REFRESH OPTIVE

Product NDC: 0023-3240
11-digit product format: 000233240
Labeler code: 0023
Product ID: 0023-3240_eb725fdd-160e-4b82-ad29-e54a6cd6f9e4
Type: HUMAN OTC DRUG
Nonproprietary name: carboxymethylcellulose sodium and glycerin
Dosage form: SOLUTION/ DROPS
Route: OPHTHALMIC
Labeler: Allergan, Inc.
Application: M018
Marketing category: OTC MONOGRAPH DRUG
Marketing start: 2006-09-06
Substance: CARBOXYMETHYLCELLULOSE SODIUM; GLYCERIN
Active strength: 5; 9 mg/mL; mg/mL
Pharmacologic classes: Allergens [CS], Cell-mediated Immunity [PE], Glycerol [CS], Increased Histamine Release [PE], Increased IgG Production [PE], Non-Standardized Chemical Allergen [EPC]
NDC exclude flag: No
Listing certified through: 2026-12-31
Current FDA listing: Yes

NDC auxiliary status#

These records are reproduced from FDA’s unfinished, excluded, and compounder listings. They describe what appeared in the source files; a missing record does not establish a regulatory status. View all current auxiliary records, including entries without an NDC. · View the auxiliary file history.

Current NDC status page 1 of 1 · 3 matching rows.

Dataset, Scope, Product NDC table
Dataset	Scope	Product NDC	Package NDC	Code	Status	Source date
excluded package	package	0023-3240	0023-3240-01	D	Discontinued by firm	2026-10-15
excluded package	package	0023-3240	0023-3240-02	D	Discontinued by firm	2026-10-15
excluded package	package	0023-3240	0023-3240-03	D	Discontinued by firm	2026-10-15

Observed NDC auxiliary status history#

This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.

Historic NDC status page 1 of 1 · 33 matching rows.

View current auxiliary records. · View the auxiliary file history.

Captured / source date, Package NDC, Snapshot table
Captured / source date	Package NDC	Snapshot	Source SHA-256
2025-12-14 17:58 UTC · source 2025-12-05	0023-3240-01	`d630ba8d3edf…`	`732f749b63fb…`
2025-12-14 17:58 UTC · source 2025-12-05	0023-3240-02	`d630ba8d3edf…`	`732f749b63fb…`
2025-12-14 17:58 UTC · source 2025-12-05	0023-3240-03	`d630ba8d3edf…`	`732f749b63fb…`
2025-08-27 00:01 UTC · source 2025-08-26	0023-3240-01	`f5e01cc5f278…`	`a2eaf40c39c3…`
2025-08-27 00:01 UTC · source 2025-08-26	0023-3240-02	`f5e01cc5f278…`	`a2eaf40c39c3…`
2025-08-27 00:01 UTC · source 2025-08-26	0023-3240-03	`f5e01cc5f278…`	`a2eaf40c39c3…`
2025-04-01 02:39 UTC · source 2025-03-31	0023-3240-01	`2ef7874e63bc…`	`57b86245f4fa…`
2025-04-01 02:39 UTC · source 2025-03-31	0023-3240-02	`2ef7874e63bc…`	`57b86245f4fa…`
2025-04-01 02:39 UTC · source 2025-03-31	0023-3240-03	`2ef7874e63bc…`	`57b86245f4fa…`
2025-03-28 20:22 UTC · source 2025-03-28	0023-3240-01	`a1b67e2a42f9…`	`c4cf2c586c0d…`
2025-03-28 20:22 UTC · source 2025-03-28	0023-3240-02	`a1b67e2a42f9…`	`c4cf2c586c0d…`
2025-03-28 20:22 UTC · source 2025-03-28	0023-3240-03	`a1b67e2a42f9…`	`c4cf2c586c0d…`
2025-03-22 03:12 UTC · source 2025-03-21	0023-3240-01	`cfe11265f3b6…`	`090c488252e2…`
2025-03-22 03:12 UTC · source 2025-03-21	0023-3240-02	`cfe11265f3b6…`	`090c488252e2…`
2025-03-22 03:12 UTC · source 2025-03-21	0023-3240-03	`cfe11265f3b6…`	`090c488252e2…`
2025-03-10 12:48 UTC · source 2025-03-10	0023-3240-01	`cdf11ea48f46…`	`ba0047e9e063…`
2025-03-10 12:48 UTC · source 2025-03-10	0023-3240-02	`cdf11ea48f46…`	`ba0047e9e063…`
2025-03-10 12:48 UTC · source 2025-03-10	0023-3240-03	`cdf11ea48f46…`	`ba0047e9e063…`
2025-02-02 03:52 UTC · source 2025-01-31	0023-3240-01	`302b2466d912…`	`e7b80fea0513…`
2025-02-02 03:52 UTC · source 2025-01-31	0023-3240-02	`302b2466d912…`	`e7b80fea0513…`
2025-02-02 03:52 UTC · source 2025-01-31	0023-3240-03	`302b2466d912…`	`e7b80fea0513…`
2025-01-20 13:05 UTC · source 2025-01-20	0023-3240-01	`ed331223b511…`	`672a5bd82f5f…`
2025-01-20 13:05 UTC · source 2025-01-20	0023-3240-02	`ed331223b511…`	`672a5bd82f5f…`
2025-01-20 13:05 UTC · source 2025-01-20	0023-3240-03	`ed331223b511…`	`672a5bd82f5f…`
2025-01-11 03:41 UTC · source 2025-01-10	0023-3240-01	`0efc9e666f02…`	`f202fb6c5f17…`
2025-01-11 03:41 UTC · source 2025-01-10	0023-3240-02	`0efc9e666f02…`	`f202fb6c5f17…`
2025-01-11 03:41 UTC · source 2025-01-10	0023-3240-03	`0efc9e666f02…`	`f202fb6c5f17…`
2024-11-09 02:27 UTC · source 2024-11-08	0023-3240-01	`ad56d346431e…`	`cc804d4bbf1e…`
2024-11-09 02:27 UTC · source 2024-11-08	0023-3240-02	`ad56d346431e…`	`cc804d4bbf1e…`
2024-11-09 02:27 UTC · source 2024-11-08	0023-3240-03	`ad56d346431e…`	`cc804d4bbf1e…`
2024-10-04 04:10 UTC · source 2024-10-03	0023-3240-01	`367a005e9d99…`	`383a685ebd0f…`
2024-10-04 04:10 UTC · source 2024-10-03	0023-3240-02	`367a005e9d99…`	`383a685ebd0f…`
2024-10-04 04:10 UTC · source 2024-10-03	0023-3240-03	`367a005e9d99…`	`383a685ebd0f…`

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

Additional Listing Data#

Finished product: Yes
Brand name base: REFRESH OPTIVE
Listing expiration: 2026-12-31

Active Ingredients#

Ingredient, Strength table
Ingredient	Strength
CARBOXYMETHYLCELLULOSE SODIUM	5 mg/mL
GLYCERIN	9 mg/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
K679OBS311	Internal UNII lookup
PDC6A3C0OX	Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
1100650	Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
7f8d88af-fd3b-4138-af61-f24c59ccebd7	Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product concept	Relation	Version	Effective
9e37788c-b1bf-42ae-aac9-b60601606144	Product name	8	20260122
30b0ac6e-02aa-0e5c-0d8b-cffdf3a282b2	Product name	5	20250304
1527ac37-808d-43be-a63e-74e1258dbe46	Product name	9	20250219
bed0530e-f939-4541-956b-6928a2f6404f	Product name	1	20241008
cefa60e2-a5b5-493e-9c54-24735b7dc509	Product name	6	20240814
08c722ec-780f-bb7b-8f14-3d4f7bf0e098	Product name	2	20240205
362d7abb-94e6-4c60-9a58-266894157713	Product name	1	20231023
9fcb7a91-de07-4f00-aabf-e4d6fda403d5	Product name	8	20230322
6bd95106-a412-1dad-b9cc-4cb74bfb27ce	Product name	2	20230315
e2f276e5-439f-b432-b5e5-b0cfa993da69	Product name	3	20220609
9badc7be-250a-44ab-aa36-926af3f02679	Product name	1	20210527
0ec3537a-6c9b-432a-896c-b9ea8723049a	Product name	9	20200701
444b3e50-f226-46ef-bfca-2e7035d140cd	Product name	1	20190611
816b97af-edc5-4060-aff1-b814bdbcad50	Product name	1	20190415
7cda52fc-125f-421c-8fea-bc1974370c49	Product name	2	20180703
7916de40-e296-41f0-b811-6d0df1a33e2c	Product name	9	20180627
cefa60e2-a5b5-493e-9c54-24735b7dc509	Product name	2	20171212
419aab54-5d5a-4146-9453-026d4a9991be	Product name	2	20170525
d5e51f11-ad28-caa4-4b49-4143974782ad	Product name	1	20150831
290f523a-f9db-9774-b5a9-e1f908ac1782	Product name	1	20150828
0ca1d589-929b-4b33-bc5b-1d84abdafa6a	Product name	1	20150324
fc363c46-397b-4476-ac0f-70e43e8e4592	Product name	1	20150324
89dac932-b90a-4410-9ab1-84c53e57de25	Product name	1	20150316
4585a4fb-0028-3d95-020c-9b1c40bf15e0	Product name	1	20140508
5668b646-cd56-c3c7-bdea-3f6b1a8840db	Product name	1	20140508
810ab97e-f109-f41c-7c83-6a652a9cbf43	Product name	1	20140508
87711080-88eb-65c5-b2dd-bf99e700a372	Product name	1	20140508
8dbefedf-0a0d-a224-5a3c-66dc9e11c2dd	Product name	1	20140508
c6b65c52-69c7-df49-550a-a50c137f6218	Product name	1	20140508
ec2149b3-5c6d-5344-f757-c86411073075	Product name	1	20140508
ed912195-5da0-0f2f-6f4b-3ef17710cbe3	Product name	1	20140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	SPL version
0023-3240-01	REFRESH OPTIVE	2 in 1 CARTON	SOLUTION/ DROPS	2	12
0023-3240-01	REFRESH OPTIVE	15 mL in 1 BOTTLE, DROPPER	SOLUTION/ DROPS	15	12
0023-3240-02	REFRESH OPTIVE	1 in 1 CARTON	SOLUTION/ DROPS	1	12
0023-3240-02	REFRESH OPTIVE	2 mL in 1 BOTTLE, DROPPER	SOLUTION/ DROPS	2	12
0023-3240-03	REFRESH OPTIVE	1 in 1 CARTON	SOLUTION/ DROPS	1	12
0023-3240-03	REFRESH OPTIVE	3 mL in 1 BOTTLE, DROPPER	SOLUTION/ DROPS	3	12
0023-3240-15	REFRESH OPTIVE	1 in 1 CARTON	SOLUTION/ DROPS	1	12
0023-3240-15	REFRESH OPTIVE	15 mL in 1 BOTTLE, DROPPER	SOLUTION/ DROPS	15	12

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDC	Billing unit	Product NDC	DailyMed indexing SPL	SPL version	Effective
0023-3240-01	ML - Milliliter	0023-3240	c28ae2fd-afee-4515-806c-686431e7e3c2	1	2012-07-24
0023-3240-10	ML - Milliliter	0023-3240	6eb0523b-0945-4574-bae9-e913626b5bf7	1	2012-07-24
0023-3240-15	ML - Milliliter	0023-3240	1ea253fb-4ecc-49c4-9ec1-22b7b4ec10a5	1	2012-07-24

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
Ingredient	Type	UNII	DailyMed label	SPL version
carboxymethylcellulose sodium	ACTIVE INGREDIENT	K679OBS311	REFRESH OPTIVE (CARBOXYMETHYLCELLULOSE SODIUM AND GLYCERIN) SOLUTION/ DROPS [ALLERGAN, INC.]	5
glycerin	ACTIVE INGREDIENT	PDC6A3C0OX	REFRESH OPTIVE (CARBOXYMETHYLCELLULOSE SODIUM AND GLYCERIN) SOLUTION/ DROPS [ALLERGAN, INC.]	5
carboxymethylcellulose	ACTIVE MOIETY	05JZI7B19X	REFRESH OPTIVE (CARBOXYMETHYLCELLULOSE SODIUM AND GLYCERIN) SOLUTION/ DROPS [ALLERGAN, INC.]	5
glycerin	ACTIVE MOIETY	PDC6A3C0OX	REFRESH OPTIVE (CARBOXYMETHYLCELLULOSE SODIUM AND GLYCERIN) SOLUTION/ DROPS [ALLERGAN, INC.]	5
boric acid	INACTIVE INGREDIENT	R57ZHV85D4	REFRESH OPTIVE (CARBOXYMETHYLCELLULOSE SODIUM AND GLYCERIN) SOLUTION/ DROPS [ALLERGAN, INC.]	5
calcium chloride	INACTIVE INGREDIENT	M4I0D6VV5M	REFRESH OPTIVE (CARBOXYMETHYLCELLULOSE SODIUM AND GLYCERIN) SOLUTION/ DROPS [ALLERGAN, INC.]	5
chlorine dioxide	INACTIVE INGREDIENT	8061YMS4RM	REFRESH OPTIVE (CARBOXYMETHYLCELLULOSE SODIUM AND GLYCERIN) SOLUTION/ DROPS [ALLERGAN, INC.]	5
erythritol	INACTIVE INGREDIENT	RA96B954X6	REFRESH OPTIVE (CARBOXYMETHYLCELLULOSE SODIUM AND GLYCERIN) SOLUTION/ DROPS [ALLERGAN, INC.]	5
levocarnitine	INACTIVE INGREDIENT	0G389FZZ9M	REFRESH OPTIVE (CARBOXYMETHYLCELLULOSE SODIUM AND GLYCERIN) SOLUTION/ DROPS [ALLERGAN, INC.]	5
magnesium chloride	INACTIVE INGREDIENT	02F3473H9O	REFRESH OPTIVE (CARBOXYMETHYLCELLULOSE SODIUM AND GLYCERIN) SOLUTION/ DROPS [ALLERGAN, INC.]	5
potassium chloride	INACTIVE INGREDIENT	660YQ98I10	REFRESH OPTIVE (CARBOXYMETHYLCELLULOSE SODIUM AND GLYCERIN) SOLUTION/ DROPS [ALLERGAN, INC.]	5
sodium borate	INACTIVE INGREDIENT	91MBZ8H3QO	REFRESH OPTIVE (CARBOXYMETHYLCELLULOSE SODIUM AND GLYCERIN) SOLUTION/ DROPS [ALLERGAN, INC.]	5
sodium chlorate	INACTIVE INGREDIENT	T95DR77GMR	REFRESH OPTIVE (CARBOXYMETHYLCELLULOSE SODIUM AND GLYCERIN) SOLUTION/ DROPS [ALLERGAN, INC.]	5
sodium chlorite	INACTIVE INGREDIENT	G538EBV4VF	REFRESH OPTIVE (CARBOXYMETHYLCELLULOSE SODIUM AND GLYCERIN) SOLUTION/ DROPS [ALLERGAN, INC.]	5
trisodium citrate dihydrate	INACTIVE INGREDIENT	B22547B95K	REFRESH OPTIVE (CARBOXYMETHYLCELLULOSE SODIUM AND GLYCERIN) SOLUTION/ DROPS [ALLERGAN, INC.]	5
water	INACTIVE INGREDIENT	059QF0KO0R	REFRESH OPTIVE (CARBOXYMETHYLCELLULOSE SODIUM AND GLYCERIN) SOLUTION/ DROPS [ALLERGAN, INC.]	5

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
0023-3240	REFRESH OPTIVE (CARBOXYMETHYLCELLULOSE SODIUM AND GLYCERIN) SOLUTION/ DROPS [ALLERGAN, INC.]	12	Current NDC, Legacy NDC, 8 package rows	20240929_7f8d88af-fd3b-4138-af61-f24c59ccebd7.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 19 of 25 · 494 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
Eye Wash	WATER	Hubei Changjian Medical Products Co., Ltd.	d57e1c5b-1edc-4a94-88bc-f9ecf347b7ea	2024-10-11	Warnings	Exact identifier application number: M018
Capasil Pain Relieving	MENTHOL, METHYL SALICYLATE	PureTek Corporation	b1a8e78c-57f0-1f3e-e053-2995a90acbd5	2024-10-01	Warnings	Exact identifier application number: M018
Mencylate Pain Relieving	MENTHOL, METHYL SALICYLATE	PureTek Corporation	f824de86-9492-2e6b-e053-6294a90a6f2a	2024-10-01	Warnings	Exact identifier application number: M018
Advanced Eye Relief/ Redness Maximum Relief	NAPHAZOLINE HYDROCHLORIDE AND HYPROMELLOSE	Bausch & Lomb Incorporated	3c11285a-7e86-4b47-b1ee-e7d59858087d	2024-09-25	Warnings	Exact identifier application number: M018
Muro 128	SODIUM CHLORIDE	Bausch & Lomb Incorporated	cc3d5bc8-9d3c-4c65-9e43-707a2db4081a	2024-09-25	Warnings	Exact identifier application number: M018
Muro 128	SODIUM CHLORIDE	Bausch & Lomb Incorporated	93fafa27-5031-4d95-b4b8-5574b7204ae2	2024-09-25	Warnings	Exact identifier application number: M018
Muro 128	SODIUM CHLORIDE	Bausch & Lomb Incorporated	454f337e-d897-46de-ab05-1c543a33061c	2024-09-25	Warnings	Exact identifier application number: M018
PURPOSE	OCTINOXATE, OCTISALATE AND OXYBENZONE	Bausch & Lomb Incorporated	a1e14135-b8da-4cee-8c5b-1893572f4de4	2024-09-25	Warnings	Exact identifier application number: M018
Soothe Night Time	WHITE PETROLATUM MINERAL OIL	Bausch & Lomb Incorporated	638d3c3f-9960-43da-956e-0e28c77f533e	2024-09-24	Warnings	Exact identifier application number: M018
blink tears	POLYETHYLENE GLYCOL 400	Bausch & Lomb Incorporated	10fcf407-6eaf-4730-9ed0-9b7715cf5701	2024-09-20	Warnings	Exact identifier application number: M018
Soothe XP Preservative Free	LIGHT MINERAL OIL AND MINERAL OIL	Bausch & Lomb Incorporated	b254d885-6d49-4c95-b6be-cfdad49c85e6	2024-09-20	Warnings	Exact identifier application number: M018
blink gel tears	POLYETHYLENE GLYCOL 400	Bausch & Lomb Incorporated	6f7e06c3-204d-459a-af8f-c46be9ad0e8d	2024-09-20	Warnings	Exact identifier application number: M018
Soothe XP	LIGHT MINERAL OIL AND MINERAL OIL	Bausch & Lomb Incorporated	c0f053da-8d22-433e-a36e-79cf15ad387f	2024-09-20	Warnings	Exact identifier application number: M018
Soothe	GLYCERIN AND PROPYLENE GLYCOL	Bausch & Lomb Incorporated	fef002ea-c4bd-4486-a42e-1bbd9d73d28d	2024-09-20	Warnings	Exact identifier application number: M018
Leader Preservative-Free Ultra Lubricating Eye Drops	POLYETHYLENE GLYCOL 400, PROPYLENE GLYCOL	Cardinal Health	2a2aa620-ca63-4698-88fd-fc263b8fa0d1	2024-09-07	Warnings	Exact identifier application number: M018
Eyesaline Emergency Eyewash	PURIFIED WATER	Honeywell Safety Products USA, Inc.	ad42a7e3-84ea-390d-e053-2a95a90a3a32	2024-06-14	Warnings	Exact identifier application number: M018
Artificial Tears	POLYVINYL ALCOHOL, POVIDONE	NuCare Pharmaceuticals,Inc.	9c1c4911-908e-3c3c-e053-2995a90abcfc	2024-06-14	Warnings	Exact identifier application number: M018
Eyes Alive Eye Wash	WATER	RIVIERA PHARMA INC	081079f4-1c06-4054-b771-00fedaa666f6	2024-06-05	Warnings	Exact identifier application number: M018
Eyes Alive Lubricating	CARBOXYMETHYLCELLULOSE SODIUM, UNSPECIFIED	RIVIERA PHARMA INC	b6966691-6884-438c-9f89-5924089226e1	2024-05-31	Warnings	Exact identifier application number: M018
Eye Wash	WATER	M-star (Hubei) Health&Care Products Co., Ltd.	71706039-e250-4f08-9687-71b2928c4e46	2024-04-01	Warnings	Exact identifier application number: M018

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
PDC6A3C0OX	GLYCERIN	56-81-5	GLYCERIN

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUI	RxNorm string	TTY	DailyMed	SPL version
1100650	carboxymethylcellulose sodium 0.5 % / glycerin 0.9 % Ophthalmic Solution	PSN	7f8d88af-fd3b-4138-af61-f24c59ccebd7	12
1100650	carboxymethylcellulose sodium 5 MG/ML / glycerin 9 MG/ML Ophthalmic Solution	SCD	7f8d88af-fd3b-4138-af61-f24c59ccebd7	12
1100650	carboxymethylcellulose sodium 0.5 % / glycerin 0.9 % Ophthalmic Solution	SY	7f8d88af-fd3b-4138-af61-f24c59ccebd7	12

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Marketing start	Marketing end	Sample	Exclude flag	Status
0023-3240-01	00023324001	2 BOTTLE, DROPPER in 1 CARTON (0023-3240-01) > 15 mL in 1 BOTTLE, DROPPER	2006-09-06	0000-00-00	No	No	Current
0023-3240-02	00023324002	1 BOTTLE, DROPPER in 1 CARTON (0023-3240-02) > 2 mL in 1 BOTTLE, DROPPER	2006-09-06	0000-00-00	Yes	No	Current
0023-3240-03	00023324003	1 BOTTLE, DROPPER in 1 CARTON (0023-3240-03) > 3 mL in 1 BOTTLE, DROPPER	2006-09-06	0000-00-00	No	No	Current
0023-3240-15	00023324015	1 BOTTLE, DROPPER in 1 CARTON (0023-3240-15) / 15 mL in 1 BOTTLE, DROPPER	2006-09-06	0000-00-00	No	No	Current