aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG Effervescent Oral Tablet [Alka-Seltzer]
- RxCUI
- 1536680
- RxNorm name
- aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG Effervescent Oral Tablet [Alka-Seltzer]
- Display name
- ALKA-SELTZER (Effervescent)
- Full name
- aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG Effervescent Oral Tablet [Alka-Seltzer]
- Term type
- SBD
- Status
- Active
- Strength
- 325-1,000-1,916 mg
- Dose form
- Tab
- Route
- Effervescent
- Updated
- 2026-09-14 22:58:22
RxNorm Status History#
- Status
- Active
- Source
- RXNORM
- Current
- YES
- Release start
- 062014
- Active start
- 062014
- Multiple ingredient
- YES
- Branded
- YES
Ingredients And Strength#
| Ingredient | Strength | Base | Basis of strength |
|---|---|---|---|
| aspirin | 325 MG / 1 EACH | aspirin | aspirin |
| citric acid | 1000 MG / 1 EACH | citric acid | citric acid |
| sodium bicarbonate | 1916 MG / 1 EACH | sodium bicarbonate | sodium bicarbonate |
Dose Form Concepts#
| Dose form | RxCUI |
|---|---|
| Effervescent Oral Tablet | 1535727 |
Derived Ingredient Concepts#
| Ingredient | RxCUI |
|---|---|
| aspirin | 1191 |
| citric acid | 21183 |
| sodium bicarbonate | 36676 |
Source Vocabulary Codes#
| Code type | Values | Count | Category |
|---|---|---|---|
| PRESCRIBABLE | Y | 1 | ATTRIBUTES |
| RXNAV_STR | ASA 325 MG / Citric Acid 1000 MG / NaHCO3 1916 MG Effervescent Oral Tablet [Alka-Seltzer] | 1 | NAMES |
| RxNorm Name | aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG Effervescent Oral Tablet [Alka-Seltzer] | 1 | NAMES |
| RxNorm Synonym | 2 | NAMES | |
| TTY | SBD | 1 | ATTRIBUTES |
| SPL_SET_ID | 5 | CODES | |
| RxCUI | 1536680 | 1 | CODES |
| MMSL_CODE | BD4500 | 1 | CODES |
FDA NDC Products And Packages#
| Package NDC | Product NDC | Name | Labeler | Application |
|---|---|---|---|---|
| 0280-4000-01 | 0280-4000 | Alka-Seltzer Original ANHYDROUS CITRIC ACID, ASPIRIN, and SODIUM BICARBONATE | Bayer HealthCare LLC. | M013 |
| 0280-4000-02 | 0280-4000 | Alka-Seltzer Original ANHYDROUS CITRIC ACID, ASPIRIN, and SODIUM BICARBONATE | Bayer HealthCare LLC. | M013 |
| 0280-4000-03 | 0280-4000 | Alka-Seltzer Original ANHYDROUS CITRIC ACID, ASPIRIN, and SODIUM BICARBONATE | Bayer HealthCare LLC. | M013 |
| 0280-4000-04 | 0280-4000 | Alka-Seltzer Original ANHYDROUS CITRIC ACID, ASPIRIN, and SODIUM BICARBONATE | Bayer HealthCare LLC. | M013 |
| 0280-4000-05 | 0280-4000 | Alka-Seltzer Original ANHYDROUS CITRIC ACID, ASPIRIN, and SODIUM BICARBONATE | Bayer HealthCare LLC. | M013 |
| 0280-4000-06 | 0280-4000 | Alka-Seltzer Original ANHYDROUS CITRIC ACID, ASPIRIN, and SODIUM BICARBONATE | Bayer HealthCare LLC. | M013 |
| 0280-4000-07 | 0280-4000 | Alka-Seltzer Original ANHYDROUS CITRIC ACID, ASPIRIN, and SODIUM BICARBONATE | Bayer HealthCare LLC. | M013 |
| 50269-307-06 | 50269-307 | Alka Seltzer Originial 1s Blister Pack ANHYDROUS CITRIC ACID, ASPIRIN, and SODIUM BICARBONATE | JC World Bell Wholesale Co., Inc. | M013 |
| 70264-014-01 | 70264-014 | Alka-Seltzer Original ANHYDROUS CITRIC ACID, ASPIRIN, and SODIUM BICARBONATE | R J General Corporation | M013 |
| 85237-1829-1 | 85237-1829 | Alka-Seltzer Original ANHYDROUS CITRIC ACID, ASPIRIN, and SODIUM BICARBONATE | Select Consumer Group | M013 |
Drugs@FDA Applications#
UNII Substances#
No records found.
openFDA label cross-check#
OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.
| Brand | Generic | Manufacturer | SPL set ID | Effective date | Available safety fields | Join |
|---|---|---|---|---|---|---|
| Alka-Seltzer Original | ANHYDROUS CITRIC ACID, ASPIRIN, AND SODIUM BICARBONATE | Select Consumer Group | 3ca80d74-1e8b-49d9-e063-6394a90a4312 | 2026-05-24 | Warnings | 85237-1829-1 85237-1829 85237182907 85237182901 85237182903 85237182906 85237182900 85237182902 85237182904 1536680 |
| Alka-Seltzer Original | ANHYDROUS CITRIC ACID, ASPIRIN, AND SODIUM BICARBONATE | Bayer HealthCare LLC. | 5be36a7f-7d1f-468d-9c29-92c8cd3ef1bc | 2025-12-04 | Warnings | 0280-4000-06 0280-4000-02 0280-4000-05 0280-4000-03 0280-4000-01 0280-4000-07 0280-4000-04 0280-4000 00280400004 00280400006 00280400007 00280400003 00280400002 00280400001 00280400005 1536680 |
| Alka-Seltzer Original | ANHYDROUS CITRIC ACID, ASPIRIN, AND SODIUM BICARBONATE | R J General Corporation | dbb0d067-71f0-45e4-bc98-548cf4a90b3a | 2025-11-17 | Warnings | 70264-014-01 70264-014 70264001401 1536680 |
DailyMed RxNorm Mappings#
| Set ID | RxNorm mappings | Terms | SPL version | Label | Effective |
|---|---|---|---|---|---|
| 5be36a7f-7d1f-468d-9c29-92c8cd3ef1bc | Alka-Seltzer 325 MG / 1000 MG / 1916 MG Effervescent Oral Tablet [PSN] · aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG Effervescent Oral Tablet [Alka-Seltzer] [SBD] · Alka-Seltzer (aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG) Effervescent Oral Tablet [SY] · ASA 325 MG / Citric Acid 1000 MG / NaHCO3 1916 MG Effervescent Oral Tablet [Alka-Seltzer] [SY] | 4 | 11 | Alka-Seltzer ® Original | 20251204 |
| dbb0d067-71f0-45e4-bc98-548cf4a90b3a | Alka-Seltzer 325 MG / 1000 MG / 1916 MG Effervescent Oral Tablet [PSN] · aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG Effervescent Oral Tablet [Alka-Seltzer] [SBD] · Alka-Seltzer (aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG) Effervescent Oral Tablet [SY] · ASA 325 MG / Citric Acid 1000 MG / NaHCO3 1916 MG Effervescent Oral Tablet [Alka-Seltzer] [SY] | 4 | 6 | Alka-Seltzer ® Original | 20251117 |
| 8876a416-6a8d-466f-932a-dddf673c32be | Alka-Seltzer 325 MG / 1000 MG / 1916 MG Effervescent Oral Tablet [PSN] · aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG Effervescent Oral Tablet [Alka-Seltzer] [SBD] · Alka-Seltzer (aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG) Effervescent Oral Tablet [SY] · ASA 325 MG / Citric Acid 1000 MG / NaHCO3 1916 MG Effervescent Oral Tablet [Alka-Seltzer] [SY] | 4 | 3 | Alka Seltzer Originial 1s Blister Pack | 20231105 |
| 73e85be6-1236-453b-b41c-37381a054773 | Alka-Seltzer 325 MG / 1000 MG / 1916 MG Effervescent Oral Tablet [PSN] · aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG Effervescent Oral Tablet [Alka-Seltzer] [SBD] · Alka-Seltzer (aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG) Effervescent Oral Tablet [SY] · ASA 325 MG / Citric Acid 1000 MG / NaHCO3 1916 MG Effervescent Oral Tablet [Alka-Seltzer] [SY] | 4 | 3 | Alka Seltzer | 20121109 |
| 4feee16b-43be-bb71-e063-6394a90af959 | Alka-Seltzer 325 MG / 1000 MG / 1916 MG Effervescent Oral Tablet [PSN] · aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG Effervescent Oral Tablet [Alka-Seltzer] [SBD] · Alka-Seltzer (aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG) Effervescent Oral Tablet [SY] · ASA 325 MG / Citric Acid 1000 MG / NaHCO3 1916 MG Effervescent Oral Tablet [Alka-Seltzer] [SY] | 4 | 1 | SurviveX Travel Med Kit | 20260507 |
| 3ca80d74-1e8b-49d9-e063-6394a90a4312 | Alka-Seltzer 325 MG / 1000 MG / 1916 MG Effervescent Oral Tablet [PSN] · aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG Effervescent Oral Tablet [Alka-Seltzer] [SBD] · Alka-Seltzer (aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG) Effervescent Oral Tablet [SY] · ASA 325 MG / Citric Acid 1000 MG / NaHCO3 1916 MG Effervescent Oral Tablet [Alka-Seltzer] [SY] | 4 | 1 | Alka-Seltzer ® Original | 20250818 |
| 973da92c-a2d9-e173-e053-2995a90a0455 | Alka-Seltzer 325 MG / 1000 MG / 1916 MG Effervescent Oral Tablet [PSN] · aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG Effervescent Oral Tablet [Alka-Seltzer] [SBD] · Alka-Seltzer (aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG) Effervescent Oral Tablet [SY] · ASA 325 MG / Citric Acid 1000 MG / NaHCO3 1916 MG Effervescent Oral Tablet [Alka-Seltzer] [SY] | 4 | 1 | Bitterfeld Alka-Seltzer Original | 20191113 |
| 8d334678-2fda-75c5-e053-2a95a90ae344 | Alka-Seltzer 325 MG / 1000 MG / 1916 MG Effervescent Oral Tablet [PSN] · aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG Effervescent Oral Tablet [Alka-Seltzer] [SBD] · Alka-Seltzer (aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG) Effervescent Oral Tablet [SY] · ASA 325 MG / Citric Acid 1000 MG / NaHCO3 1916 MG Effervescent Oral Tablet [Alka-Seltzer] [SY] | 4 | 1 | Alka Seltzer Original | 20190708 |
| 3b37ab81-2717-4afd-8f66-89a7bed1140e | Alka-Seltzer 325 MG / 1000 MG / 1916 MG Effervescent Oral Tablet [PSN] · aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG Effervescent Oral Tablet [Alka-Seltzer] [SBD] · Alka-Seltzer (aspirin 325 MG / citric acid 1000 MG / sodium bicarbonate 1916 MG) Effervescent Oral Tablet [SY] · ASA 325 MG / Citric Acid 1000 MG / NaHCO3 1916 MG Effervescent Oral Tablet [Alka-Seltzer] [SY] | 4 | 1 | Alka-Seltzer ® Original | 20160314 |
Recently Linked DailyMed Labels#
| Set ID | Title | Manufacturer | Effective |
|---|---|---|---|
| 3ca80d74-1e8b-49d9-e063-6394a90a4312 | Alka-Seltzer ® Original | Select Consumer Group | 20260524 |
| 5be36a7f-7d1f-468d-9c29-92c8cd3ef1bc | Alka-Seltzer ® Original | Bayer HealthCare LLC. | 20251204 |
| dbb0d067-71f0-45e4-bc98-548cf4a90b3a | Alka-Seltzer ® Original | R J General Corporation | 20251117 |
| 3ca80d74-1e8b-49d9-e063-6394a90a4312 | Alka-Seltzer ® Original | Select Consumer Group | 20250818 |
| fbfa46b6-1773-4053-b323-66f4321d6472 | Alka-Seltzer ® | Lil' Drug Store Products, Inc | 20231215 |
| da6b52eb-694a-fa8e-e053-2a95a90aaa18 | Alka-Seltzer ® | Lil' Drug Store Products, Inc. | 20231214 |
| f05a1c0a-58ef-3810-e053-2a95a90a82ec | Alka Seltzer Original Flavor | Lil' Drug Store Products, Inc. | 20231206 |
| 8876a416-6a8d-466f-932a-dddf673c32be | Alka Seltzer Originial 1s Blister Pack | JC World Bell Wholesale Co., Inc. | Bayer HealthCare LLC | 20231105 |
| fbf52eee-b307-4640-8f90-909bebe54a42 | Alka Seltzer Original | Navajo Manufacturing Company Inc. | 20230301 |
| 973da92c-a2d9-e173-e053-2995a90a0455 | Bitterfeld Alka-Seltzer Original | Bayer Bitterfeld GMBH | 20191113 |
| 8d334678-2fda-75c5-e053-2a95a90ae344 | Alka Seltzer Original | Savings Distributors LLC | 20190708 |
| 3b37ab81-2717-4afd-8f66-89a7bed1140e | Alka-Seltzer ® Original | Your Safety Company | 20160314 |
| 73e85be6-1236-453b-b41c-37381a054773 | Alka Seltzer | Salimex, S.A. | Bayer de Mexico, S.A. de CV | 20121109 |
Drug Classes#
| Source | Class ID | Class | Type | Relationship | Drug concept |
|---|---|---|---|---|---|
| ATC | A09AB | Acid preparations | ATC1-4 | citric acid | |
| ATC | B05XA | Electrolyte solutions | ATC1-4 | sodium bicarbonate | |
| ATC | A01AD | Other agents for local oral treatment | ATC1-4 | aspirin | |
| ATC | B01AC | Platelet aggregation inhibitors excl. heparin | ATC1-4 | aspirin | |
| ATC | N02BA | Salicylic acid and derivatives | ATC1-4 | aspirin | |
| ATC | B05CB | Salt solutions | ATC1-4 | sodium bicarbonate | |
| FDASPL | N0000175722 | Nonsteroidal Anti-inflammatory Drug | EPC | has_epc | aspirin |
| FDASPL | N0000175578 | Platelet Aggregation Inhibitor | EPC | has_epc | aspirin |
| MEDRT | D001241 | Aspirin | CHEM | has_ingredient | aspirin |
| MEDRT | D019343 | Citric Acid | CHEM | has_ingredient | citric acid |
| MEDRT | D017693 | Sodium Bicarbonate | CHEM | has_ingredient | sodium bicarbonate |
| MEDRT | D000141 | Acidosis, Renal Tubular | DISEASE | may_treat | sodium bicarbonate |
| MEDRT | D000141 | Acidosis, Renal Tubular | DISEASE | may_treat | citric acid |
| MEDRT | D000224 | Addison Disease | DISEASE | ci_with | citric acid |
| MEDRT | D000471 | Alkalosis | DISEASE | ci_with | sodium bicarbonate |
| MEDRT | D001002 | Anuria | DISEASE | ci_with | citric acid |
| MEDRT | D001172 | Arthritis, Rheumatoid | DISEASE | may_treat | aspirin |
| MEDRT | D001778 | Blood Coagulation Disorders | DISEASE | ci_with | aspirin |
| MEDRT | D001791 | Blood Platelet Disorders | DISEASE | ci_with | aspirin |
| MEDRT | D002544 | Cerebral Infarction | DISEASE | may_prevent | aspirin |
| MEDRT | D002644 | Chickenpox | DISEASE | ci_with | aspirin |
| MEDRT | D002675 | Child, Preschool | DISEASE | ci_with | aspirin |
| MEDRT | D003681 | Dehydration | DISEASE | ci_with | citric acid |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | sodium bicarbonate |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | aspirin |
| MEDRT | D004342 | Drug Hypersensitivity | DISEASE | ci_with | citric acid |
| MEDRT | D062787 | Drug Overdose | DISEASE | may_treat | sodium bicarbonate |
| MEDRT | D064420 | Drug-Related Side Effects and Adverse Reactions | DISEASE | may_prevent | sodium bicarbonate |
| MEDRT | D004415 | Dyspepsia | DISEASE | may_treat | sodium bicarbonate |
| MEDRT | D004487 | Edema | DISEASE | ci_with | sodium bicarbonate |
| MEDRT | D005334 | Fever | DISEASE | may_treat | aspirin |
| MEDRT | D005764 | Gastroesophageal Reflux | DISEASE | may_treat | sodium bicarbonate |
| MEDRT | D006073 | Gout | DISEASE | may_treat | aspirin |
| MEDRT | D006323 | Heart Arrest | DISEASE | may_treat | sodium bicarbonate |
| MEDRT | D006356 | Heartburn | DISEASE | may_treat | sodium bicarbonate |
| MEDRT | D006396 | Hematemesis | DISEASE | ci_with | aspirin |
| MEDRT | D006474 | Hemorrhagic Disorders | DISEASE | ci_with | aspirin |
| MEDRT | D006947 | Hyperkalemia | DISEASE | may_treat | sodium bicarbonate |
| MEDRT | D006947 | Hyperkalemia | DISEASE | ci_with | citric acid |
| MEDRT | D006955 | Hypernatremia | DISEASE | ci_with | sodium bicarbonate |
| MEDRT | D006996 | Hypocalcemia | DISEASE | ci_with | sodium bicarbonate |
| MEDRT | D007223 | Infant | DISEASE | ci_with | aspirin |
| MEDRT | D007249 | Inflammation | DISEASE | may_treat | aspirin |
| MEDRT | D002546 | Ischemic Attack, Transient | DISEASE | may_prevent | aspirin |
| MEDRT | D008551 | Melena | DISEASE | ci_with | aspirin |
| MEDRT | D009203 | Myocardial Infarction | DISEASE | may_prevent | aspirin |
| MEDRT | D009298 | Nasal Polyps | DISEASE | ci_with | aspirin |
| MEDRT | D010003 | Osteoarthritis | DISEASE | may_treat | aspirin |
| MEDRT | D010146 | Pain | DISEASE | may_prevent | aspirin |
| MEDRT | D010146 | Pain | DISEASE | may_treat | aspirin |
| MEDRT | D011225 | Pre-Eclampsia | DISEASE | may_prevent | aspirin |
| MEDRT | D011263 | Pregnancy Trimester, Third | DISEASE | ci_with | aspirin |
| MEDRT | D011654 | Pulmonary Edema | DISEASE | ci_with | sodium bicarbonate |
| MEDRT | D051437 | Renal Insufficiency | DISEASE | ci_with | citric acid |
| MEDRT | D012213 | Rheumatic Fever | DISEASE | may_treat | aspirin |
| MEDRT | D014555 | Urination Disorders | DISEASE | may_treat | citric acid |
| MEDRT | N0000000226 | Acid-Base Activity | MOA | has_moa | sodium bicarbonate |
| MEDRT | N0000000236 | Alkylating Activity | MOA | has_moa | citric acid |
| MEDRT | N0000000160 | Cyclooxygenase Inhibitors | MOA | has_moa | aspirin |
| MEDRT | N0000000220 | Electrolyte Activity | MOA | has_moa | sodium bicarbonate |
| MEDRT | N0000008831 | Decreased Platelet Activating Factor Production | PE | has_pe | aspirin |
| MEDRT | N0000008832 | Decreased Platelet Aggregation | PE | has_pe | aspirin |
| MEDRT | N0000008836 | Decreased Prostaglandin Production | PE | has_pe | aspirin |
| MEDRT | N0000009006 | Decreased Thromboxane Production | PE | has_pe | aspirin |
| MEDRT | N0000009054 | Gastric Acid Alteration | PE | has_pe | sodium bicarbonate |
| MEDRT | N0000009549 | Increased Renal HCO3- Excretion | PE | has_pe | citric acid |
| MEDRT | N0000009549 | Increased Renal HCO3- Excretion | PE | has_pe | sodium bicarbonate |
| MEDRT | N0000000026 | Hepatic Metabolism | PK | has_pk | aspirin |
| MEDRT | N0000000042 | Renal Excretion | PK | has_pk | aspirin |
Properties#
| Category | Property | Value |
|---|---|---|
| ATTRIBUTES | AVAILABLE_STRENGTH | 325 MG / 1000 MG / 1916 MG |
| ATTRIBUTES | GENERAL_CARDINALITY | MULTI |
| ATTRIBUTES | HUMAN_DRUG | US |
| ATTRIBUTES | RXNAV_HUMAN_DRUG | US |
| ATTRIBUTES | SCHEDULE | 0 |
| NAMES | Prescribable Synonym | Alka-Seltzer 325 MG / 1000 MG / 1916 MG Effervescent Oral Tablet |
| SOURCES | Source | Gold Standard Alchemy |
| SOURCES | Source | Metathesaurus FDA Structured Product Labels |
| SOURCES | Source | Micromedex RED BOOK |
| SOURCES | Source | Multum MediSource Lexicon |