ORKAMBI

Product NDC
51167-809
Requested package NDC
51167-809-01
11-digit product format
511670809
Labeler code
51167
Product ID
51167-809_e746b83a-cec1-40ab-8dba-7d8c1781e8b1
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
lumacaftor and ivacaftor
Dosage form
TABLET, FILM COATED
Route
ORAL
Labeler
Vertex Pharmaceuticals Incorporated
Application
NDA206038
Marketing category
NDA
Marketing start
2015-07-02
Substance
IVACAFTOR; LUMACAFTOR
Active strength
125; 200 mg/1; mg/1
Pharmacologic classes
Chloride Channel Activation Potentiators [MoA], Cystic Fibrosis Transmembrane Conductance Regulator Potentiator [EPC], Cytochrome P450 2B6 Inducers [MoA], Cytochrome P450 2C19 Inducers [MoA], Cytochrome P450 2C8 Inducers [MoA], Cytochrome P450 2C8 Inhibitors [MoA], Cytochrome P450 2C9 Inducers [MoA], Cytochrome P450 2C9 Inhibitors [MoA], Cytochrome P450 2C9 Inhibitors [MoA], Cytochrome P450 3A Inducers [MoA], Cytochrome P450 3A Inhibitors [MoA], P-Glycoprotein Inducers [MoA], P-Glycoprotein Inhibitors [MoA], P-Glycoprotein Inhibitors [MoA]
NDC exclude flag
No
Listing certified through
2027-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 2 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
N206038-001ORKAMBIIVACAFTOR; LUMACAFTOR125MG;200MGTABLET / ORALRLD, RS2015-07-02
N206038-002ORKAMBIIVACAFTOR; LUMACAFTOR125MG;100MGTABLET / ORALRLD2016-09-28

Orange Book patents#

Current patent rows page 1 of 2 · 94 matching rows.

Application-product, Patent, Expiration table
Application-productPatentExpirationUse codeCoverage / statusSubmission date
N206038-00179730382026-11-08U-19732016-10-21
N206038-00187419332026-11-08U-17172015-07-22
N206038-00187419332026-11-08U-19092015-07-22
N206038-00192169692026-11-08Drug substance, Drug product2016-03-15
N206038-00184102742026-12-28Drug product2015-07-22
N206038-00187542242026-12-28Drug substance, Drug product2015-07-22
N206038-00196701632026-12-28U-1911Drug product2017-07-05
N206038-00199313342026-12-28U-2276Drug product2018-05-02
N206038-0017973038*PED2027-05-08Pediatric extension
N206038-0018741933*PED2027-05-08Pediatric extension
N206038-0019216969*PED2027-05-08Pediatric extension
N206038-00174951032027-05-20Drug substance, Drug product2015-07-22
N206038-0018410274*PED2027-06-28Pediatric extension
N206038-0018754224*PED2027-06-28Pediatric extension
N206038-0019670163*PED2027-06-28Pediatric extension
N206038-0019931334*PED2027-06-28Pediatric extension
N206038-00183242422027-08-05U-13112015-07-22
N206038-00183242422027-08-05U-19112015-07-22
N206038-0017495103*PED2027-11-20Pediatric extension
N206038-0018324242*PED2028-02-05Pediatric extension
N206038-001100765132028-12-04U-2411Drug product2018-10-18
N206038-001105973842028-12-04U-2777Drug substance, Drug product2020-04-23
N206038-001110520752028-12-04U-3181Drug product2021-08-04
N206038-001120654322028-12-04U-39842024-09-18
N206038-00186531032028-12-04Drug product2015-07-22
N206038-00191505522028-12-04U-19082016-10-21
N206038-00110076513*PED2029-06-04Pediatric extension
N206038-00110597384*PED2029-06-04Pediatric extension
N206038-00111052075*PED2029-06-04Pediatric extension
N206038-00112065432*PED2029-06-04Pediatric extension
N206038-0018653103*PED2029-06-04Pediatric extension
N206038-0019150552*PED2029-06-04Pediatric extension
N206038-00188467182029-07-02U-17172015-07-22
N206038-00188467182029-07-02U-19082015-07-22
N206038-001106464812029-08-13Drug product2020-06-11
N206038-001115649162029-08-13U-35292023-02-28
N206038-001124586352029-08-13U-4338Drug product2025-11-26
N206038-00191926062029-09-29U-1912Drug product2016-10-21
N206038-0018846718*PED2030-01-02Pediatric extension
N206038-00110646481*PED2030-02-13Pediatric extension
N206038-00111564916*PED2030-02-13Pediatric extension
N206038-00112458635*PED2030-02-13Pediatric extension
N206038-0019192606*PED2030-03-29Pediatric extension
N206038-00185075342030-09-20Drug substance, Drug product2015-07-22
N206038-00187163382030-09-20U-1718Drug product2015-07-22
N206038-00187163382030-09-20U-1910Drug product2015-07-22
N206038-00189936002030-12-11Drug product2015-07-22
N206038-0018507534*PED2031-03-20Pediatric extension
N206038-0018716338*PED2031-03-20Pediatric extension
N206038-0018993600*PED2031-06-11Pediatric extension
N206038-00279730382026-11-08U-19732016-10-21
N206038-00287419332026-11-08U-19092016-10-21
N206038-00292169692026-11-08Drug product2016-10-21
N206038-00284102742026-12-28Drug product2016-10-21
N206038-00287542242026-12-28Drug substance, Drug product2016-10-21
N206038-00296701632026-12-28U-1911Drug product2017-07-05
N206038-00299313342026-12-28U-2276Drug product2018-05-02
N206038-0027973038*PED2027-05-08Pediatric extension
N206038-0028741933*PED2027-05-08Pediatric extension
N206038-0029216969*PED2027-05-08Pediatric extension
N206038-00274951032027-05-20Drug substance, Drug product2016-10-21
N206038-0028410274*PED2027-06-28Pediatric extension
N206038-0028754224*PED2027-06-28Pediatric extension
N206038-0029670163*PED2027-06-28Pediatric extension
N206038-0029931334*PED2027-06-28Pediatric extension
N206038-00283242422027-08-05U-19112016-10-21
N206038-0027495103*PED2027-11-20Pediatric extension
N206038-0028324242*PED2028-02-05Pediatric extension
N206038-002105973842028-12-04U-2777Drug substance, Drug product2020-04-23
N206038-002110520752028-12-04U-3181Drug product2021-08-04
N206038-002120654322028-12-04U-39842024-09-18
N206038-00286531032028-12-04Drug product2016-10-21
N206038-00291505522028-12-04U-19082016-10-21
N206038-00210597384*PED2029-06-04Pediatric extension
N206038-00211052075*PED2029-06-04Pediatric extension
N206038-00212065432*PED2029-06-04Pediatric extension
N206038-0028653103*PED2029-06-04Pediatric extension
N206038-0029150552*PED2029-06-04Pediatric extension
N206038-00288467182029-07-02U-19082016-10-21
N206038-002106464812029-08-13Drug product2020-06-11

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 3 · 82 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02N206038-001ORKAMBI125MG;200MGTABLET / ORALRLD, RS2015-07-02011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-002ORKAMBI125MG;100MGTABLET / ORALRLD2016-09-28011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N206038-001ORKAMBI125MG;200MGTABLET / ORALRLD, RS2015-07-0231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N206038-002ORKAMBI125MG;100MGTABLET / ORALRLD2016-09-2831067a03dcf5…
2025-08-23 18:47 UTC2025-08N206038-001ORKAMBI125MG;200MGTABLET / ORALRLD, RS2015-07-026a471c1ec25d…
2025-08-23 18:47 UTC2025-08N206038-002ORKAMBI125MG;100MGTABLET / ORALRLD2016-09-286a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N206038-001ORKAMBI125MG;200MGTABLET / ORALRLD, RS2015-07-02fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N206038-002ORKAMBI125MG;100MGTABLET / ORALRLD2016-09-28fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N206038-001ORKAMBI125MG;200MGTABLET / ORALRLD, RS2015-07-02b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N206038-002ORKAMBI125MG;100MGTABLET / ORALRLD2016-09-28b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N206038-001ORKAMBI125MG;200MGTABLET / ORALRLD, RS2015-07-0203ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N206038-002ORKAMBI125MG;100MGTABLET / ORALRLD2016-09-2803ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N206038-001ORKAMBI125MG;200MGTABLET / ORALRLD, RS2015-07-022680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N206038-002ORKAMBI125MG;100MGTABLET / ORALRLD2016-09-282680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N206038-001ORKAMBI125MG;200MGTABLET / ORALRLD, RS2015-07-025bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N206038-002ORKAMBI125MG;100MGTABLET / ORALRLD2016-09-285bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N206038-001ORKAMBI125MG;200MGTABLET / ORALRLD, RS2015-07-02d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N206038-002ORKAMBI125MG;100MGTABLET / ORALRLD2016-09-28d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N206038-001ORKAMBI125MG;200MGTABLET / ORALRLD, RS2015-07-02d06236e962d9…
2024-10-29 15:01 UTC2024-10N206038-002ORKAMBI125MG;100MGTABLET / ORALRLD2016-09-28d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N206038-001ORKAMBI125MG;200MGTABLET / ORALRLD, RS2015-07-0279d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N206038-002ORKAMBI125MG;100MGTABLET / ORALRLD2016-09-2879d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N206038-001ORKAMBI125MG;200MGTABLET / ORALRLD, RS2015-07-02301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N206038-002ORKAMBI125MG;100MGTABLET / ORALRLD2016-09-28301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N206038-001ORKAMBI125MG;200MGTABLET / ORALRLD, RS2015-07-021e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N206038-002ORKAMBI125MG;100MGTABLET / ORALRLD2016-09-281e350fbaab3a…
2024-05-31 18:47 UTC2024-05N206038-001ORKAMBI125MG;200MGTABLET / ORALRLD, RS2015-07-028072bd15b7f6…
2024-05-31 18:47 UTC2024-05N206038-002ORKAMBI125MG;100MGTABLET / ORALRLD2016-09-288072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N206038-001ORKAMBI125MG;200MGTABLET / ORALRLD, RS2015-07-025c6f7cd8ea54…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N206038-002ORKAMBI125MG;100MGTABLET / ORALRLD2016-09-285c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04N206038-001ORKAMBI125MG;200MGTABLET / ORALRLD, RS2015-07-025d02ea3f76ae…
2022-04-08 23:34 UTC2022-04N206038-002ORKAMBI125MG;100MGTABLET / ORALRLD2016-09-285d02ea3f76ae…
2022-04-04 05:41 UTC2022-04N206038-001ORKAMBI125MG;200MGTABLET / ORALRLD, RS2015-07-024b0b4de00fa7…
2022-04-04 05:41 UTC2022-04N206038-002ORKAMBI125MG;100MGTABLET / ORALRLD2016-09-284b0b4de00fa7…
2019-12-13 00:20 UTC2019-12N206038-001ORKAMBI125MG;200MGTABLET / ORALRLD, RS2015-07-0274a2ff9319b5…
2019-12-13 00:20 UTC2019-12N206038-002ORKAMBI125MG;100MGTABLET / ORALRLD2016-09-2874a2ff9319b5…
2022-03-09 01:35 UTC2022-03N206038-001ORKAMBI125MG;200MGTABLET / ORALRLD, RS2015-07-02bb7c543d1eb4…
2022-03-09 01:35 UTC2022-03N206038-002ORKAMBI125MG;100MGTABLET / ORALRLD2016-09-28bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12N206038-001ORKAMBI125MG;200MGTABLET / ORALRLD, RS2015-07-02782e0a99824c…
2021-12-28 21:50 UTC2021-12N206038-002ORKAMBI125MG;100MGTABLET / ORALRLD2016-09-28782e0a99824c…

Observed Orange Book patent history#

Patent history page 1 of 51 · 2,024 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productPatentExpirationUse codeCoverage / statusSubmission dateSource SHA-256
2026-02-19 14:30 UTC2026-02N206038-00179730382026-11-08U-19732016-10-21011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-00187419332026-11-08U-19092015-07-22011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-00187419332026-11-08U-17172015-07-22011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-00192169692026-11-08Drug substance, Drug product2016-03-15011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-00184102742026-12-28Drug product2015-07-22011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-00187542242026-12-28Drug substance, Drug product2015-07-22011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-00196701632026-12-28U-1911Drug product2017-07-05011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-00199313342026-12-28U-2276Drug product2018-05-02011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-0017973038*PED2027-05-08Pediatric extension011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-0018741933*PED2027-05-08Pediatric extension011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-0019216969*PED2027-05-08Pediatric extension011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-00174951032027-05-20Drug substance, Drug product2015-07-22011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-0018410274*PED2027-06-28Pediatric extension011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-0018754224*PED2027-06-28Pediatric extension011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-0019670163*PED2027-06-28Pediatric extension011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-0019931334*PED2027-06-28Pediatric extension011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-00183242422027-08-05U-13112015-07-22011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-00183242422027-08-05U-19112015-07-22011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-0017495103*PED2027-11-20Pediatric extension011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-0018324242*PED2028-02-05Pediatric extension011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-001100765132028-12-04U-2411Drug product2018-10-18011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-001105973842028-12-04U-2777Drug substance, Drug product2020-04-23011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-001110520752028-12-04U-3181Drug product2021-08-04011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-001120654322028-12-04U-39842024-09-18011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-00186531032028-12-04Drug product2015-07-22011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-00191505522028-12-04U-19082016-10-21011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-00110076513*PED2029-06-04Pediatric extension011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-00110597384*PED2029-06-04Pediatric extension011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-00111052075*PED2029-06-04Pediatric extension011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-00112065432*PED2029-06-04Pediatric extension011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-0018653103*PED2029-06-04Pediatric extension011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-0019150552*PED2029-06-04Pediatric extension011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-00188467182029-07-02U-17172015-07-22011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-00188467182029-07-02U-19082015-07-22011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-001106464812029-08-13Drug product2020-06-11011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-001115649162029-08-13U-35292023-02-28011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-001124586352029-08-13U-4338Drug product2025-11-26011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-00191926062029-09-29U-1912Drug product2016-10-21011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-0018846718*PED2030-01-02Pediatric extension011fe1cb6892…
2026-02-19 14:30 UTC2026-02N206038-00110646481*PED2030-02-13Pediatric extension011fe1cb6892…

Observed Orange Book exclusivity history#

Exclusivity history page 1 of 3 · 118 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productExclusivity codeExpirationSource SHA-256
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N206038-001ODE-932022-07-025c6f7cd8ea54…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N206038-001ODE-1232023-09-285c6f7cd8ea54…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N206038-002ODE-932022-07-025c6f7cd8ea54…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N206038-002ODE-1232023-09-285c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04N206038-001ODE-932022-07-025d02ea3f76ae…
2022-04-08 23:34 UTC2022-04N206038-001ODE-1232023-09-285d02ea3f76ae…
2022-04-08 23:34 UTC2022-04N206038-002ODE-932022-07-025d02ea3f76ae…
2022-04-08 23:34 UTC2022-04N206038-002ODE-1232023-09-285d02ea3f76ae…
2022-04-04 05:41 UTC2022-04N206038-001ODE-932022-07-024b0b4de00fa7…
2022-04-04 05:41 UTC2022-04N206038-001ODE-1232023-09-284b0b4de00fa7…
2022-04-04 05:41 UTC2022-04N206038-002ODE-932022-07-024b0b4de00fa7…
2022-04-04 05:41 UTC2022-04N206038-002ODE-1232023-09-284b0b4de00fa7…
2019-12-13 00:20 UTC2019-12N206038-001NCE2020-07-0274a2ff9319b5…
2019-12-13 00:20 UTC2019-12N206038-001M-2182021-01-2574a2ff9319b5…
2019-12-13 00:20 UTC2019-12N206038-001ODE-932022-07-0274a2ff9319b5…
2019-12-13 00:20 UTC2019-12N206038-001ODE-1232023-09-2874a2ff9319b5…
2019-12-13 00:20 UTC2019-12N206038-002NPP2019-09-2874a2ff9319b5…
2019-12-13 00:20 UTC2019-12N206038-002NCE2020-07-0274a2ff9319b5…
2019-12-13 00:20 UTC2019-12N206038-002M-2182021-01-2574a2ff9319b5…
2019-12-13 00:20 UTC2019-12N206038-002ODE-932022-07-0274a2ff9319b5…
2019-12-13 00:20 UTC2019-12N206038-002ODE-1232023-09-2874a2ff9319b5…
2022-03-09 01:35 UTC2022-03N206038-001ODE-932022-07-02bb7c543d1eb4…
2022-03-09 01:35 UTC2022-03N206038-001ODE-1232023-09-28bb7c543d1eb4…
2022-03-09 01:35 UTC2022-03N206038-002ODE-932022-07-02bb7c543d1eb4…
2022-03-09 01:35 UTC2022-03N206038-002ODE-1232023-09-28bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12N206038-001M-2182021-01-25782e0a99824c…
2021-12-28 21:50 UTC2021-12N206038-001ODE-932022-07-02782e0a99824c…
2021-12-28 21:50 UTC2021-12N206038-001ODE-1232023-09-28782e0a99824c…
2021-12-28 21:50 UTC2021-12N206038-002M-2182021-01-25782e0a99824c…
2021-12-28 21:50 UTC2021-12N206038-002ODE-932022-07-02782e0a99824c…
2021-12-28 21:50 UTC2021-12N206038-002ODE-1232023-09-28782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N206038-001M-2182021-01-2587673890dc5c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N206038-001ODE-932022-07-0287673890dc5c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N206038-001ODE-1232023-09-2887673890dc5c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N206038-002M-2182021-01-2587673890dc5c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N206038-002ODE-932022-07-0287673890dc5c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N206038-002ODE-1232023-09-2887673890dc5c…
2021-03-12 10:30 UTC2021-03N206038-001M-2182021-01-255aa47cf7b7d7…
2021-03-12 10:30 UTC2021-03N206038-001ODE-932022-07-025aa47cf7b7d7…
2021-03-12 10:30 UTC2021-03N206038-001ODE-1232023-09-285aa47cf7b7d7…

Additional Listing Data#

Finished product
Yes
Brand name base
ORKAMBI
Listing expiration
2027-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
LUMACAFTOR125 mg/1
IVACAFTOR200 mg/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1Y740ILL1ZInternal UNII lookup
EGP8L81APKInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 10 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1655928Internal RxNorm lookup
1655934Internal RxNorm lookup
1812468Internal RxNorm lookup
1812470Internal RxNorm lookup
2053509Internal RxNorm lookup
2053512Internal RxNorm lookup
2053517Internal RxNorm lookup
2053519Internal RxNorm lookup
2611458Internal RxNorm lookup
2611460Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
3fc1c40e-cfac-47a1-9e1a-61ead3570600Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
362d7abb-94e6-4c60-9a58-266894157713Product name120231023
3345c65e-7c51-4ee3-a410-af7ec8592f92Product name220231010
31b21435-431d-4752-a7c5-89c6a41c6338Product name420230626
816b97af-edc5-4060-aff1-b814bdbcad50Product name120190415
eaf14f5a-a483-45c2-b6bb-bda37f923e37Product name120180508
419aab54-5d5a-4146-9453-026d4a9991beProduct name220170525
1c108d2a-865b-9f48-5b3a-b52233297e1dProduct name220150417
89dac932-b90a-4410-9ab1-84c53e57de25Product name120150316
d723478e-ad4a-ec23-6bd7-cfe33e1e3840Product name120140508

FDA-Initiated Inactive NDC Indexing#

Effective, Related label table
EffectiveRelated label
2024-01-30These highlights do not include all the information needed to use ORKAMBI safely and effectively. See full prescribing information for ORKAMBI. ORKAMBI ® (lumacaftor and ivacaftor) tablets, for oral use ORKAMBI ® (lumacaftor and ivacaftor) oral granules Initial U.S. Approval: 2015
2024-01-30These highlights do not include all the information needed to use ORKAMBI safely and effectively. See full prescribing information for ORKAMBI. ORKAMBI ® (lumacaftor and ivacaftor) tablets, for oral use ORKAMBI ® (lumacaftor and ivacaftor) oral granules Initial U.S. Approval: 2015
2024-01-30These highlights do not include all the information needed to use ORKAMBI safely and effectively. See full prescribing information for ORKAMBI. ORKAMBI ® (lumacaftor and ivacaftor) tablets, for oral use ORKAMBI ® (lumacaftor and ivacaftor) oral granules Initial U.S. Approval: 2015
2022-08-04These highlights do not include all the information needed to use ORKAMBI safely and effectively. See full prescribing information for ORKAMBI. ORKAMBI ® (lumacaftor and ivacaftor) tablets, for oral use ORKAMBI ® (lumacaftor and ivacaftor) oral granules Initial U.S. Approval: 2015
2022-08-04These highlights do not include all the information needed to use ORKAMBI safely and effectively. See full prescribing information for ORKAMBI. ORKAMBI ® (lumacaftor and ivacaftor) tablets, for oral use ORKAMBI ® (lumacaftor and ivacaftor) oral granules Initial U.S. Approval: 2015
2022-08-04These highlights do not include all the information needed to use ORKAMBI safely and effectively. See full prescribing information for ORKAMBI. ORKAMBI ® (lumacaftor and ivacaftor) tablets, for oral use ORKAMBI ® (lumacaftor and ivacaftor) oral granules Initial U.S. Approval: 2015
2022-07-29These highlights do not include all the information needed to use ORKAMBI safely and effectively. See full prescribing information for ORKAMBI. ORKAMBI ® (lumacaftor and ivacaftor) tablets, for oral use ORKAMBI ® (lumacaftor and ivacaftor) oral granules Initial U.S. Approval: 2015
2022-07-29These highlights do not include all the information needed to use ORKAMBI safely and effectively. See full prescribing information for ORKAMBI. ORKAMBI ® (lumacaftor and ivacaftor) tablets, for oral use ORKAMBI ® (lumacaftor and ivacaftor) oral granules Initial U.S. Approval: 2015
2022-07-29These highlights do not include all the information needed to use ORKAMBI safely and effectively. See full prescribing information for ORKAMBI. ORKAMBI ® (lumacaftor and ivacaftor) tablets, for oral use ORKAMBI ® (lumacaftor and ivacaftor) oral granules Initial U.S. Approval: 2015

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
51167-809-01ORKAMBI4 in 1 BOXTABLET, FILM COATED424
51167-809-01ORKAMBI7 in 1 CARTONTABLET, FILM COATED724

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
51167-809-01EA - Each51167-80941a379ae-6308-4b2e-a8e0-7b197f139f0912015-08-04

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
IngredientTypeUNIIDailyMed labelSPL versionUploaded
ivacaftorACTIVE INGREDIENT1Y740ILL1ZORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
lumacaftorACTIVE INGREDIENTEGP8L81APKORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
ivacaftorACTIVE MOIETY1Y740ILL1ZORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
lumacaftorACTIVE MOIETYEGP8L81APKORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
AMMONIAINACTIVE INGREDIENT5138Q19F1XORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
CARMINIC ACIDINACTIVE INGREDIENTCID8Z8N95NORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
CELLULOSE, MICROCRYSTALLINEINACTIVE INGREDIENTOP1R32D61UORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
CROSCARMELLOSE SODIUMINACTIVE INGREDIENTM28OL1HH48ORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
FD&C Blue No. 1INACTIVE INGREDIENTH3R47K3TBDORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
FD&C Blue No. 2INACTIVE INGREDIENTL06K8R7DQKORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
FERROSOFERRIC OXIDEINACTIVE INGREDIENTXM0M87F357ORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
HYPROMELLOSE ACETATE SUCCINATE 06081224 (3 MM2/S)INACTIVE INGREDIENT6N003M473WORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
MAGNESIUM STEARATEINACTIVE INGREDIENT70097M6I30ORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
POLYETHYLENE GLYCOL 3350INACTIVE INGREDIENTG2M7P15E5PORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
POLYVINYL ALCOHOLINACTIVE INGREDIENT532B59J990ORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
POVIDONESINACTIVE INGREDIENTFZ989GH94EORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
PROPYLENE GLYCOLINACTIVE INGREDIENT6DC9Q167V3ORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
SHELLACINACTIVE INGREDIENT46N107B71OORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
SODIUM LAURYL SULFATEINACTIVE INGREDIENT368GB5141JORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
TALCINACTIVE INGREDIENT7SEV7J4R1UORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
TITANIUM DIOXIDEINACTIVE INGREDIENT15FIX9V2JPORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
51167-809ORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED ORKAMBI (LUMACAFTOR AND IVACAFTOR) GRANULE [VERTEX PHARMACEUTICALS INCORPORATED]21Current NDC, Legacy NDC, 2 package rows20241222_3fc1c40e-cfac-47a1-9e1a-61ead3570600.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
ORKAMBILUMACAFTOR AND IVACAFTORVertex Pharmaceuticals Incorporated3fc1c40e-cfac-47a1-9e1a-61ead35706002026-03-24Warnings, Adverse reactionsExact identifier
application applno (NDA): 206038
application number: NDA206038
ndc (package): 51167-809-01
ndc (product): 51167-809
ndc11 (package): 51167080901

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
2053509ivacaftor 125 MG / lumacaftor 100 MG Oral GranulesPSN3fc1c40e-cfac-47a1-9e1a-61ead357060024
2053517ivacaftor 188 MG / lumacaftor 150 MG Oral GranulesPSN3fc1c40e-cfac-47a1-9e1a-61ead357060024
2611458ivacaftor 94 MG / lumacaftor 75 MG Oral GranulesPSN3fc1c40e-cfac-47a1-9e1a-61ead357060024
1812468lumacaftor 100 MG / ivacaftor 125 MG Oral TabletPSN3fc1c40e-cfac-47a1-9e1a-61ead357060024
1655928lumacaftor 200 MG / ivacaftor 125 MG Oral TabletPSN3fc1c40e-cfac-47a1-9e1a-61ead357060024
2053512ORKAMBI 100 MG / 125 MG Oral GranulesPSN3fc1c40e-cfac-47a1-9e1a-61ead357060024
1812470ORKAMBI 100 MG / 125 MG Oral TabletPSN3fc1c40e-cfac-47a1-9e1a-61ead357060024
2053519ORKAMBI 150 MG / 188 MG Oral GranulesPSN3fc1c40e-cfac-47a1-9e1a-61ead357060024
1655934ORKAMBI 200 MG / 125 MG Oral TabletPSN3fc1c40e-cfac-47a1-9e1a-61ead357060024
2611460ORKAMBI 94 MG / 75 MG Oral GranulesPSN3fc1c40e-cfac-47a1-9e1a-61ead357060024
2053512ivacaftor 125 MG / lumacaftor 100 MG Oral Granules [ORKAMBI]SBD3fc1c40e-cfac-47a1-9e1a-61ead357060024
1812470ivacaftor 125 MG / lumacaftor 100 MG Oral Tablet [ORKAMBI]SBD3fc1c40e-cfac-47a1-9e1a-61ead357060024
1655934ivacaftor 125 MG / lumacaftor 200 MG Oral Tablet [ORKAMBI]SBD3fc1c40e-cfac-47a1-9e1a-61ead357060024
2053519ivacaftor 188 MG / lumacaftor 150 MG Oral Granules [ORKAMBI]SBD3fc1c40e-cfac-47a1-9e1a-61ead357060024
2611460ivacaftor 94 MG / lumacaftor 75 MG Oral Granules [ORKAMBI]SBD3fc1c40e-cfac-47a1-9e1a-61ead357060024
2053509ivacaftor 125 MG / lumacaftor 100 MG Oral GranulesSCD3fc1c40e-cfac-47a1-9e1a-61ead357060024
1812468ivacaftor 125 MG / lumacaftor 100 MG Oral TabletSCD3fc1c40e-cfac-47a1-9e1a-61ead357060024
1655928ivacaftor 125 MG / lumacaftor 200 MG Oral TabletSCD3fc1c40e-cfac-47a1-9e1a-61ead357060024
2053517ivacaftor 188 MG / lumacaftor 150 MG Oral GranulesSCD3fc1c40e-cfac-47a1-9e1a-61ead357060024
2611458ivacaftor 94 MG / lumacaftor 75 MG Oral GranulesSCD3fc1c40e-cfac-47a1-9e1a-61ead357060024
2053512ORKAMBI (ivacaftor 125 MG / lumacaftor 100 MG) Oral GranulesSY3fc1c40e-cfac-47a1-9e1a-61ead357060024
2053519ORKAMBI (ivacaftor 188 MG / lumacaftor 150 MG) Oral GranulesSY3fc1c40e-cfac-47a1-9e1a-61ead357060024
2611460ORKAMBI (ivacaftor 94 MG / lumacaftor 75 MG) Oral GranulesSY3fc1c40e-cfac-47a1-9e1a-61ead357060024
1812470ORKAMBI (lumacaftor 100 MG / ivacaftor 125 MG) Oral TabletSY3fc1c40e-cfac-47a1-9e1a-61ead357060024
1655934ORKAMBI (lumacaftor 200 MG / ivacaftor 125 MG) Oral TabletSY3fc1c40e-cfac-47a1-9e1a-61ead357060024

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
51167-809-01511670809014 CARTON in 1 BOX (51167-809-01) / 7 BLISTER PACK in 1 CARTON / 4 TABLET, FILM COATED in 1 BLISTER PACK4 carton2015-07-020000-00-00NoNoCurrent