Home NDC 0023-4491 REFRESH OPTIVE Advanced
Product NDC 0023-4491
11-digit product format 000234491
Labeler code 0023
Product ID 0023-4491_74f3d119-623c-4bd1-a5aa-e92db774f116
Type HUMAN OTC DRUG
Nonproprietary name carboxymethylcellulose sodium, glycerin, polysorbate 80
Dosage form SOLUTION/ DROPS
Route OPHTHALMIC
Labeler Allergan, Inc.
Application M018
Marketing category OTC MONOGRAPH DRUG
Marketing start 2013-01-15
Substance CARBOXYMETHYLCELLULOSE SODIUM; GLYCERIN; POLYSORBATE 80
Active strength 5; 10; 5 mg/mL; mg/mL; mg/mL
Pharmacologic classes Allergens [CS], Cell-mediated Immunity [PE], Glycerol [CS], Increased Histamine Release [PE], Increased IgG Production [PE], Non-Standardized Chemical Allergen [EPC]
NDC exclude flag No
Listing certified through 2026-12-31
Current FDA listing Yes Observed NDC auxiliary status history# This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.
Historic NDC status page 1 of 1 · 2 matching rows.
View current auxiliary records. · View the auxiliary file history.
Captured / source date, Dataset, Scope table Captured / source date Dataset Scope Product NDC Package NDC Code Status Reporting period Archive Snapshot Source SHA-256 2024-11-09 02:27 UTC · source 2024-11-08 excluded package package 0023-4491 0023-4491-05 D Discontinued by firm excluded / ndc_excluded.zip ad56d346431e…cc804d4bbf1e…2024-10-04 04:10 UTC · source 2024-10-03 excluded package package 0023-4491 0023-4491-05 D Discontinued by firm excluded / ndc_excluded.zip 367a005e9d99…383a685ebd0f…
Reported adverse events (FAERS/openFDA)# Adverse event summaries are temporarily unavailable. Other product information remains available.
Additional Listing Data#
Finished product Yes
Brand name base REFRESH OPTIVE Advanced
Listing expiration 2026-12-31 Active Ingredients# Ingredient, Strength table Ingredient Strength CARBOXYMETHYLCELLULOSE SODIUM 5 mg/mL GLYCERIN 10 mg/mL POLYSORBATE 80 5 mg/mL
Harmonized UNII identifiers# UNII identifiers page 1 of 1 · 3 matching rows.
Identifier, FDA.report destination table Identifier FDA.report destination K679OBS311 Internal UNII lookup PDC6A3C0OX Internal UNII lookup 6OZP39ZG8H Internal UNII lookup
Harmonized RxCUI identifiers# RxCUI identifiers page 1 of 1 · 1 matching rows.
Identifier, FDA.report destination table Identifier FDA.report destination 1241471 Internal RxNorm lookup
Harmonized SPL set identifiers# SPL set identifiers page 1 of 1 · 1 matching rows.
DailyMed Product Concepts# DailyMed Package Descriptions# Package NDC, Product, Description table Package NDC Product Description Form Quantity Strength SPL version 0023-4491-05 REFRESH OPTIVE Advanced 0.4 mL in 1 VIAL, SINGLE-USE SOLUTION/ DROPS 0.4 11 0023-4491-05 REFRESH OPTIVE Advanced 5 in 1 CARTON SOLUTION/ DROPS 5 11 0023-4491-30 REFRESH OPTIVE Advanced 30 in 1 CARTON SOLUTION/ DROPS 30 11 0023-4491-30 REFRESH OPTIVE Advanced 0.4 mL in 1 VIAL, SINGLE-USE SOLUTION/ DROPS 0.4 11
DailyMed Socrata Ingredients# Ingredient, Type, UNII table Ingredient Type UNII DailyMed label SPL version Uploaded carboxymethylcellulose sodium ACTIVE INGREDIENT K679OBS311 REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.] 2 glycerin ACTIVE INGREDIENT PDC6A3C0OX REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.] 2 polysorbate 80 ACTIVE INGREDIENT 6OZP39ZG8H REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.] 2 carboxymethylcellulose ACTIVE MOIETY 05JZI7B19X REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.] 2 glycerin ACTIVE MOIETY PDC6A3C0OX REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.] 2 polysorbate 80 ACTIVE MOIETY 6OZP39ZG8H REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.] 2 boric acid INACTIVE INGREDIENT R57ZHV85D4 REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.] 2 carbomer copolymer type A INACTIVE INGREDIENT 71DD5V995L REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.] 2 castor oil INACTIVE INGREDIENT D5340Y2I9G REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.] 2 erythritol INACTIVE INGREDIENT RA96B954X6 REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.] 2 levocarnitine INACTIVE INGREDIENT 0G389FZZ9M REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.] 2 sodium hydroxide INACTIVE INGREDIENT 55X04QC32I REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.] 2 water INACTIVE INGREDIENT 059QF0KO0R REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.] 2
DailyMed Dashboard NDC Coverage# NDC, Dashboard title, SPL version table NDC Dashboard title SPL version Validation Dashboard ZIP 0023-4491 REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.] 10 Current NDC, Legacy NDC, 4 package rows 20241207_ebd0839e-2e1d-4e0e-986c-19f1f5c76358.zip
openFDA label cross-check# OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.
Matched openFDA labels page 4 of 25 · 494 matching rows.
Brand, Generic, Manufacturer table Brand Generic Manufacturer SPL set ID Effective date Available safety fields Join SODIUM CHLORIDE 1 GRAM SODIUM CHLORIDE Gendose Pharmaceuticals, LLC ce988ae5-61c6-4324-90e1-a94c8a54d0d0 2026-04-13 Warnings Exact identifier application number: M018 Artificial Tears Lubricant Eye Drops GLYCERIN, PROPYLENE GLYCOL CVS Pharmacy 28297fee-8185-4869-8f39-5bfbf8bf8bfd 2026-04-13 Warnings Exact identifier application number: M018 blink boost GLYCERIN Bausch & Lomb Incorporated e765c224-1718-488f-99b2-976eb60c1d63 2026-04-13 Warnings Exact identifier application number: M018 Retaine Ultra PF POLYETHYLENE GLYCOL OCuSOFT LLC a5aaaf06-772d-44d3-8601-f978ddc48ad7 2026-04-13 Warnings Exact identifier application number: M018 Exovisse Preservative-Free Artificial Tears LUBRICANT EYE GEL DROPS YD BIO USA, INC. 4f20191a-9124-2525-e063-6294a90a8428 2026-04-10 Warnings Exact identifier application number: M018 WE FRESH Lubricating Eye Drops GLYCERIN Oculus Surgical, Inc. 4f253b5d-001b-091e-e063-6394a90a9d39 2026-04-09 Warnings Exact identifier application number: M018 FreshKote Preservative Free Lubricant Eye Drops POVIDONE, POLYVINYL ALCOHOL Eyevance Pharmaceuticals f51c50c3-43ae-4169-9d2b-22b239461dd1 2026-04-08 Warnings Exact identifier application number: M018 Walgreens Sodium Chloride Ophthalmic 5 Percent Hypertonicity Eye SODIUM CHLORIDE Walgreen Company bda3b9db-5fc4-408c-a5ae-d1eeb3ee308d 2026-04-06 Warnings Exact identifier application number: M018 LensMate Preservative-Free Artificial Tears LUBRICANT EYE DROPS YD BIO USA, INC. 4ebacb2b-9b2d-6bc1-e063-6294a90a3426 2026-04-05 Warnings Exact identifier application number: M018 Exovisse Preservative-Free Artificial Tears LUBRICANT EYE GEL DROPS YD BIO USA, INC. 4ebc154b-128b-9dde-e063-6294a90ae00e 2026-04-05 Warnings Exact identifier application number: M018 Sodium Chloride Ophthalmic 5 Percent Hypertonicity Eye SODIUM CHLORIDE Hanlim 4ee80e16-1bb1-8238-e063-6294a90aa719 2026-04-04 Warnings Exact identifier application number: M018 Redness Relief GLYCERIN, NAPHAZOLINE HCL Pharmadel LLC 4c113bb9-814f-d92d-e063-6294a90a8302 2026-03-30 Warnings Exact identifier application number: M018 Moisture Oyster GLYCERIN Moisture Oyster Inc 4e45317a-437f-4d88-e063-6294a90a98d0 2026-03-30 Warnings Exact identifier application number: M018 Crocodile Tears Lubricant Eye Drops GLYCERIN, HYPROMELLOSE, POLYETHYLENE GLYCOL 400 Crocodile Tears LLC 4df29336-ea0c-0484-e063-6294a90a685a 2026-03-26 Warnings Exact identifier application number: M018 Artificial Tears Lubricant Eye Drops GLYCERIN, HYPROMELLOSE, POLYETHYLENE GLYCOL 400 KC Pharmaceuticals, Inc 4de5c844-85ca-ff9f-e063-6394a90ac12c 2026-03-25 Warnings Exact identifier application number: M018 NOVEHA NIGHTTIME WHITE PETROLATUM Bullet Point LLC 4da24578-e98b-8ce1-e063-6294a90a8bf6 2026-03-24 Warnings Exact identifier application number: M018 BLINK TRIPLE CARE POLYETHYLENE GLYCOL 400 Bausch & Lomb Incorporated a2b34eb0-001b-4f42-a8cc-c2a0150fafcc 2026-03-20 Warnings Exact identifier application number: M018 SODIUM CHLORIDE HYPERTONICITY SODIUM CHLORIDE YYBA CORP 439653b9-99b8-4799-8d67-4a2ada9c6783 2026-03-20 Warnings Exact identifier application number: M018 Altachlore Sodium Chloride Hypertonicity Ophthalmic 5 Percent SODIUM CHLORIDE Altaire Pharmaceuticals Inc. e13fd053-9420-490c-a43e-e14b0930cb4e 2026-03-18 Warnings Exact identifier application number: M018 Lubricant Eye Drops CARBOXYMETHYLCELLULOSE SODIUM KC Pharmaceuticals, Inc. 4d1d9b3a-ac5f-db27-e063-6294a90afc3f 2026-03-16 Warnings Exact identifier application number: M018
DailyMed RxNorm Mappings# Packages# Package NDC, 11-digit format, Description table Package NDC 11-digit format Description Marketing start Marketing end Sample Exclude flag Status 0023-4491-05 00023449105 5 VIAL, SINGLE-USE in 1 CARTON (0023-4491-05) / .4 mL in 1 VIAL, SINGLE-USE 2013-01-15 0000-00-00 Yes No Current 0023-4491-30 00023449130 30 VIAL, SINGLE-USE in 1 CARTON (0023-4491-30) / .4 mL in 1 VIAL, SINGLE-USE 2013-01-15 0000-00-00 No No Current