Application 210166

Type
NDA
Sponsor
SHIRE DEV LLC

Application Products#

Product, Drug, Ingredient table
ProductDrugIngredientFormStrengthReference drugReference standard
001MOTEGRITYPRUCALOPRIDE SUCCINATETABLET;ORALEQ 1MG BASEYesNo
002MOTEGRITYPRUCALOPRIDE SUCCINATETABLET;ORALEQ 2MG BASEYesYes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 2 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
N210166-001MOTEGRITYPRUCALOPRIDE SUCCINATEEQ 1MG BASETABLET / ORALABRLD2018-12-14
N210166-002MOTEGRITYPRUCALOPRIDE SUCCINATEEQ 2MG BASETABLET / ORALABRLD, RS2018-12-14

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 2 matching rows.

Application-product, TE code table
Application-productTE code
N210166-001AB
N210166-002AB

Orange Book exclusivity#

Current exclusivity rows page 1 of 1 · 2 matching rows.

Application-product, Exclusivity code, Expiration table
Application-productExclusivity codeExpiration
N210166-001M-142028-07-10
N210166-002M-142028-07-10

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 3 · 82 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02N210166-001MOTEGRITYEQ 1MG BASETABLET / ORALABRLD2018-12-14011fe1cb6892…
2026-02-19 14:30 UTC2026-02N210166-002MOTEGRITYEQ 2MG BASETABLET / ORALABRLD, RS2018-12-14011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N210166-001MOTEGRITYEQ 1MG BASETABLET / ORALABRLD2018-12-1431067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N210166-002MOTEGRITYEQ 2MG BASETABLET / ORALABRLD, RS2018-12-1431067a03dcf5…
2025-08-23 18:47 UTC2025-08N210166-001MOTEGRITYEQ 1MG BASETABLET / ORALABRLD2018-12-146a471c1ec25d…
2025-08-23 18:47 UTC2025-08N210166-002MOTEGRITYEQ 2MG BASETABLET / ORALABRLD, RS2018-12-146a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N210166-001MOTEGRITYEQ 1MG BASETABLET / ORALABRLD2018-12-14fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N210166-002MOTEGRITYEQ 2MG BASETABLET / ORALABRLD, RS2018-12-14fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N210166-001MOTEGRITYEQ 1MG BASETABLET / ORALABRLD2018-12-14b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N210166-002MOTEGRITYEQ 2MG BASETABLET / ORALABRLD, RS2018-12-14b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N210166-001MOTEGRITYEQ 1MG BASETABLET / ORALABRLD2018-12-1403ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N210166-002MOTEGRITYEQ 2MG BASETABLET / ORALABRLD, RS2018-12-1403ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N210166-001MOTEGRITYEQ 1MG BASETABLET / ORALRLD2018-12-142680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N210166-002MOTEGRITYEQ 2MG BASETABLET / ORALRLD, RS2018-12-142680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N210166-001MOTEGRITYEQ 1MG BASETABLET / ORALRLD2018-12-145bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N210166-002MOTEGRITYEQ 2MG BASETABLET / ORALRLD, RS2018-12-145bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N210166-001MOTEGRITYEQ 1MG BASETABLET / ORALRLD2018-12-14d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N210166-002MOTEGRITYEQ 2MG BASETABLET / ORALRLD, RS2018-12-14d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N210166-001MOTEGRITYEQ 1MG BASETABLET / ORALRLD2018-12-14d06236e962d9…
2024-10-29 15:01 UTC2024-10N210166-002MOTEGRITYEQ 2MG BASETABLET / ORALRLD, RS2018-12-14d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N210166-001MOTEGRITYEQ 1MG BASETABLET / ORALRLD2018-12-1479d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N210166-002MOTEGRITYEQ 2MG BASETABLET / ORALRLD, RS2018-12-1479d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N210166-001MOTEGRITYEQ 1MG BASETABLET / ORALRLD2018-12-14301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N210166-002MOTEGRITYEQ 2MG BASETABLET / ORALRLD, RS2018-12-14301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N210166-001MOTEGRITYEQ 1MG BASETABLET / ORALRLD2018-12-141e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N210166-002MOTEGRITYEQ 2MG BASETABLET / ORALRLD, RS2018-12-141e350fbaab3a…
2024-05-31 18:47 UTC2024-05N210166-001MOTEGRITYEQ 1MG BASETABLET / ORALRLD2018-12-148072bd15b7f6…
2024-05-31 18:47 UTC2024-05N210166-002MOTEGRITYEQ 2MG BASETABLET / ORALRLD, RS2018-12-148072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N210166-001MOTEGRITYEQ 1MG BASETABLET / ORALRLD2018-12-145c6f7cd8ea54…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N210166-002MOTEGRITYEQ 2MG BASETABLET / ORALRLD, RS2018-12-145c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04N210166-001MOTEGRITYEQ 1MG BASETABLET / ORALRLD2018-12-145d02ea3f76ae…
2022-04-08 23:34 UTC2022-04N210166-002MOTEGRITYEQ 2MG BASETABLET / ORALRLD, RS2018-12-145d02ea3f76ae…
2022-04-04 05:41 UTC2022-04N210166-001MOTEGRITYEQ 1MG BASETABLET / ORALRLD2018-12-144b0b4de00fa7…
2022-04-04 05:41 UTC2022-04N210166-002MOTEGRITYEQ 2MG BASETABLET / ORALRLD, RS2018-12-144b0b4de00fa7…
2019-12-13 00:20 UTC2019-12N210166-001MOTEGRITYEQ 1MG BASETABLET / ORALRLD2018-12-1474a2ff9319b5…
2019-12-13 00:20 UTC2019-12N210166-002MOTEGRITYEQ 2MG BASETABLET / ORALRLD, RS2018-12-1474a2ff9319b5…
2022-03-09 01:35 UTC2022-03N210166-001MOTEGRITYEQ 1MG BASETABLET / ORALRLD2018-12-14bb7c543d1eb4…
2022-03-09 01:35 UTC2022-03N210166-002MOTEGRITYEQ 2MG BASETABLET / ORALRLD, RS2018-12-14bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12N210166-001MOTEGRITYEQ 1MG BASETABLET / ORALRLD2018-12-14782e0a99824c…
2021-12-28 21:50 UTC2021-12N210166-002MOTEGRITYEQ 2MG BASETABLET / ORALRLD, RS2018-12-14782e0a99824c…

Observed Orange Book normalized TE history#

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02N210166-001AB1011fe1cb6892…
2026-02-19 14:30 UTC2026-02N210166-002AB1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N210166-001AB131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N210166-002AB131067a03dcf5…
2025-08-23 18:47 UTC2025-08N210166-001AB16a471c1ec25d…
2025-08-23 18:47 UTC2025-08N210166-002AB16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N210166-001AB1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N210166-002AB1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N210166-001AB1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N210166-002AB1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N210166-001AB103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N210166-002AB103ed91905a0d…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06N210166-001AB1a50c72e98297…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06N210166-002AB1a50c72e98297…

Observed Orange Book exclusivity history#

Exclusivity history page 1 of 2 · 54 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productExclusivity codeExpirationSource SHA-256
2026-02-19 14:30 UTC2026-02N210166-001M-142028-07-10011fe1cb6892…
2026-02-19 14:30 UTC2026-02N210166-002M-142028-07-10011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N210166-001M-142028-07-1031067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N210166-002M-142028-07-1031067a03dcf5…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N210166-001NCE2023-12-145c6f7cd8ea54…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N210166-002NCE2023-12-145c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04N210166-001NCE2023-12-145d02ea3f76ae…
2022-04-08 23:34 UTC2022-04N210166-002NCE2023-12-145d02ea3f76ae…
2022-04-04 05:41 UTC2022-04N210166-001NCE2023-12-144b0b4de00fa7…
2022-04-04 05:41 UTC2022-04N210166-002NCE2023-12-144b0b4de00fa7…
2019-12-13 00:20 UTC2019-12N210166-001NCE2023-12-1474a2ff9319b5…
2019-12-13 00:20 UTC2019-12N210166-002NCE2023-12-1474a2ff9319b5…
2022-03-09 01:35 UTC2022-03N210166-001NCE2023-12-14bb7c543d1eb4…
2022-03-09 01:35 UTC2022-03N210166-002NCE2023-12-14bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12N210166-001NCE2023-12-14782e0a99824c…
2021-12-28 21:50 UTC2021-12N210166-002NCE2023-12-14782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N210166-001NCE2023-12-1487673890dc5c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N210166-002NCE2023-12-1487673890dc5c…
2021-03-12 10:30 UTC2021-03N210166-001NCE2023-12-145aa47cf7b7d7…
2021-03-12 10:30 UTC2021-03N210166-002NCE2023-12-145aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12N210166-001NCE2023-12-148869cabd3fbd…
2020-12-22 03:56 UTC2020-12N210166-002NCE2023-12-148869cabd3fbd…
2020-11-12 02:37 UTC2020-11N210166-001NCE2023-12-14c0c555d07b60…
2020-11-12 02:37 UTC2020-11N210166-002NCE2023-12-14c0c555d07b60…
2019-12-14 00:12 UTC2019-12N210166-001NCE2023-12-143f01610625f2…
2019-12-14 00:12 UTC2019-12N210166-002NCE2023-12-143f01610625f2…
2019-09-15 20:21 UTC2019-09N210166-001NCE2023-12-14b00525d2431f…
2019-09-15 20:21 UTC2019-09N210166-002NCE2023-12-14b00525d2431f…
2019-07-19 19:46 UTC2019-07N210166-001NCE2023-12-14ea99ee380514…
2019-07-19 19:46 UTC2019-07N210166-002NCE2023-12-14ea99ee380514…
2023-12-20 04:57 UTC2023-12N210166-001NCE2023-12-14ea1830bbd6c7…
2023-12-20 04:57 UTC2023-12N210166-002NCE2023-12-14ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11N210166-001NCE2023-12-14a72a2bbeb626…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11N210166-002NCE2023-12-14a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10N210166-001NCE2023-12-149b2671bbb829…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10N210166-002NCE2023-12-149b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07N210166-001NCE2023-12-14a67488948f0b…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07N210166-002NCE2023-12-14a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06N210166-001NCE2023-12-143f0d92c62455…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06N210166-002NCE2023-12-143f0d92c62455…

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
MOTEGRITYPRUCALOPRIDETakeda Pharmaceuticals America, Inc.bca1e4c6-4b2b-4876-8ab3-654629c4ff1b2025-07-17Warnings, Adverse reactionsExact identifier
application applno (NDA): 210166
application number: NDA210166
ndc (product): 54092-547
ndc (product): 54092-546

NDC Listings For This Application#

NDC listings for this application page 1 of 1 · 14 matching rows.

NDC, Name, Nonproprietary name table
NDCNameNonproprietary nameLabelerMarketing categoryStatus
54092-546MOTEGRITYPRUCALOPRIDETakeda Pharmaceuticals America, Inc.NDACurrent
54092-546MOTEGRITYPRUCALOPRIDETakeda Pharmaceuticals America, Inc.NDACurrent
54092-546MOTEGRITYPRUCALOPRIDEShire US Manufacturing Inc.NDACurrent
54092-546MOTEGRITYPRUCALOPRIDETakeda Pharmaceuticals America, Inc.NDACurrent
54092-546MOTEGRITYPRUCALOPRIDETakeda Pharmaceuticals America, Inc.NDACurrent
54092-546MOTEGRITYPRUCALOPRIDETakeda Pharmaceuticals America, Inc.NDACurrent
54092-546MOTEGRITYPRUCALOPRIDEShire US Manufacturing Inc.NDACurrent
54092-547MOTEGRITYPRUCALOPRIDETakeda Pharmaceuticals America, Inc.NDACurrent
54092-547MOTEGRITYPRUCALOPRIDETakeda Pharmaceuticals America, Inc.NDACurrent
54092-547MOTEGRITYPRUCALOPRIDEShire US Manufacturing Inc.NDACurrent
54092-547MOTEGRITYPRUCALOPRIDETakeda Pharmaceuticals America, Inc.NDACurrent
54092-547MOTEGRITYPRUCALOPRIDETakeda Pharmaceuticals America, Inc.NDACurrent
54092-547MOTEGRITYPRUCALOPRIDETakeda Pharmaceuticals America, Inc.NDACurrent
54092-547MOTEGRITYPRUCALOPRIDEShire US Manufacturing Inc.NDACurrent

Documents#

Document, Submission type, Date table
DocumentSubmission typeDate
82816SUPPL 2025-07-11
82786SUPPL 2025-07-11
65195SUPPL2020-11-12
65181SUPPL2020-11-10
57043ORIG2018-12-28
56890ORIG2018-12-20
56744ORIG2018-12-14