Home Applications 211358 Application 211358
Type NDA
Sponsor VERTEX PHARMS INC Application Products# Product, Drug, Ingredient table Product Drug Ingredient Form Strength Reference drug Reference standard 001 ORKAMBI IVACAFTOR; LUMACAFTOR GRANULE;ORAL 125MG/PACKET;100MG/PACKET Yes No 002 ORKAMBI IVACAFTOR; LUMACAFTOR GRANULE;ORAL 188MG/PACKET;150MG/PACKET Yes Yes 003 ORKAMBI IVACAFTOR; LUMACAFTOR GRANULE;ORAL 94MG/PACKET;75MG/PACKET Yes No
Source provenance: Browse the complete Orange Book source catalog · source snapshot 42 .
Orange Book products# Current product rows page 1 of 1 · 3 matching rows.
Application-product, Trade name, Ingredient table Application-product Trade name Ingredient Strength Dosage form / route TE codes RLD / RS Approval date N211358-001 ORKAMBI IVACAFTOR; LUMACAFTOR 125MG/PACKET;100MG/PACKET GRANULE / ORAL RLD 2018-08-07 N211358-002 ORKAMBI IVACAFTOR; LUMACAFTOR 188MG/PACKET;150MG/PACKET GRANULE / ORAL RLD, RS 2018-08-07 N211358-003 ORKAMBI IVACAFTOR; LUMACAFTOR 94MG/PACKET;75MG/PACKET GRANULE / ORAL RLD 2022-09-02
Orange Book patents# Current patent rows page 1 of 2 · 126 matching rows.
Application-product, Patent, Expiration table Application-product Patent Expiration Use code Coverage / status Submission date N211358-001 7973038 2026-11-08 U-2374 2018-09-06 N211358-001 8741933 2026-11-08 U-2374 2018-09-06 N211358-001 9216969 2026-11-08 Drug product 2018-09-06 N211358-001 8410274 2026-12-28 Drug product 2018-09-06 N211358-001 8754224 2026-12-28 Drug substance, Drug product 2018-09-06 N211358-001 9670163 2026-12-28 U-2376 Drug product 2018-09-06 N211358-001 9931334 2026-12-28 U-2376 Drug product 2018-09-06 N211358-001 7973038*PED 2027-05-08 Pediatric extension N211358-001 8741933*PED 2027-05-08 Pediatric extension N211358-001 9216969*PED 2027-05-08 Pediatric extension N211358-001 7495103 2027-05-20 Drug substance, Drug product 2018-09-06 N211358-001 8410274*PED 2027-06-28 Pediatric extension N211358-001 8754224*PED 2027-06-28 Pediatric extension N211358-001 9670163*PED 2027-06-28 Pediatric extension N211358-001 9931334*PED 2027-06-28 Pediatric extension N211358-001 8324242 2027-08-05 U-2374 2018-09-06 N211358-001 7495103*PED 2027-11-20 Pediatric extension N211358-001 8324242*PED 2028-02-05 Pediatric extension N211358-001 10597384 2028-12-04 U-2778 Drug substance, Drug product 2020-04-23 N211358-001 12065432 2028-12-04 U-3983 2024-09-18 N211358-001 8653103 2028-12-04 Drug product 2018-09-06 N211358-001 9150552 2028-12-04 U-2375 2018-09-06 N211358-001 10597384*PED 2029-06-04 Pediatric extension N211358-001 12065432*PED 2029-06-04 Pediatric extension N211358-001 8653103*PED 2029-06-04 Pediatric extension N211358-001 9150552*PED 2029-06-04 Pediatric extension N211358-001 8846718 2029-07-02 U-2375 2018-09-06 N211358-001 10646481 2029-08-13 Drug product 2020-06-11 N211358-001 11564916 2029-08-13 U-3526 2023-02-28 N211358-001 12458635 2029-08-13 U-4335 Drug product 2025-11-26 N211358-001 9192606 2029-09-29 U-2397 Drug product 2018-09-06 N211358-001 8846718*PED 2030-01-02 Pediatric extension N211358-001 10646481*PED 2030-02-13 Pediatric extension N211358-001 11564916*PED 2030-02-13 Pediatric extension N211358-001 12458635*PED 2030-02-13 Pediatric extension N211358-001 9192606*PED 2030-03-29 Pediatric extension N211358-001 8507534 2030-09-20 Drug substance, Drug product 2018-09-06 N211358-001 8716338 2030-09-20 U-2396 Drug product 2018-09-06 N211358-001 8993600 2030-12-11 Drug product 2018-09-06 N211358-001 8507534*PED 2031-03-20 Pediatric extension N211358-001 8716338*PED 2031-03-20 Pediatric extension N211358-001 8993600*PED 2031-06-11 Pediatric extension N211358-002 7973038 2026-11-08 U-2374 2018-09-06 N211358-002 8741933 2026-11-08 U-2374 2018-09-06 N211358-002 9216969 2026-11-08 Drug product 2018-09-06 N211358-002 8410274 2026-12-28 Drug product 2018-09-06 N211358-002 8754224 2026-12-28 Drug substance, Drug product 2018-09-06 N211358-002 9670163 2026-12-28 U-2376 Drug product 2018-09-06 N211358-002 9931334 2026-12-28 U-2376 Drug product 2018-09-06 N211358-002 7973038*PED 2027-05-08 Pediatric extension N211358-002 8741933*PED 2027-05-08 Pediatric extension N211358-002 9216969*PED 2027-05-08 Pediatric extension N211358-002 7495103 2027-05-20 Drug substance, Drug product 2018-09-06 N211358-002 8410274*PED 2027-06-28 Pediatric extension N211358-002 8754224*PED 2027-06-28 Pediatric extension N211358-002 9670163*PED 2027-06-28 Pediatric extension N211358-002 9931334*PED 2027-06-28 Pediatric extension N211358-002 8324242 2027-08-05 U-2374 2018-09-06 N211358-002 7495103*PED 2027-11-20 Pediatric extension N211358-002 8324242*PED 2028-02-05 Pediatric extension N211358-002 10597384 2028-12-04 U-2778 Drug substance, Drug product 2020-04-23 N211358-002 12065432 2028-12-04 U-3983 2024-09-18 N211358-002 8653103 2028-12-04 Drug product 2018-09-06 N211358-002 9150552 2028-12-04 U-2375 2018-09-06 N211358-002 10597384*PED 2029-06-04 Pediatric extension N211358-002 12065432*PED 2029-06-04 Pediatric extension N211358-002 8653103*PED 2029-06-04 Pediatric extension N211358-002 9150552*PED 2029-06-04 Pediatric extension N211358-002 8846718 2029-07-02 U-2375 2018-09-06 N211358-002 10646481 2029-08-13 Drug product 2020-06-11 N211358-002 11564916 2029-08-13 U-3526 2023-02-28 N211358-002 12458635 2029-08-13 U-4335 Drug product 2025-11-26 N211358-002 9192606 2029-09-29 U-2397 Drug product 2018-09-06 N211358-002 8846718*PED 2030-01-02 Pediatric extension N211358-002 10646481*PED 2030-02-13 Pediatric extension N211358-002 11564916*PED 2030-02-13 Pediatric extension N211358-002 12458635*PED 2030-02-13 Pediatric extension N211358-002 9192606*PED 2030-03-29 Pediatric extension N211358-002 8507534 2030-09-20 Drug substance, Drug product 2018-09-06 N211358-002 8716338 2030-09-20 U-2396 Drug product 2018-09-06
Orange Book exclusivity# Current exclusivity rows page 1 of 1 · 12 matching rows.
Observed Orange Book product history# Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.
Product history page 1 of 3 · 111 observed states.
Captured, Edition, Application-product table Captured Edition Application-product Trade name Strength Dosage form / route Product TE source text RLD / RS Approval date Source SHA-256 2026-08-18 06:07:40 2026-07 N211358-001 ORKAMBI 125MG/PACKET;100MG/PACKET GRANULE / ORAL RLD 2018-08-07 caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-002 ORKAMBI 188MG/PACKET;150MG/PACKET GRANULE / ORAL RLD, RS 2018-08-07 caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-003 ORKAMBI 94MG/PACKET;75MG/PACKET GRANULE / ORAL RLD 2022-09-02 caaa826d4ba7…2026-02-19 14:30 UTC 2026-02 N211358-001 ORKAMBI 125MG/PACKET;100MG/PACKET GRANULE / ORAL RLD 2018-08-07 011fe1cb6892…2026-02-19 14:30 UTC 2026-02 N211358-002 ORKAMBI 188MG/PACKET;150MG/PACKET GRANULE / ORAL RLD, RS 2018-08-07 011fe1cb6892…2026-02-19 14:30 UTC 2026-02 N211358-003 ORKAMBI 94MG/PACKET;75MG/PACKET GRANULE / ORAL RLD 2022-09-02 011fe1cb6892…2025-12-14 10:44 UTC · 2 captures of this ZIP 2025-12 N211358-001 ORKAMBI 125MG/PACKET;100MG/PACKET GRANULE / ORAL RLD 2018-08-07 31067a03dcf5…2025-12-14 10:44 UTC · 2 captures of this ZIP 2025-12 N211358-002 ORKAMBI 188MG/PACKET;150MG/PACKET GRANULE / ORAL RLD, RS 2018-08-07 31067a03dcf5…2025-12-14 10:44 UTC · 2 captures of this ZIP 2025-12 N211358-003 ORKAMBI 94MG/PACKET;75MG/PACKET GRANULE / ORAL RLD 2022-09-02 31067a03dcf5…2025-08-23 18:47 UTC 2025-08 N211358-001 ORKAMBI 125MG/PACKET;100MG/PACKET GRANULE / ORAL RLD 2018-08-07 6a471c1ec25d…2025-08-23 18:47 UTC 2025-08 N211358-002 ORKAMBI 188MG/PACKET;150MG/PACKET GRANULE / ORAL RLD, RS 2018-08-07 6a471c1ec25d…2025-08-23 18:47 UTC 2025-08 N211358-003 ORKAMBI 94MG/PACKET;75MG/PACKET GRANULE / ORAL RLD 2022-09-02 6a471c1ec25d…2025-03-22 03:13 UTC · 3 captures of this ZIP 2025-03 N211358-001 ORKAMBI 125MG/PACKET;100MG/PACKET GRANULE / ORAL RLD 2018-08-07 fd3edfee7708…2025-03-22 03:13 UTC · 3 captures of this ZIP 2025-03 N211358-002 ORKAMBI 188MG/PACKET;150MG/PACKET GRANULE / ORAL RLD, RS 2018-08-07 fd3edfee7708…2025-03-22 03:13 UTC · 3 captures of this ZIP 2025-03 N211358-003 ORKAMBI 94MG/PACKET;75MG/PACKET GRANULE / ORAL RLD 2022-09-02 fd3edfee7708…2025-02-26 10:13 UTC · 3 captures of this ZIP 2025-02 N211358-001 ORKAMBI 125MG/PACKET;100MG/PACKET GRANULE / ORAL RLD 2018-08-07 b8a1b40f171c…2025-02-26 10:13 UTC · 3 captures of this ZIP 2025-02 N211358-002 ORKAMBI 188MG/PACKET;150MG/PACKET GRANULE / ORAL RLD, RS 2018-08-07 b8a1b40f171c…2025-02-26 10:13 UTC · 3 captures of this ZIP 2025-02 N211358-003 ORKAMBI 94MG/PACKET;75MG/PACKET GRANULE / ORAL RLD 2022-09-02 b8a1b40f171c…2025-01-19 17:59 UTC · 7 captures of this ZIP 2025-01 N211358-001 ORKAMBI 125MG/PACKET;100MG/PACKET GRANULE / ORAL RLD 2018-08-07 03ed91905a0d…2025-01-19 17:59 UTC · 7 captures of this ZIP 2025-01 N211358-002 ORKAMBI 188MG/PACKET;150MG/PACKET GRANULE / ORAL RLD, RS 2018-08-07 03ed91905a0d…2025-01-19 17:59 UTC · 7 captures of this ZIP 2025-01 N211358-003 ORKAMBI 94MG/PACKET;75MG/PACKET GRANULE / ORAL RLD 2022-09-02 03ed91905a0d…2024-12-13 21:23 UTC · 2 captures of this ZIP 2024-12 N211358-001 ORKAMBI 125MG/PACKET;100MG/PACKET GRANULE / ORAL RLD 2018-08-07 2680178bc6a6…2024-12-13 21:23 UTC · 2 captures of this ZIP 2024-12 N211358-002 ORKAMBI 188MG/PACKET;150MG/PACKET GRANULE / ORAL RLD, RS 2018-08-07 2680178bc6a6…2024-12-13 21:23 UTC · 2 captures of this ZIP 2024-12 N211358-003 ORKAMBI 94MG/PACKET;75MG/PACKET GRANULE / ORAL RLD 2022-09-02 2680178bc6a6…2024-09-14 05:58 UTC · 2 captures of this ZIP 2024-09 N211358-001 ORKAMBI 125MG/PACKET;100MG/PACKET GRANULE / ORAL RLD 2018-08-07 5bbf6a4d5a75…2024-09-14 05:58 UTC · 2 captures of this ZIP 2024-09 N211358-002 ORKAMBI 188MG/PACKET;150MG/PACKET GRANULE / ORAL RLD, RS 2018-08-07 5bbf6a4d5a75…2024-09-14 05:58 UTC · 2 captures of this ZIP 2024-09 N211358-003 ORKAMBI 94MG/PACKET;75MG/PACKET GRANULE / ORAL RLD 2022-09-02 5bbf6a4d5a75…2024-11-08 22:44 UTC · 3 captures of this ZIP 2024-11 N211358-001 ORKAMBI 125MG/PACKET;100MG/PACKET GRANULE / ORAL RLD 2018-08-07 d8e5a09893c0…2024-11-08 22:44 UTC · 3 captures of this ZIP 2024-11 N211358-002 ORKAMBI 188MG/PACKET;150MG/PACKET GRANULE / ORAL RLD, RS 2018-08-07 d8e5a09893c0…2024-11-08 22:44 UTC · 3 captures of this ZIP 2024-11 N211358-003 ORKAMBI 94MG/PACKET;75MG/PACKET GRANULE / ORAL RLD 2022-09-02 d8e5a09893c0…2024-10-29 15:01 UTC 2024-10 N211358-001 ORKAMBI 125MG/PACKET;100MG/PACKET GRANULE / ORAL RLD 2018-08-07 d06236e962d9…2024-10-29 15:01 UTC 2024-10 N211358-002 ORKAMBI 188MG/PACKET;150MG/PACKET GRANULE / ORAL RLD, RS 2018-08-07 d06236e962d9…2024-10-29 15:01 UTC 2024-10 N211358-003 ORKAMBI 94MG/PACKET;75MG/PACKET GRANULE / ORAL RLD 2022-09-02 d06236e962d9…2024-08-13 05:28 UTC · 3 captures of this ZIP 2024-08 N211358-001 ORKAMBI 125MG/PACKET;100MG/PACKET GRANULE / ORAL RLD 2018-08-07 79d66fd596c7…2024-08-13 05:28 UTC · 3 captures of this ZIP 2024-08 N211358-002 ORKAMBI 188MG/PACKET;150MG/PACKET GRANULE / ORAL RLD, RS 2018-08-07 79d66fd596c7…2024-08-13 05:28 UTC · 3 captures of this ZIP 2024-08 N211358-003 ORKAMBI 94MG/PACKET;75MG/PACKET GRANULE / ORAL RLD 2022-09-02 79d66fd596c7…2024-07-13 05:37 UTC · 2 captures of this ZIP 2024-07 N211358-001 ORKAMBI 125MG/PACKET;100MG/PACKET GRANULE / ORAL RLD 2018-08-07 301d65b070ca…2024-07-13 05:37 UTC · 2 captures of this ZIP 2024-07 N211358-002 ORKAMBI 188MG/PACKET;150MG/PACKET GRANULE / ORAL RLD, RS 2018-08-07 301d65b070ca…2024-07-13 05:37 UTC · 2 captures of this ZIP 2024-07 N211358-003 ORKAMBI 94MG/PACKET;75MG/PACKET GRANULE / ORAL RLD 2022-09-02 301d65b070ca…2024-06-18 03:08 UTC · 5 captures of this ZIP 2024-06 N211358-001 ORKAMBI 125MG/PACKET;100MG/PACKET GRANULE / ORAL RLD 2018-08-07 1e350fbaab3a…
Observed Orange Book patent history# Patent history page 1 of 62 · 2,471 observed states.
Captured, Edition, Application-product table Captured Edition Application-product Patent Expiration Use code Coverage / status Submission date Source SHA-256 2026-08-18 06:07:40 2026-07 N211358-001 7973038 2026-11-08 U-2374 2018-09-06 caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 8741933 2026-11-08 U-2374 2018-09-06 caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 9216969 2026-11-08 Drug product 2018-09-06 caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 8410274 2026-12-28 Drug product 2018-09-06 caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 8754224 2026-12-28 Drug substance, Drug product 2018-09-06 caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 9670163 2026-12-28 U-2376 Drug product 2018-09-06 caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 9931334 2026-12-28 U-2376 Drug product 2018-09-06 caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 7973038*PED 2027-05-08 Pediatric extension caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 8741933*PED 2027-05-08 Pediatric extension caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 9216969*PED 2027-05-08 Pediatric extension caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 7495103 2027-05-20 Drug substance, Drug product 2018-09-06 caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 8410274*PED 2027-06-28 Pediatric extension caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 8754224*PED 2027-06-28 Pediatric extension caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 9670163*PED 2027-06-28 Pediatric extension caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 9931334*PED 2027-06-28 Pediatric extension caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 8324242 2027-08-05 U-2374 2018-09-06 caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 7495103*PED 2027-11-20 Pediatric extension caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 8324242*PED 2028-02-05 Pediatric extension caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 10597384 2028-12-04 U-2778 Drug substance, Drug product 2020-04-23 caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 12065432 2028-12-04 U-3983 2024-09-18 caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 8653103 2028-12-04 Drug product 2018-09-06 caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 9150552 2028-12-04 U-2375 2018-09-06 caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 10597384*PED 2029-06-04 Pediatric extension caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 12065432*PED 2029-06-04 Pediatric extension caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 8653103*PED 2029-06-04 Pediatric extension caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 9150552*PED 2029-06-04 Pediatric extension caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 8846718 2029-07-02 U-2375 2018-09-06 caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 10646481 2029-08-13 Drug product 2020-06-11 caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 11564916 2029-08-13 U-3526 2023-02-28 caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 12458635 2029-08-13 U-4335 Drug product 2025-11-26 caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 9192606 2029-09-29 U-2397 Drug product 2018-09-06 caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 8846718*PED 2030-01-02 Pediatric extension caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 10646481*PED 2030-02-13 Pediatric extension caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 11564916*PED 2030-02-13 Pediatric extension caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 12458635*PED 2030-02-13 Pediatric extension caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 9192606*PED 2030-03-29 Pediatric extension caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 8507534 2030-09-20 Drug substance, Drug product 2018-09-06 caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 8716338 2030-09-20 U-2396 Drug product 2018-09-06 caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 8993600 2030-12-11 Drug product 2018-09-06 caaa826d4ba7…2026-08-18 06:07:40 2026-07 N211358-001 8507534*PED 2031-03-20 Pediatric extension caaa826d4ba7…
Observed Orange Book exclusivity history# Exclusivity history page 1 of 8 · 309 observed states.
openFDA label cross-check# OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.
Matched openFDA labels page 1 of 1 · 1 matching rows.
NDC Listings For This Application# NDC listings for this application page 1 of 1 · 14 matching rows.
NDC, Name, Nonproprietary name table NDC Name Nonproprietary name Labeler Marketing category Status 51167-122 ORKAMBI lumacaftor and ivacaftor Vertex Pharmaceuticals Incorporated NDA Current 51167-122 ORKAMBI lumacaftor and ivacaftor Vertex Pharmaceuticals Incorporated NDA Current 51167-500 ORKAMBI lumacaftor and ivacaftor Vertex Pharmaceuticals Incorporated NDA Current 51167-500 ORKAMBI lumacaftor and ivacaftor Vertex Pharmaceuticals Incorporated NDA Current 51167-500 ORKAMBI lumacaftor and ivacaftor Vertex Pharmaceuticals Incorporated NDA Current 51167-500 ORKAMBI lumacaftor and ivacaftor Vertex Pharmaceuticals Incorporated NDA Current 51167-500 ORKAMBI lumacaftor and ivacaftor Vertex Pharmaceuticals Incorporated NDA Current 51167-500 ORKAMBI lumacaftor and ivacaftor Vertex Pharmaceuticals Incorporated NDA Current 51167-900 ORKAMBI lumacaftor and ivacaftor Vertex Pharmaceuticals Incorporated NDA Current 51167-900 ORKAMBI lumacaftor and ivacaftor Vertex Pharmaceuticals Incorporated NDA Current 51167-900 ORKAMBI lumacaftor and ivacaftor Vertex Pharmaceuticals Incorporated NDA Current 51167-900 ORKAMBI lumacaftor and ivacaftor Vertex Pharmaceuticals Incorporated NDA Current 51167-900 ORKAMBI lumacaftor and ivacaftor Vertex Pharmaceuticals Incorporated NDA Current 51167-900 ORKAMBI lumacaftor and ivacaftor Vertex Pharmaceuticals Incorporated NDA Current
Documents# Document, Submission type, Date table Document Submission type Date 85476 SUPPL 2026-03-24 85412 SUPPL 2026-03-19 83565 SUPPL 2025-09-26 83553 SUPPL 2025-09-26 80596 SUPPL 2024-12-16 80595 SUPPL 2024-12-16 80581 SUPPL 2024-12-16 74995 SUPPL 2023-08-04 74988 SUPPL 2023-08-04 72035 SUPPL 2022-09-07 72018 SUPPL 2022-09-06 55155 ORIG 2018-08-10 55142 ORIG 2018-08-09 58157 ORIG 2018-08-07