-00199313342026-12-28U-3031Drug product2019-11-14
N212273-00199313342026-12-28U-3155Drug product2019-11-14
N212273-00199313342026-12-28U-4078Drug product2019-11-14
N212273-00199313342026-12-28U-4479Drug product2019-11-14
N212273-001100223522027-04-09U-2651Drug product2019-11-14
N212273-001100223522027-04-09U-3156Drug product2019-11-14
N212273-001102398672027-04-09U-3033Drug substance, Drug product2019-11-14
N212273-001102398672027-04-09U-3158Drug substance, Drug product2019-11-14
N212273-001102398672027-04-09U-4056Drug substance, Drug product2019-11-14
N212273-001102398672027-04-09U-4475Drug substance, Drug product2019-11-14
N212273-001116393472027-04-09U-3587Drug substance, Drug product2023-05-24
N212273-001116393472027-04-09U-4056Drug substance, Drug product2023-05-24
N212273-001116393472027-04-09U-4475Drug substance, Drug product2023-05-24
N212273-00199747812027-04-09U-3028Drug product2019-11-14
N212273-00199747812027-04-09U-3144Drug product2019-11-14
N212273-00199747812027-04-09U-4073Drug product2019-11-14
N212273-00199747812027-04-09U-4475Drug product2019-11-14
N212273-00176457892027-05-01Drug substance, Drug product2019-11-14
N212273-00185981812027-05-01U-30282019-11-14
N212273-00185981812027-05-01U-31442019-11-14
N212273-00185981812027-05-01U-40562019-11-14
N212273-00185981812027-05-01U-44752019-11-14
N212273-00186239052027-05-01Drug substance, Drug product2019-11-14
N212273-00174951032027-05-20Drug substance, Drug product2019-11-14
N212273-00177769052027-06-03Drug substance, Drug product2019-11-14
N212273-00183242422027-08-05U-30282019-11-14
N212273-00183242422027-08-05U-31442019-11-14
N212273-00183242422027-08-05U-40732019-11-14
N212273-00183242422027-08-05U-44752019-11-14
N212273-00184153872027-11-12U-30282019-11-14
N212273-00184153872027-11-12U-31442019-11-14
N212273-00184153872027-11-12U-40732019-11-14
N212273-00184153872027-11-12U-44752019-11-14
N212273-001106464812029-08-13Drug product2020-06-08
N212273-001115649162029-08-13U-35252023-02-28
N212273-001115649162029-08-13U-40632023-02-28
N212273-001115649162029-08-13U-44912023-02-28
N212273-001124586352029-08-13U-4330Drug product2025-11-21
N212273-001124586352029-08-13U-4486Drug product2025-11-21
N212273-001100816212031-03-25U-3032Drug product2019-11-14
N212273-001100816212031-03-25U-3157Drug product2019-11-14
N212273-001100816212031-03-25U-4075Drug product2019-11-14
N212273-001100816212031-03-25U-4480Drug product2019-11-14
N212273-001115780622031-03-25U-3544Drug product2023-03-15
N212273-001115780622031-03-25U-4054Drug product2023-03-15
N212273-001115780622031-03-25U-4490Drug product2023-03-15
N212273-001RE504532031-07-10Drug substance, Drug product2025-07-11
N212273-00190124962033-07-15U-26492019-11-14
N212273-00190124962033-07-15U-31542019-11-14
N212273-001107585342035-10-06U-3028Drug substance, Drug product2020-09-22
N212273-001107585342035-10-06U-3144Drug substance, Drug product2020-09-22
N212273-001107585342035-10-06U-4073Drug substance, Drug product2020-09-22
N212273-001107585342035-10-06U-4475Drug substance, Drug product2020-09-22
N212273-001114264072035-10-06U-3425Drug substance, Drug product2022-09-26
N212273-001114264072035-10-06U-4070Drug substance, Drug product2022-09-26
N212273-001114264072035-10-06U-4475Drug substance, Drug product2022-09-26
N212273-001107935472037-12-08U-3028Drug substance, Drug product2020-10-29
N212273-001107935472037-12-08U-3144Drug substance, Drug product2020-10-29
N212273-001107935472037-12-08U-4073Drug substance, Drug product2020-10-29
N212273-001107935472037-12-08U-4475Drug substance, Drug product2020-10-29
N212273-001111793672037-12-08U-3253Drug product2021-12-14
N212273-001111793672037-12-08U-4071Drug product2021-12-14
N212273-001111793672037-12-08U-4487Drug product2021-12-14
N212273-001114536552037-12-08Drug substance, Drug product2022-10-21
N212273-001115175642037-12-08U-3498Drug product2023-01-05
N212273-001115175642037-12-08U-4067Drug product2023-01-05
N212273-001115175642037-12-08U-4475Drug product2023-01-05
N212273-001123502622038-07-17U-42212025-07-30
N212273-001123502622038-07-17U-44752025-07-30
N212273-00283544272026-07-06U-31452021-06-29
N212273-00284102742026-12-28Drug product2021-06-29
N212273-00287542242026-12-28Drug substance, Drug product2021-06-29

Orange Book exclusivity#

Current exclusivity rows page 1 of 1 · 12 matching rows.

Application-product, Exclusivity code, Expiration table
Application-productExclusivity codeExpiration
N212273-001ODE-2752026-10-21
N212273-001M-3132027-12-20
N212273-001ODE-3232027-12-21
N212273-001ODE-3572028-06-08
N212273-001ODE-5122031-12-20
N212273-001ODE-5432033-03-27
N212273-002ODE*2026-10-21
N212273-002M-3132027-12-20
N212273-002ODE*2027-12-21
N212273-002ODE-3572028-06-08
N212273-002ODE-5122031-12-20
N212273-002ODE-5432033-03-27

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 74 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-08-18 06:07:402026-07N212273-001TRIKAFTA (COPACKAGED)100MG,75MG,50MG; 150MGTABLET / ORALRLD, RS2019-10-21caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-002TRIKAFTA (COPACKAGED)50MG,37.5MG,25MG; 75MGTABLET / ORALRLD2021-06-08caaa826d4ba7…
2026-02-19 14:30 UTC2026-02N212273-001TRIKAFTA (COPACKAGED)100MG,75MG,50MG; 150MGTABLET / ORALRLD, RS2019-10-21011fe1cb6892…
2026-02-19 14:30 UTC2026-02N212273-002TRIKAFTA (COPACKAGED)50MG,37.5MG,25MG; 75MGTABLET / ORALRLD2021-06-08011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N212273-001TRIKAFTA (COPACKAGED)100MG,75MG,50MG; 150MGTABLET / ORALRLD, RS2019-10-2131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N212273-002TRIKAFTA (COPACKAGED)50MG,37.5MG,25MG; 75MGTABLET / ORALRLD2021-06-0831067a03dcf5…
2025-08-23 18:47 UTC2025-08N212273-001TRIKAFTA (COPACKAGED)100MG,75MG,50MG; 150MGTABLET / ORALRLD, RS2019-10-216a471c1ec25d…
2025-08-23 18:47 UTC2025-08N212273-002TRIKAFTA (COPACKAGED)50MG,37.5MG,25MG; 75MGTABLET / ORALRLD2021-06-086a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N212273-001TRIKAFTA (COPACKAGED)100MG,75MG,50MG; 150MGTABLET / ORALRLD, RS2019-10-21fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N212273-002TRIKAFTA (COPACKAGED)50MG,37.5MG,25MG; 75MGTABLET / ORALRLD2021-06-08fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N212273-001TRIKAFTA (COPACKAGED)100MG,75MG,50MG; 150MGTABLET / ORALRLD, RS2019-10-21b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N212273-002TRIKAFTA (COPACKAGED)50MG,37.5MG,25MG; 75MGTABLET / ORALRLD2021-06-08b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N212273-001TRIKAFTA (COPACKAGED)100MG,75MG,50MG; 150MGTABLET / ORALRLD, RS2019-10-2103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N212273-002TRIKAFTA (COPACKAGED)50MG,37.5MG,25MG; 75MGTABLET / ORALRLD2021-06-0803ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N212273-001TRIKAFTA (COPACKAGED)100MG,75MG,50MG; 150MGTABLET / ORALRLD, RS2019-10-212680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N212273-002TRIKAFTA (COPACKAGED)50MG,37.5MG,25MG; 75MGTABLET / ORALRLD2021-06-082680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N212273-001TRIKAFTA (COPACKAGED)100MG,75MG,50MG; 150MGTABLET / ORALRLD, RS2019-10-215bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N212273-002TRIKAFTA (COPACKAGED)50MG,37.5MG,25MG; 75MGTABLET / ORALRLD2021-06-085bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N212273-001TRIKAFTA (COPACKAGED)100MG,75MG,50MG; 150MGTABLET / ORALRLD, RS2019-10-21d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N212273-002TRIKAFTA (COPACKAGED)50MG,37.5MG,25MG; 75MGTABLET / ORALRLD2021-06-08d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N212273-001TRIKAFTA (COPACKAGED)100MG,75MG,50MG; 150MGTABLET / ORALRLD, RS2019-10-21d06236e962d9…
2024-10-29 15:01 UTC2024-10N212273-002TRIKAFTA (COPACKAGED)50MG,37.5MG,25MG; 75MGTABLET / ORALRLD2021-06-08d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N212273-001TRIKAFTA (COPACKAGED)100MG,75MG,50MG; 150MGTABLET / ORALRLD, RS2019-10-2179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N212273-002TRIKAFTA (COPACKAGED)50MG,37.5MG,25MG; 75MGTABLET / ORALRLD2021-06-0879d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N212273-001TRIKAFTA (COPACKAGED)100MG,75MG,50MG; 150MGTABLET / ORALRLD, RS2019-10-21301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N212273-002TRIKAFTA (COPACKAGED)50MG,37.5MG,25MG; 75MGTABLET / ORALRLD2021-06-08301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N212273-001TRIKAFTA (COPACKAGED)100MG,75MG,50MG; 150MGTABLET / ORALRLD, RS2019-10-211e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N212273-002TRIKAFTA (COPACKAGED)50MG,37.5MG,25MG; 75MGTABLET / ORALRLD2021-06-081e350fbaab3a…
2024-05-31 18:47 UTC2024-05N212273-001TRIKAFTA (COPACKAGED)100MG,75MG,50MG; 150MGTABLET / ORALRLD, RS2019-10-218072bd15b7f6…
2024-05-31 18:47 UTC2024-05N212273-002TRIKAFTA (COPACKAGED)50MG,37.5MG,25MG; 75MGTABLET / ORALRLD2021-06-088072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N212273-001TRIKAFTA (COPACKAGED)100MG,75MG,50MG; 150MGTABLET / ORALRLD, RS2019-10-215c6f7cd8ea54…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N212273-002TRIKAFTA (COPACKAGED)50MG,37.5MG,25MG; 75MGTABLET / ORALRLD2021-06-085c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04N212273-001TRIKAFTA (COPACKAGED)100MG,75MG,50MG; 150MGTABLET / ORALRLD, RS2019-10-215d02ea3f76ae…
2022-04-08 23:34 UTC2022-04N212273-002TRIKAFTA (COPACKAGED)50MG,37.5MG,25MG; 75MGTABLET / ORALRLD2021-06-085d02ea3f76ae…
2022-04-04 05:41 UTC2022-04N212273-001TRIKAFTA (COPACKAGED)100MG,75MG,50MG; 150MGTABLET / ORALRLD, RS2019-10-214b0b4de00fa7…
2022-04-04 05:41 UTC2022-04N212273-002TRIKAFTA (COPACKAGED)50MG,37.5MG,25MG; 75MGTABLET / ORALRLD2021-06-084b0b4de00fa7…
2019-12-13 00:20 UTC2019-12N212273-001TRIKAFTA (COPACKAGED)100MG,75MG,50MG;N/A,150MG,N/ATABLET, TABLET / ORALRLD, RS2019-10-2174a2ff9319b5…
2022-03-09 01:35 UTC2022-03N212273-001TRIKAFTA (COPACKAGED)100MG,75MG,50MG; 150MGTABLET / ORALRLD, RS2019-10-21bb7c543d1eb4…
2022-03-09 01:35 UTC2022-03N212273-002TRIKAFTA (COPACKAGED)50MG,37.5MG,25MG; 75MGTABLET / ORALRLD2021-06-08bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12N212273-001TRIKAFTA (COPACKAGED)100MG,75MG,50MG; 150MGTABLET / ORALRLD, RS2019-10-21782e0a99824c…

Observed Orange Book patent history#

Patent history page 1 of 76 · 3,003 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productPatentExpirationUse codeCoverage / statusSubmission dateSource SHA-256
2026-08-18 06:07:402026-07N212273-00183544272026-07-06U-30292019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-00183544272026-07-06U-31452019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-00184102742026-12-28Drug product2019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-00187542242026-12-28Drug substance, Drug product2019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-00196701632026-12-28U-4078Drug product2019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-00196701632026-12-28U-3031Drug product2019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-00196701632026-12-28U-3155Drug product2019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-00196701632026-12-28U-4477Drug product2019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-00199313342026-12-28U-4078Drug product2019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-00199313342026-12-28U-3031Drug product2019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-00199313342026-12-28U-3155Drug product2019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-00199313342026-12-28U-4479Drug product2019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-001100223522027-04-09U-2651Drug product2019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-001100223522027-04-09U-3156Drug product2019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-001102398672027-04-09U-3158Drug substance, Drug product2019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-001102398672027-04-09U-4056Drug substance, Drug product2019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-001102398672027-04-09U-3033Drug substance, Drug product2019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-001102398672027-04-09U-4475Drug substance, Drug product2019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-001116393472027-04-09U-3587Drug substance, Drug product2023-05-24caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-001116393472027-04-09U-4056Drug substance, Drug product2023-05-24caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-001116393472027-04-09U-4475Drug substance, Drug product2023-05-24caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-00199747812027-04-09U-3028Drug product2019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-00199747812027-04-09U-3144Drug product2019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-00199747812027-04-09U-4073Drug product2019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-00199747812027-04-09U-4475Drug product2019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-00176457892027-05-01Drug substance, Drug product2019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-00185981812027-05-01U-30282019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-00185981812027-05-01U-31442019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-00185981812027-05-01U-40562019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-00185981812027-05-01U-44752019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-00186239052027-05-01Drug substance, Drug product2019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-00174951032027-05-20Drug substance, Drug product2019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-00177769052027-06-03Drug substance, Drug product2019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-00183242422027-08-05U-40732019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-00183242422027-08-05U-30282019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-00183242422027-08-05U-31442019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-00183242422027-08-05U-44752019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-00184153872027-11-12U-40732019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-00184153872027-11-12U-30282019-11-14caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-00184153872027-11-12U-31442019-11-14caaa826d4ba7…

Observed Orange Book exclusivity history#

Exclusivity history page 1 of 9 · 329 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productExclusivity codeExpirationSource SHA-256
2026-08-18 06:07:402026-07N212273-001ODE-2752026-10-21caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-001M-3132027-12-20caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-001ODE-3232027-12-21caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-001ODE-3572028-06-08caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-001ODE-5122031-12-20caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-001ODE-5432033-03-27caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-002ODE*2026-10-21caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-002M-3132027-12-20caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-002ODE*2027-12-21caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-002ODE-3572028-06-08caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-002ODE-5122031-12-20caaa826d4ba7…
2026-08-18 06:07:402026-07N212273-002ODE-5432033-03-27caaa826d4ba7…
2026-02-19 14:30 UTC2026-02N212273-001ODE-2752026-10-21011fe1cb6892…
2026-02-19 14:30 UTC2026-02N212273-001M-3132027-12-20011fe1cb6892…
2026-02-19 14:30 UTC2026-02N212273-001ODE-3232027-12-21011fe1cb6892…
2026-02-19 14:30 UTC2026-02N212273-001ODE-3572028-06-08011fe1cb6892…
2026-02-19 14:30 UTC2026-02N212273-001ODE-5122031-12-20011fe1cb6892…
2026-02-19 14:30 UTC2026-02N212273-002ODE*2026-10-21011fe1cb6892…
2026-02-19 14:30 UTC2026-02N212273-002M-3132027-12-20011fe1cb6892…
2026-02-19 14:30 UTC2026-02N212273-002ODE*2027-12-21011fe1cb6892…
2026-02-19 14:30 UTC2026-02N212273-002ODE-3572028-06-08011fe1cb6892…
2026-02-19 14:30 UTC2026-02N212273-002ODE-5122031-12-20011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N212273-001ODE-2752026-10-2131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N212273-001M-3132027-12-2031067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N212273-001ODE-3232027-12-2131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N212273-001ODE-3572028-06-0831067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N212273-001ODE-5122031-12-2031067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N212273-002ODE*2026-10-2131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N212273-002M-3132027-12-2031067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N212273-002ODE*2027-12-2131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N212273-002ODE-3572028-06-0831067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N212273-002ODE-5122031-12-2031067a03dcf5…
2025-08-23 18:47 UTC2025-08N212273-001ODE-2752026-10-216a471c1ec25d…
2025-08-23 18:47 UTC2025-08N212273-001M-3132027-12-206a471c1ec25d…
2025-08-23 18:47 UTC2025-08N212273-001ODE-3232027-12-216a471c1ec25d…
2025-08-23 18:47 UTC2025-08N212273-001ODE-3572028-06-086a471c1ec25d…
2025-08-23 18:47 UTC2025-08N212273-001ODE-5122031-12-206a471c1ec25d…
2025-08-23 18:47 UTC2025-08N212273-002ODE*2026-10-216a471c1ec25d…
2025-08-23 18:47 UTC2025-08N212273-002M-3132027-12-206a471c1ec25d…
2025-08-23 18:47 UTC2025-08N212273-002ODE*2027-12-216a471c1ec25d…

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
TrikaftaELEXACAFTOR, TEZACAFTOR, AND IVACAFTORVertex Pharmaceuticals Incorporatedf354423a-85c2-41c3-a9db-0f3aee135d8d2026-06-22Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (NDA): 212273
application number: NDA212273
ndc (product): 51167-106
ndc (product): 51167-331

NDC Listings For This Application#

NDC listings for this application page 1 of 1 · 10 matching rows.

NDC, Name, Nonproprietary name table
NDCNameNonproprietary nameLabelerMarketing categoryStatus
51167-106TrikaftaElexacaftor, Tezacaftor, and IvacaftorVertex Pharmaceuticals IncorporatedNDACurrent
51167-106TrikaftaElexacaftor, Tezacaftor, and IvacaftorVertex Pharmaceuticals IncorporatedNDACurrent
51167-106TrikaftaElexacaftor, Tezacaftor, and IvacaftorVertex Pharmaceuticals IncorporatedNDACurrent
51167-331TrikaftaElexacaftor, Tezacaftor, and IvacaftorVertex Pharmaceuticals IncorporatedNDACurrent
51167-331TrikaftaElexacaftor, Tezacaftor, and IvacaftorVertex Pharmaceuticals IncorporatedNDACurrent
51167-331TrikaftaElexacaftor, Tezacaftor, and IvacaftorVertex Pharmaceuticals IncorporatedNDACurrent
51167-331TrikaftaElexacaftor, Tezacaftor, and IvacaftorVertex Pharmaceuticals IncorporatedNDACurrent
51167-331TrikaftaElexacaftor, Tezacaftor, and IvacaftorVertex Pharmaceuticals IncorporatedNDACurrent
51167-331TrikaftaElexacaftor, Tezacaftor, and IvacaftorVertex Pharmaceuticals IncorporatedNDACurrent
51167-331TrikaftaElexacaftor, Tezacaftor, and IvacaftorVertex Pharmaceuticals IncorporatedNDACurrent

Documents#

Document, Submission type, Date table
DocumentSubmission typeDate
85896SUPPL 2026-05-13
85659SUPPL 2026-04-09
85582SUPPL 2026-03-30
85478SUPPL 2026-03-24
85413SUPPL 2026-03-19
83562SUPPL 2025-09-26
83551SUPPL 2025-09-26
81653SUPPL 2025-07-25
81651SUPPL 2025-07-25
81647SUPPL 2025-07-25
81646SUPPL 2025-07-25
74997SUPPL 2023-08-04
74983SUPPL 2023-08-04
74101SUPPL 2023-04-27
74089SUPPL 2023-04-27
68893SUPPL2021-10-06
68877SUPPL2021-10-05
67752SUPPL2021-06-09
67749SUPPL2021-06-09
65745SUPPL2020-12-28
65725SUPPL2020-12-23
65295SUPPL2020-11-19
65280SUPPL2020-11-19
61040ORIG2019-11-25
60631ORIG2019-10-22
60624ORIG2019-10-22