DOTTI

Product NDC
72162-2035
Requested package NDC
72162-2035-2
11-digit product format
721622035
Labeler code
72162
Product ID
72162-2035_1b1ed832-032e-405d-b3ef-cd88afac5210
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Estradiol
Dosage form
PATCH, EXTENDED RELEASE
Route
TRANSDERMAL
Labeler
Bryant Ranch Prepack
Application
ANDA211293
Marketing category
ANDA
Marketing start
2019-02-04
Substance
ESTRADIOL
Active strength
.075 mg/d
Pharmacologic classes
Estradiol Congeners [CS], Estrogen Receptor Agonists [MoA], Estrogen [EPC]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 43.

Orange Book products#

Current product rows page 1 of 1 · 5 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A211293-001ESTRADIOLESTRADIOL0.025MG/24HRSYSTEM / TRANSDERMALAB12019-02-04
A211293-002ESTRADIOLESTRADIOL0.0375MG/24HRSYSTEM / TRANSDERMALAB12019-02-04
A211293-003ESTRADIOLESTRADIOL0.05MG/24HRSYSTEM / TRANSDERMALAB12019-02-04
A211293-004ESTRADIOLESTRADIOL0.075MG/24HRSYSTEM / TRANSDERMALAB12019-02-04
A211293-005ESTRADIOLESTRADIOL0.1MG/24HRSYSTEM / TRANSDERMALAB12019-02-04

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 5 matching rows.

Application-product, TE code table
Application-productTE code
A211293-001AB1
A211293-002AB1
A211293-003AB1
A211293-004AB1
A211293-005AB1

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 6 · 215 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-09-14 22:38:342026-08A211293-001ESTRADIOL0.025MG/24HRSYSTEM / TRANSDERMALAB12019-02-0484e616aacf4f…
2026-09-14 22:38:342026-08A211293-002ESTRADIOL0.0375MG/24HRSYSTEM / TRANSDERMALAB12019-02-0484e616aacf4f…
2026-09-14 22:38:342026-08A211293-003ESTRADIOL0.05MG/24HRSYSTEM / TRANSDERMALAB12019-02-0484e616aacf4f…
2026-09-14 22:38:342026-08A211293-004ESTRADIOL0.075MG/24HRSYSTEM / TRANSDERMALAB12019-02-0484e616aacf4f…
2026-09-14 22:38:342026-08A211293-005ESTRADIOL0.1MG/24HRSYSTEM / TRANSDERMALAB12019-02-0484e616aacf4f…
2026-08-18 06:07:402026-07A211293-001ESTRADIOL0.025MG/24HRSYSTEM / TRANSDERMALAB12019-02-04caaa826d4ba7…
2026-08-18 06:07:402026-07A211293-002ESTRADIOL0.0375MG/24HRSYSTEM / TRANSDERMALAB12019-02-04caaa826d4ba7…
2026-08-18 06:07:402026-07A211293-003ESTRADIOL0.05MG/24HRSYSTEM / TRANSDERMALAB12019-02-04caaa826d4ba7…
2026-08-18 06:07:402026-07A211293-004ESTRADIOL0.075MG/24HRSYSTEM / TRANSDERMALAB12019-02-04caaa826d4ba7…
2026-08-18 06:07:402026-07A211293-005ESTRADIOL0.1MG/24HRSYSTEM / TRANSDERMALAB12019-02-04caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A211293-001ESTRADIOL0.025MG/24HRSYSTEM / TRANSDERMALAB12019-02-04011fe1cb6892…
2026-02-19 14:30 UTC2026-02A211293-002ESTRADIOL0.0375MG/24HRSYSTEM / TRANSDERMALAB12019-02-04011fe1cb6892…
2026-02-19 14:30 UTC2026-02A211293-003ESTRADIOL0.05MG/24HRSYSTEM / TRANSDERMALAB12019-02-04011fe1cb6892…
2026-02-19 14:30 UTC2026-02A211293-004ESTRADIOL0.075MG/24HRSYSTEM / TRANSDERMALAB12019-02-04011fe1cb6892…
2026-02-19 14:30 UTC2026-02A211293-005ESTRADIOL0.1MG/24HRSYSTEM / TRANSDERMALAB12019-02-04011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A211293-001ESTRADIOL0.025MG/24HRSYSTEM / TRANSDERMALAB12019-02-0431067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A211293-002ESTRADIOL0.0375MG/24HRSYSTEM / TRANSDERMALAB12019-02-0431067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A211293-003ESTRADIOL0.05MG/24HRSYSTEM / TRANSDERMALAB12019-02-0431067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A211293-004ESTRADIOL0.075MG/24HRSYSTEM / TRANSDERMALAB12019-02-0431067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A211293-005ESTRADIOL0.1MG/24HRSYSTEM / TRANSDERMALAB12019-02-0431067a03dcf5…
2025-08-23 18:47 UTC2025-08A211293-001ESTRADIOL0.025MG/24HRSYSTEM / TRANSDERMALAB12019-02-046a471c1ec25d…
2025-08-23 18:47 UTC2025-08A211293-002ESTRADIOL0.0375MG/24HRSYSTEM / TRANSDERMALAB12019-02-046a471c1ec25d…
2025-08-23 18:47 UTC2025-08A211293-003ESTRADIOL0.05MG/24HRSYSTEM / TRANSDERMALAB12019-02-046a471c1ec25d…
2025-08-23 18:47 UTC2025-08A211293-004ESTRADIOL0.075MG/24HRSYSTEM / TRANSDERMALAB12019-02-046a471c1ec25d…
2025-08-23 18:47 UTC2025-08A211293-005ESTRADIOL0.1MG/24HRSYSTEM / TRANSDERMALAB12019-02-046a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A211293-001ESTRADIOL0.025MG/24HRSYSTEM / TRANSDERMALAB12019-02-04fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A211293-002ESTRADIOL0.0375MG/24HRSYSTEM / TRANSDERMALAB12019-02-04fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A211293-003ESTRADIOL0.05MG/24HRSYSTEM / TRANSDERMALAB12019-02-04fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A211293-004ESTRADIOL0.075MG/24HRSYSTEM / TRANSDERMALAB12019-02-04fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A211293-005ESTRADIOL0.1MG/24HRSYSTEM / TRANSDERMALAB12019-02-04fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A211293-001ESTRADIOL0.025MG/24HRSYSTEM / TRANSDERMALAB12019-02-04b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A211293-002ESTRADIOL0.0375MG/24HRSYSTEM / TRANSDERMALAB12019-02-04b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A211293-003ESTRADIOL0.05MG/24HRSYSTEM / TRANSDERMALAB12019-02-04b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A211293-004ESTRADIOL0.075MG/24HRSYSTEM / TRANSDERMALAB12019-02-04b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A211293-005ESTRADIOL0.1MG/24HRSYSTEM / TRANSDERMALAB12019-02-04b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A211293-001ESTRADIOL0.025MG/24HRSYSTEM / TRANSDERMALAB12019-02-0403ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A211293-002ESTRADIOL0.0375MG/24HRSYSTEM / TRANSDERMALAB12019-02-0403ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A211293-003ESTRADIOL0.05MG/24HRSYSTEM / TRANSDERMALAB12019-02-0403ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A211293-004ESTRADIOL0.075MG/24HRSYSTEM / TRANSDERMALAB12019-02-0403ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A211293-005ESTRADIOL0.1MG/24HRSYSTEM / TRANSDERMALAB12019-02-0403ed91905a0d…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 6 · 215 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-09-14 22:38:342026-08A211293-001AB1184e616aacf4f…
2026-09-14 22:38:342026-08A211293-002AB1184e616aacf4f…
2026-09-14 22:38:342026-08A211293-003AB1184e616aacf4f…
2026-09-14 22:38:342026-08A211293-004AB1184e616aacf4f…
2026-09-14 22:38:342026-08A211293-005AB1184e616aacf4f…
2026-08-18 06:07:402026-07A211293-001AB11caaa826d4ba7…
2026-08-18 06:07:402026-07A211293-002AB11caaa826d4ba7…
2026-08-18 06:07:402026-07A211293-003AB11caaa826d4ba7…
2026-08-18 06:07:402026-07A211293-004AB11caaa826d4ba7…
2026-08-18 06:07:402026-07A211293-005AB11caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A211293-001AB11011fe1cb6892…
2026-02-19 14:30 UTC2026-02A211293-002AB11011fe1cb6892…
2026-02-19 14:30 UTC2026-02A211293-003AB11011fe1cb6892…
2026-02-19 14:30 UTC2026-02A211293-004AB11011fe1cb6892…
2026-02-19 14:30 UTC2026-02A211293-005AB11011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A211293-001AB1131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A211293-002AB1131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A211293-003AB1131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A211293-004AB1131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A211293-005AB1131067a03dcf5…
2025-08-23 18:47 UTC2025-08A211293-001AB116a471c1ec25d…
2025-08-23 18:47 UTC2025-08A211293-002AB116a471c1ec25d…
2025-08-23 18:47 UTC2025-08A211293-003AB116a471c1ec25d…
2025-08-23 18:47 UTC2025-08A211293-004AB116a471c1ec25d…
2025-08-23 18:47 UTC2025-08A211293-005AB116a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A211293-001AB11fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A211293-002AB11fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A211293-003AB11fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A211293-004AB11fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A211293-005AB11fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A211293-001AB11b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A211293-002AB11b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A211293-003AB11b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A211293-004AB11b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A211293-005AB11b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A211293-001AB1103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A211293-002AB1103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A211293-003AB1103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A211293-004AB1103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A211293-005AB1103ed91905a0d…

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

Additional Listing Data#

Finished product
Yes
Brand name base
DOTTI
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
ESTRADIOL.075 mg/d

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
4TI98Z838EInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1149632Internal RxNorm lookup
2110783Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
b119df4a-c514-4804-b1a8-b09c6058e80dAvailable on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
5bec24fd-caeb-8b32-1ff0-ca0dd1751379Product name220250618
3fcaf367-cbc2-4d1e-845e-e1ce4b0d86a6Product name220250616
4ca088c7-0c0e-114d-ffaa-d1b94f9eadc1Product name620250311
99d68ea7-fba4-0d7b-b5fa-468e21dd1cbfProduct name220250204
a1c50ef5-9c2c-d846-1ca1-70fabf2428e1Product name320240507
66263a7f-f64d-41c4-90f1-2cee106617ccProduct name120240501
76820076-f087-4073-b1d1-aa04b361335eProduct name220220921
132e7bcf-ca42-94e4-3c78-c44ae7819a94Product name320220126
0a040ba8-1f34-4328-bb07-4f64503daaabProduct name220210513
833edb59-a012-45c2-aff5-2ed74b66fa59Product name120201207
f4d31098-441e-52d3-27f1-49c829f8a3a1Product name520190703
001f367b-fa14-49a0-865b-b395f2553601Product name220190611
3f090665-4687-4bb4-8790-8efb1930ee74Product name120180801
7a549f52-8b99-472c-8b1d-3a70c53c9bf4Product name120160623
3ca8d96e-517a-05ea-5690-f8e1d3726540Product name120140508
5f44c957-835a-ada0-662f-5b1071b7a68bProduct name120140508
7d6c8f26-fe65-2465-c993-66dd6e1c1183Product name120140508
83cac4be-cfee-33c1-5b8e-bb83ae18bce4Product name120140508
c3f7be78-e6d7-47c9-c840-70c566e8d5c4Product name120140508
d6b36b6b-65d6-a810-0fa7-61ddf1a96352Product name120140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
72162-2035-2DOTTI8 in 1 CARTONPATCH, EXTENDED RELEASE8102
72162-2035-4DOTTI1 d in 1 POUCHPATCH, EXTENDED RELEASE1102

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
72162-2035-2EA - Each72162-203599be2de3-92f5-47d2-aa3d-dd3e615feb6412023-08-08

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
72162-2035DOTTI (ESTRADIOL) PATCH, EXTENDED RELEASE [BRYANT RANCH PREPACK]102Current NDC, 2 package rows20240830_b119df4a-c514-4804-b1a8-b09c6058e80d.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 7 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
DOTTIESTRADIOLBryant Ranch Prepack75fc6d3a-49b6-47ad-b704-410692010d3a2024-08-12Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 211293
application number: ANDA211293
DOTTIESTRADIOLBryant Ranch Prepackb119df4a-c514-4804-b1a8-b09c6058e80d2024-08-12Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 211293
application number: ANDA211293
ndc (package): 72162-2035-2
ndc (product): 72162-2035
ndc11 (package): 72162203502
DOTTIESTRADIOLBryant Ranch Prepackf419192a-eb95-4087-9fe0-0eea639ef51b2024-08-12Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 211293
application number: ANDA211293
DOTTIESTRADIOLBryant Ranch Prepack779751dc-243a-4dc2-ae67-3669f196b2052024-08-12Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 211293
application number: ANDA211293
DOTTIESTRADIOLBryant Ranch Prepack99b889a0-6200-4727-97d3-f5a0b7814e1b2024-07-17Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 211293
application number: ANDA211293
EstradiolESTRADIOLAmneal Pharmaceuticals NY LLC0500ee9b-bf4a-4432-9afe-20a7d60a6fe52024-05-14Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 211293
application number: ANDA211293
DOTTIESTRADIOLAmneal Pharmaceuticals LLC53016d30-6b5f-49da-ac16-85ef415a58052024-05-14Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 211293
application number: ANDA211293

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
2110783DOTTI 0.075 MG/Day Twice Weekly Transdermal SystemPSNb119df4a-c514-4804-b1a8-b09c6058e80d102
1149632estradiol 0.075 MG/Day Twice Weekly Transdermal SystemPSNb119df4a-c514-4804-b1a8-b09c6058e80d102
211078384 HR estradiol 0.00313 MG/HR Transdermal System [Dotti]SBDb119df4a-c514-4804-b1a8-b09c6058e80d102
114963284 HR estradiol 0.00313 MG/HR Transdermal SystemSCDb119df4a-c514-4804-b1a8-b09c6058e80d102
211078384 HR Dotti 0.00313 MG/HR Transdermal SystemSYb119df4a-c514-4804-b1a8-b09c6058e80d102
2110783Dotti 0.075 MG/24HR Twice Weekly Transdermal SystemSYb119df4a-c514-4804-b1a8-b09c6058e80d102
1149632estradiol 0.00313 MG/HR 84 HR Transdermal PatchSYb119df4a-c514-4804-b1a8-b09c6058e80d102
1149632estradiol 0.075 MG/Day Twice Weekly Transdermal SystemSYb119df4a-c514-4804-b1a8-b09c6058e80d102
1149632estradiol 75 MCG/Day Twice Weekly Transdermal PatchSYb119df4a-c514-4804-b1a8-b09c6058e80d102

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startSampleExclude flagStatus
72162-2035-2721622035028 POUCH in 1 CARTON (72162-2035-2) / 1 d in 1 POUCH (72162-2035-4) 8 pouch2019-02-04NoNoCurrent